Cholesterol And Lipoproteins - Block 3
Questions and Answers
- 1.
In ___________ cells dietary cholesterol is esterified and packaged into _____________ for transport to the ______________.
- A.
Hepatic, HDL, intestine
- B.
Mucosal, chylomicrons, intestine
- C.
Mucosal, chylomicrons, liver
- D.
Mucosal, HDL, Intestine
Correct Answer
C. Mucosal, chylomicrons, liver -
- 2.
Dietary cholesterol can be stored in the body in free form.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Dietary Cholesterol can only be stored in the body esterifed by Lecithin-cholesterol acyltransferase (LCAT) or by acyl CoA cholesterol acyltransferase 1 and 2 (ACAT 1 and ACAT 2).Rate this question:
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- 3.
Lecithin-cholesterol acyltransferase (LCAT) is found only in _____________________.
- A.
Mucosal cells
- B.
Intestine
- C.
Plasma
- D.
Liver
Correct Answer
C. PlasmaExplanation
LCAT is an enzyme responsible for converting cholesterol into cholesterol esters. It is primarily found in plasma, which is the liquid component of blood. LCAT plays a crucial role in maintaining cholesterol balance and preventing the buildup of excess cholesterol in the bloodstream. While it is possible for LCAT to be present in other tissues, its main location is in the plasma, where it carries out its function of esterifying cholesterol. Therefore, the correct answer is plasma.Rate this question:
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- 4.
The rate limiting enzyme of cholesterol biosynthesis is HMG-CoA reductase.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
HMG-CoA reductase is the rate limiting enzyme in cholesterol biosynthesis. This means that the activity of this enzyme determines the overall rate of cholesterol production in the body. When the activity of HMG-CoA reductase is inhibited, the synthesis of cholesterol is reduced. Therefore, the statement "The rate limiting enzyme of cholesterol biosynthesis is HMG-CoA reductase" is true.Rate this question:
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- 5.
Acyl-coenzyme A (CoA) -cholesterol acyl transferase (ACAT) converts exess cholesterol into _____________________ that are stored in the cell.
- A.
Highly soluble cholesterol esters
- B.
Highly insolube cholesterol esters
- C.
Moderaltely souble free cholesterols
- D.
Highly insoluble free cholesterols
Correct Answer
B. Highly insolube cholesterol estersExplanation
ACAT converts excess cholesterol into highly insoluble cholesterol esters that are stored in the cell.Rate this question:
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- 6.
When HMG-CoA is phosphyrolated it is in its active state.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
HMG-CoA is inactive when it is phosphorylated. It is dephosphorylated by HMG-CoA reductase phosphatase.Rate this question:
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- 7.
Regulation of intracellular cholesterol are up regluated by __________________ transcription factor.
- A.
HMG-CoA reductase
- B.
Sterol regulatory element binding protein (SREBP)
- C.
Sterol proteolytic enzymes
- D.
HMG-CoA
Correct Answer
B. Sterol regulatory element binding protein (SREBP)Explanation
The correct answer is sterol regulatory element binding protein (SREBP). SREBP is a transcription factor that plays a crucial role in regulating the synthesis and uptake of cholesterol in cells. When cellular cholesterol levels are low, SREBP is activated and translocates to the nucleus, where it binds to sterol regulatory elements on target genes, including HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. This leads to the upregulation of HMG-CoA reductase and other genes involved in cholesterol synthesis and uptake, helping to restore cellular cholesterol levels.Rate this question:
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- 8.
SREBP is attached to the ER and proteolytically cleaved to enter the ______________.
- A.
Golgi
- B.
Ribosomes
- C.
Nucleus
- D.
Smooth ER
Correct Answer
C. NucleusExplanation
SREBP, or Sterol Regulatory Element Binding Protein, is initially attached to the endoplasmic reticulum (ER). It undergoes proteolytic cleavage, which allows it to detach from the ER and enter the nucleus. Once in the nucleus, SREBP can regulate the expression of genes involved in lipid metabolism and cholesterol synthesis. Therefore, the correct answer is the nucleus.Rate this question:
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- 9.
Translation of HMG-CoA reductase takes place in _____________________.
- A.
Nucleus
- B.
Ribosomes
- C.
Cytosol
- D.
ER
Correct Answer
C. CytosolExplanation
Translation is the process by which a protein is synthesized from an mRNA template. In eukaryotic cells, translation occurs in the cytoplasm. Ribosomes, the cellular structures responsible for protein synthesis, are located in the cytosol. Therefore, the correct answer is cytosol.Rate this question:
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- 10.
HMG-CoA reductase is deactived by ________________
- A.
Protein Kinase
- B.
Phospho-protien phosphatase
- C.
SREBP
- D.
HMG-CoA
Correct Answer
A. Protein KinaseExplanation
Protein Kinase deactivates HMG-CoA reductase. Protein Kinase is an enzyme that adds a phosphate group to a protein, which can alter its function or activity. In this case, when Protein Kinase adds a phosphate group to HMG-CoA reductase, it inhibits its activity, leading to its deactivation.Rate this question:
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- 11.
HMG-CoA + HMG-CoA reductase -->
- A.
Cholesterol
- B.
Mevalonic acid
- C.
SREBP
- D.
Translation protein
Correct Answer
B. Mevalonic acidExplanation
The correct answer is mevalonic acid. HMG-CoA is converted into mevalonic acid by the enzyme HMG-CoA reductase. Mevalonic acid is a key intermediate in the biosynthesis of cholesterol. This process is regulated by SREBP (sterol regulatory element-binding protein), which controls the transcription of genes involved in cholesterol synthesis. The translation protein mentioned in the question is not directly related to this specific pathway.Rate this question:
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- 12.
When intracellular proteins are high; gene expression is activated and HMG-CoA reductase is synthesized.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
When intracellular proteins are low; gene expression is activated and HMG-CoA reductase is synthesized.Rate this question:
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- 13.
When cholesterol is high the whole system is switched off and no synthesis of HMG-CoA reductase is produced.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
When cholesterol levels are high, it signals the body to downregulate the production of HMG-CoA reductase, which is an enzyme involved in cholesterol synthesis. This is a regulatory mechanism to prevent excessive cholesterol production when it is already abundant in the body. Therefore, when cholesterol is high, the synthesis of HMG-CoA reductase is switched off, leading to a decrease in cholesterol production. Hence, the statement is true.Rate this question:
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- 14.
Chylomicrons are mainly ___________________________.
- A.
Proteins
- B.
Available when no cholesterol is needed.
- C.
Triglycerides
- D.
Endogenous
Correct Answer
C. TriglyceridesExplanation
Chylomicrons are mainly composed of triglycerides. Triglycerides are a type of fat that is formed from glycerol and three fatty acids. Chylomicrons are large lipoprotein particles that transport dietary triglycerides from the intestines to various tissues in the body. They are formed in the intestinal cells after the digestion and absorption of dietary fats. Chylomicrons play a crucial role in the transportation and utilization of dietary fats for energy or storage in adipose tissue.Rate this question:
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- 15.
Chylomicrons are exogenous proteins becuase they are synthesized in the liver.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Chylomicrons are exogenous, but they are synthesized in the intestines.Rate this question:
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- 16.
A patience presents to you for a complete CBC. You not knowing she just had a high dietary fat meal less than 15 minutes ago. You agrees to run the blood test. What will you find in the blood screening?
- A.
High level of HMG-COA reductase
- B.
Chylomicrons
- C.
High density lipoproteins
- D.
Huge red blood cells
Correct Answer
B. ChylomicronsExplanation
Chylomicrons have a short half life of one hour. So, if the blood test was done within the hour chlyomicrons will be detected. If more than one hour from your patients big meal, no chylomicrons should be found in blood work, in a normally healthy person.Rate this question:
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- 17.
VLDL is an abbrevation for
- A.
Very light density ligands
- B.
Very light density lipoprotein
- C.
Very little density lipoprotein
- D.
Very long density lipoprotein
Correct Answer
B. Very light density lipoproteinExplanation
VLDL stands for Very Light Density Lipoprotein. Lipoproteins are responsible for transporting lipids (such as cholesterol and triglycerides) in the bloodstream. VLDL is a type of lipoprotein that carries triglycerides from the liver to various tissues in the body. It is considered "very light density" because it contains a higher proportion of triglycerides compared to other lipoproteins like LDL and HDL.Rate this question:
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- 18.
VLDL is synthesized in _______________ and secreted in the _____________.
- A.
ER, intestines
- B.
Intestine, blood
- C.
Nucleus, cytosol
- D.
Liver, blood
Correct Answer
D. Liver, bloodExplanation
VLDL (Very Low-Density Lipoprotein) is synthesized in the liver and then secreted into the blood. The liver is responsible for the production of VLDL, which is a type of lipoprotein that transports triglycerides from the liver to other tissues in the body. Once in the blood, VLDL undergoes various transformations and eventually gets converted into LDL (Low-Density Lipoprotein) and HDL (High-Density Lipoprotein). Therefore, the correct answer is liver, blood.Rate this question:
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- 19.
VLDL is a endogenous fat carrying protein.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
VLDL stands for very low-density lipoprotein, which is a type of lipoprotein produced by the liver. It is responsible for carrying triglycerides, a type of fat, from the liver to other tissues in the body. Therefore, VLDL is indeed an endogenous fat-carrying protein, making the statement "VLDL is an endogenous fat carrying protein" true.Rate this question:
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- 20.
Low Density Lipoproteins (LDL) are _________________carrying proteins.
- A.
Triglycerides
- B.
Protein
- C.
Cholesterol
- D.
50% cholesterol and 50% protein
Correct Answer
C. CholesterolExplanation
LDL, also known as "bad cholesterol," are lipoproteins that primarily carry cholesterol in the bloodstream. They are responsible for delivering cholesterol to various cells in the body. LDL particles contain approximately 50% cholesterol and 50% protein, along with other lipids such as triglycerides. Therefore, the correct answer is "50% cholesterol and 50% protein."Rate this question:
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- 21.
LDL is associated with ______________________.
- A.
Coronary heart disease
- B.
Intestinal obstruction
- C.
Sickle cell anemia
- D.
Liver cancer
Correct Answer
A. Coronary heart diseaseExplanation
LDL, also known as low-density lipoprotein, is commonly referred to as "bad cholesterol." High levels of LDL in the blood can lead to the buildup of plaque in the arteries, increasing the risk of coronary heart disease. Therefore, LDL is associated with coronary heart disease.Rate this question:
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- 22.
You have a patient that presents with tendon xanthomas, a type of inherited hyerplipoproteinemia. What would be the likelu cause?
- A.
Eating too much ice cream
- B.
Deficiency in chylomicrons
- C.
LDL receptors defective
- D.
Deficiency in LPL
Correct Answer
C. LDL receptors defectiveExplanation
Tendon Xanthomas is a hyerpcholesterolemia. Resulting in a defect of the LDL receptor. The reduced LDL clearance leads to high LDL resulting in coronary artery disease and plaques.Rate this question:
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- 23.
Tendon Xanthomas is a hypercholesterolemia disorder.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
Tendon xanthomas are a characteristic feature of familial hypercholesterolemia, a genetic disorder characterized by high levels of cholesterol in the blood. These xanthomas are deposits of cholesterol that accumulate in the tendons, causing them to appear yellowish and nodular. Therefore, it is correct to say that tendon xanthomas are associated with hypercholesterolemia.Rate this question:
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- 24.
Tendon Xanthomas is located in the lower medial part of the thigh.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Tendon Xanthomas is usually seen on the achilles tendon. TYPE IIa - inherited hyperlipoproteinemia.Rate this question:
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- 25.
Homozygous for hypercholesterolemia will need a liver transplant. But, Heterozygous will be able to clear cholesterol with the help of cholesterol clearing drugs.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
Individuals who are homozygous for hypercholesterolemia have two copies of the gene mutation that causes the condition, resulting in extremely high cholesterol levels that cannot be effectively cleared from the body. This can lead to serious health complications, including the need for a liver transplant. On the other hand, individuals who are heterozygous for hypercholesterolemia have only one copy of the gene mutation and are able to clear cholesterol with the help of cholesterol clearing drugs. Therefore, the statement is true.Rate this question:
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- 26.
Low Density Lipoprotein (LDL) is synthesized ___________________ and __________________.
- A.
Nucleus, cytoplasm
- B.
Plasma VLDL and intestine
- C.
Plasma VLDL and liver
- D.
Liver and intestine
Correct Answer
C. Plasma VLDL and liverExplanation
LDL is synthesized in the liver and intestine. It is formed from very low-density lipoprotein (VLDL) in the plasma. The liver is responsible for producing VLDL, which is then converted into LDL. The intestine also plays a role in synthesizing LDL by absorbing dietary cholesterol and triglycerides, which are then packaged into VLDL and eventually converted into LDL. Therefore, both the liver and the plasma VLDL contribute to the synthesis of LDL.Rate this question:
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- 27.
High Density lipoproteins (HDL) are _______________ .
- A.
Mainily fat carrying.
- B.
Mainly cholesterol carrying
- C.
Mainly protein carrying.
- D.
25% protein and 25% protein, and 50% fat
Correct Answer
C. Mainly protein carrying.Explanation
HDL, also known as "good cholesterol," primarily carries proteins. These proteins help remove excess cholesterol from the bloodstream and transport it to the liver for disposal. While HDL does contain small amounts of fat and cholesterol, its main role is to carry proteins that aid in cholesterol metabolism and maintain cardiovascular health.Rate this question:
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- 28.
HDL are known as the protective lipoprotein because it takes cholesterol away from cells.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
HDL, also known as high-density lipoprotein, is often referred to as the "good" cholesterol. It is considered protective because it helps remove excess cholesterol from cells and carries it back to the liver, where it is broken down and eliminated from the body. This process helps prevent the buildup of cholesterol in the arteries, reducing the risk of heart disease and other cardiovascular problems. Therefore, the statement that HDL takes cholesterol away from cells is true.Rate this question:
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- 29.
When lipoproteins were isolated via electrophoresis: ________________________ will gravitate towardsthe negative end (origin) and __________________would go towards the positive end (alpha region) and___________________ will go towards the middle (beta region)
- A.
LDL, HDL, VLDL
- B.
Chylomicrons, LDL, HDL
- C.
Chylomicrons, HDL and LDL
- D.
HDL, chylomicrons, LDL
Correct Answer
C. Chylomicrons, HDL and LDL -
- 30.
When isolating lipoproteins in an aqueous solution, you are measuring the density range by mixing with salt solution and ultracentrifuging; _____________________ will float to the top because it has a lot of fat.
- A.
HDL
- B.
Chylomicrons
- C.
Glucose
- D.
Liver cells
Correct Answer
B. ChylomicronsExplanation
When isolating lipoproteins in an aqueous solution, the density range is measured by mixing with a salt solution and ultracentrifuging. Chylomicrons will float to the top because they have a lot of fat.Rate this question:
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- 31.
The hardest lipoprotein to separate is ____________________, because it has high protein content.
- A.
LDL
- B.
VLDL
- C.
HDL
- D.
IDL
Correct Answer
C. HDLExplanation
HDL, or high-density lipoprotein, is the hardest lipoprotein to separate because it has high protein content. Lipoproteins are particles that transport cholesterol and triglycerides in the bloodstream. HDL is considered the "good" cholesterol as it helps remove excess cholesterol from the blood and carries it back to the liver for processing. Its high protein content makes it denser and more difficult to separate from other lipoproteins using traditional separation techniques.Rate this question:
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- 32.
In the lipoprotein metabolism pathway, all metabolism takes place __________________.
- A.
Where they are synthsized
- B.
In the cytoplasm
- C.
In the plasma compartment of the blood.
- D.
In urine.
Correct Answer
C. In the plasma compartment of the blood.Explanation
Lipoprotein metabolism refers to the process of metabolizing lipoproteins, which are particles that transport lipids (such as cholesterol and triglycerides) in the blood. This metabolism primarily occurs in the plasma compartment of the blood, where lipoproteins are synthesized, modified, and cleared from circulation. The lipoproteins are responsible for transporting lipids to various tissues and organs, where they are utilized or stored. Therefore, the correct answer is "in the plasma compartment of the blood."Rate this question:
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- 33.
Chylomicrons metabolism begins by secretion of chylomicron from __________________ cells.
- A.
Muscosa (in intestine)
- B.
Liver
- C.
Pancreas
- D.
Gall bladder
Correct Answer
A. Muscosa (in intestine)Explanation
Chylomicrons are large lipoprotein particles that transport dietary fats from the intestines to various tissues in the body. The metabolism of chylomicrons starts with their secretion from the mucosa cells in the intestine. These cells package dietary fats into chylomicrons and release them into the lymphatic system. From there, the chylomicrons enter the bloodstream and deliver the fats to different tissues for energy production or storage. The liver also plays a role in chylomicron metabolism by removing remnants of these particles from the bloodstream. However, the initial secretion of chylomicrons occurs in the mucosa cells of the intestine.Rate this question:
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- 34.
When chylomicrons are secreted they are carried by the lymphatics to ____________________.
- A.
Blood
- B.
Liver
- C.
Intestines
- D.
Stomach
Correct Answer
A. BloodExplanation
When chylomicrons are secreted, they are carried by the lymphatics to the blood. Chylomicrons are large lipoprotein particles that are formed in the intestines during the process of fat digestion. They contain dietary fats and fat-soluble vitamins and are too large to directly enter the bloodstream. Instead, they are transported through the lymphatic system and eventually enter the bloodstream, where they can deliver their cargo to various tissues in the body. Therefore, the correct answer is blood.Rate this question:
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- 35.
When chylomicrons are secreted in the blood, they are considered ______________ chylomicrons with _____________ apoproteins attached.
- A.
Big; large
- B.
Nascent; B-48
- C.
Mature; CII
- D.
Nascent; A1
Correct Answer
B. Nascent; B-48Explanation
Chylomicrons are large molecules that transport dietary fats in the blood. When they are secreted, they are considered nascent chylomicrons, meaning they are newly formed or in an early stage. These nascent chylomicrons have B-48 apoproteins attached to them, which are necessary for their function in transporting fats. The term "nascent" indicates the early stage of formation, while "B-48" refers to the specific apoprotein attached to the chylomicrons.Rate this question:
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- 36.
Because the nascent chylomicron does not have all the proteins it needs, it gets C-II and E from ____________________.
- A.
LDL secreted by the liver
- B.
HDL secreted by the liver
- C.
Mature chylomicrons
- D.
VLDL
Correct Answer
B. HDL secreted by the liverExplanation
The nascent chylomicron does not have all the proteins it needs, so it obtains C-II and E from HDL secreted by the liver. HDL, or high-density lipoprotein, is responsible for transporting cholesterol from the peripheral tissues back to the liver. It is rich in proteins, including C-II and E, which are transferred to the nascent chylomicron to complete its formation and functionality. LDL, VLDL, and mature chylomicrons do not provide the necessary proteins for the nascent chylomicron.Rate this question:
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- 37.
HDL is secreted from the liver and gives to the nascent chylomicron which proteins?
- A.
A-1 and B-48
- B.
C-II and E
- C.
B-100 and B-48
- D.
A-1 and CII
Correct Answer
B. C-II and EExplanation
Once the nascent chylomicron receives from HDL the C-II and E proteins, it is now considered mature.Rate this question:
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- 38.
The mature chylomicron has three apoproteins on it. they are _____.
- A.
Apo A-1, Apo A-II, Apo B-48
- B.
Apo B-48, Apo C-II, Apo E
- C.
Apo E, Apo H, Apo A-1
- D.
Apo (a), Apo A1, Apo B-48
Correct Answer
B. Apo B-48, Apo C-II, Apo EExplanation
The mature chylomicron has three apoproteins on it: Apo B-48, Apo C-II, and Apo E.Rate this question:
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- 39.
Apo-CII is necessary on the chylomicron to _______________________.
- A.
Inactivate HDL cascade
- B.
Activate VLDL cascade
- C.
Activate lipoprotein lipase
- D.
Inactivate lipoprotein kinase
Correct Answer
C. Activate lipoprotein lipaseExplanation
Apo-CII is necessary on the chylomicron to activate lipoprotein lipase. Lipoprotein lipase is an enzyme that plays a crucial role in the breakdown of triglycerides in chylomicrons, which are particles that transport dietary fat in the bloodstream. Apo-CII acts as a cofactor for lipoprotein lipase, allowing it to bind to the surface of chylomicrons and initiate the breakdown of triglycerides into fatty acids. This process is essential for the efficient utilization of dietary fat by various tissues in the body.Rate this question:
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- 40.
What hydrolyzes fatty acids from chylomicrons into adipocytes?
- A.
Protein kinase
- B.
Lipophosphatase
- C.
Lipoprotein lipase
- D.
Protein phosphatase
Correct Answer
C. Lipoprotein lipaseExplanation
Lipoprotein lipase is the enzyme that hydrolyzes fatty acids from chylomicrons into adipocytes. Chylomicrons are large lipoprotein particles that transport dietary triglycerides from the intestines to various tissues, including adipocytes. Lipoprotein lipase acts on the surface of adipocytes and breaks down the triglycerides present in chylomicrons into free fatty acids and glycerol, which can then be taken up and stored by the adipocytes. Therefore, lipoprotein lipase plays a crucial role in lipid metabolism and storage in adipose tissue.Rate this question:
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- 41.
Fatty acides which are hydrolyzed adn taken up by muscle and other tissues are used for providing energy.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
Fatty acids are a major source of energy for the body. When they are hydrolyzed (broken down) and taken up by muscle and other tissues, they can be used as fuel for energy production. Therefore, the statement that fatty acids are used for providing energy is true.Rate this question:
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- 42.
Once hydrolysis takes place, the mature chylomicron is taken back up to the liver with Apo B-48, C-II and E still attached.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Once the fatty acids are hydrolyzed, the C-II is sent back to the HDL. The chlomicron reminant is taken back up into the liver with B-48 and Apo E still attached and are mediated endocytosized on the liver via B/E receptors.Rate this question:
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- 43.
What is the main protein of HDL?
- A.
Apo E
- B.
Apo A1
- C.
Apo AII
- D.
Apo C1
Correct Answer
B. Apo A1Explanation
Apo A1 is the main protein of HDL, also known as high-density lipoprotein. HDL is responsible for transporting cholesterol from the body's tissues to the liver, where it can be broken down and eliminated. Apo A1 plays a crucial role in this process by binding to cholesterol and other lipids, forming a complex that can be recognized by receptors in the liver. This allows HDL to effectively remove excess cholesterol from the bloodstream, reducing the risk of cardiovascular diseases.Rate this question:
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- 44.
Apo A-1 can be found and HDL and ________________.
- A.
LDL
- B.
VLDL
- C.
Chylomicrons
- D.
IDL
Correct Answer
C. ChylomicronsExplanation
Apo A-1 can be found in HDL and chylomicrons.Rate this question:
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- 45.
LCAT is activated by
- A.
Apo A-1
- B.
Apo B-48
- C.
Apo B-48 and Apo B-100
- D.
Apo E
Correct Answer
A. Apo A-1Explanation
Remember: LCAT esterifies cholesterolRate this question:
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- 46.
What is the function of Apo A1 on chylomicrons?
- A.
It allows chylomicron to metabolize quickly
- B.
It makes it soluble in the lymph and blood
- C.
It helps metabolize the fats
- D.
It makes it insoluble in the lymph and blood
Correct Answer
B. It makes it soluble in the lymph and bloodExplanation
Apo A1 is a protein that plays a crucial role in the metabolism of chylomicrons. Chylomicrons are large particles that transport dietary fats from the intestines to various tissues in the body. Apo A1 binds to chylomicrons and helps to make them soluble in the lymph and blood. This solubility allows chylomicrons to be transported efficiently through the circulatory system, ensuring that the fats they carry can be delivered to cells for energy production or storage. Without Apo A1, chylomicrons would be insoluble and unable to effectively transport fats throughout the body.Rate this question:
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- 47.
Which apoprotien is the ligand for the LDL receptor.
- A.
Apo AI
- B.
Apo B-48
- C.
Apo E
- D.
Apo 100
Correct Answer
D. Apo 100 -
- 48.
Which Apoprotein is exclusively found on chylomicrons?
- A.
Apo B-100
- B.
Apo B-48
- C.
Apo CII
- D.
Apo A1
Correct Answer
B. Apo B-48Explanation
Apo B-48 is exclusively found on chylomicrons. This apoprotein is synthesized in the intestine and is responsible for the assembly and secretion of chylomicrons, which are lipoprotein particles that transport dietary triglycerides from the intestine to other tissues. Apo B-48 is unique to chylomicrons and is different from Apo B-100, which is found on other lipoproteins like VLDL and LDL. Apo CII and Apo A1 are also apoproteins found on different lipoproteins, but they are not exclusively found on chylomicrons.Rate this question:
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- 49.
Apo C-I are found on ______________.
- A.
Chylomicrons
- B.
VLDL
- C.
IDL
- D.
HDL
- E.
All of the above
Correct Answer
E. All of the aboveExplanation
Apo C-I is found on chylomicrons, VLDL, IDL, and HDL. Chylomicrons are lipoproteins that transport dietary triglycerides, VLDL are lipoproteins that transport endogenously synthesized triglycerides, IDL are intermediate-density lipoproteins that result from the metabolism of VLDL, and HDL are high-density lipoproteins that play a role in reverse cholesterol transport. Therefore, Apo C-I can be found on all of these lipoproteins.Rate this question:
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- 50.
Apo B-100 are found on chylomicrons.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
Apo B-100 is found on VLDL, IDL, and LDL. It is the only protein of LDL. It is the LDL receptor ligand. One of the longest known protein in humans.Rate this question:
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