Block 9 Viral Replication MCQ's

12 Questions | By Chachelly | Updated: Mar 22, 2022 | Attempts: 708

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1.

What type of virus causes swine flu?
- A.
  
  Ds RNA virus
- B.
  
  Ds DNA virus
- C.
  
  Ss negative sense RNA virus
- D.
  
  Ss positive sense RNA virus
2.

Swine flu is caused by a member of which family of viruses?
- A.
  
  Orthomyxoviridae
- B.
  
  Filoviridae
- C.
  
  Paramyxoviridae
- D.
  
  Arenaviridae
3.

For swine flu to replicate in the host cell it must carry an enzyme for nucleic acid replication. Which enzyme is this?
- A.
  
  RNA-dependent DNA polymerase
- B.
  
  DNA dependent DNA polymerase
- C.
  
  RNA-dependent RNA polymerase
- D.
  
  DNA dependent RNA polymerase
4.

One of the three main shapes for the viral capsid is the icosahedron. How many faces does an icosahedron have?
- A.
  
  21
- B.
  
  24
- C.
  
  20
- D.
  
  18
- E.
  
  16
5.

The common cold, polio and hepatitis A can all be caused by a virus of the same family. Which family is this?
- A.
  
  Picornaviridae
- B.
  
  Poxviridae
- C.
  
  Filoviridae
- D.
  
  Coronaviridae
6.

Researchers discover a new molecule they think could be used as an antiviral against picornaviruses. To test their hypothesis, they perform the following experiment using a cell line permissive to picornavirus infection: Condition 1: The cells are neither treated with the test compound nor exposed to the virus. Condition 2: The cells are not treated with the test molecule but are infected with the virus. Condition 3: The cells are treated with the test molecule but are not exposed to the virus. Condition 4: The cells are treated with the test compound and exposed to the virus. After a 5 minute incubation period, all cell cultures are thoroughly washed to eliminate the test molecule and virus. A fluorescent nucleic acid probe, complementary to the viral RNA, is then used to demonstrate the presence of viral RNA inside the cells by fluorescence microscopy. Results are as follow: Which viral molecule is the most likely target of this potential antiviral?
- A.
  
  RNA
- B.
  
  RNA polymerase
- C.
  
  Envelope glycoprotein
- D.
  
  Envelope lipid
- E.
  
  Capsid protein
7.

During your fellowship in infectious diseases, you are studying a viral pathogen by manipulating its nucleic acid genorne using molecular biology methods. One morning following a late night at the lab, you accidentally stick yourself in a finger with a syringe containing a suspension of the wild-type nucleic acid genome of the virus you are studying. You therefore consult immediately with the infectious disease specialist on call that day who, after a careful examination of your case, prompts you to return should any signs of infection occur. Five days later you are febrile. Which of the following molecules was in the suspension you accidentally injected yourself with?
- A.
  
  Positive-sense single-stranded DNA
- B.
  
  Positive-sense single-stranded RNA
- C.
  
  Negative-sense single-stranded DNA
- D.
  
  Negative-sense single-stranded RNA
8.

The national regulatory body overseeing the transport of biohazard material in your country has asked you to provide an expert opinion concerning the safety level of an engineered composite virus that needs to be shipped from one laboratory to another. The complete virion composition is the following: a capsid derived from Human Papilloma Virus- 16 (HPV) that contains Hantavirus (-) ssRNA. The nucleocapsid is surrounded with a Papihantabolavirus matrix, in turn surrounded by an envelope containing the Ebola virus GP peplomer spikes. If this virus were to infect permissive cells, which kind of virus would be generated?
- A.
  
  A Human papillornavirus-16
- B.
  
  A Hantavirus
- C.
  
  An Ebola virus
- D.
  
  A Papihantabolavirus
- E.
  
  No virus would be generated
9.

In the previous example, which virus component would intervene in cell susceptibility?
- A.
  
  The HPV-16 capsid protein
- B.
  
  The Hantavirus RNA
- C.
  
  The Papihantabolavirus matrix protein
- D.
  
  The Ebola virus GP peplomer spikes
- E.
  
  None of the above
10.

A virology research lab (Dead End Empirical Technologies Inc.) engineers a composite virus with the following characteristics: The virion possesses a capsid derived from simian virus 40 (SV40; Polyornaviridae) containing HBV (hepatitis B virus; Hepadnaviridae) gapped dsDNA, HAV (hepatitis A virus; Picornaviridae) RNA-dependent RNA po)ymerase, and human immunodeficiency virus type 1 (HIV-1; Retroviridae) reverse transcriptase. The nucleocapsid is surrounded by an envelope derived from HEK 293 cells (human embryonic kidney 293 cells) containing murine VSV (rnurine vesicular stomatitis virus; Rhabdoviridae) G proteins. If this virion were to infect permissive cells, which kind of virus would be generated?
- A.
  
  Simian virus 40 (SV40)
- B.
  
  Hepatitis B virus (HBV)
- C.
  
  Hepatitis A virus (HAV)
- D.
  
  Human immunodeficiency virus type 1 (HIV-1)
- E.
  
  Murine vesicular stomatitis virus (V5V)
11.

Maraviroc is a recently FDA (Food and Drug Administration) approved chemokine receptor antagonist that binds to human chernokine receptor CCR5. Given the function of CCR5 in the replication cycle of human immunodeficiency virus type 1 (HIV-1), which event is affected by this drug?
- A.
  
  HIV-1 attachment to the cell
- B.
  
  HIV-1 entry into the cell
- C.
  
  HIV-1 uncoating
- D.
  
  HIV-1 release from the cell
- E.
  
  HIV-1 maturation
12.

The replicative intermediate of a positive RNA virus is:
- A.
  
  The mRNA
- B.
  
  The same as the genornic RNA
- C.
  
  Identical to the progeny RNA
- D.
  
  Negative RNA
- E.
  
  Positive RNA