Cholesterol And Lipoproteins - Block 3

52 Questions | Total Attempts: 1681

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Cholesterol Quizzes & Trivia

Questions and Answers
  • 1. 
    In ___________ cells dietary cholesterol is esterified and packaged into _____________ for transport to the ______________.
    • A. 

      Hepatic, HDL, intestine

    • B. 

      Mucosal, chylomicrons, intestine

    • C. 

      Mucosal, chylomicrons, liver

    • D. 

      Mucosal, HDL, Intestine

  • 2. 
    Dietary cholesterol can be stored in the body in free form.
    • A. 

      True

    • B. 

      False

  • 3. 
    Lecithin-cholesterol acyltransferase (LCAT) is found only in _____________________.
    • A. 

      Mucosal cells

    • B. 

      Intestine

    • C. 

      Plasma

    • D. 

      Liver

  • 4. 
    The rate limiting enzyme of cholesterol biosynthesis is HMG-CoA reductase.
    • A. 

      True

    • B. 

      False

  • 5. 
    Acyl-coenzyme A (CoA) -cholesterol acyl transferase (ACAT) converts exess cholesterol into _____________________ that are stored in the cell.
    • A. 

      Highly soluble cholesterol esters

    • B. 

      Highly insolube cholesterol esters

    • C. 

      Moderaltely souble free cholesterols

    • D. 

      Highly insoluble free cholesterols

  • 6. 
    When HMG-CoA is phosphyrolated it is in its active state.
    • A. 

      True

    • B. 

      False

  • 7. 
    Regulation of intracellular cholesterol are up regluated by __________________ transcription factor.
    • A. 

      HMG-CoA reductase

    • B. 

      Sterol regulatory element binding protein (SREBP)

    • C. 

      Sterol proteolytic enzymes

    • D. 

      HMG-CoA

  • 8. 
    SREBP is attached to the ER and proteolytically cleaved to enter the ______________.
    • A. 

      Golgi

    • B. 

      Ribosomes

    • C. 

      Nucleus

    • D. 

      Smooth ER

  • 9. 
    Translation of HMG-CoA reductase takes place in _____________________.
    • A. 

      Nucleus

    • B. 

      Ribosomes

    • C. 

      Cytosol

    • D. 

      ER

  • 10. 
    HMG-CoA reductase is deactived by ________________
    • A. 

      Protein Kinase

    • B. 

      Phospho-protien phosphatase

    • C. 

      SREBP

    • D. 

      HMG-CoA

  • 11. 
    HMG-CoA + HMG-CoA reductase -->
    • A. 

      Cholesterol

    • B. 

      Mevalonic acid

    • C. 

      SREBP

    • D. 

      Translation protein

  • 12. 
    When intracellular proteins are high; gene expression is activated and HMG-CoA reductase is synthesized.
    • A. 

      True

    • B. 

      False

  • 13. 
    When cholesterol is high the whole system is switched off and no synthesis of HMG-CoA reductase is produced.
    • A. 

      True

    • B. 

      False

  • 14. 
    Chylomicrons are mainly ___________________________.
    • A. 

      Proteins

    • B. 

      Available when no cholesterol is needed.

    • C. 

      Triglycerides

    • D. 

      Endogenous

  • 15. 
    Chylomicrons are exogenous proteins becuase they are synthesized in the liver.
    • A. 

      True

    • B. 

      False

  • 16. 
    A patience presents to you for a complete CBC.  You not knowing she just had a high dietary fat meal less than 15 minutes ago.  You agrees to run the blood test.  What will you find in the blood screening?
    • A. 

      High level of HMG-COA reductase

    • B. 

      Chylomicrons

    • C. 

      High density lipoproteins

    • D. 

      Huge red blood cells

  • 17. 
    VLDL is an abbrevation for
    • A. 

      Very light density ligands

    • B. 

      Very light density lipoprotein

    • C. 

      Very little density lipoprotein

    • D. 

      Very long density lipoprotein

  • 18. 
    VLDL is synthesized in _______________ and secreted in the _____________.
    • A. 

      ER, intestines

    • B. 

      Intestine, blood

    • C. 

      Nucleus, cytosol

    • D. 

      Liver, blood

  • 19. 
    VLDL is a endogenous fat carrying protein.
    • A. 

      True

    • B. 

      False

  • 20. 
    Low Density Lipoproteins (LDL) are _________________carrying proteins.
    • A. 

      Triglycerides

    • B. 

      Protein

    • C. 

      Cholesterol

    • D. 

      50% cholesterol and 50% protein

  • 21. 
    LDL is associated with ______________________.
    • A. 

      Coronary heart disease

    • B. 

      Intestinal obstruction

    • C. 

      Sickle cell anemia

    • D. 

      Liver cancer

  • 22. 
    You have a patient that presents with tendon xanthomas, a type of inherited hyerplipoproteinemia.  What would be the likelu cause?
    • A. 

      Eating too much ice cream

    • B. 

      Deficiency in chylomicrons

    • C. 

      LDL receptors defective

    • D. 

      Deficiency in LPL

  • 23. 
    Tendon Xanthomas is a hypercholesterolemia disorder.
    • A. 

      True

    • B. 

      False

  • 24. 
    Tendon Xanthomas is located in the lower medial part of the thigh.
    • A. 

      True

    • B. 

      False

  • 25. 
    Homozygous for hypercholesterolemia will need a liver transplant.  But, Heterozygous will be able to clear cholesterol with the help of cholesterol clearing drugs.
    • A. 

      True

    • B. 

      False

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