1.
Depression will be the highest cause of morbidity by 2020.
2.
The Etiological factors include Biological, Psychological and Social factors.
3.
Symptoms of depression include; sadness, anxious and hopelessness.
4.
Treatment for depression include: Psychotherapy, Electroconvulsive Therapy, Natural Therapy and Medication.
5.
SSRI’s are used because they very well known, have good efficacy and good safety
6.
SSRI’s on the SA Market include; citalopram, escitalopram, fluoxetine, paroxetine and sertraline.
7.
SSRI Side Effects include Nausea, vomiting and drowsiness.
8.
Sertraline’s DOPAMINERGIC properties may give an activating action.
9.
Sertraline is an SNRI
10.
Sertraline is indicated in SA for Depression, Obsessive Compulsive Disorder and Panic Disorder.
11.
Sertraline has a half-life of 23 hours
12.
Sertraline’s pharmacokinetic’ s is linear
13.
Dyna Sertraline will be available in 50 mg and 100 mg.
14.
Dyna Sertraline tablet is not scored
15.
Serdep 50 mg & 100 mg(Cipla) is the market leader generic sertraline.
16.
Zoloft (Pfizer) is the originator
17.
Sertra is the “clone” of Zoloft.
18.
Sertraline may act as dual agent with both serotonin reuptake and dopaminergic reuptake.
19.
Sertraline is the best documented cardio safety of any antidepressant.
20.
Sertraline is proven to be safe for patients with recent myocardial infarction.
21.
Define Pharmacovigilance? (2)
22.
Side effects are wanted but natural and anticipated consequences of medical treatment
23.
Adverse Drug reactions are unwanted and unintended consequence of medical treatment” This may include lack of efficacy and events relating to abuse or overdose.
24.
Adverse events are adverse effects that may or may not be caused by the suspect drug
25.
What does NADEMC stand for?