Immunology Quiz- Major Histocompatibility Complex (Mhc)

17 Questions | By Smb6 | Last updated: Mar 22, 2022 | Total Attempts: 7564

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Immunology Quiz- Major Histocompatibility Complex (Mhc) - Quiz

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1.

Class III MHC genes encode for which of the following
- A.
  
  CD4+ T cells
- B.
  
  CD8+ T cells
- C.
  
  Compliment molecules
- D.
  
  Cytokine molecules
- E.
  
  C & D
2.

MHC class I has three genes (HLA-A, HLA-B, & HLA-C). Which of the following is the correct order from most alleles (most polymorphic) to least alleles?
- A.
  
  A > B > C
- B.
  
  A > C > B
- C.
  
  B > A > C
- D.
  
  B > C > A
- E.
  
  C > A > B
- F.
  
  C > B > A
3.

How many genes does MHC class II have?
- A.
  
  2 (HLA-DP alpha/beta)
- B.
  
  2 (HLA-DQ alpha/beta)
- C.
  
  4 (HLA-DP alpha/beta, HLA-DQ alpha/beta)
- D.
  
  4 (HLA-DQ alpha/beta, HLA-DR alpha/beta)
- E.
  
  6 (HLA-DP alpha/beta, HLA-DQ alpha/beta, HLA-DR alpha/beta)
4.

Which of the following MHC class II genes has the most alleles (most polymorphic)?
- A.
  
  DP alpha
- B.
  
  DP beta
- C.
  
  DQ alpha
- D.
  
  DQ beta
- E.
  
  DR alpha
- F.
  
  DR beta
5.

Which of the following MHC class II genes has the lease alleles?
- A.
  
  DP alpha
- B.
  
  DP beta
- C.
  
  DQ alpha
- D.
  
  DQ beta
- E.
  
  DR alpha
- F.
  
  DR beta
6.

MHC molecules exhibit____ and immunoglobulin/TCR molecules exhibit____.
- A.
  
  Allelic exclusion; Allelic exclusion
- B.
  
  Allelic exclusion; Co-dominant expression
- C.
  
  Co-dominant expression; Co-dominant expression
- D.
  
  Co-dominant expression; Allelic exclusion
7.

Because of a lack of genetic recombination in the MHC, blocks of alleles (haplotypes) are inherited together, and they are identical in families. Which of the following is the likely result of this?
- A.
  
  Family members have identical combinations of HLA alleles, thus tissue transplantation is simple
- B.
  
  Family members have identical combinations of HLA alleles, thus tissue transplantation is difficult
- C.
  
  No family members have identical combinations of HLA alleles, thus tissue transplantation is simple
- D.
  
  No family members have identical combinations of HLA alleles, thus tissue transplantation is difficult
8.

Class II MHC molecules accommodate____ peptides and thus____ be referred to analogously as a “hotdog in a bun”, in contrast to class I MHC molecules.
- A.
  
  Smaller; Would
- B.
  
  Smaller; Would not
- C.
  
  Larger; Would
- D.
  
  Larger; Would not
9.

Which of the following is NOT a structural chain in class I MHC?
- A.
  
  Alpha1
- B.
  
  Alpha2
- C.
  
  Alpha3
- D.
  
  Beta1
- E.
  
  Beta2
10.

Evidence is accumulating showing that polymorphism in the MHC may be advantageous. Homozygosity at HLA class I has been shown to be a(n)____ with respect to HIV/AIDS. Similarly, there is evidence that homozygosity at HLA class II____ the risk of hepatitis B virus infection persisting.
- A.
  
  Advantage; Decreases
- B.
  
  Advantage; Increases
- C.
  
  Disadvantage; Decrease
- D.
  
  Disadvantage; Increase
11.

Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type: Ankylosing spondylitis
- A.
  
  B27
- B.
  
  DR2
- C.
  
  DR3
- D.
  
  DR4
- E.
  
  DQ2
12.

Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type: Insulin-dependent diabetes mellitus
- A.
  
  B27
- B.
  
  DR2
- C.
  
  DR3
- D.
  
  DR4
- E.
  
  DQ2
13.

Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Pemphigus vulgaris
- A.
  
  B27
- B.
  
  DR2
- C.
  
  DR3
- D.
  
  DR4
- E.
  
  DQ2
14.

Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Systemic lupus erythematosus
- A.
  
  B27
- B.
  
  DR2
- C.
  
  DR3
- D.
  
  DR4
- E.
  
  DQ2
15.

Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Good pasture’s syndrome
- A.
  
  B27
- B.
  
  DR2
- C.
  
  DR3
- D.
  
  DR4
- E.
  
  DQ2
16.

Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Multiple sclerosis
- A.
  
  B27
- B.
  
  DR2
- C.
  
  DR3
- D.
  
  DR4
- E.
  
  DQ2
17.

Certain MHC haplotypes are associated with autoimmune disease. Match the disease with the HLA type:Rhematoid arthritis
- A.
  
  B27
- B.
  
  DR2
- C.
  
  DR3
- D.
  
  DR4
- E.
  
  DQ2