BCID Module 5 Quiz

2.

Beta-lactam antibiotics have which of the following mechanism of action:

Inhibit cell wall synthesis
Inhibit nucleic acid synthesis
Inhibit bacterial conjugation
Inhibit protein synthesis

Correct Answer

A. Inhibit cell wall synthesis

Explanation

Beta-lactam antibiotics inhibit cell wall synthesis. The cell wall is essential for the structural integrity of bacteria, and beta-lactam antibiotics target enzymes called penicillin-binding proteins (PBPs) that are involved in the formation of the cell wall. These antibiotics bind to PBPs and prevent them from cross-linking the peptidoglycan strands, which weakens the cell wall and leads to cell lysis. By inhibiting cell wall synthesis, beta-lactam antibiotics effectively kill the bacteria and are widely used to treat bacterial infections.

Rate this question:

3.

Which piece of information would not be helpful in determining appropriate antibiotic therapy?

Cell wall membrane scan
Resistance marker detection
Antibiogram
Antimicrobial susceptibility profile

Correct Answer

A. Cell wall membrane scan

Explanation

A cell wall membrane scan would not be helpful in determining appropriate antibiotic therapy because it does not provide information about the susceptibility or resistance of the bacteria to different antibiotics. Antibiotic therapy decisions are typically based on the results of tests such as resistance marker detection, antibiogram, and antimicrobial susceptibility profile, which provide information about the effectiveness of different antibiotics against the specific bacteria causing the infection.

Rate this question:

4.

All of the following technologies have Antibiotic Susceptibility Testing (AST) capabilities, except:

Cepheid GeneXpert
BD Phoenix
BioMerieux Vitek 2
BioMerieux Vitek MS MALDI-TOF

Correct Answer

A. Cepheid GeneXpert

Explanation

The Cepheid GeneXpert is the only technology listed that does not have Antibiotic Susceptibility Testing (AST) capabilities. The BD Phoenix, bioMerieux Vitek 2, and bioMerieux Vitek MS MALDI-TOF are all commonly used technologies for performing AST, which is a method used to determine the effectiveness of antibiotics against specific bacteria. The Cepheid GeneXpert, on the other hand, is a molecular diagnostic platform that is primarily used for the detection of specific pathogens or genetic mutations, rather than for AST.

Rate this question:

5.

Biofire's mecA target includes the detection of the staphylococcal cassette mec junction.

True
False

Correct Answer

A. False

Explanation

Biofire's mecA target does not include the detection of the staphylococcal cassette mec junction.

Rate this question:

6.

Which of the following are gram-positive resistance marker(s) found on current molecular panels?

KPC
MecD
VanA/vanB
A and b
All of the Above

Correct Answer

A. VanA/vanB

Explanation

The gram-positive resistance markers vanA/vanB are found on current molecular panels. These markers are associated with vancomycin resistance in gram-positive bacteria. The mecD marker is not a gram-positive resistance marker, and KPC is associated with carbapenem resistance in gram-negative bacteria. Therefore, the correct answer is "a and b" because vanA/vanB are gram-positive resistance markers found on current molecular panels.

Rate this question:

7.

Which of the following are gram-negative resistance marker(s) found on current molecular panels?

MecA
IMP
OZO
CTX-M
B and d only

Correct Answer

A. B and d only

Explanation

The gram-negative resistance markers found on current molecular panels are IMP and CTX-M. mecA and OZO are not gram-negative resistance markers. Therefore, the correct answer is b and d only.

Rate this question:

8.

Which of the following bacteria is commonly found to be resistant to antibiotics?

Staphylococcus
Klebsiella
Enterococcus faecium
Only a and b
All of the above

Correct Answer

A. All of the above

Explanation

All of the above bacteria are commonly found to be resistant to antibiotics. Staphylococcus, Klebsiella, and Enterococcus faecium are known to possess antibiotic resistance mechanisms that allow them to survive and multiply in the presence of antibiotics. This resistance can make infections caused by these bacteria difficult to treat and may require the use of alternative or stronger antibiotics.

Rate this question:

9.

What are outcomes of the recent Verigene BC-GP study publication covered in this training?

Increased length of stay with BC-GP
Decreased overall hospital costs with BC-GP
Significantly lower mortality with BC-GP
Increased duration of antibiotics use with BC-GP

Correct Answer

A. Decreased overall hospital costs with BC-GP

Explanation

The Verigene BC-GP study publication covered in this training shows that there is a decrease in overall hospital costs with BC-GP. This means that implementing the Verigene BC-GP system in hospitals can lead to cost savings for the healthcare facility.

Rate this question:

10.

Which of the following is a benefit of resistance gene detection over AST?

It is much faster
It shows physical response of bacteria to a specific dose of antibiotic
It relies on growth of the organism in culture
It tells the minimum inhibitory concentration of antibiotic to use

Correct Answer

A. It is much faster

Explanation

Resistance gene detection is a beneficial approach over AST (antibiotic susceptibility testing) because it provides a much faster result. This means that the resistance gene detection method can quickly identify whether a particular bacteria has acquired genes that make it resistant to antibiotics. In contrast, AST relies on the growth of the organism in culture, which takes longer to obtain results. Therefore, the speed of resistance gene detection allows for prompt decision-making in terms of selecting the appropriate antibiotic treatment, leading to more efficient and effective patient care.

Rate this question:

11.

Gram-negative bacteria are usually more resistant to antibiotics than Gram-positive bacteria.

True
False

Correct Answer

A. True

Explanation

Gram-negative bacteria have an outer membrane that provides an additional barrier against antibiotics, making them more resistant compared to Gram-positive bacteria which lack this outer membrane. The outer membrane of Gram-negative bacteria contains lipopolysaccharides that act as a protective shield, preventing antibiotics from entering the cell. Additionally, Gram-negative bacteria possess efflux pumps that can actively pump out antibiotics, further contributing to their resistance. Therefore, it is true that Gram-negative bacteria are usually more resistant to antibiotics than Gram-positive bacteria.

Rate this question:

12.

Bacteria that are susceptible to an antibiotic are not inhibited by the usual concentrations of the antimicrobial agent.

True
False

Correct Answer

A. False

Explanation

This statement is false. Bacteria that are susceptible to an antibiotic are indeed inhibited by the usual concentrations of the antimicrobial agent. When a bacteria is susceptible, it means that the antibiotic can effectively kill or inhibit its growth. Therefore, the usual concentrations of the antibiotic will be effective in inhibiting the susceptible bacteria.

Rate this question:

Bcid Module 5 Quiz

Antimicrobial Stewardship programs are designed to do all of the following, except:

Quiz Preview

Beta-lactam antibiotics have which of the following mechanism of action:

Which piece of information would not be helpful in determining appropriate antibiotic therapy?

All of the following technologies have Antibiotic Susceptibility Testing (AST) capabilities, except:

Biofire's mecA target includes the detection of the staphylococcal cassette mec junction.

Which of the following are gram-positive resistance marker(s) found on current molecular panels?

Which of the following are gram-negative resistance marker(s) found on current molecular panels?

Which of the following bacteria is commonly found to be resistant to antibiotics?

What are outcomes of the recent Verigene BC-GP study publication covered in this training?

Which of the following is a benefit of resistance gene detection over AST?

Gram-negative bacteria are usually more resistant to antibiotics than Gram-positive bacteria.

Bacteria that are susceptible to an antibiotic are not inhibited by the usual concentrations of the antimicrobial agent.