Insulin - High Yield Topic

By Kar
Kar, Assistant Professor (Biochemistry)
Karthikeyan Pethusamy is an assistant professor in the Department of Biochemistry at the All India Institute of Medical Sciences in New Delhi
Quizzes Created: 33 | Total Attempts: 43,785
, Assistant Professor (Biochemistry)
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Questions: 10 | Attempts: 270

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Insulin Quizzes & Trivia

Questions and Answers
  • 1. 

    Hyperinsulinemia is seen in Type 2 diabetes

    • A.

      True

    • B.

      False

    Correct Answer
    A. True
    Explanation
    Insulin resistance leads to more production of insulin.

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  • 2. 

    Who discovered the primary structure of insulin ?

    • A.

      Karry B mullis

    • B.

      Hoffman

    • C.

      Sanger

    • D.

      Banting & Best

    Correct Answer
    C. Sanger
    Explanation
    Banting & Best discovered insulin. Karry B mullis developed PCR.

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  • 3. 

    The so called "Honeymoon phase" is seen in 

    • A.

      Type I DM

    • B.

      Type II DM

    • C.

      Both

    • D.

      None

    Correct Answer
    A. Type I DM
    Explanation
    Honeymoon phase is requirement of less exogenous insulin in type I DM.

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  • 4. 

    True about somogyi effect 

    • A.

      Due to secretion of counter-regulatory hormones

    • B.

      Dose of insulin has to be raised

    • C.

      Rebound hyperglycemia

    • D.

      None

    Correct Answer
    C. Rebound hyperglycemia
    Explanation
    Rebound hyperglycemia is a true statement about the Somogyi effect. This phenomenon occurs when there is a rapid drop in blood sugar levels during the night, leading to the release of counter-regulatory hormones such as glucagon, cortisol, and growth hormone. These hormones stimulate the liver to produce glucose, causing a rebound increase in blood sugar levels. As a result, the dose of insulin may need to be raised to prevent further episodes of rebound hyperglycemia.

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  • 5. 

    Number of amino acids in Insulin

    • A.

      83

    • B.

      71

    • C.

      61

    • D.

      51

    Correct Answer
    D. 51
    Explanation
    Insulin is a peptide hormone composed of two polypeptide chains, an A chain and a B chain, linked by disulfide bonds. The A chain has 21 amino acids, while the B chain has 30 amino acids. Therefore, the total number of amino acids in insulin is 51.

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  • 6. 

    Which is NOT an ultra short acting insulin

    • A.

      Lispro

    • B.

      Aspart

    • C.

      Glargine

    • D.

      Glulisine

    Correct Answer
    C. Glargine
    Explanation
    Glargine is not an ultra short acting insulin. It is actually a long-acting insulin that provides a steady level of insulin in the body over a longer period of time. Ultra short acting insulins, such as Lispro, Aspart, and Glulisine, have a rapid onset of action and are used to control blood sugar levels during meals. Glargine, on the other hand, is used to provide a basal level of insulin throughout the day and night.

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  • 7. 

    Which is not a non-diabetic use of insulin

    • A.

      Hypokalemia

    • B.

      Hyperkalemia

    • C.

      Anterior pituitary assesment

    • D.

      Assessment of completeness of truncal vagotomy

    Correct Answer
    A. Hypokalemia
    Explanation
    Insulin is not used for the treatment of hypokalemia. Hypokalemia is a condition characterized by low levels of potassium in the blood. Insulin is primarily used to manage diabetes by helping to regulate blood sugar levels. It works by facilitating the uptake of glucose into cells, thereby lowering blood glucose levels. In the context of hypokalemia, other treatments such as potassium supplements or changes in diet may be used to address the low potassium levels.

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  • 8. 

    Insulin dependent glucose uptake happens in 

    • A.

      Muscles

    • B.

      Liver

    • C.

      Pancreatic beta cells

    • D.

      None

    Correct Answer
    A. Muscles
    Explanation
    Insulin is a hormone that regulates glucose uptake in the body. In the case of insulin-dependent glucose uptake, it occurs in muscles. When insulin is released into the bloodstream, it binds to receptors on muscle cells, allowing glucose to enter the cells and be used for energy. This process is essential for maintaining normal blood sugar levels and providing energy for muscle contraction and movement.

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  • 9. 

    Select the FALSE statement

    • A.

      Insulin induces glucokinase

    • B.

      Insulin releasing action by oral of glucose is higher than the same amount of iv glucose

    • C.

      Insulin inhibits lipoprotein lipase

    • D.

      None

    Correct Answer
    C. Insulin inhibits lipoprotein lipase
    Explanation
    Reason for the second option is release of incretins.

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  • 10. 

    Gold standard method for measurement of insulin resistance

    • A.

      HOMA-IR

    • B.

      Frequently sampled IGTT

    • C.

      Adiponectin assay

    • D.

      Euglycemic clamp

    Correct Answer
    D. Euglycemic clamp
    Explanation
    The euglycemic clamp is considered the gold standard method for measuring insulin resistance. This method involves infusing insulin into the bloodstream at a constant rate to maintain a stable blood glucose level. By measuring the amount of glucose needed to maintain this stable level, the body's response to insulin can be assessed. This method provides a direct and accurate measurement of insulin resistance and is commonly used in research and clinical settings.

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Kar |Assistant Professor (Biochemistry) |
Karthikeyan Pethusamy is an assistant professor in the Department of Biochemistry at the All India Institute of Medical Sciences in New Delhi

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