Diabetes care Exam: Quiz!

20 Questions | By Worldheartdayaay | Last updated: Mar 21, 2022 | Total Attempts: 235

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1.

The United Kingdom Prospective Diabetes Study (UKPDS) showed that intensive therapy (mean A1C value of 7%) with OHAs of insulin resulted in a decreased risk of microvascular complications compared with conventional therapy with diet (mean A1C value of 7.9%) at the end of the study 1997. According to UKPDS 0.9% reduction in A1C at 10 years was associated with a ___ reduction in microvascular endpoints.
- A.
  
  5%
- B.
  
  15%
- C.
  
  25%
- D.
  
  35%
2.

According to a meta-analysis of intensive glucose-lowering trials, the benefit of different interventions with 5-year treatment, which of the following results in better reduction of CV events?
- A.
  
  Reduction of systolic BP (4 mmHg)
- B.
  
  Reduction of HbA1C (0.9%)
- C.
  
  Reduction of LDL cholesterol (38.6 mg/dL)
- D.
  
  All of the above
3.

In elderly long-standing diabetes with comorbidities the HBA1C goal is
- A.
  
  6-6.5%
- B.
  
  6.5-7%
- C.
  
  7-7.5%
- D.
  
  7.5-8%
4.

According to East-West Study:
- A.
  
  Patients with DM but no CHD experience a higher rate of MI as patients without DM but with CHD
- B.
  
  Patients with DM but no CHD experience a lower rate of MI as patients without DM but with CHD
- C.
  
  Patients with DM but no CHD experience a similar rate of MI as patients without DM but with CHD
5.

According to ADA guidelines diagnostic criteria for diabetes by HbA1C
- A.
  
  Diabetes is diagnosed if HbA1c ≥ 6% in at least 2 measurements
- B.
  
  Diabetes is diagnosed if HbA1c ≥ 6.5% in at least 2 measurements
- C.
  
  Diabetes is diagnosed if HbA1c ≥ 7% in at least 2 measurements
- D.
  
  Diabetes is diagnosed if HbA1c ≥ 7.5% in at least 2 measurements
6.

A 50-year-old man with a history of myocardial infarction has new-onset type 2 diabetes with HbA1C 8%. You are considering drug treatment, the first drug to be considered is
- A.
  
  Metformin
- B.
  
  Gliptins
- C.
  
  SGLT2 inhibitor
- D.
  
  GLP-1 agonists
7.

According to ADA all of the following are the criteria for the diagnosis of diabetes except
- A.
  
  FPG ≥ 110 mg/dL
- B.
  
  HbA1C ≥ 6.5%
- C.
  
  2-h PG ≥ 200 mg/dL
- D.
  
  Classical symptoms of hyperglycemia and random PG ≥ 200 mg/dL
8.

According to ADA guidelines, the following combination of drugs is not recommended in the treatment of T2D.
- A.
  
  DPP-4 inhibitors and GLP-1 agonists
- B.
  
  GLP-1 agonists and SGLT2 inhibitors
- C.
  
  SGLT2 inhibitors and TZDs
- D.
  
  DPP-4 inhibitors and TZDs
9.

The following drugs have shown cardiovascular benefits by decreasing MACE
- A.
  
  Metformin and insulin
- B.
  
  DPP4 inhibitors and Metformin
- C.
  
  SGLT2 inhibitors and GLP-1 agonists
- D.
  
  SGLT2 inhibitors and long acting GLP-1 agonists
10.

The following drugs are not to be used in T2D patients with CHF.
- A.
  
  GLP1 agonists and SGLT2i
- B.
  
  α-glucosidase inhibitors and Linagliptin
- C.
  
  Linagliptin and Dapagliflozin
- D.
  
  TZDs and Saxagliptin
11.

One of the following drugs has shown benefit in cardiovascular outcomes in CHF in patients with and without T2DM?
- A.
  
  Liraglutide
- B.
  
  Empagliflozin
- C.
  
  Metformin
- D.
  
  Dapagliflozin
12.

Hypoglycemia is more common with the following drug/drugs.
- A.
  
  Dapagliflozin
- B.
  
  Linagliptin
- C.
  
  Glimepride
- D.
  
  2&3
- E.
  
  All of the above
13.

Which of the following drugs has shown significant cardiovascular benefit in T2D with high CVD risk?
- A.
  
  Empagliflozin
- B.
  
  Dapagliflozin
- C.
  
  Sitagliptin
- D.
  
  Insulin
14.

Which of the following drugs can be used in patients with CKD (eGFR < 30ml/min)
- A.
  
  Metformin
- B.
  
  Glibenclamide
- C.
  
  Linagliptin
- D.
  
  Empagliflozin
15.

Testing for diabetes in asymptomatic individuals should be considered in overweight or obese who have one or more of the following risk factors except:
- A.
  
  First-degree relative with diabetes
- B.
  
  Hypertension (≥140/90 mmHg or therapy for hypertension)
- C.
  
  Active smoker
- D.
  
  Women with polycystic ovary syndrome
16.

Which of the following drug/drugs on long term treatment requires least number of patients to prevent one CV death (NNT) in T2D?
- A.
  
  Statins
- B.
  
  Antihypertensives
- C.
  
  Aspirin
- D.
  
  Empagliflozin
- E.
  
  Liraglutide
17.

Fournier’s gangrene (acute perineal necrotizing fasciitis) is a serious complication of drug treatment of T2D. Which drug/drug class has been associated with this complication?
- A.
  
  Saxagliptin
- B.
  
  SGLT2i
- C.
  
  GLP-1 agonists
- D.
  
  Rosiglitazone
18.

Multiple gas-containing cysts in the submucosal or subserosal layer of the intestine (Pneumatosis) It may be associated with a range of GI conditions such as bowel gangrene to inflammatory bowel disease and rarely with mechanical ventilation and endoscopic procedures. Which antidiabetic drug is associated with this rare condition?
- A.
  
  Rosiglitazone
- B.
  
  Dapagliflozin
- C.
  
  Saxagliptin
- D.
  
  Acarbose
19.

The following class of drugs acts by stimulating the pancreas to produce more insulin.
- A.
  
  Sulfonylureas
- B.
  
  Meglitinides
- C.
  
  Gliptins
- D.
  
  A and b
- E.
  
  A and c
20.

The following oral hypoglycemic agent raised serious concern about cardiovascular safety resulting in FDA guidance to industry to evaluate CV risk in new therapies to treat T2D in 2008.
- A.
  
  Saxagliptin
- B.
  
  Rosiglitazone
- C.
  
  Repaglinide
- D.
  
  Exenatide