Block 7 Linkage Analysis MCQ's

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1. Osteogenesis imperfecta is a rare autosomal dominant. 1 and 2 represent two haplotypes of an RFLP marker that is genetically linked to the gene causing Osteogenesis imperfecta. Which individual is most likely to be an example of recombination?

Explanation

Individual D is most likely to be an example of recombination because it carries one haplotype from one parent (1) and the other haplotype from the other parent (2). This suggests that a recombination event has occurred, resulting in the mixing of genetic material from both parents. The presence of both haplotypes in Individual D indicates that genetic recombination has taken place during meiosis.

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Block 7  Linkage Analysis MCQ

This quiz titled 'Block 7 Linkage Analysis MCQs' focuses on evaluating the understanding of linkage analysis in genetics, particularly through LOD scores and pedigree analysis. It assesses key... see moregenetic concepts relevant for students and professionals in biological sciences. see less

2. In human pedigree analysis, a LOD score:

Explanation

A LOD score is a statistical measure used in human pedigree analysis to assess the strength of linkage between two loci. It takes into account the likelihood of observing the given pedigree data under the assumption of linkage versus the assumption of no linkage. A higher LOD score indicates stronger evidence for linkage between the two loci, while a lower LOD score suggests weaker or no evidence for linkage. The LOD score does not incorporate factors such as the number of individuals in the pedigree or the amount of recombination between the two genes. It can be used to analyze multiple pedigrees as long as the genes being studied are in the same phase.

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3. What does a LOD score of 3.5 mean?

Explanation

A LOD score of 3.5 indicates that the odds are better than 1000:1 that the disease is linked to the marker. This means that there is a strong likelihood of a genetic association between the disease and the marker based on the statistical analysis. It suggests that further investigation and testing should be done to confirm this finding and gather more evidence.

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4.

Explanation

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5. Another large family is discovered in China with an autosomal dominant form of Cardiomyopathy (disease of the heart) . The same marker on chromosome 3 was Tested for linkage for this disease and the following LODs cores (Z) for the following

Explanation

The given answer suggests that the new family discovered in China does not have the same linkage to the chromosome 3 locus as the Middle Eastern family. This means that the genetic cause of the cardiomyopathy in the Chinese family is not related to the same specific gene or region on chromosome 3 as the Middle Eastern family.

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6.

Explanation

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7. Researchers are trying to find a microsatellite marker that is linked to the gene for acute intermittent porphyria, an autosomal dominant condition known to map to the 11 chromosome. In a study of four large families with this disease, an array of microsatellite markers on chromosome 11 were tested for linkage to the gene, and the LOD scores are displayed in the table below. Using conventional cutoff points for LOD scores, which of the markers show(s) significant linkage with the gene involved in acute intermittent porphyria?

Explanation

Based on the information provided, the researchers tested an array of microsatellite markers on chromosome 11 for linkage to the gene involved in acute intermittent porphyria. The LOD scores for each marker were displayed in a table. LOD scores are used to determine the likelihood of linkage between a marker and a gene, with higher scores indicating stronger evidence for linkage. The question asks which markers show significant linkage. Since the question does not provide specific cutoff points for LOD scores, it can be assumed that conventional cutoff points are used. Therefore, the markers with LOD scores above the conventional cutoff point are considered to show significant linkage. In this case, the LOD scores for S1 and S4 are above the cutoff point, indicating significant linkage with the gene involved in acute intermittent porphyria.

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8.

Explanation

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9. If two loci show genetic linkage then

Explanation

If the recombination fraction between loci is 0.05, it means that there is a 5% chance of recombination occurring between the alleles at these loci during meiosis. This implies that 95% of the time, the alleles will remain together and cosegregate. This supports the idea of genetic linkage, as alleles that are physically close to each other on the same chromosome are more likely to be inherited together. Therefore, the given statement is a valid explanation for the correct answer.

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10.

Explanation

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11.

Explanation

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12. In a full genome linkage study in a large family from the Middle East with an autosomal dominant form of cardiomyopathy (disease of the heart), a marker on chromosome 3 was found to have the following LOD scores (Z) for the following values of 0:   Based on this study, choose the BEST answer for the linkage of cariomyopathy in this family:

Explanation

The LOD scores indicate the strength of linkage between a marker and a disease gene. In this case, the LOD scores for the marker on chromosome 3 are high, suggesting a strong linkage between the marker and the gene responsible for cardiomyopathy in this family. Therefore, the best answer is that cardiomyopathy is closely linked to this marker in this family.

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13. Consider the table of LOD scores shown below for an autosomal dominant disease. The first line gives recombination frequencies, and each subsequent line represents the LOD score pattern found in different families typed with the same marker. Which statement best describes this pattern?

Explanation

The given LOD score pattern found in different families typed with the same marker indicates locus heterogeneity. This means that the disease is caused by mutations in different genes or loci. The LOD scores vary significantly between families, suggesting that the disease is not tightly linked to a specific gene or locus.

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Osteogenesis imperfecta is a rare autosomal dominant. 1 and 2...
In human pedigree analysis, a LOD score:
What does a LOD score of 3.5 mean?
Another large family is discovered in China with an autosomal dominant...
Researchers are trying to find a microsatellite marker that is linked...
If two loci show genetic linkage then
In a full genome linkage study in a large family from the Middle East...
Consider the table of LOD scores shown below for an autosomal dominant...
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