Biomed II Exam II Lecture 1
- 1.Which Statement is TRUE?
- A.
Hemocytoblasts are multipotent hematopoietic stem cells
- B.
A blastocyst is the ultimate stem cell
- C.
Telomeres extend for 20,000 bases in humans
- D.
Telomeres lose 700 bases with each cell division
- 2.What percent of tumors have telomerase?
- A.
75%
- B.
60%
- C.
80%
- D.
85%
- 3.Which of the following is FALSE?
- A.
Telomerase can replenish telomeres to allow for continued replication of special cells (this is seen in germ cells and stem cells)
- B.
As we age, telomeres get longer, sending cells into senescence
- C.
Stem cells can not migrate which is a key trait of cancer
- D.
Stem cells are in almost all tissue
- 4.Benign tumor=cancer
- A.
True
- B.
False
- 5.Which of the following is TRUE?
- A.
Inherited mutations are less likely the sole cause of cancer
- B.
Acquired mutations are less likely the sole cause of cancer
- C.
The cause of a tumor is 75% inherited
- D.
Epstein-barr is a liver cancer
- 6.The causes of tumors are _____% Environmental
- A.
25
- B.
85
- C.
75
- D.
65
- 7.Select the FALSE statements:
- A.
Smoking causes lung cancer
- B.
Carcinogens in food causes lung cancer
- C.
Radon causes colon cancer
- D.
Asbestos causes lung cancer
- 8.Which cells replicate a lot?
- A.
Cells lining the colon
- B.
Skin cells
- C.
Muscle cells
- D.
Neurons
- 9.Brain cancer is cancer of ____cells
- 10.Which is TRUE?
- A.
Ras stimulates cell death
- B.
EGF binds to EGFR
- C.
EGF binds to Ras
- D.
ETFR activates ras protein
- 11.Overstimulation of ras causes cancers of:
- A.
Breast
- B.
Liver
- C.
Ovary
- D.
Stomach
- 12.Large amounts of unrepairable DNA damage activates:
- A.
P16
- B.
BRCA1/BRCA2
- C.
P53
- D.
BRCA1/BRCA2/BRCA3
- 13.Activation of normal p53 leads to cell cycle arrest in G1 and induction of DNA repair by transcriptional up-regulation of:
- A.
GADD45
- B.
P16
- C.
CDKN1A (p21)
- D.
Cb3
- 14.P53 is most frequently mutated gene in human cancer
- A.
True
- B.
False
- 15.Which statement is TRUE?
- A.
Humans have the most apoptotic cells in vitro in response to radiation
- B.
Elephants have 2 copies of p53 gene
- C.
Humans missing p53 copy have over 90% lifetime risk of cancer
- D.
Elephants have fewest apoptotic cells
- 16.Cells without nuclei and DNA are removed by the:
- A.
Kidneys
- B.
Liver
- C.
Small intestines
- D.
Lungs
- 17.What is true of necrosis:
- A.
Blobs fuse and become larger
- B.
Organelles located in the blobs
- C.
Organelles are not functional
- D.
Organelles are functional
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