Retail Test 05 May 2014

The given statement is true. Symptoms of depression commonly include feelings of sadness, anxiety, and hopelessness. These emotions are often persistent and can significantly impact a person's daily life, relationships, and overall well-being. It is important to recognize these symptoms and seek appropriate support and treatment if needed.

SSRIs, or selective serotonin reuptake inhibitors, are commonly used in the treatment of various mental health disorders. They are well-known among healthcare professionals due to their extensive use and research. SSRIs have been proven to be effective in managing symptoms of depression, anxiety, and other conditions. Additionally, they are considered safe for most patients when used appropriately. Therefore, the statement that SSRIs are used because they are well known, have good efficacy, and good safety is true.

The statement is true because SSRI's (Selective Serotonin Reuptake Inhibitors) such as citalopram, escitalopram, fluoxetine, paroxetine, and sertraline are indeed available on the South African market. These medications are commonly prescribed for the treatment of depression, anxiety disorders, and other mental health conditions.

SSRI (Selective Serotonin Reuptake Inhibitor) medications are commonly used to treat depression and anxiety disorders. One of the most common side effects of SSRIs is gastrointestinal discomfort, which can manifest as nausea and vomiting. Additionally, SSRIs can cause drowsiness as a side effect. Therefore, the statement that SSRI side effects include nausea, vomiting, and drowsiness is true.

Sertraline is a medication that is indeed indicated for the treatment of depression, obsessive-compulsive disorder (OCD), and panic disorder. It is classified as a selective serotonin reuptake inhibitor (SSRI) and works by increasing the levels of serotonin in the brain. Sertraline is commonly prescribed to individuals suffering from these conditions to help alleviate symptoms and improve overall mental well-being. Therefore, the statement "Sertraline is indicated in SA for Depression, Obsessive Compulsive Disorder, and Panic Disorder" is true.

The statement is true because it clearly states that Dyna Sertraline will be available in both 50 mg and 100 mg doses. This implies that individuals will have the option to choose between these two dosage strengths when taking this medication.

Zoloft, manufactured by Pfizer, is indeed the originator. This means that Pfizer was the first company to develop and market Zoloft, making it the original brand-name drug.

Sertraline is a medication commonly used to treat depression and anxiety disorders. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs), which work by increasing the levels of serotonin in the brain. However, studies have shown that sertraline may also have an effect on dopamine reuptake, another neurotransmitter involved in mood regulation. This means that sertraline may act as a dual agent, affecting both serotonin and dopamine reuptake. Therefore, the statement "Sertraline may act as a dual agent with both serotonin reuptake and dopaminergic reuptake" is true.

The given statement is true because adverse events refer to any undesirable effects that occur after the administration of a drug, regardless of whether the drug is the cause of the event or not. Adverse events can include side effects, allergic reactions, or any other negative outcomes that may occur during or after drug use. It is important to distinguish adverse events from adverse drug reactions, which specifically refer to negative effects that are caused by the drug itself.

Bioequivalence refers to the absence of a significant difference in bioavailability between two pharmaceutically equivalent products or two pharmaceutically alternative products. This means that both products release the active pharmaceutical ingredient (API) in a similar manner under similar conditions. Therefore, the statement "True" is correct as it accurately describes the concept of bioequivalence.

The statement is true because etiological factors refer to the causes or origins of a particular condition or disease. In the context of this question, the etiological factors include biological, psychological, and social factors. These three categories encompass various aspects such as genetic predispositions, mental health conditions, environmental influences, social support, and cultural factors that contribute to the development or manifestation of a particular condition. Therefore, it is accurate to say that etiological factors include biological, psychological, and social factors.

Sertraline is a selective serotonin reuptake inhibitor (SSRI), commonly used as an antidepressant. While its primary mechanism of action is to increase serotonin levels in the brain, it also has dopaminergic properties. Dopamine is a neurotransmitter associated with motivation, reward, and arousal. Therefore, the dopaminergic properties of sertraline can potentially contribute to its activating action, making the statement true.

The statement suggests that Sertraline has the best evidence supporting its safety in terms of cardiovascular effects compared to other antidepressants. This implies that research and studies have consistently shown Sertraline to have a lower risk of adverse cardiovascular events compared to other antidepressant medications. Therefore, the answer "True" indicates that Sertraline is indeed the best documented antidepressant in terms of cardio safety.

Sertraline is proven to be safe for patients with recent myocardial infarction. This means that studies and research have shown that sertraline does not pose any significant risks or adverse effects for patients who have recently experienced a heart attack. Therefore, it is considered safe to use sertraline in this particular patient population.

The statement is true because adverse drug reactions refer to the negative and unintended effects that occur as a result of medical treatment. These reactions can include both lack of effectiveness of the medication and events related to abuse or overdose. Therefore, adverse drug reactions are indeed unwanted and unintended consequences of medical treatment.

The statement is true because it states that Serdep 50 mg & 100 mg (Cipla) is the market leader generic sertraline. This implies that Serdep, manufactured by Cipla, is the most popular and widely used generic version of sertraline in the market.

Sertra being the "clone" of Zoloft means that it is a generic version of Zoloft. Generic drugs are identical or bioequivalent to brand-name drugs in terms of dosage form, safety, strength, route of administration, quality, and performance characteristics. Therefore, the statement is true.

The statement is true because if the 90% confidence interval of the ratio of a log-transformed exposure measure falls completely within the range of 80-125%, it means that there is no statistically significant difference between the two treatments. This range is commonly used as the acceptance criteria for bioequivalence studies, indicating that the treatments are considered equivalent in terms of their exposure measures.

The given statement is true. Treatment for depression can include various approaches such as psychotherapy, electroconvulsive therapy, natural therapy, and medication. Psychotherapy involves talking to a mental health professional to explore and address the underlying causes of depression. Electroconvulsive therapy is a procedure that uses electric currents to stimulate the brain and can be effective for severe cases. Natural therapies may include lifestyle changes, exercise, and relaxation techniques. Medication, such as antidepressants, may also be prescribed to help manage symptoms. Therefore, the statement is correct.

Sertraline's pharmacokinetics being linear means that the drug's absorption, distribution, metabolism, and elimination processes are proportional to the dose administered. In other words, as the dose of sertraline increases, the drug's concentration in the body increases in a predictable and consistent manner. This is important in determining the appropriate dosage for patients and ensuring that the drug's effects are consistent and reliable.

Sertraline has a half-life of 26 hours

Sertraline is an SSRI

Dyna Sertraline tablet is scored

Side effects are unwanted but natural and anticipated consequences of medical treatment

Depression is a mental health disorder characterized by persistent feelings of sadness, loss of interest, and a lack of motivation. It is a widespread condition that affects millions of people worldwide. The statement suggests that by the year 2020, depression will become the leading cause of morbidity, which refers to the state of being diseased or the incidence of illness. This prediction aligns with the increasing prevalence of depression globally and the impact it has on individuals' overall well-being. Therefore, the answer "True" indicates that depression is expected to be the highest cause of morbidity by 2020.

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