Immunology Quiz- Major Histocompatibility Complex (MHC)

17 Questions
Immunology Quizzes & Trivia
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Questions and Answers
  • 1. 
    Class III MHC genes encode for which of the following
    • A. 

      CD4+ T cells

    • B. 

      CD8+ T cells

    • C. 

      Compliment molecules

    • D. 

      Cytokine molecules

    • E. 

      C & D

  • 2. 
    • A. 

      A > B > C

    • B. 

      A > C > B

    • C. 

      B > A > C

    • D. 

      B > C > A

    • E. 

      C > A > B

    • F. 

      C > B > A

  • 3. 
    • A. 

      2 (HLA-DP alpha/beta)

    • B. 

      2 (HLA-DQ alpha/beta)

    • C. 

      4 (HLA-DP alpha/beta, HLA-DQ alpha/beta)

    • D. 

      4 (HLA-DQ alpha/beta, HLA-DR alpha/beta)

    • E. 

      6 (HLA-DP alpha/beta, HLA-DQ alpha/beta, HLA-DR alpha/beta)

  • 4. 
    Which of the following MHC class II genes has the most alleles (most polymorphic)?
    • A. 

      DP alpha

    • B. 

      DP beta

    • C. 

      DQ alpha

    • D. 

      DQ beta

    • E. 

      DR alpha

    • F. 

      DR beta

  • 5. 
    Which of the following MHC class II genes has the lease alleles?
    • A. 

      DP alpha

    • B. 

      DP beta

    • C. 

      DQ alpha

    • D. 

      DQ beta

    • E. 

      DR alpha

    • F. 

      DR beta

  • 6. 
    MHC molecules exhibit____ and immunoglobulin/TCR molecules exhibit____.
    • A. 

      Allelic exclusion; Allelic exclusion

    • B. 

      Allelic exclusion; Co-dominant expression

    • C. 

      Co-dominant expression; Co-dominant expression

    • D. 

      Co-dominant expression; Allelic exclusion

  • 7. 
    • A. 

      Family members have identical combinations of HLA alleles, thus tissue transplantation is simple

    • B. 

      Family members have identical combinations of HLA alleles, thus tissue transplantation is difficult

    • C. 

      No family members have identical combinations of HLA alleles, thus tissue transplantation is simple

    • D. 

      No family members have identical combinations of HLA alleles, thus tissue transplantation is difficult

  • 8. 
    Class II MHC molecules accommodate____ peptides and thus____ be referred to analogously as a “hotdog in a bun”, in contrast to class I MHC molecules.
    • A. 

      Smaller; Would

    • B. 

      Smaller; Would not

    • C. 

      Larger; Would

    • D. 

      Larger; Would not

  • 9. 
    • A. 

      Alpha1

    • B. 

      Alpha2

    • C. 

      Alpha3

    • D. 

      Beta1

    • E. 

      Beta2

  • 10. 
    Evidence is accumulating showing that polymorphism in the MHC may be advantageous. Homozygosity at HLA class I has been shown to be a(n)____ with respect to HIV/AIDS. Similarly, there is evidence that homozygosity at HLA class II____ the risk of hepatitis B virus infection persisting.
    • A. 

      Advantage; Decreases

    • B. 

      Advantage; Increases

    • C. 

      Disadvantage; Decrease

    • D. 

      Disadvantage; Increase

  • 11. 
    Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type: Ankylosing spondylitis
    • A. 

      B27

    • B. 

      DR2

    • C. 

      DR3

    • D. 

      DR4

    • E. 

      DQ2

  • 12. 
    • A. 

      B27

    • B. 

      DR2

    • C. 

      DR3

    • D. 

      DR4

    • E. 

      DQ2

  • 13. 
    Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Pemphigus vulgaris
    • A. 

      B27

    • B. 

      DR2

    • C. 

      DR3

    • D. 

      DR4

    • E. 

      DQ2

  • 14. 
    Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Systemic lupus erythematosus
    • A. 

      B27

    • B. 

      DR2

    • C. 

      DR3

    • D. 

      DR4

    • E. 

      DQ2

  • 15. 
    Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Good pasture’s syndrome
    • A. 

      B27

    • B. 

      DR2

    • C. 

      DR3

    • D. 

      DR4

    • E. 

      DQ2

  • 16. 
    Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Multiple sclerosis
    • A. 

      B27

    • B. 

      DR2

    • C. 

      DR3

    • D. 

      DR4

    • E. 

      DQ2

  • 17. 
    Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Rhematoid arthritis
    • A. 

      B27

    • B. 

      DR2

    • C. 

      DR3

    • D. 

      DR4

    • E. 

      DQ2