A Quiz On The Epidemiology, Virology And Pathogenesis Of Human Papillomavirus (HPV) Infections

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| By Mariarowenaraymu
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Mariarowenaraymu
Community Contributor
Quizzes Created: 1 | Total Attempts: 242
Questions: 15 | Attempts: 243

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This quiz assesses whether the learner knows the basic epidemiology, virology and pathogenesis of Human Papillomavirus (HPV) infections.


Questions and Answers
  • 1. 

    If a woman acquires an HPV infection which goes away after four months, is she protected from getting another episode of HPV infection again? 

  • 2. 

    If a woman acquires an infection from a high-risk type of HPV, does it mean that she will develop cancer?  

  • 3. 

    Genital HPV is the most common sexually transmitted infection in the world. 

    • A.

      True

    • B.

      False

    Correct Answer
    A. True
    Explanation
    Genital HPV is indeed the most common sexually transmitted infection in the world. This is supported by extensive research and data from various sources, including the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC). HPV, or human papillomavirus, is highly prevalent and can be transmitted through sexual contact. It is estimated that around 80% of sexually active individuals will contract HPV at some point in their lives. Therefore, the statement "Genital HPV is the most common sexually transmitted infection in the world" is true.

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  • 4. 

    At least 80%  of sexually active people worldwide are infected with HPV at some point in their lives.  

    • A.

      True

    • B.

      False

    Correct Answer
    B. False
    Explanation
    At least 50% of sexually active people worldwide are infected with HPV at some point in their lives.

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  • 5. 

    One-third of people who have sexual contact with an infected partner will develop a HPV infection within three months. 

    • A.

      True

    • B.

      False

    Correct Answer
    B. False
    Explanation
    Two-thirds of people who have sexual contact with an infected partner will develop a HPV infection within three months

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  • 6. 

    The highest rates of genital HPV infection are found in adults 35-45 years of age. 

    • A.

      True

    • B.

      False

    Correct Answer
    B. False
    Explanation
    The highest rates of genital HPV infection are found in adults 18-28 years of age.

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  • 7. 

    70% of newly acquired genital HPV infections clear within one year.    

    • A.

      True

    • B.

      False

    Correct Answer
    A. True
    Explanation
    70% of newly acquired genital HPV infections clear within one year. This means that the majority of people who contract genital HPV will naturally clear the infection within 12 months without any medical intervention. Therefore, the statement is true.

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  • 8. 

    The   three functional coding regions of the human papillomavirus (HPV) are  ____________,  ____________ and____________. Name one of them.

    Correct Answer
    E
    L
    LCR
    Explanation
    The three functional coding regions of the human papillomavirus (HPV) are E, L, and LCR. These regions are responsible for encoding various proteins and regulatory elements that are essential for the virus's replication and infection process. The E region encodes early proteins involved in viral DNA replication and transcriptional regulation. The L region encodes late proteins that form the viral capsid. The LCR region, also known as the long control region, contains regulatory elements that control the expression of viral genes.

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  • 9. 

    The two major oncoproteins in HPV which are significant in high-risk HPV and its relation with cervical cancer are ___________________ and __________________. Name one of them.

    Correct Answer
    E6
    E7
    Explanation
    The two major oncoproteins in HPV that are significant in high-risk HPV and its relation with cervical cancer are E6 and E7. These oncoproteins are responsible for promoting cell growth and inhibiting cell death, leading to the development of cervical cancer. They interact with various cellular proteins, including tumor suppressor proteins, to disrupt normal cell functions and promote the survival and proliferation of infected cells.

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  • 10. 

    Which layer of epithelium is the only tissue in which low risk HPV types can replicate?

    • A.

      Stratum corneum

    • B.

      Stratum granulosum

    • C.

      Stratum spinosum

    • D.

      Stratum basale

    Correct Answer
    D. Stratum basale
    Explanation
    HPV infection is limited to the basal cells of stratified epithelium, the only tissue in which they replicate.

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  • 11. 

    Which lesions are most likely associated with low-risk types of genital HPV?

    • A.

      Plantar warts

    • B.

      Flat warts

    • C.

      Respiratory papillomatosis

    • D.

      CIN3

    Correct Answer
    C. Respiratory papillomatosis
    Explanation
    Plantar warts and flat warts are non-genital types of HPV. CIN 3 is caused by genital HPV of the high-risk type. Genital HPV types 6 and 11 can cause a rare condition known as recurrent respiratory papillomatosis, in which warts form on the larynx or other areas of the respiratory tract. HPV is acquired through oral-genital sexual contact, or when a mother with genital warts passes it to her baby during childbirth.

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  • 12. 

    What percentage of individuals infected with high-risk HPV infections clear the viral infection within two years?

    • A.

      90%

    • B.

      70%

    • C.

      50%

    • D.

      30%

    Correct Answer
    A. 90%
    Explanation
    90% of individuals infected with high-risk HPV infections clear the viral infection within two years.

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  • 13. 

    Which of the following is considered a high-grade lesion that may regress spontaneously in 40 percent of women?

    • A.

      CIN1

    • B.

      CIN2

    • C.

      CIN3

    • D.

      CIS

    Correct Answer
    B. CIN2
    Explanation
    CIN2 is considered a high-grade lesion that may regress spontaneously in 40 percent of women.

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  • 14. 

    Which high-risk HPV type is strongly associated with adenocarcinoma, a less common but aggressive cancer arising from the endocervical  glandular epithelium?

    • A.

      Type 16

    • B.

      Type 18

    • C.

      Type 31

    • D.

      Type 45

    Correct Answer
    D. Type 45
    Explanation
    HPV Type 45 is a high-risk HPV type which is strongly associated with adenocarcinoma, a less common but aggressive cancer arising from the endocervical glandular epithelium.

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Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Mar 22, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Oct 23, 2013
    Quiz Created by
    Mariarowenaraymu
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