HIV/AIDS & Tumor Immunology
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- 1.Which HIV cell surface protein is responsible for binding a helper T cell?
- A.
Gp41
- B.
Reverse transcriptase
- C.
Gp120
- D.
Proviral DNA
- 2.Select the correct order of the HIV infection process of a Helper T cell.
- A.
Binding of gp41 --> Proviral DNA--> Genomic viral DNA --> Synthesis of new Viral proteins --> Integration of provirus DNA
- B.
Binding of gp120--> Genomic viral DNA --> reverse transcription into Proviral DNA -->Integration of Provirus DNA -->Synthesis of new viral proteins
- C.
Binding of gp120 --> Proviral DNA --> reverse transcription into Genomic DNA --> Integration into host DNA --> Synthesis of new HIV proteins
- D.
Binding of gp41 --> Genomic DNA --> Integration into host DNA --> Reverse transcription into proviral DNA --> Synthesis of new HIV proteins.
- 3.In a person with AIDS, which type of cell is mainly being attacked/depleted? (Select 2)
- A.
CD4+ T
- B.
CD8+ T
- C.
Helper T Cell
- D.
Natural Killer Cells
- 4.Someone infected with HIV may be asymptomatic for years
- A.
True
- B.
False
- 5.AIDS is diagnosed when
- A.
A person has become infected by the HIV virus
- B.
Antibodies to the proteins encoded by gag, pol, and env are found in the blood
- C.
Chronic fever, weight loss, and diarrhea are present with the virus
- D.
A person is infected with the HIV Virus and has been infected by opportunistic infections
- 6.The most common AIDS diagnostic test is one that isolates the virus from a blood sample.
- A.
True
- B.
False
- 7.Which of the following AIDS diagnostic tests use electrophoresis and detects up to 9 HIV viral proteins?
- A.
ELISA
- B.
Western Blot
- C.
PCR
- D.
IFA
- 8.Which test should be used as a starting point in the diagnosis of AIDS?
- A.
ELISA
- B.
Western Blot
- C.
IFA
- D.
PCR
- 9.Which of the following is a reason to HIV's resistance to drugs?
- A.
HIV has a high mutation rate due to reverse transcriptase errors
- B.
It uses reverse transcriptase
- C.
It isn't very resistant to drugs
- D.
Most drugs are protease inhibitors, which treat symptoms and not the viral infection
- 10.An absolute CD4+T cell count of 150 in a cubic millimeter of blood would indicate
- A.
The person is an antibody-positive asymptomatic carrier
- B.
The patient is vulnerable to an opportunistic infection
- C.
The patient is in category 1 of the CD4+T categories.
- D.
The patient is not at risk for AIDS
- 11.An opportunistic infection that occurs in the eye is the ________
- A.
Human papilloma virus
- B.
Hepatitis C virus
- C.
MAC
- D.
Cytomegalovirus
- 12.Which of the following is incorrect regarding CMV retinitis?
- A.
If untreated, the disease can cause blindness within 4 weeks
- B.
It is a member of the herpes virus family
- C.
Treatment is a one time regiment lasting 6 months
- D.
The CMV virus, if untreated, will cause blindness to both eyes
- 13.Which of the following are oncofetal genes? (Select 2)
- A.
CEA
- B.
AFP
- C.
RAS
- D.
P53
- 14.The membrane attack complex (MAC) is involved in the destruction of tumor cells.
- A.
True
- B.
False
- 15.Which of the following would aid in tumor escape?
- A.
Increased immune surveillance
- B.
Tumor decreasing production of immunosuppressive cytokines
- C.
Reduced levels of MHC-1 molecule on the tumor
- D.
Increased levels of Tumor associated and tumor specific antigens
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