Manufacturing Internship Trivia Quiz

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Quizzes Created: 1 | Total Attempts: 144
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  • 1/50 Questions

    Examples of primary packaging component, EXCEPT:

    • Ampules
    • Bottles
    • Package boxes
    • Vials
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About This Quiz

Embark on a journey through the realm of manufacturing with the "Manufacturing Internship Trivia Quiz"! This captivating quiz is designed to challenge manufacturing enthusiasts, engineering minds, and those curious about the production processes that shape our world. Explore the intricacies of materials, lean principles, quality control, automation, and more. From assembly lines to cutting-edge technologies, this quiz covers a spectrum of manufacturing concepts. With a blend of fundamental and advanced questions, it gauges your grasp of industrial processes and innovations. Whether you're an aspiring engineer or intrigued by how things are made, take the plunge into this quiz to assess your manufacturing knowledge and gain deeper insights into the backbone of modern production.

Manufacturing Internship Trivia Quiz - Quiz

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  • 2. 

    Enteric coated tablets resist the action of gastric juices but disintegrate in the intestine.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    Enteric coated tablets are designed to resist the action of gastric juices in the stomach. This is because certain medications can be sensitive to the acidic environment of the stomach and may be degraded or inactivated by gastric juices. By having an enteric coating, these tablets are able to pass through the stomach intact and reach the intestine where they disintegrate and release the medication for absorption. Therefore, the statement that enteric coated tablets resist the action of gastric juices but disintegrate in the intestine is true.

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  • 3. 

    Glidants are substances that glue powders together and cause them to form granules

    • True

    • False

    Correct Answer
    A. False
    Explanation
    Glidants are substances that are used to reduce the friction between particles in a powder mixture, allowing them to flow more easily. They do not glue powders together or cause them to form granules. Therefore, the statement that glidants glue powders together and cause them to form granules is incorrect.

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  • 4. 

    There should be a balance between the amounts of the binder and the lubricant considering the tablet’s release characteristics and maintenance of integrity during handling.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The statement suggests that in order to achieve the desired release characteristics and maintain the tablet's integrity during handling, it is important to have a balance between the amounts of the binder and the lubricant. This implies that if there is an imbalance between these two components, it could affect the tablet's performance and structural integrity. Therefore, the statement is true.

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  • 5. 

    Capping is the unequal distribution of color on the surface of the tablet.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    Mottling' is the term used to describe an unequal distribution of colour on a tablet, with light or dark spots standing out in an otherwise uniform surface

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  • 6. 

    Poor flow of the tablet granules may result in incompletely filled dies resulting to thickness variation

    • True

    • False

    Correct Answer
    A. True
    Explanation
    The statement is explaining that if the flow of the tablet granules is poor, it can lead to incomplete filling of the dies, which in turn can cause thickness variation in the tablets. This means that some tablets may be thicker or thinner than others due to the inconsistent filling process. Therefore, the statement is true.

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  • 7. 

    The following are examples of small-volume parenterals, EXCEPT:

    • Dialysate

    • Ampules

    • Vials

    • Pre-filled syringes

    Correct Answer
    A. Dialysate
    Explanation
    Dialysate volumes are usually large.

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  • 8. 

    The bioavailability of the drug is dependent on tablet

    • Hardness

    • Dissolution

    • Thickness

    • Weight

    Correct Answer
    A. Dissolution
    Explanation
    The bioavailability of a drug refers to the extent and rate at which it is absorbed into the bloodstream and becomes available for the body to use. In this context, dissolution refers to the process by which the drug dissolves in the gastrointestinal tract. The faster and more completely a drug dissolves, the higher its bioavailability. Therefore, the dissolution of the tablet is a crucial factor in determining the bioavailability of the drug.

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  • 9. 

    Starch can be a diluent a binder and a disintegrator

    • True

    • False

    Correct Answer
    A. True
    Explanation
    Starch can serve multiple purposes in various pharmaceutical formulations. As a diluent, it helps to increase the bulk of the formulation and facilitate the manufacturing process. As a binder, it helps to hold the ingredients together and provide cohesion to the tablet or capsule. Additionally, starch can act as a disintegrator, promoting the breakdown of the dosage form in the gastrointestinal tract for better drug absorption. Therefore, the statement that starch can be a diluent, binder, and disintegrator is true.

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  • 10. 

    The inert substance used to increase the bulk of the tablet

    • Diluent

    • Binder

    • Glidant

    • Granulator

    Correct Answer
    A. Diluent
    Explanation
    A diluent is an inert substance that is added to a tablet formulation to increase its bulk. It helps in achieving the desired tablet size and shape. Diluents do not have any therapeutic effect but are necessary for the manufacturing process and to ensure uniformity in tablet weight. They are typically non-reactive and easily compressible, allowing for easy tablet formation. Binders, on the other hand, are used to hold the tablet ingredients together, glidants improve the flow properties of the powder mixture, and granulators are used to form granules from the powdered ingredients.

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  • 11. 

    The part of the tablet machine used for compacting the materials

    • Dies

    • Feed frame

    • Punches

    • Cam

    Correct Answer
    A. Punches
    Explanation
    The part of the tablet machine used for compacting the materials is called punches. The punches are responsible for exerting pressure on the materials to form them into tablets. They apply force to compress the powder or granules in the die cavity, resulting in the formation of a solid tablet. The punches typically have a specific shape and size that determines the shape and dimensions of the tablet.

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  • 12. 

    Composed of 2 security doors that can’t be opened at the same time

    • Air-lock system

    • HEPA filter

    • Positive pressure cubicle

    • HVAC

    Correct Answer
    A. Air-lock system
    Explanation
    An air-lock system is composed of 2 security doors that cannot be opened at the same time. This system is designed to control the flow of air and prevent the entry of contaminants from outside. It is commonly used in environments where contamination control is crucial, such as cleanrooms or laboratories. The air-lock system ensures that there is no direct access between the outside and the controlled environment, maintaining the integrity of the space and protecting it from external pollutants.

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  • 13. 

    The following are considered as sterile products, EXCEPT:

    • Syrups

    • Irrigating solutions

    • Dialysates

    • Ophthalmic preparations

    Correct Answer
    A. Syrups
    Explanation
    Sterility is not required in syrups.

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  • 14. 

    The following is a reason for sieving:

    • To reduce agglomerates

    • Prevent stratification

    • For uniformity of particle size

    • All of the choices

    Correct Answer
    A. All of the choices
    Explanation
    Sieving is a process used to separate particles based on their size. The reason for sieving can be to reduce agglomerates, which are clumps of particles that can affect the accuracy of measurements or cause problems in processing. Sieving can also prevent stratification, which is the separation of particles based on their size or density. By sieving, particles of different sizes can be mixed together to achieve uniformity of particle size. Therefore, all of the choices - reducing agglomerates, preventing stratification, and achieving uniformity of particle size - are valid reasons for sieving.

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  • 15. 

    The use of too much binder will adversely affect

    • Bioavailability

    • Disintegration time

    • Dissolution rate

    • All of the choices

    Correct Answer
    A. All of the choices
    Explanation
    Using too much binder in a formulation can have negative effects on bioavailability, disintegration time, and dissolution rate. Binder is used to hold the ingredients together in a tablet or capsule, but an excessive amount can hinder the release and absorption of the active ingredient. It can slow down the disintegration of the dosage form, making it difficult for the drug to break down and be absorbed by the body. Additionally, an excessive binder can impede the dissolution rate, reducing the drug's ability to dissolve and become available for absorption. Therefore, all of the choices are adversely affected by the excessive use of binder.

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  • 16. 

    Type of tablet not requiring disntegration testing

    • Chewable tablet

    • Sugar-coated tablet

    • Enteric-coated tablet

    • Modified-release tablet

    Correct Answer
    A. Chewable tablet
    Explanation
    Chewable tablets do not require disintegration testing because they are designed to be chewed and dissolved in the mouth rather than swallowed whole. Disintegration testing is conducted to ensure that a tablet breaks down and disperses its active ingredients within a specified time frame. However, chewable tablets are formulated to disintegrate quickly in the mouth, allowing for easy administration and absorption of the medication. Therefore, they do not need to undergo disintegration testing.

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  • 17. 

    An inert gas that is usually incorporated into an ampule to prevent API oxidation

    • Nitrogen

    • Hydrogen

    • Oxygen

    • Ethylene oxide

    Correct Answer
    A. Nitrogen
    Explanation
    Oxygen is responsible for oxidation of API's and must be excluded from parenteral preparations. Hydrogen is not an inert gas and is very reactive while ethylene oxide is not suitable for parenteral preparations, in fact, it is hazardous and is widely used as an industrial gas and healthcare sterilant.

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  • 18. 

    The following are advantages of aerosols as dosage forms, EXCEPT:

    • Inexpensive

    • Easy application

    • Fine particle size

    • Freedom from contamination

    Correct Answer
    A. Inexpensive
    Explanation
    Aerosols are advantageous dosage forms due to their easy application, fine particle size, and freedom from contamination. However, the given answer, "inexpensive," is incorrect because aerosols can often be more expensive compared to other dosage forms. This is because they require specialized packaging and propellant systems, which can increase production costs.

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  • 19. 

    The separation of the tablet into 2 or more layers

    • Picking

    • Mottling

    • Capping

    • Lamination

    Correct Answer
    A. Lamination
    Explanation
    Lamination refers to the separation of a tablet into two or more layers. This can occur when there is an issue with the tablet formulation or manufacturing process, causing the layers to separate. It may result from inadequate compression during tablet production or the use of incompatible excipients. Lamination can affect the integrity and effectiveness of the tablet, leading to potential issues with drug release and absorption.

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  • 20. 

    Insulin preparations are usually administered by

    • SQ

    • IM

    • ID

    • IV

    Correct Answer
    A. SQ
    Explanation
    Insulin preparations are usually administered subcutaneously (SQ) because this route allows for slow and steady absorption of the insulin into the bloodstream. Subcutaneous injections are given just below the skin, into the fatty tissue, which helps to ensure a more consistent and prolonged effect of the medication. Intramuscular (IM) injections are not commonly used for insulin administration as they can lead to faster absorption and potentially unpredictable blood sugar levels. Intradermal (ID) injections are typically used for skin testing, not for insulin administration. Intravenous (IV) administration of insulin is reserved for emergency situations or in a hospital setting.

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  • 21. 

    The following are methods of sterilization, EXCEPT;

    • Use of antimicrobials

    • Dry heat sterilization

    • Ionizing radiation

    • Filtration

    Correct Answer
    A. Use of antimicrobials
    Explanation
    The use of antimicrobials is not a method of sterilization. Antimicrobials are substances that inhibit the growth of microorganisms, but they do not completely eliminate all forms of microbial life. Sterilization, on the other hand, refers to the complete destruction or removal of all forms of microbial life, including bacteria, viruses, and spores. Therefore, the use of antimicrobials cannot be considered a method of sterilization.

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  • 22. 

    Drugs with narrow therapeutic index do not require geometric dilution once added with diluents

    • True

    • False

    Correct Answer
    A. False
    Explanation
    Geometric dilution is a mixing process that is used when combining two or more ingredients of varying quantities together to achieve a homogeneous mixture

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  • 23. 

    Antiperspirants retard perspiration because their active ingredients have ____ properties

    • Astringent

    • Hygroscopic

    • Antibacterial

    • Moisturizing

    Correct Answer
    A. Astringent
    Explanation
    Antiperspirants retard perspiration because their active ingredients have astringent properties. Astringents are substances that cause the contraction of body tissues, which in this case, would include the sweat ducts. By constricting the sweat ducts, antiperspirants reduce the amount of sweat that is able to reach the skin's surface, thereby reducing perspiration.

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  • 24. 

    Consist of one or more sterile drugs added to an IV fluid

    • IV admixture

    • Dialysate

    • Irrigating solutions

    • Electrolytes

    Correct Answer
    A. IV admixture
    Explanation
    An IV admixture refers to a solution that consists of one or more sterile drugs added to an IV fluid. This solution is prepared specifically for intravenous administration to patients. It is commonly used in healthcare settings to deliver medications directly into the bloodstream for immediate effect. IV admixtures are carefully prepared to ensure the correct dosage and combination of drugs, making them a crucial component in patient care.

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  • 25. 

    Colors and dyes in tablet formulations serve these purposes , EXCEPT:

    • To disguise off-colored drugs

    • To disguise unpleasant-tasting drugs

    • To provide product identification

    • To produce more elegant products

    Correct Answer
    A. To disguise unpleasant-tasting drugs
    Explanation
    The purpose of colors and dyes in tablet formulations is to disguise off-colored drugs, provide product identification, and produce more elegant products. However, it is not used to disguise unpleasant-tasting drugs.

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  • 26. 

    The ability of a formulation to remain within its physical, chemical, therapeutic and toxicological specification is termed

    • Stability

    • Shelf life

    • Expiration date

    • Beyond use date

    Correct Answer
    A. Stability
    Explanation
    Stability refers to the ability of a formulation to maintain its physical, chemical, therapeutic, and toxicological properties within the specified range. It ensures that the formulation remains effective and safe for use over a period of time. Shelf life refers to the duration during which a product can be stored and used without significant deterioration. Expiration date is the date after which a product should not be used as it may no longer be safe or effective. Beyond use date is used in compounding pharmacies and refers to the date after which a compounded product should not be used. Therefore, stability is the most appropriate term to describe the ability of a formulation to maintain its specifications.

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  • 27. 

    The reason why surfactant is used in the non-aqueous film coat

    • To prevent mottling

    • To prevent bridging

    • To quicken spreading of the coat before complete evaporation occurs

    • To make the solvent evaporation slow

    Correct Answer
    A. To quicken spreading of the coat before complete evaporation occurs
    Explanation
    Surfactants are used in the non-aqueous film coat to quicken the spreading of the coat before complete evaporation occurs. Surfactants are compounds that lower the surface tension of a liquid, allowing it to spread more easily. In the case of a non-aqueous film coat, the surfactant helps to evenly distribute the coat over the surface before it evaporates. This prevents mottling, which is the uneven distribution of the film coat, and also prevents bridging, which is the formation of gaps or unevenness in the coat. By quickening the spreading process, the surfactant ensures a smooth and uniform film coat.

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  • 28. 

    The length of time that a drug is within the required specification is defined as

    • Stability

    • Beyond use date

    • Shelf life

    • Expiration date

    Correct Answer
    A. Shelf life
    Explanation
    The term "shelf life" refers to the length of time that a drug remains stable and maintains its effectiveness while stored under proper conditions. It is the period during which the drug is expected to retain its quality, potency, and safety. The shelf life of a drug is determined through various stability studies and testing, and it is typically indicated by an expiration date on the drug packaging. Therefore, "shelf life" is the correct answer to the question.

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  • 29. 

    Common uses of LVP solutions without additives include the following, EXCEPT:

    • Therapeutic agent

    • Correction of electrolyte and fluid balance disturbances

    • Nutrition

    • Vehicle for administering other drugs

    Correct Answer
    A. Therapeutic agent
    Explanation
    Only API's require additives like antioxidants, buffers, etc.

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  • 30. 

    The following are examples of non-aqeous parenteral vehicles, EXCEPT:

    • Magnesium stearate

    • Glycerin

    • Polyethylene glycols

    • Fixed vegetable oils

    Correct Answer
    A. Magnesium stearate
    Explanation
    Magnesium stearate is used as lubricant in tablets.

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  • 31. 

    Aerosol component which supplies the necessary force to expel the product from the package

    • Propellant

    • Actuator

    • Valve

    • API concentrate

    Correct Answer
    A. Propellant
    Explanation
    The propellant supplies the necessary pressure within an aerosol system to expel material from the container and, in combination with other components, to convert the material into the desired physical form.

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  • 32. 

    Added substance for multiple-dose parenterals

    • Buffers

    • Antioxidants

    • Antimicrobials

    • All of the above

    Correct Answer
    A. Buffers
    Explanation
    Antioxidants are added to parenterals to ensure stability of the API, preservatives prevent contamination brought about by multiple withdrawals from the same container, and buffers ensure solubility of the API by maintaining the desired pH.

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  • 33. 

    Aerosol preparations are used to treat problems with the following,  EXCEPT:

    • GIT

    • Vaginal

    • Respiratory

    • Dermal

    Correct Answer
    A. GIT
    Explanation
    Aerosol preparations are used to treat problems with the gastrointestinal tract (GIT), respiratory system, and dermal conditions. However, they are not typically used to treat vaginal problems. Vaginal issues are usually addressed with specific medications or treatments designed for that area. Therefore, the correct answer is GIT.

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  • 34. 

    The equipment/method that can provide the shortest drying time for wet granulations

    • Sun drying

    • Fluid bed dryer

    • Oven dryer

    • Incubator

    Correct Answer
    A. Fluid bed dryer
    Explanation
    A fluid bed dryer is the equipment/method that can provide the shortest drying time for wet granulations. This type of dryer uses hot air to fluidize the particles, creating a fluid-like motion that allows for efficient and rapid drying. The hot air is evenly distributed throughout the bed of granules, ensuring uniform drying and minimizing drying time. This makes the fluid bed dryer a preferred choice for industries that require fast and efficient drying of wet granulations.

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  • 35. 

    The part of sugar coating process employed to round off tablet contours

    • Polishing

    • Subcoating

    • Sealing

    • Finishing

    Correct Answer
    A. Subcoating
    Explanation
    Subcoating is the correct answer because it refers to the part of the sugar coating process that is used to round off tablet contours. In the sugar coating process, subcoating involves applying a layer of syrup or other coating material to the tablet to create a smooth surface. This layer helps to round off any sharp edges or contours on the tablet, resulting in a more polished and finished appearance.

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  • 36. 

    The following are considered as tablets for solution, EXCEPT:

    • Effervescent tablet

    • Hypodermic tablet

    • None of the choices

    • Sublingual tablet

    Correct Answer
    A. Sublingual tablet
    Explanation
    Sublingual tablets are not considered tablets for solution because they are designed to be placed under the tongue and allowed to dissolve, rather than being dissolved in a liquid for consumption. Effervescent tablets are designed to dissolve in water to create a fizzy solution, hypodermic tablets are designed to be dissolved in a liquid for injection, and "none of the choices" implies that all of the options listed are considered tablets for solution. Therefore, the correct answer is sublingual tablet.

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  • 37. 

    The best  method to compress two ingredients which are chemically incompatible with each other

    • Direct compression

    • Layered compression

    • Dry granulation

    • Wet granulation

    Correct Answer
    A. Layered compression
    Explanation
    Layered compression is the best method to compress two ingredients that are chemically incompatible with each other. In layered compression, the two ingredients are compressed separately into individual layers and then combined together. This method ensures that the incompatible ingredients do not come into direct contact with each other, reducing the chances of any chemical reactions or incompatibilities. Layered compression allows for effective compression of the ingredients while maintaining their stability and preventing any undesirable interactions.

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  • 38. 

    A necessary component particularly for multiple dose parenterals.

    • Antimicrobials

    • Antioxidants

    • Buffers

    • Tonicity adjusters

    Correct Answer
    A. Antimicrobials
    Explanation
    Multiple dose parenterals require antimicrobials due to the possibility of contamination due to multiple withdrawals.

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  • 39. 

    The usual administration site for spinal anesthesia

    • Intrathecal

    • Epidural

    • Vertebral

    • MOM

    Correct Answer
    A. Intrathecal
    Explanation
    A spinal anaesthetic delivers drug to the intrathecal space (the CSF), and acts on the spinal cord directly. An epidural delivers drugs outside the dura (outside CSF), and has its main effect on nerve roots leaving the dura at the level of the epidural, rather than on the spinal cord itself.

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  • 40. 

    Blows pre-filtered air to a controlled area to sweep off contaminants.

    • HEPA filter

    • HVAC

    • Air-lock system

    • Positive pressure cubicle

    Correct Answer
    A. HEPA filter
    Explanation
    A HEPA filter is a type of air filter that is designed to capture very small particles, including contaminants and allergens, from the air. It works by forcing air through a fine mesh that traps these particles, preventing them from circulating in the environment. In the given context, using a HEPA filter would help to remove contaminants from the air by blowing pre-filtered air to a controlled area, ensuring a cleaner and healthier environment.

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  • 41. 

    ____ is a vegetable dye, used for centuries to impart a red tint to the hair

    • Henna

    • Zirconium

    • Coal tar dyes

    • Azo dyes

    Correct Answer
    A. Henna
    Explanation
    Henna is a vegetable dye that has been used for centuries to give a red tint to the hair. It is a natural and safe alternative to chemical hair dyes. Henna is derived from the leaves of the henna plant and is known for its conditioning properties as well. It is commonly used in various cultures for body art and hair coloring purposes.

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  • 42. 

    Which is done to prevent sedimentation in preparing ointments using heat?

    • Continuous stirring while cooling

    • Pre-dissolution

    • Allowing the preparation to stand while cooling

    • Levigation

    Correct Answer
    A. Continuous stirring while cooling
    Explanation
    Continuous stirring while cooling is done to prevent sedimentation in preparing ointments using heat. This is because stirring helps to distribute the ingredients evenly throughout the mixture, preventing them from settling at the bottom. By continuously stirring while the ointment is cooling, the ingredients remain suspended and do not separate or form sediment. This ensures a homogeneous and smooth consistency in the final product.

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  • 43. 

    The following affect significantly the disintegration time of tablets, EXCEPT:

    • Diluent

    • Binder

    • Disintegrant

    • Lubricant

    Correct Answer
    A. Diluent
    Explanation
    The disintegration time of tablets is affected by various factors, such as the type and amount of binder, disintegrant, and lubricant used. However, the diluent does not have a significant impact on the disintegration time. Diluents are used to increase the bulk of the tablet and aid in the manufacturing process, but they do not directly influence the disintegration process. Therefore, the correct answer is diluent.

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  • 44. 

    Disintegration is required as a QC test for tablets because it determines ability of the tablet to be dissolved

    • True

    • False

    Correct Answer
    A. True
    Explanation
    Disintegration is an important quality control test for tablets because it assesses the tablet's ability to dissolve. The test involves placing the tablet in a liquid medium and measuring the time it takes for the tablet to break down into smaller particles. This is crucial because if a tablet does not disintegrate properly, it may not dissolve in the body and therefore may not deliver the intended medication effectively. Therefore, the statement that disintegration is required as a QC test for tablets because it determines the ability of the tablet to be dissolved is true.

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  • 45. 

    Which of the following is not a source of pyrogens in parenterals?

    • Freshly distilled water

    • Equipment

    • Container

    • API

    Correct Answer
    A. Freshly distilled water
    Explanation
    freshly distilled water does not contain microorganisms or their endotoxins causing fever in patients.

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  • 46. 

    Why is it not necessary for single dose parenteral preparations to carry preservatives?

    • There is no danger of contamination

    • Single-dose powders for reconstitution are already sterilized

    • It does not guarantee prevention of contamination

    • It is not pyrogen-free

    Correct Answer
    A. There is no danger of contamination
    Explanation
    since single-dose parenterals are consumed fully after opening, there is no danger of contamination.

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  • 47. 

    Products which need to be sterile and pyrogen-free, EXCEPT:

    • Otic solutions

    • Ophthalmic solutions

    • Irrigating solutions

    • Injectables

    Correct Answer
    A. Otic solutions
    Explanation
    Otic solutions are not required to be sterile and pyrogen-free. Otic solutions are used for ear-related issues, such as ear infections, and do not need to be sterile because the ear is a self-cleaning organ. Additionally, otic solutions are not typically injected into the body, so they do not need to be pyrogen-free, which means free from fever-inducing substances. On the other hand, ophthalmic solutions, irrigating solutions, and injectables need to be sterile and pyrogen-free to ensure safety and prevent infections when used in the eyes, for irrigation, or when injected into the body, respectively.

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  • 48. 

    Why should bacteriostatic water for injection be used at a maximum of 5 ml only?

    • It contains high conc of preservative.

    • It is not pyrogen-free.

    • It does not guarantee prevention of contamination.

    • It does not contain a preservative.

    Correct Answer
    A. It contains high conc of preservative.
    Explanation
    it contains high conc of preservative which already harmful to the patient

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  • 49. 

    The following are mechanisms of disintegrant action, EXCEPT:

    • Swelling

    • Air displacement

    • Effervescence

    • All of the choices

    Correct Answer
    A. All of the choices
    Explanation
    The correct answer is "all of the choices." This means that all of the given mechanisms, including swelling, air displacement, and effervescence, are not mechanisms of disintegrant action. Disintegrants are substances that help in the breakdown of tablets or capsules into smaller particles, aiding in their dissolution and absorption in the body. However, none of the mechanisms mentioned in the options are associated with this action.

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  • Current Version
  • Aug 23, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • May 12, 2017
    Quiz Created by
    VanbethCamson

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