Hf Quiz Pharma2

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Quizzes Created: 48 | Total Attempts: 48,926
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  • 1/15 Questions

    Which is important to monitor in patients taking Digoxin?

    • Chloride
    • Potassium 
    • Sodium 
    • Zink
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About This Quiz

The HF quiz Pharma2 assesses knowledge on heart failure (HF) management, focusing on physiological impacts, treatment strategies like preload and afterload reduction, and complications such as arrhythmias due to electrolyte imbalances. It's designed for healthcare professionals to enhance understanding of chronic HF treatment and compensatory mechanisms.

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  • 2. 

    What is the source of Digoxin drug ?

    • Digitalis 

    • Digoxic lanta

    • Opoium -poppy 

    Correct Answer
    A. Digitalis 
    Explanation
    Digitalis is the correct source of Digoxin drug. Digoxin is derived from the leaves of the Digitalis plant. The plant contains compounds called cardiac glycosides, which have a positive inotropic effect on the heart. These compounds, including Digoxin, are used to treat various heart conditions such as congestive heart failure and atrial fibrillation.

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  • 3. 

    How do Beta blockers improve cardiac function in HF?

    • By decreasing cardiac remodelling

    • By increasing Heart rate

    • By increasing renin release 

    • By activating NE

    Correct Answer
    A. By decreasing cardiac remodelling
    Explanation
    Beta blockers improve cardiac function in HF by decreasing cardiac remodeling. In heart failure, the heart undergoes structural changes such as enlargement and thickening of the muscle, which can further impair its function. Beta blockers work by blocking the effects of adrenaline on the heart, reducing the workload on the heart and preventing further remodeling. This helps to improve cardiac function, reduce symptoms, and improve overall outcomes in patients with heart failure.

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  • 4. 

    Beta blockers are used in :

    • Acute HF.

    • Chronic HF.

    Correct Answer
    A. Chronic HF.
    Explanation
    Beta blockers are used in chronic heart failure (HF) because they help to improve the symptoms and outcomes of the condition. Beta blockers work by blocking the effects of adrenaline on the heart, which reduces the heart's workload and helps it to pump more efficiently. This can lead to a decrease in symptoms such as shortness of breath and fatigue, and can also improve survival rates in patients with chronic HF. In contrast, beta blockers are not typically used in acute HF, as they can initially worsen symptoms and may be contraindicated in certain cases.

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  • 5. 

    Which of the following is not the major intrinsic compensatory mechanism in HF patients?

    • Myocardial hypotrophy.

    • Myocardial hypertrophy.

    • None of the mentioned.

    Correct Answer
    A. Myocardial hypotrophy.
    Explanation
    Myocardial hypertrophy is a major intrinsic compensatory mechanism in HF patients. In heart failure, the heart muscle becomes weakened and is unable to pump blood effectively. To compensate for this, the heart undergoes hypertrophy, which means the heart muscle cells increase in size. This allows the heart to generate more force and pump blood more efficiently. Myocardial hypertrophy is an adaptive response to maintain cardiac output in HF patients. On the other hand, myocardial hypotrophy, or a decrease in the size of heart muscle cells, is not a compensatory mechanism in HF patients.

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  • 6. 

    Leakage of this substance can lead to Arrhythmia:

    • Ca+2\due to excessive beta activation

    • Ca+2\due to excessive beta inhibition

    • K+\due to excessive beta activation

    • K+\due to excessive beta inhibition

    Correct Answer
    A. Ca+2\due to excessive beta activation
    Explanation
    Excessive beta activation can lead to the leakage of Ca+2, which can result in arrhythmia. Beta activation increases the influx of calcium ions into the cells, causing an imbalance in the electrical conduction system of the heart. This disruption can lead to irregular heart rhythms, known as arrhythmias. Therefore, the leakage of Ca+2 due to excessive beta activation can be a potential cause of arrhythmia.

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  • 7. 

    Which of the following routes of administration bypasses the first-pass metabolism in the liver?

    • Oral 

    • Intravenous 

    • Subcutaneous 

    • Intramuscular

    Correct Answer
    A. Intravenous 
    Explanation
    Intravenous administration delivers drugs directly into the bloodstream, bypassing the digestive system and liver. This avoids the first-pass metabolism, where a significant portion of the drug can be metabolized and inactivated before reaching the systemic circulation.

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  • 8. 

    We need to adjust Digoxin dosage in patients with :

    • Renal failure 

    • Renal failure

    • Renal failure 

    • عشان ماتنسوها :P 

    Correct Answer
    A. Renal failure 
    Explanation
    The correct answer is renal failure. Digoxin is primarily eliminated through the kidneys, so patients with renal failure may have impaired clearance of the drug. This can lead to an accumulation of digoxin in the body, increasing the risk of toxicity. Therefore, adjusting the dosage is necessary to prevent adverse effects.

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  • 9. 

    Which of the following statements is CORRECT :

    • In HF patients , SV is lesser compared to normal individuals.

    • In HF patients , EF is much more compared to normal individuals.

    • Anemia is not related to HF.

    • None of the mentioned is correct

    Correct Answer
    A. In HF patients , SV is lesser compared to normal individuals.
    Explanation
    In patients with heart failure (HF), stroke volume (SV) is lower compared to normal individuals. SV refers to the amount of blood pumped out of the heart with each heartbeat. In HF, the heart is unable to pump efficiently, leading to a decrease in SV. This can result in symptoms such as fatigue, shortness of breath, and fluid retention. Therefore, the statement "In HF patients, SV is lesser compared to normal individuals" is correct.

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  • 10. 

    Which of the following graphs represents the early after depolarization (Ca+2 overload)?  

    • Option 1

    • Option 2

    • Option 3

    Correct Answer
    A. Option 2
  • 11. 

    In treatment of HF we should:

    • Increase the preload & decrease the afterload

    • Decrease the preload & increase the afterload.

    • Increase the preload & afterload

    • Decrease the preload & the afterload

    Correct Answer
    A. Decrease the preload & the afterload
    Explanation
    In the treatment of heart failure (HF), it is important to decrease the preload and the afterload. Preload refers to the amount of blood filling the heart before it contracts, and decreasing it can help reduce the workload on the heart. Afterload, on the other hand, refers to the resistance the heart has to overcome to pump blood out to the body, and decreasing it can also relieve the strain on the heart. By decreasing both the preload and the afterload, the heart's workload is reduced, allowing it to function more efficiently and improving symptoms of heart failure.

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  • 12. 

    Toxicity regarding Digoxin includes :

    • Hyperkalemia

    • Hypokalemia

    • Hypercalcemia

    • A+B

    • B+C

    Correct Answer
    A. B+C
    Explanation
    The correct answer is B+C. Digoxin toxicity can cause both hypokalemia (low potassium levels) and hypercalcemia (high calcium levels). Hypokalemia occurs because digoxin inhibits the sodium-potassium ATPase pump, leading to increased intracellular sodium levels and subsequent exchange of potassium from the cells. Hypercalcemia can occur due to the inhibition of the sodium-calcium exchanger, leading to increased intracellular calcium levels. Both of these electrolyte imbalances can contribute to the toxic effects of digoxin on the heart and other organs.

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  • 13. 

    Which of the following statements is CORRECT:

    • Prolonged beta activation decreases caspases

    • Down regulation takes place after increased sympathetic stimulation

    • Vagal activity is increased in order to compensate HF

    • All of the mentioned .

    Correct Answer
    A. Down regulation takes place after increased sympathetic stimulation
    Explanation
    Down regulation refers to a decrease in the number or sensitivity of receptors in response to increased stimulation. Sympathetic stimulation activates the sympathetic nervous system, which is responsible for the "fight or flight" response. Therefore, it is logical to assume that down regulation would take place after increased sympathetic stimulation, as the body tries to maintain homeostasis by decreasing the number or sensitivity of receptors.

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  • 14. 

    Which describes  the mechanism of action of milirinone in HF?

    • Decreases intracellular Ca+2

    • Increases cardiac contractility 

    • Decreases cAMP

    • Activates phosphodiesterase

    Correct Answer
    A. Increases cardiac contractility 
    Explanation
    Milrinone is a phosphodiesterase inhibitor that increases cardiac contractility by inhibiting the breakdown of cyclic adenosine monophosphate (cAMP). This leads to increased levels of cAMP in cardiac cells, which activates protein kinase A and ultimately enhances cardiac contractility. Therefore, the correct answer is "Increases cardiac contractility".

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  • 15. 

    Which of the following is correct regarding Digoxin when used for atrial fibrillation

    • Digoxin works by blocking voltage-sensitive calcium channels

    • Digoxin is used for rhythm control in patients with atrial fibrillation

    • Digoxin increases conduction velocity through the AV node

    • Digoxin levels of 1 to 2ng\ml are desirable in the treatment of atrial fibrillation

    Correct Answer
    A. Digoxin levels of 1 to 2ng\ml are desirable in the treatment of atrial fibrillation
    Explanation
    Digoxin levels of 1 to 2ng/ml are desirable in the treatment of atrial fibrillation because this range ensures therapeutic efficacy while minimizing the risk of toxicity. Digoxin is a medication commonly used for rate control in atrial fibrillation, but not for rhythm control. It works by inhibiting the sodium-potassium ATPase pump, leading to increased intracellular calcium levels and enhanced contractility of the heart. Digoxin does not block voltage-sensitive calcium channels and it actually decreases conduction velocity through the AV node. Therefore, the correct answer is that maintaining digoxin levels of 1 to 2ng/ml is desirable in the treatment of atrial fibrillation.

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Quiz Review Timeline (Updated): Jan 13, 2025 +

Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Jan 13, 2025
    Quiz Edited by
    ProProfs Editorial Team
  • Apr 03, 2020
    Quiz Created by
    Pharmacgy
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