Block 7 Linkage Analysis MCQ's
.JPG "Block 7 Linkage Analysis MCQ")
- 1.
In human pedigree analysis, a LOD score:
- A.
Assesses the strength of linkage between two loci
- B.
Incorporates the factor 0 which assesses the number of individuals in the pedigree
- C.
Incorporates the factor 0 which assesses the amount of recombination between the two genes
- D.
Allows the incorporation of multiple pedigrees provided the genes are in the same phase
Correct Answer
A. Assesses the strength of linkage between two lociExplanation
A LOD score is a statistical measure used in human pedigree analysis to assess the strength of linkage between two loci. It takes into account the likelihood of observing the given pedigree data under the assumption of linkage versus the assumption of no linkage. A higher LOD score indicates stronger evidence for linkage between the two loci, while a lower LOD score suggests weaker or no evidence for linkage. The LOD score does not incorporate factors such as the number of individuals in the pedigree or the amount of recombination between the two genes. It can be used to analyze multiple pedigrees as long as the genes being studied are in the same phase.Rate this question:
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- 2.
What does a LOD score of 3.5 mean?
- A.
The disease and the marker are not linked
- B.
The result is uninformative
- C.
The DNA typing has had problems
- D.
The result is promising, but more members of the pedigree must be typed to get a meaningful result
- E.
The odds are better than 1000:1 that the disease is linked to this marker
Correct Answer
E. The odds are better than 1000:1 that the disease is linked to this markerExplanation
A LOD score of 3.5 indicates that the odds are better than 1000:1 that the disease is linked to the marker. This means that there is a strong likelihood of a genetic association between the disease and the marker based on the statistical analysis. It suggests that further investigation and testing should be done to confirm this finding and gather more evidence.Rate this question:
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- 3.
If two loci show genetic linkage then
- A.
They are not always on the same chromosome
- B.
Mutations at both loci cause the same disease
- C.
Alleles at the same loci interact to cause the same disease
- D.
If recombination fraction between loci is 0.05 then this means that on average alleles in coupling at these loci will cosegregate in 95% of meioses
- E.
Alleles at these loci must show linkage disequilibrium
Correct Answer
D. If recombination fraction between loci is 0.05 then this means that on average alleles in coupling at these loci will cosegregate in 95% of meiosesExplanation
If the recombination fraction between loci is 0.05, it means that there is a 5% chance of recombination occurring between the alleles at these loci during meiosis. This implies that 95% of the time, the alleles will remain together and cosegregate. This supports the idea of genetic linkage, as alleles that are physically close to each other on the same chromosome are more likely to be inherited together. Therefore, the given statement is a valid explanation for the correct answer.Rate this question:
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- 4.
Osteogenesis imperfecta is a rare autosomal dominant. 1 and 2 represent two haplotypes of an RFLP marker that is genetically linked to the gene causing Osteogenesis imperfecta. Which individual is most likely to be an example of recombination?
- A.
Individual A
- B.
Individual B
- C.
Individual C
- D.
Individual D
- E.
Individual E
Correct Answer
D. Individual DExplanation
Individual D is most likely to be an example of recombination because it carries one haplotype from one parent (1) and the other haplotype from the other parent (2). This suggests that a recombination event has occurred, resulting in the mixing of genetic material from both parents. The presence of both haplotypes in Individual D indicates that genetic recombination has taken place during meiosis.Rate this question:
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- 5.
Consider the table of LOD scores shown below for an autosomal dominant disease. The first line gives recombination frequencies, and each subsequent line represents the LOD score pattern found in different families typed with the same marker. Which statement best describes this pattern?
- A.
Tight linkage
- B.
Allelic heterogeneity
- C.
Loose linkage
- D.
Linkage disequilibrium
- E.
Locus heterogeneity
Correct Answer
E. Locus heterogeneityExplanation
The given LOD score pattern found in different families typed with the same marker indicates locus heterogeneity. This means that the disease is caused by mutations in different genes or loci. The LOD scores vary significantly between families, suggesting that the disease is not tightly linked to a specific gene or locus.Rate this question:
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- 6.
Researchers are trying to find a microsatellite marker that is linked to the gene for acute intermittent porphyria, an autosomal dominant condition known to map to the 11 chromosome. In a study of four large families with this disease, an array of microsatellite markers on chromosome 11 were tested for linkage to the gene, and the LOD scores are displayed in the table below. Using conventional cutoff points for LOD scores, which of the markers show(s) significant linkage with the gene involved in acute intermittent porphyria?
- A.
S1
- B.
S2
- C.
S4
- D.
S1 and S4
- E.
S1, S2 and S4
Correct Answer
D. S1 and S4Explanation
Based on the information provided, the researchers tested an array of microsatellite markers on chromosome 11 for linkage to the gene involved in acute intermittent porphyria. The LOD scores for each marker were displayed in a table. LOD scores are used to determine the likelihood of linkage between a marker and a gene, with higher scores indicating stronger evidence for linkage. The question asks which markers show significant linkage. Since the question does not provide specific cutoff points for LOD scores, it can be assumed that conventional cutoff points are used. Therefore, the markers with LOD scores above the conventional cutoff point are considered to show significant linkage. In this case, the LOD scores for S1 and S4 are above the cutoff point, indicating significant linkage with the gene involved in acute intermittent porphyria.Rate this question:
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- 7.
In a full genome linkage study in a large family from the Middle East with an autosomal dominant form of cardiomyopathy (disease of the heart), a marker on chromosome 3 was found to have the following LOD scores (Z) for the following values of 0: Based on this study, choose the BEST answer for the linkage of cariomyopathy in this family:
- A.
Cardiomyopathy must be on a gene exactly 5 cM from the chromosome 3 marker
- B.
Cardiomyopathy is closely linked to this marker in this family.
- C.
This must be a critical gene for cardiomyopathy since the LOD score is so high
- D.
Cardiomyopathy could be lined to this marker, but you will need to confirm linkage in another family.
- E.
Cardiomyopathy is linked somewhere on chromosome 3.
Correct Answer
B. Cardiomyopathy is closely linked to this marker in this family.Explanation
The LOD scores indicate the strength of linkage between a marker and a disease gene. In this case, the LOD scores for the marker on chromosome 3 are high, suggesting a strong linkage between the marker and the gene responsible for cardiomyopathy in this family. Therefore, the best answer is that cardiomyopathy is closely linked to this marker in this family.Rate this question:
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- 8.
Another large family is discovered in China with an autosomal dominant form of Cardiomyopathy (disease of the heart) . The same marker on chromosome 3 was Tested for linkage for this disease and the following LODs cores (Z) for the following
- A.
Is not linked to the same chromosome three locus as the Middle Eastern family.
- B.
May be l inked to chromosome 3 , but further away from this marker
- C.
Shows that the linkage results from Middle Eastern family were misleading
- D.
Is also linked in this family, since the combined LOD (Z) scores obtained by Adding these two families are still greater than 3
- E.
Is due to genetic drift
Correct Answer
A. Is not linked to the same chromosome three locus as the Middle Eastern family.Explanation
The given answer suggests that the new family discovered in China does not have the same linkage to the chromosome 3 locus as the Middle Eastern family. This means that the genetic cause of the cardiomyopathy in the Chinese family is not related to the same specific gene or region on chromosome 3 as the Middle Eastern family.Rate this question:
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- 9.
- A.
A
- B.
B
- C.
C
- D.
D
- E.
E
Correct Answer
C. C -
- 10.
- A.
A
- B.
B
- C.
C
- D.
D
- E.
E
Correct Answer
B. B -
- 11.
- A.
A
- B.
B
- C.
C
- D.
D
- E.
E
Correct Answer
B. B -
- 12.
- A.
A
- B.
B
- C.
C
- D.
D
- E.
E
Correct Answer
B. B -
- 13.
- A.
A
- B.
B
- C.
C
- D.
D
- E.
E
Correct Answer
B. B -
.JPG "Consider the table of LOD scores shown below for an autosomal dominant disease. The first line gives recombination frequencies, and each subsequent line represents the LOD score pattern found in different families typed with the same marker. Which statement best describes this pattern?")
.JPG "Researchers are trying to find a microsatellite marker that is linked to the gene for acute intermittent porphyria, an autosomal dominant condition known to map to the 11 chromosome. In a study of four large families with this disease, an array of microsatellite markers on chromosome 11 were tested for linkage to the gene, and the LOD scores are displayed in the table below. Using conventional cutoff points for LOD scores, which of the markers show(s) significant linkage with the gene involved in acute intermittent porphyria?")
.JPG "In a full genome linkage study in a large family from the Middle East with an autosomal dominant form of cardiomyopathy (disease of the heart), a marker on chromosome 3 was found to have the following LOD scores (Z) for the following values of 0:
Based on this study, choose the BEST answer for the linkage of cariomyopathy in this family:")
.JPG "Another large family is discovered in China with an autosomal dominant form of
Cardiomyopathy (disease of the heart) . The same marker on chromosome 3 was
Tested for linkage for this disease and the following LODs cores (Z) for the following")
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