Central Nervous System Infections

20 Questions | By Aliciaperkins | Last updated: Mar 21, 2022 | Total Attempts: 878

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Central Nervous System Infections - Quiz

Questions and Answers

1.

Encephalitis is the result of parenchyma infiltration and blood-borne invasion across what barrier?
- A.
  
  CSF
- B.
  
  Blood-brain barrier
- C.
  
  Epithelial cells
- D.
  
  Mucosal lining
2.

Polio and rabies viruses invade
- A.
  
  Neurons
- B.
  
  Oligodendrocytes
- C.
  
  Macrophages
- D.
  
  CD 4+ T cells
3.

Where is the rabies virus shed?
- A.
  
  Lungs
- B.
  
  Gut
- C.
  
  Salivary glands
- D.
  
  Feces
4.

HSV and VZV are favorable for infection of the CNS because they remain latent in
- A.
  
  Neurons
- B.
  
  Dorsal root ganglion
- C.
  
  Macrophages
- D.
  
  Oligodendrocytes
5.

Which type of meningitis is associated with negative bacterial cultures of CSF?
- A.
  
  Acute bacterial
- B.
  
  Viral
- C.
  
  Aseptic
- D.
  
  Fungal
6.

Which of the following is TRUE about bacterial meningitis?
- A.
  
  More common than viral meningitis
- B.
  
  Typically presents as a mild infection
- C.
  
  Most commonly caused by Neisseria meningitidis
- D.
  
  Will see increase in CD8+ T cells in CSF
7.

A patient presents to the ED with a headache, fever, and a stiff neck. You preform a lumbar puncture because you suspect bacterial meningitis and the CSF culture comes back positive with the causative agent being a gram (+) bacteria. What do you suspect as the likely causative agent?
- A.
  
  Neisseria meningitidis
- B.
  
  Haemophilus influenzae
- C.
  
  Streptococcus pneumoniae
- D.
  
  Staphylococcus aureus
8.

_____________ is an important mediator of protection against bacterial invasion and deficiencies have been shown to increase the susceptibility to bacteremia. (associated with meningococcal meningitis)
- A.
  
  Macrophages
- B.
  
  Complement (C5-C9)
- C.
  
  Opsonization
- D.
  
  Normal flora
9.

In meningococcal meningitis, hemorrhagic skin rash with petechiae is indicative of
- A.
  
  Renal failure
- B.
  
  Septicemia
- C.
  
  Resolution of infection
- D.
  
  Loss of neural stimulation
10.

___________ presents with bleeding into the brain and adrenal glands as a result of acute Addisonian crisis seen in severe cases of meningococcal meningitis.
- A.
  
  Cushing's Disease
- B.
  
  Wilson's Disease
- C.
  
  Waterhouse-Friedrichsen syndrome
- D.
  
  Wirsung syndrome
11.

Consequences of neonatal meningitis are more associated with immune sequelae than microbial sequelae.
- A.
  
  True
- B.
  
  False
12.

The primary site of infection for tuberculous meningitis is in the
- A.
  
  Brain
- B.
  
  Lungs
- C.
  
  Gut
- D.
  
  Normal flora
13.

Irritation and swelling (inflammation) of the brain is known as what?
14.

The key diagnostic test for HSV is
- A.
  
  ELISA
- B.
  
  PCR analysis
- C.
  
  Urine dipstick
- D.
  
  Cytochrome cell culture
15.

What type of HSV is responsible for 95% of HSE cases?
- A.
  
  HSV-1
- B.
  
  HSV-2
16.

What type of HSV is the second leading cause of aseptic meningitis?
- A.
  
  HSV-1
- B.
  
  HSV-2
17.

Lumbosacral radiculitis is a neurological manifestation of HSV in adults resulting in infected nerves and nerve roots and is classified as what syndrome?
- A.
  
  Waterhouse-Friederich syndrome
- B.
  
  Elsberg syndrome
- C.
  
  Karposi's sarcoma
- D.
  
  Wilson's Disease
18.

HSV neonatal disease is associated with HSV-2 infection during what stage of pregnancy
- A.
  
  1st trimester
- B.
  
  2nd trimester
- C.
  
  3rd trimester
- D.
  
  During delivery
19.

Route of transmission for HSV-1 and HSV-2 are (respectively)
- A.
  
  Genital, oral
- B.
  
  Oral, genital