Immunology Quiz- Major Histocompatibility Complex (Mhc)
(258).jpg "Immunology Quiz- Major Histocompatibility Complex (Mhc)")
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- 1.Class III MHC genes encode for which of the following
- A.
CD4+ T cells
- B.
CD8+ T cells
- C.
Compliment molecules
- D.
Cytokine molecules
- E.
C & D
- 2.MHC class I has three genes (HLA-A, HLA-B, & HLA-C). Which of the following is the correct order from most alleles (most polymorphic) to least alleles?
- A.
A > B > C
- B.
A > C > B
- C.
B > A > C
- D.
B > C > A
- E.
C > A > B
- F.
C > B > A
- 3.How many genes does MHC class II have?
- A.
2 (HLA-DP alpha/beta)
- B.
2 (HLA-DQ alpha/beta)
- C.
4 (HLA-DP alpha/beta, HLA-DQ alpha/beta)
- D.
4 (HLA-DQ alpha/beta, HLA-DR alpha/beta)
- E.
6 (HLA-DP alpha/beta, HLA-DQ alpha/beta, HLA-DR alpha/beta)
- 4.Which of the following MHC class II genes has the most alleles (most polymorphic)?
- A.
DP alpha
- B.
DP beta
- C.
DQ alpha
- D.
DQ beta
- E.
DR alpha
- F.
DR beta
- 5.Which of the following MHC class II genes has the lease alleles?
- A.
DP alpha
- B.
DP beta
- C.
DQ alpha
- D.
DQ beta
- E.
DR alpha
- F.
DR beta
- 6.MHC molecules exhibit____ and immunoglobulin/TCR molecules exhibit____.
- A.
Allelic exclusion; Allelic exclusion
- B.
Allelic exclusion; Co-dominant expression
- C.
Co-dominant expression; Co-dominant expression
- D.
Co-dominant expression; Allelic exclusion
- 7.Because of a lack of genetic recombination in the MHC, blocks of alleles (haplotypes) are inherited together, and they are identical in families. Which of the following is the likely result of this?
- A.
Family members have identical combinations of HLA alleles, thus tissue transplantation is simple
- B.
Family members have identical combinations of HLA alleles, thus tissue transplantation is difficult
- C.
No family members have identical combinations of HLA alleles, thus tissue transplantation is simple
- D.
No family members have identical combinations of HLA alleles, thus tissue transplantation is difficult
- 8.Class II MHC molecules accommodate____ peptides and thus____ be referred to analogously as a “hotdog in a bun”, in contrast to class I MHC molecules.
- A.
Smaller; Would
- B.
Smaller; Would not
- C.
Larger; Would
- D.
Larger; Would not
- 9.Which of the following is NOT a structural chain in class I MHC?
- A.
Alpha1
- B.
Alpha2
- C.
Alpha3
- D.
Beta1
- E.
Beta2
- 10.Evidence is accumulating showing that polymorphism in the MHC may be advantageous. Homozygosity at HLA class I has been shown to be a(n)____ with respect to HIV/AIDS. Similarly, there is evidence that homozygosity at HLA class II____ the risk of hepatitis B virus infection persisting.
- A.
Advantage; Decreases
- B.
Advantage; Increases
- C.
Disadvantage; Decrease
- D.
Disadvantage; Increase
- 11.Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type: Ankylosing spondylitis
- A.
B27
- B.
DR2
- C.
DR3
- D.
DR4
- E.
DQ2
- 12.Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type: Insulin-dependent diabetes mellitus
- A.
B27
- B.
DR2
- C.
DR3
- D.
DR4
- E.
DQ2
- 13.Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Pemphigus vulgaris
- A.
B27
- B.
DR2
- C.
DR3
- D.
DR4
- E.
DQ2
- 14.Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Systemic lupus erythematosus
- A.
B27
- B.
DR2
- C.
DR3
- D.
DR4
- E.
DQ2
- 15.Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Good pasture’s syndrome
- A.
B27
- B.
DR2
- C.
DR3
- D.
DR4
- E.
DQ2
- 16.Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Multiple sclerosis
- A.
B27
- B.
DR2
- C.
DR3
- D.
DR4
- E.
DQ2
- 17.Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Rhematoid arthritis
- A.
B27
- B.
DR2
- C.
DR3
- D.
DR4
- E.
DQ2
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