Case - Autoimmune Hepatitis
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- 1.
Which of the following statements is most accurate?
- A.
Autoimmune hepatitis is a rare condition which is decreasing in incidence
- B.
Approximately 20% of patients with hepatitis C will present with an acute hepatitic illness characterised by the presence of jaundice
- C.
Antibiotics are a well recognised cause of drug-induced liver disease
- D.
Wilsons disease is a disorder or iron homeostasis
- E.
Approximately 40% of heavy alcohol consumers will develop alcoholic liver diseas
Correct Answer
C. Antibiotics are a well recognised cause of drug-induced liver diseaseExplanation
Antibiotics are known to be a common cause of drug-induced liver disease. This means that taking certain antibiotics can lead to liver damage or dysfunction. It is important for healthcare professionals to be aware of this potential side effect and monitor patients closely when prescribing antibiotics, especially in individuals who may already have liver disease or other risk factors.Rate this question:
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- 2.
Which of the following statements is most accurate?
- A.
The mortality rate from a liver biopsy is less than 0.001%
- B.
The elevated levels of immunoglobulin seen in patients with autoimmune disease consist almost entirely of autoantibodies
- C.
IgM elevation is a characteristic feature of autoimmune hepatitis
- D.
The peak age for the diagnosis of AIH is 45-55
- E.
Anti-LKM antibodies are seen in hepatitis C infections as well as AIH
Correct Answer
E. Anti-LKM antibodies are seen in hepatitis C infections as well as AIH -
- 3.
Which of the following statements is most accurate?
- A.
The combination of anti-double-stranded DNA antibodies and anti-nuclear antibodies is diagnostic of SLE.
- B.
2. The ANA pattern characteristic of PBC is multiple nuclear dots and rim-like staining
- C.
It is difficult to distinguish between hepatitis B and AIH on liver biopsy
- D.
Complement levels are typically elevated in SLE
- E.
SLE never affects the liver
Correct Answer
A. The combination of anti-double-stranded DNA antibodies and anti-nuclear antibodies is diagnostic of SLE.Explanation
The combination of anti-double-stranded DNA antibodies and anti-nuclear antibodies is diagnostic of SLE because these antibodies are commonly found in individuals with systemic lupus erythematosus (SLE). The presence of both antibodies helps to confirm the diagnosis of SLE, as they are not typically seen in other autoimmune diseases. Anti-double-stranded DNA antibodies specifically target DNA and are highly specific for SLE, while anti-nuclear antibodies are more commonly found in autoimmune diseases but when combined with anti-double-stranded DNA antibodies, they provide a strong indication of SLE.Rate this question:
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- 4.
Which of the following statements is most accurate?
- A.
Tetracycline is a well recognised trigger for AIH
- B.
Minocycline is a well recognised trigger for AIH
- C.
Hepatitis C virus is a well recognised trigger for AIH
- D.
CMV is a well recognised trigger for AIH
- E.
Environmental pollution can trigger autoimmune disease
Correct Answer
B. Minocycline is a well recognised trigger for AIHExplanation
Minocycline is a well-recognized trigger for AIH. Autoimmune hepatitis (AIH) is a condition where the immune system mistakenly attacks the liver, leading to inflammation and liver damage. Minocycline, an antibiotic commonly used to treat acne, has been associated with drug-induced AIH. Studies have shown that minocycline can cause liver injury and trigger an autoimmune response in susceptible individuals, leading to the development of AIH. Therefore, minocycline is considered a recognized trigger for AIH.Rate this question:
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- 5.
Which of the following statements is most accurate?
- A.
IgA levels provide an accurate measure for activity of alcoholic liver disease
- B.
IgM levels provide an accurate measure for activity of PBC
- C.
Changes in autoantibody level are a more accurate measure of AIH activity than IgG levels
- D.
Specific reduction in the level of IgG through plasmapheresis has been shown to be an effective treatment in AIH
- E.
IgG level is a more valuable marker for disease activity than alkaline phosphatase level in AIH
Correct Answer
E. IgG level is a more valuable marker for disease activity than alkaline phosphatase level in AIHExplanation
IgG level is a more valuable marker for disease activity than alkaline phosphatase level in AIH. This statement suggests that in autoimmune hepatitis (AIH), the level of IgG is a better indicator of disease activity compared to the level of alkaline phosphatase. This implies that monitoring the IgG level can provide more accurate information about the progression and severity of AIH. Alkaline phosphatase may still be relevant in assessing liver function, but IgG is considered a more reliable marker for disease activity in AIH.Rate this question:
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- 6.
Which of the following statements is most accurate.
- A.
Tacrolimus is used as first line treatment for AIH in approximately 20% of patients in the UK
- B.
Patients who are unable to, tolerate azathioprine because of side effects are usually able to take MMF despite the common structure of the drugs
- C.
The vast majority of patient taking prednisolone will develop osteoporosis.
- D.
Prednisolone therapy should always be stopped after 6 months in patients with AIH
- E.
Liver toxicity precludes the use of cyclosporine for the treatment of AIH
Correct Answer
B. Patients who are unable to, tolerate azathioprine because of side effects are usually able to take MMF despite the common structure of the drugsExplanation
This statement suggests that patients who cannot tolerate azathioprine due to side effects can usually tolerate MMF (mycophenolate mofetil) despite the drugs having a common structure. This implies that MMF may have a different side effect profile or mechanism of action compared to azathioprine, making it a viable alternative for these patients.Rate this question:
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- 7.
Which of the following statements is most accurate.
- A.
Graft versus host disease (GVHD) is a common occurrence following liver transplantation
- B.
Chronic GVHD can mimic PBC
- C.
Heart and lung transplantation is more complex than lung transplantation alone
- D.
First year survival after liver transplantation is typically 65-70%
- E.
Breast cancer 7 years previously would be an absolute contra-indication to lung transplantation
Correct Answer
B. Chronic GVHD can mimic PBCExplanation
Chronic graft-versus-host disease (GVHD) can mimic primary biliary cholangitis (PBC). Both conditions can cause liver damage and have similar symptoms such as fatigue, jaundice, and itching. Chronic GVHD occurs when the transplanted cells attack the recipient's tissues, including the liver. This can lead to bile duct damage and inflammation, similar to what is seen in PBC. Therefore, chronic GVHD can present with clinical and histological features that mimic PBC, making it important to consider this possibility in patients with a history of transplantation and suspected PBC.Rate this question:
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- 8.
Which of the following statements is most accurate.
- A.
It is normal to commence immuno-suppressive treatment in the 24 hours before a transplant operation
- B.
Patients undergoing liver transplantation typically require greater levels of immuno-suppression than those undergoing bone marrow transplantation
- C.
Matching for blood group is important for renal transplant but not liver transplant success
- D.
Pre-transplant blood transfusion reduces the risk of rejection in renal transplantation
- E.
The combination of tacrolimus and cyclosporine is particularly effective at preventing organ
Correct Answer
D. Pre-transplant blood transfusion reduces the risk of rejection in renal transplantation -
- 9.
Which of the following statements is most accurate.
- A.
Mouse monoclonal antibodies are safe to give to humans
- B.
Most monoclonal antibodies used for the treatment of humans are humanised mouse antibodies
- C.
OKT3 (anti-CD3) is used in approximately 25% of liver transplant patients
- D.
The characteristic infection seen in patients receiving infliximab (anti-TNF) is herpes simplex
- E.
Rituximab (anti-CD20) is particularly effective for the treatment of T-cell lymphomas
Correct Answer
B. Most monoclonal antibodies used for the treatment of humans are humanised mouse antibodiesExplanation
Most monoclonal antibodies used for the treatment of humans are humanised mouse antibodies. This means that the antibodies are derived from mice but have been modified to be more similar to human antibodies, reducing the risk of adverse reactions when used in humans. Humanising the antibodies allows for better compatibility and effectiveness in human patients.Rate this question:
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- 10.
Which of the following statements is most accurate?
- A.
Skin malignancy is a common problem in post-transplant patients
- B.
Post-Transplant Lymphoproliferative Disorder (PTLD) is a form of lymphoma driven by CMV infection
- C.
CMV is only rarely seen post-tranplant
- D.
Cyclosporine but not tacrolimus can cause renal impairment
- E.
Neurological effects are a common problem with azathioprine treatment
Correct Answer
A. Skin malignancy is a common problem in post-transplant patientsExplanation
Skin malignancy is a common problem in post-transplant patients. This statement suggests that individuals who have undergone a transplant procedure are at a higher risk of developing skin cancer. This could be due to the immunosuppressive medications that transplant patients typically take, which can weaken the immune system and make it more difficult for the body to fight off cancerous cells. Regular monitoring and skin cancer screenings are important for post-transplant patients to detect and treat any malignancies early.Rate this question:
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Current Version
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Mar 21, 2023Quiz Edited by
ProProfs Editorial Team -
Dec 05, 2011Quiz Created by
Roberth5
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