Central Nervous System Infections
(204).jpg "Central Nervous System Infections")
- 1.Encephalitis is the result of parenchyma infiltration and blood-borne invasion across what barrier?
- A.
CSF
- B.
Blood-brain barrier
- C.
Epithelial cells
- D.
Mucosal lining
- 2.Polio and rabies viruses invade
- A.
Neurons
- B.
Oligodendrocytes
- C.
Macrophages
- D.
CD 4+ T cells
- 3.Where is the rabies virus shed?
- A.
Lungs
- B.
Gut
- C.
Salivary glands
- D.
Feces
- 4.HSV and VZV are favorable for infection of the CNS because they remain latent in
- A.
Neurons
- B.
Dorsal root ganglion
- C.
Macrophages
- D.
Oligodendrocytes
- 5.Which type of meningitis is associated with negative bacterial cultures of CSF?
- A.
Acute bacterial
- B.
Viral
- C.
Aseptic
- D.
Fungal
- 6.Which of the following is TRUE about bacterial meningitis?
- A.
More common than viral meningitis
- B.
Typically presents as a mild infection
- C.
Most commonly caused by Neisseria meningitidis
- D.
Will see increase in CD8+ T cells in CSF
- 7.A patient presents to the ED with a headache, fever, and a stiff neck. You preform a lumbar puncture because you suspect bacterial meningitis and the CSF culture comes back positive with the causative agent being a gram (+) bacteria. What do you suspect as the likely causative agent?
- A.
Neisseria meningitidis
- B.
Haemophilus influenzae
- C.
Streptococcus pneumoniae
- D.
Staphylococcus aureus
- 8._____________ is an important mediator of protection against bacterial invasion and deficiencies have been shown to increase the susceptibility to bacteremia. (associated with meningococcal meningitis)
- A.
Macrophages
- B.
Complement (C5-C9)
- C.
Opsonization
- D.
Normal flora
- 9.In meningococcal meningitis, hemorrhagic skin rash with petechiae is indicative of
- A.
Renal failure
- B.
Septicemia
- C.
Resolution of infection
- D.
Loss of neural stimulation
- 10.___________ presents with bleeding into the brain and adrenal glands as a result of acute Addisonian crisis seen in severe cases of meningococcal meningitis.
- A.
Cushing's Disease
- B.
Wilson's Disease
- C.
Waterhouse-Friedrichsen syndrome
- D.
Wirsung syndrome
- 11.Consequences of neonatal meningitis are more associated with immune sequelae than microbial sequelae.
- A.
True
- B.
False
- 12.The primary site of infection for tuberculous meningitis is in the
- A.
Brain
- B.
Lungs
- C.
Gut
- D.
Normal flora
- 13.Irritation and swelling (inflammation) of the brain is known as what?
- 14.The key diagnostic test for HSV is
- A.
ELISA
- B.
PCR analysis
- C.
Urine dipstick
- D.
Cytochrome cell culture
- 15.What type of HSV is responsible for 95% of HSE cases?
- A.
HSV-1
- B.
HSV-2
- 16.What type of HSV is the second leading cause of aseptic meningitis?
- A.
HSV-1
- B.
HSV-2
- 17.Lumbosacral radiculitis is a neurological manifestation of HSV in adults resulting in infected nerves and nerve roots and is classified as what syndrome?
- A.
Waterhouse-Friederich syndrome
- B.
Elsberg syndrome
- C.
Karposi's sarcoma
- D.
Wilson's Disease
- 18.HSV neonatal disease is associated with HSV-2 infection during what stage of pregnancy
- A.
1st trimester
- B.
2nd trimester
- C.
3rd trimester
- D.
During delivery
- 19.Route of transmission for HSV-1 and HSV-2 are (respectively)
- A.
Genital, oral
- B.
Oral, genital
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