Cholesterol And Lipoproteins - Block 3
- 1.In ___________ cells dietary cholesterol is esterified and packaged into _____________ for transport to the ______________.
- A.
Hepatic, HDL, intestine
- B.
Mucosal, chylomicrons, intestine
- C.
Mucosal, chylomicrons, liver
- D.
Mucosal, HDL, Intestine
- 2.Dietary cholesterol can be stored in the body in free form.
- A.
True
- B.
False
- 3.Lecithin-cholesterol acyltransferase (LCAT) is found only in _____________________.
- A.
Mucosal cells
- B.
Intestine
- C.
Plasma
- D.
Liver
- 4.The rate limiting enzyme of cholesterol biosynthesis is HMG-CoA reductase.
- A.
True
- B.
False
- 5.Acyl-coenzyme A (CoA) -cholesterol acyl transferase (ACAT) converts exess cholesterol into _____________________ that are stored in the cell.
- A.
Highly soluble cholesterol esters
- B.
Highly insolube cholesterol esters
- C.
Moderaltely souble free cholesterols
- D.
Highly insoluble free cholesterols
- 6.When HMG-CoA is phosphyrolated it is in its active state.
- A.
True
- B.
False
- 7.Regulation of intracellular cholesterol are up regluated by __________________ transcription factor.
- A.
HMG-CoA reductase
- B.
Sterol regulatory element binding protein (SREBP)
- C.
Sterol proteolytic enzymes
- D.
HMG-CoA
- 8.SREBP is attached to the ER and proteolytically cleaved to enter the ______________.
- A.
Golgi
- B.
Ribosomes
- C.
Nucleus
- D.
Smooth ER
- 9.Translation of HMG-CoA reductase takes place in _____________________.
- A.
Nucleus
- B.
Ribosomes
- C.
Cytosol
- D.
ER
- 10.HMG-CoA reductase is deactived by ________________
- A.
Protein Kinase
- B.
Phospho-protien phosphatase
- C.
SREBP
- D.
HMG-CoA
- 11.HMG-CoA + HMG-CoA reductase -->
- A.
Cholesterol
- B.
Mevalonic acid
- C.
SREBP
- D.
Translation protein
- 12.When intracellular proteins are high; gene expression is activated and HMG-CoA reductase is synthesized.
- A.
True
- B.
False
- 13.When cholesterol is high the whole system is switched off and no synthesis of HMG-CoA reductase is produced.
- A.
True
- B.
False
- 14.Chylomicrons are mainly ___________________________.
- A.
Proteins
- B.
Available when no cholesterol is needed.
- C.
Triglycerides
- D.
Endogenous
- 15.Chylomicrons are exogenous proteins becuase they are synthesized in the liver.
- A.
True
- B.
False
- 16.A patience presents to you for a complete CBC. You not knowing she just had a high dietary fat meal less than 15 minutes ago. You agrees to run the blood test. What will you find in the blood screening?
- A.
High level of HMG-COA reductase
- B.
Chylomicrons
- C.
High density lipoproteins
- D.
Huge red blood cells
- 17.VLDL is an abbrevation for
- A.
Very light density ligands
- B.
Very light density lipoprotein
- C.
Very little density lipoprotein
- D.
Very long density lipoprotein
- 18.VLDL is synthesized in _______________ and secreted in the _____________.
- A.
ER, intestines
- B.
Intestine, blood
- C.
Nucleus, cytosol
- D.
Liver, blood
- 19.VLDL is a endogenous fat carrying protein.
- A.
True
- B.
False
- 20.Low Density Lipoproteins (LDL) are _________________carrying proteins.
- A.
Triglycerides
- B.
Protein
- C.
Cholesterol
- D.
50% cholesterol and 50% protein
- 21.LDL is associated with ______________________.
- A.
Coronary heart disease
- B.
Intestinal obstruction
- C.
Sickle cell anemia
- D.
Liver cancer
- 22.You have a patient that presents with tendon xanthomas, a type of inherited hyerplipoproteinemia. What would be the likelu cause?
- A.
Eating too much ice cream
- B.
Deficiency in chylomicrons
- C.
LDL receptors defective
- D.
Deficiency in LPL
- 23.Tendon Xanthomas is a hypercholesterolemia disorder.
- A.
True
- B.
False
- 24.Tendon Xanthomas is located in the lower medial part of the thigh.
- A.
True
- B.
False
- 25.Homozygous for hypercholesterolemia will need a liver transplant. But, Heterozygous will be able to clear cholesterol with the help of cholesterol clearing drugs.
- A.
True
- B.
False
Questions: 9 | Attempts: 1558 | Last updated: Jun 4, 2019
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