Case - Autoimmune Hepatitis

10 Questions

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Hepatitis Quizzes & Trivia

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Questions and Answers
  • 1. 
    Which of the following statements is most accurate?
    • A. 

      Autoimmune hepatitis is a rare condition which is decreasing in incidence

    • B. 

      Approximately 20% of patients with hepatitis C will present with an acute hepatitic illness characterised by the presence of jaundice

    • C. 

      Antibiotics are a well recognised cause of drug-induced liver disease

    • D. 

      Wilsons disease is a disorder or iron homeostasis

    • E. 

      Approximately 40% of heavy alcohol consumers will develop alcoholic liver diseas

  • 2. 
    Which of the following statements is most accurate?
    • A. 

      The mortality rate from a liver biopsy is less than 0.001%

    • B. 

      The elevated levels of immunoglobulin seen in patients with autoimmune disease consist almost entirely of autoantibodies

    • C. 

      IgM elevation is a characteristic feature of autoimmune hepatitis

    • D. 

      The peak age for the diagnosis of AIH is 45-55

    • E. 

      Anti-LKM antibodies are seen in hepatitis C infections as well as AIH

  • 3. 
    Which of the following statements is most accurate?
    • A. 

      The combination of anti-double-stranded DNA antibodies and anti-nuclear antibodies is diagnostic of SLE.

    • B. 

      2. The ANA pattern characteristic of PBC is multiple nuclear dots and rim-like staining

    • C. 

      It is difficult to distinguish between hepatitis B and AIH on liver biopsy

    • D. 

      Complement levels are typically elevated in SLE

    • E. 

      SLE never affects the liver

  • 4. 
    Which of the following statements is most accurate?
    • A. 

      Tetracycline is a well recognised trigger for AIH

    • B. 

      Minocycline is a well recognised trigger for AIH

    • C. 

      Hepatitis C virus is a well recognised trigger for AIH

    • D. 

      CMV is a well recognised trigger for AIH

    • E. 

      Environmental pollution can trigger autoimmune disease

  • 5. 
    Which of the following statements is most accurate?
    • A. 

      IgA levels provide an accurate measure for activity of alcoholic liver disease

    • B. 

      IgM levels provide an accurate measure for activity of PBC

    • C. 

      Changes in autoantibody level are a more accurate measure of AIH activity than IgG levels

    • D. 

      Specific reduction in the level of IgG through plasmapheresis has been shown to be an effective treatment in AIH

    • E. 

      IgG level is a more valuable marker for disease activity than alkaline phosphatase level in AIH

  • 6. 
    Which of the following statements is most accurate.
    • A. 

      Tacrolimus is used as first line treatment for AIH in approximately 20% of patients in the UK

    • B. 

      Patients who are unable to, tolerate azathioprine because of side effects are usually able to take MMF despite the common structure of the drugs

    • C. 

      The vast majority of patient taking prednisolone will develop osteoporosis.

    • D. 

      Prednisolone therapy should always be stopped after 6 months in patients with AIH

    • E. 

      Liver toxicity precludes the use of cyclosporine for the treatment of AIH

  • 7. 
    Which of the following statements is most accurate.
    • A. 

      Graft versus host disease (GVHD) is a common occurrence following liver transplantation

    • B. 

      Chronic GVHD can mimic PBC

    • C. 

      Heart and lung transplantation is more complex than lung transplantation alone

    • D. 

      First year survival after liver transplantation is typically 65-70%

    • E. 

      Breast cancer 7 years previously would be an absolute contra-indication to lung transplantation

  • 8. 
    Which of the following statements is most accurate.
    • A. 

      It is normal to commence immuno-suppressive treatment in the 24 hours before a transplant operation

    • B. 

      Patients undergoing liver transplantation typically require greater levels of immuno-suppression than those undergoing bone marrow transplantation

    • C. 

      Matching for blood group is important for renal transplant but not liver transplant success

    • D. 

      Pre-transplant blood transfusion reduces the risk of rejection in renal transplantation

    • E. 

      The combination of tacrolimus and cyclosporine is particularly effective at preventing organ

  • 9. 
    Which of the following statements is most accurate.
    • A. 

      Mouse monoclonal antibodies are safe to give to humans

    • B. 

      Most monoclonal antibodies used for the treatment of humans are humanised mouse antibodies

    • C. 

      OKT3 (anti-CD3) is used in approximately 25% of liver transplant patients

    • D. 

      The characteristic infection seen in patients receiving infliximab (anti-TNF) is herpes simplex

    • E. 

      Rituximab (anti-CD20) is particularly effective for the treatment of T-cell lymphomas

  • 10. 
    Which of the following statements is most accurate?
    • A. 

      Skin malignancy is a common problem in post-transplant patients

    • B. 

      Post-Transplant Lymphoproliferative Disorder (PTLD) is a form of lymphoma driven by CMV infection

    • C. 

      CMV is only rarely seen post-tranplant

    • D. 

      Cyclosporine but not tacrolimus can cause renal impairment

    • E. 

      Neurological effects are a common problem with azathioprine treatment