Central Nervous System Infections

20 Questions | Total Attempts: 467

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Central Nervous System Infections


Questions and Answers
  • 1. 
    Encephalitis is the result of parenchyma infiltration and blood-borne invasion across what barrier?
    • A. 

      CSF

    • B. 

      Blood-brain barrier

    • C. 

      Epithelial cells

    • D. 

      Mucosal lining

  • 2. 
    Polio and rabies viruses invade 
    • A. 

      Neurons

    • B. 

      Oligodendrocytes

    • C. 

      Macrophages

    • D. 

      CD 4+ T cells

  • 3. 
    Where is the rabies virus shed?
    • A. 

      Lungs

    • B. 

      Gut

    • C. 

      Salivary glands

    • D. 

      Feces

  • 4. 
    HSV and VZV are favorable for infection of the CNS because they remain latent in
    • A. 

      Neurons

    • B. 

      Dorsal root ganglion

    • C. 

      Macrophages

    • D. 

      Oligodendrocytes

  • 5. 
    Which type of meningitis is associated with negative bacterial cultures of CSF?
    • A. 

      Acute bacterial

    • B. 

      Viral

    • C. 

      Aseptic

    • D. 

      Fungal

  • 6. 
    Which of the following is TRUE about bacterial meningitis?
    • A. 

      More common than viral meningitis

    • B. 

      Typically presents as a mild infection

    • C. 

      Most commonly caused by Neisseria meningitidis

    • D. 

      Will see increase in CD8+ T cells in CSF

  • 7. 
    A patient presents to the ED with a headache, fever, and a stiff neck. You preform a lumbar puncture because you suspect bacterial meningitis and the CSF culture comes back positive with the causative agent being a gram (+) bacteria. What do you suspect as the likely causative agent?
    • A. 

      Neisseria meningitidis

    • B. 

      Haemophilus influenzae

    • C. 

      Streptococcus pneumoniae

    • D. 

      Staphylococcus aureus

  • 8. 
    _____________ is an important mediator of protection against bacterial invasion and deficiencies have been shown to increase the susceptibility to bacteremia. (associated with meningococcal meningitis)
    • A. 

      Macrophages

    • B. 

      Complement (C5-C9)

    • C. 

      Opsonization

    • D. 

      Normal flora

  • 9. 
    In meningococcal meningitis, hemorrhagic skin rash with petechiae is indicative of 
    • A. 

      Renal failure

    • B. 

      Septicemia

    • C. 

      Resolution of infection

    • D. 

      Loss of neural stimulation

  • 10. 
    ___________ presents with bleeding into the brain and adrenal glands as a result of acute Addisonian crisis seen in severe cases of meningococcal meningitis. 
    • A. 

      Cushing's Disease

    • B. 

      Wilson's Disease

    • C. 

      Waterhouse-Friedrichsen syndrome

    • D. 

      Wirsung syndrome

  • 11. 
    Consequences of neonatal meningitis are more associated with immune sequelae than microbial sequelae.
    • A. 

      True

    • B. 

      False

  • 12. 
    The primary site of infection for tuberculous meningitis is in the
    • A. 

      Brain

    • B. 

      Lungs

    • C. 

      Gut

    • D. 

      Normal flora

  • 13. 
    Irritation and swelling (inflammation) of the brain is known as what?
  • 14. 
    The key diagnostic test for HSV is
    • A. 

      ELISA

    • B. 

      PCR analysis

    • C. 

      Urine dipstick

    • D. 

      Cytochrome cell culture

  • 15. 
    What type of HSV is responsible for 95% of HSE cases?
    • A. 

      HSV-1

    • B. 

      HSV-2

  • 16. 
    What type of HSV is the second leading cause of aseptic  meningitis?
    • A. 

      HSV-1

    • B. 

      HSV-2

  • 17. 
    Lumbosacral radiculitis is a neurological manifestation of HSV in adults resulting in infected nerves and nerve roots and is classified as what syndrome?
    • A. 

      Waterhouse-Friederich syndrome

    • B. 

      Elsberg syndrome

    • C. 

      Karposi's sarcoma

    • D. 

      Wilson's Disease

  • 18. 
    HSV neonatal disease is associated with HSV-2 infection during what stage of pregnancy
    • A. 

      1st trimester

    • B. 

      2nd trimester

    • C. 

      3rd trimester

    • D. 

      During delivery

  • 19. 
    Route of transmission for HSV-1 and HSV-2 are (respectively)
    • A. 

      Genital, oral

    • B. 

      Oral, genital

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