A Quiz On The Epidemiology, Virology And Pathogenesis Of Human Papillomavirus (HPV) Infections

Genital HPV is indeed the most common sexually transmitted infection in the world. This is supported by extensive research and data from various sources, including the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC). HPV, or human papillomavirus, is highly prevalent and can be transmitted through sexual contact. It is estimated that around 80% of sexually active individuals will contract HPV at some point in their lives. Therefore, the statement "Genital HPV is the most common sexually transmitted infection in the world" is true.

70% of newly acquired genital HPV infections clear within one year. This means that the majority of people who contract genital HPV will naturally clear the infection within 12 months without any medical intervention. Therefore, the statement is true.

The highest rates of genital HPV infection are found in adults 18-28 years of age.

90% of individuals infected with high-risk HPV infections clear the viral infection within two years.

HPV infection is limited to the basal cells of stratified epithelium, the only tissue in which they replicate.

HPV Types 6 and 11 are low-risk types which cause benign disease.
HPV Types 16 and 18 are high-risk types which can cause cancers and high-grade cytologic abnormalities.

Plantar warts and flat warts are non-genital types of HPV. CIN 3 is caused by genital HPV of the high-risk type. Genital HPV types 6 and 11 can cause a rare condition known as recurrent respiratory papillomatosis, in which warts form on the larynx or other areas of the respiratory tract. HPV is acquired through oral-genital sexual contact, or when a mother with genital warts passes it to her baby during childbirth.

CIN2 is considered a high-grade lesion that may regress spontaneously in 40 percent of women.

Two-thirds of people who have sexual contact with an infected partner will develop a HPV infection within three months

At least 50% of sexually active people worldwide are infected with HPV at some point in their lives.

HPV Type 45 is a high-risk HPV type which is strongly associated with adenocarcinoma, a less common but aggressive cancer arising from the endocervical glandular epithelium.

The two major oncoproteins in HPV that are significant in high-risk HPV and its relation with cervical cancer are E6 and E7. These oncoproteins are responsible for promoting cell growth and inhibiting cell death, leading to the development of cervical cancer. They interact with various cellular proteins, including tumor suppressor proteins, to disrupt normal cell functions and promote the survival and proliferation of infected cells.

The three functional coding regions of the human papillomavirus (HPV) are E, L, and LCR. These regions are responsible for encoding various proteins and regulatory elements that are essential for the virus's replication and infection process. The E region encodes early proteins involved in viral DNA replication and transcriptional regulation. The L region encodes late proteins that form the viral capsid. The LCR region, also known as the long control region, contains regulatory elements that control the expression of viral genes.