Pharm Anxiety Sedative Hypnotics

20 Questions | By Chachelly | Last updated: Nov 6, 2018

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Anxiety disorders have a complicated network of causes. The most commonly used sedative-hypnotic drugs are the benzodiazepines. Do you think you can properly diagnose a patient suffering from this and give him the correct medicines? Take this test on pharm anxiety sedative hypnotic’s drugs and see for yourself. All the best!

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Questions and Answers

1.

Directions: questions 1-6 Match each sedative hypnotic drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): A partial agonist at 5-HT1A receptors
- A.
  
  Alprazolam
- B.
  
  Buspirone
- C.
  
  Clonazepam
- D.
  
  Flumazenil
- E.
  
  Flunitrazepam
- F.
  
  Lorazepam
- G.
  
  Midazolam
- H.
  
  Phenobarbital
- I.
  
  Thiopental
- J.
  
  Zolpidem
2.

Directions: questions 1-6 Match each sedative hypnotic drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): A competitive antagonist at benzodiazepine receptors
- A.
  
  Alprazolam
- B.
  
  Buspirone
- C.
  
  Clonazepam
- D.
  
  Flumazenil
- E.
  
  Flunitrazepam
- F.
  
  Lorazepam
- G.
  
  Midazolam
- H.
  
  Phenobarbital
- I.
  
  Thiopental
- J.
  
  Zolpidem
3.

Directions: questions 1-6 Match each sedative hypnotic drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): A hypnotic drug with negligible effects on sleep architecture and stages
- A.
  
  Alprazolam
- B.
  
  Buspirone
- C.
  
  Clonazepam
- D.
  
  Flumazenil
- E.
  
  Flunitrazepam
- F.
  
  Lorazepam
- G.
  
  Midazolam
- H.
  
  Phenobarbital
- I.
  
  Thiopental
- J.
  
  Zolpidem
4.

Directions: questions 1-6 Match each sedative hypnotic drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): The most frequently used drug to induce general anesthesia
- A.
  
  Alprazolam
- B.
  
  Buspirone
- C.
  
  Clonazepam
- D.
  
  Flumazenil
- E.
  
  Flunitrazepam
- F.
  
  Lorazepam
- G.
  
  Midazolam
- H.
  
  Phenobarbital
- I.
  
  Thiopental
- J.
  
  Zolpidem
5.

Directions: questions 1-6 Match each sedative hypnotic drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): A benzodiazepine with a very short half life (.2 hours)
- A.
  
  Alprazolam
- B.
  
  Buspirone
- C.
  
  Clonazepam
- D.
  
  Flumazenil
- E.
  
  Flunitrazepam
- F.
  
  Lorazepam
- G.
  
  Midazolam
- H.
  
  Phenobarbital
- I.
  
  Thiopental
- J.
  
  Zolpidem
6.

Directions: questions 1-6 Match each sedative hypnotic drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): An anxiolytic drug with negligible abuse liability
- A.
  
  Alprazolam
- B.
  
  Buspirone
- C.
  
  Clonazepam
- D.
  
  Flumazenil
- E.
  
  Flunitrazepam
- F.
  
  Lorazepam
- G.
  
  Midazolam
- H.
  
  Phenobarbital
- I.
  
  Thiopental
- J.
  
  Zolpidem
7.

A 54-year-old man was admitted to the hospital for a laparoscopic hernia repair under general anesthesia. A suitable dose of diazepam was given IV and the patient lost consciousness in two minutes. He regained consciousness about 45 minutes later. Knowing that the half-life of diazepam is about 40 hours, which of the following phrases best explains the short action of the drug?

Discuss
- A.
  
  Rapid metabolism of the drug within the CNS
- B.
  
  Rapid excretion of the drug by the kidney
- C.
  
  Redistribution of the drug from CNS to other tissues
- D.
  
  Biotransformation of the drug to active metabolites by the liver
- E.
  
  Development of a rapid tolerance to drug effects
8.

A 35-year-old man complained to his physician of attacks of intense terror during sleep, such as feeling crushed, and often wakes up with scream, but cannot remember any specific dream. He also felt anxious and restless from time to time during the day. Which of the following drugs would show good short-term decrease of patient’s symptoms?

Discuss
- A.
  
  Lithium
- B.
  
  Temazepam
- C.
  
  Haloperidol
- D.
  
  Imipramine
- E.
  
  Phenobarbital
9.

A 62-year-old woman recently diagnosed with generalized anxiety disorder had been on a treatment with venlafaxine but the therapy was stopped because of a persistent headache that the psychiatrist thought drug related. A treatment with buspirone was started. Which of the following brain regions was most likely involved in the therapeutic effect of the drug?

Discuss
- A.
  
  Auditory cortex
- B.
  
  Amygdala
- C.
  
  Putamen
- D.
  
  Nucleus accumbens
- E.
  
  Area postrema
10.

A 66-year-old female who recently lost her husband told her physician that she was not sleeping at night. Further questioning indicated that she did not have depression or substance abuse. The physician decided to start a short treatment with a drug that acts by increasing the inhibitory action of short interneurons in several brain areas. Which of the following drug was most likely prescribed?

Discuss
- A.
  
  Diazepam
- B.
  
  Buspirone
- C.
  
  Paroxetine
- D.
  
  Oxazepam
- E.
  
  Clomipramine
- F.
  
  Haloperidol
11.

A 47-year-old woman complained to her physician that she could get to sleep when she went to bed but woke up several times during the night an never felt refreshed in the morning. The woman had no medical problems and took no medications. Which of the following drugs would be appropriate for this patient?

Discuss
- A.
  
  Flunitrazepam
- B.
  
  Buspirone
- C.
  
  Eszopiclone
- D.
  
  Fluoxetine
- E.
  
  Haloperidol
- F.
  
  Imipramine
12.

A 25-year-old man, suffering from cerebral palsy and seizures secondary to a head injury, was admitted to the hospital for a control visit. He was spastic and unable to walk. Medical history indicated that, for the month prior to the visit to the hospital, his seizures had not been well controlled. Which of the following drugs would be appropriate to improve his seizure and muscle spasm?
- A.
  
  Buspirone
- B.
  
  Lithium
- C.
  
  Donepezil
- D.
  
  Haloperidol
- E.
  
  Fluoxetine
- F.
  
  Diazepam
13.

A 66-year-old man, who had been an heavy smoker for 30 years, was undergoing bronchoscopy for a suspected bronchogenic carcinoma. Before starting the intervention the anesthesiologist administered a drug in order to prevent the situational anxiety and to provide anterograde amnesia of the procedure. Which of the following drugs was most likely given?

Discuss
- A.
  
  Buspirone
- B.
  
  Chlorpromazine
- C.
  
  Zolpidem
- D.
  
  Triazolam
- E.
  
  Haloperidol
14.

A 34-year-old woman rushed to the emergency room complaining that, ‘out of the blue’, she had been seized by overwhelming symptoms. She felt light-headed, dizzy and feared of losing control or going crazy. She also felt nausea, a lump in her throat, shortness of breath and palpitations. The woman had never had similar symptoms in the past and denied past or present use of any illicit drugs or alcohol. A preliminary diagnosis was made and a drug was given IV to offset the patient’s symptoms. Which of the following drugs was most likely given?

Discuss
- A.
  
  Venlafaxine
- B.
  
  Thiopental
- C.
  
  Buspirone
- D.
  
  Midazolam
- E.
  
  Eszopiclone
15.

Benzodiazepines have many different effects on the CNS. However they are devoid of which of the following effects?

Discuss
- A.
  
  Sedative
- B.
  
  Hypnotic
- C.
  
  Muscle relaxant
- D.
  
  Antipsychotic
- E.
  
  Anticonvulsant
16.

A 66-year-old man was brought to the hospital by his daughter who referred that he has been confused and lethargic during the last two days. Past history of the patient was significant for a transient ischemic attack three years ago, and for a long-lasting habit of drinking large quantities of grapefruit juice. Recently the patient became anxious and fearful of imminent death, and the physician prescribed alprazolam, two tablets daily. Which of the following phrases best explains the most likely cause of the patient’s symptoms?

Discuss
- A.
  
  Grapefruit juice induced inhibition of alprazolam metabolism
- B.
  
  Increased brain sensitivity to alprazolam due to previous ischemic attack
- C.
  
  Grapefruit juice induced decrease of alprazolam elimination by the kidney
- D.
  
  Increased brain sensitivity to alprazolam due to old age
- E.
  
  Grapefruit juice induced increase of alprazolam intestinal absorption
17.

A 25-year-old man was brought into the emergency room in an unconscious state by his roommate. The roommate stated that the man was very depressed during the last few days and that he had been drinking whisky all day. The roommate also said he found an empty, not labeled drug bottle next to him on the bed. Which of the following drug most likely caused the patient’s intoxication?
- A.
  
  Ramelteon
- B.
  
  Diazepam
- C.
  
  Amphetamine
- D.
  
  Amitriptyline
- E.
  
  Lithium
- F.
  
  Fluoxetine
18.

A 61-year-old obese man complained of difficulty in falling asleep and asked his physician for a sleeping pill. The man had been recently diagnosed with obstructive sleep apnea, most likely due to obesity. Which of the following drugs would be contraindicated for this patient?

Discuss
- A.
  
  Temazepam
- B.
  
  Acetazolamide
- C.
  
  Imipramine
- D.
  
  Medroxyprogesterone
- E.
  
  Protriptyline
19.

A 45-year-old man recently diagnosed with a panic disorder, had started a treatment which sertraline but the drug caused some sexual dysfunction and the physician decided to switch to alprazolam, two tablet daily. Which of the following molecular actions on neuron membranes most likely mediated the therapeutic effect of the drug in the patient’s disorder?

Discuss
- A.
  
  Decreased outward Na+ current
- B.
  
  Increased inward Cl- current
- C.
  
  Decreased outward K+ current
- D.
  
  Increased inward Ca++ current
- E.
  
  Increased inward H+ current
20.

A 42-year-old man, suffering from rectal bleeding, was admitted to the hospital for a colonoscopy. An IV injection of diazepam was given before the procedure to induce a conscious sedation. Which of the following symptoms did the patient most likely experience upon recovery from sedation?

Discuss
- A.
  
  Nausea and vomiting
- B.
  
  Increased respiratory rate
- C.
  
  Anterograde amnesia
- D.
  
  Limb muscle spasms
- E.
  
  Delusional thoughts

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