A = basal layer (single cell layer, cuboidal cells, stem cells originate here that generate "transit-amplifying cells that give rise to replacement keratinocytes")
B = prickle cell layer (above basal cell layer, round or ovoid, desmosomes increase in # and become more obvious than basal)
C = granular layer (increased in maturation, cells are larger and flatter contain keratohyaline granules w/ filaggrin that binds keratin filaments together into a stable network)
D = keratinized layer (final stage of maturation, loss of all organelles, autolysis due to proteases. Filled entirely with tonofilaments surrounded by matrix protein filaggrin)