Block 7 Repro Chromoso & Popul Genet MCQ's

16 Questions | Total Attempts: 366

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Block 7 Repro Chromoso & Popul Genet MCQ

Questions and Answers
  • 1. 
    In which of the following situations are you likely to observe a maternal age effect?
    • A. 

      Trisomy of the X chromosome

    • B. 

      Down syndrome with Robertsonian translocation

    • C. 

      Cri-du-Chat syndrome

    • D. 

      DiGeorge syndrome

  • 2. 
    A spectral karyotype is a specialized form of FISH where the probe is painting all chromosome regions corresponding to a given standard chromosome in the same color. This method is better than standard banded karyotype in detection of which kind of abnormality?
    • A. 

      Deletion

    • B. 

      Robertsonian translocation

    • C. 

      Ring chromosome

    • D. 

      Inversion

    • E. 

      Reciprocal translocation

  • 3. 
    A genetic engineer announces the birth of a baby with an artificial chromosome that carries an extra copy of the gene for telomerase. The gene is engineered with an inducible promoter that causes transcription in response to the insect hormone ecdyson. Why should people with this artificial chromosome want to take ecdysone pills?
    • A. 

      To reduce the cancer risk

    • B. 

      To be resistant to viral infections

    • C. 

      To delay aging

    • D. 

      To get a high

    • E. 

      To cure cancer

  • 4. 
    The loss of genes from the short arm of chromosome 5 is known to lead to the severe mental retardation of cri-du-chat syndrome. A chromosome painting probe reveals that you are missing most of the short arm of one copy of your chromosome 5, but this chromosome 5 material is found to be attached to the long arm of chromosome 10. What does this mean?
    • A. 

      You have cri-du-chat syndrome, and probably are so retarded that you never noticed

    • B. 

      This is a benign condition, both for you and your future children

    • C. 

      You are most likely phenotypically normal, but you can produce retarded children

    • D. 

      You are most likely phenotypically normal, and your children will be at risk of mental retardation only if you produce them with a partner who has the same chromosome aberration

    • E. 

      You are dead, because this kind of abnormality is incompatible with life

  • 5. 
    The unaffected sister of an albino is married to a man from a different family. Now she asks you how likely it is that this marriage will produce an albino child. If we know that 1% of the populations are carriers for this type of albinism, we can predict a risk of:
    • A. 

      1 in 50

    • B. 

      1 in 600

    • C. 

      1 in 150

    • D. 

      1 in 200

    • E. 

      1 in 25

  • 6. 
    1% of all Pima Indians are albinos. Approximately, what proportion of Pima Indians are carriers of the albino gene?
    • A. 

      1 in 2

    • B. 

      1 in 5

    • C. 

      1 in 10

    • D. 

      1 in 25

    • E. 

      1 in 50

  • 7. 
    Since the publication of Francis GaltOn's classic Hereditary Genius in 1869, genes are thought to play a role in this trait. If genius is inherited as an autosomal recessive trait and one in ten thousand people is a genius, what proportion of the population are heterozygous for the genius gene?
    • A. 

      1 in 20

    • B. 

      1 in 50

    • C. 

      1 in 100

    • D. 

      1 in 200

    • E. 

      1 in 500

  • 8. 
    A male chauvinist has claimed that the genius gene has X-linked recessive inheritance, that means, a female will express it only if she has it both on the first and the second X chromosome. If the genius gene is X-linked recessive and one out of ten thousand males is a genius, how common are female geniuses?
    • A. 

      One in twenty thousand

    • B. 

      One in ten thousand

    • C. 

      One in hundred thousand

    • D. 

      One in one million

    • E. 

      One in hundred million

  • 9. 
    A feminist claims that the genius gene is actually an X-linked dominant trait. In that case, if one in ten thousand males is a genius, then the prevalence of female geniuses will be approximately
    • A. 

      1 in 500

    • B. 

      1 in 1000

    • C. 

      1 in 5000

    • D. 

      1 in ten thousand

    • E. 

      1 in twenty thousand

  • 10. 
    The pedigree below represents a family with cystic fibrosis (autosomal recessive). What is the risk that individual 11-2 will have an affected child if the prevalence of cystic fibrosis is in 2500 individuals?
    • A. 

      1/50

    • B. 

      1/100

    • C. 

      1/200

    • D. 

      1/300

    • E. 

      1/400

  • 11. 
    The most common form of color blindness occurs with a frequency of 5% in the male population. What is the gene frequency of this X-linked recessive trait??
    • A. 

      25%

    • B. 

      10%

    • C. 

      5%

    • D. 

      0.25%

    • E. 

      2.5%

  • 12. 
    Genetic screening of 200 people shows that two are heterozygous for the three-base­pair deletion that is the most common cause of cystic fibrosis in Europe, and additionally, one homozygote was identified. The other 197 do not carry this mutation. This means that the allele frequency (="gene frequency") for this mutation is about
    • A. 

      1 in 1000 (0.1%)

    • B. 

      1 in 400 (0.25%)

    • C. 

      1 in 50 (2 %)

    • D. 

      1 in 100 (1%)

    • E. 

      1 in 200 (0.5%)

  • 13. 
    Imagine a species of Giraffes living on the savanna in Africa. The overall size of these varies as expected for a quantitative trait. The smallest giraffes have difficulty surviving, because they cannot reach the leafs on the trees that this species feed on. The largest giraffes have difficulty growing muscle large enough to move the massive bones needed for supporting this size of an animal. Therefore, the giraffes closest to the average size stand the best chance of surviving and reproducing. This is an example of which special concept?
    • A. 

      Stabilizing selection

    • B. 

      Disruptive selection

    • C. 

      Directional selection

    • D. 

      Founder effect

    • E. 

      Genetic drift

  • 14. 
    If you have high cholesterol, you may consider taking statins to help lowerthe levels. If you have desirable alleles in both the cholesteryl ester transfer protein and multidrug resistance transporter genes, the statin Fluvostatin will work well. However, if you have only undesirable alleles in both genes you will want to avoid Fluvostatin. If you have a mixture of desirable and undesirable alleles, then the number of each will determine the outcome. This description best fit which of the following concepts?
    • A. 

      Assortative mating

    • B. 

      Allele sharing

    • C. 

      Additive effects

    • D. 

      Low heritability

    • E. 

      Anticipation

  • 15. 
    A syndrome is known to cause excessive height ,reduced IQ, and the cells exhibit 2 Barr bodies. Which karyotype is compatible with the above description?
    • A. 

      45X

    • B. 

      46XX

    • C. 

      47XXX

    • D. 

      47XXY

    • E. 

      47XYY

  • 16. 
    The BCR-ABL gene is involved in causing:
    • A. 

      Alzheimer in Down syndrome

    • B. 

      The specific sound of the cry in Cri-du-Chat

    • C. 

      Polydactyly in Patau syndrome

    • D. 

      Cell growth in leukemias

    • E. 

      Hyperactivity in XYY syndrome

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