Nutrient macromolecules, such as proteins and nucleic acids, need to be broken down into their monomers (amino acids and nucleotides) before they can be absorbed by the cells in the digestive tract. This allows the body to utilize these monomers for various cellular processes. Energy-storage macromolecules like starch and fat, on the other hand, are absorbed whole without being broken down into monomers. The breakdown of macromolecules is regulated based on the body's immediate need for monomers, ensuring that only the necessary monomers are produced.