Mononucleosis And HIV Retrovirus

13 Questions | Total Attempts: 182

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Mononucleosis And HIV Retrovirus - Quiz

Mononucleosis, often referred to simply as “mono”, and the human immunodeficiency virus are both up for discussion in the following quiz, as we look at the two viral conditions which are most commonly known to be contracted via intimate acts such as kissing and intercourse. What can you tell us?


Questions and Answers
  • 1. 
    A 17-year old woman presents with a sore throat, fever and fatigue. A rapid serologic test revealed the presence of heterophile antibodies. Which cells are infected and which may become transformed?
    • A. 

      Lymph node dendritic cells and T cells, respectively

    • B. 

      Oropharyngeal cells and B cells, resp.

    • C. 

      Monocytes and hepatocytes, resp.

    • D. 

      T cells and macrophages

    • E. 

      Skin cells and Downey Type cells

  • 2. 
    ………..continuation: A 17-year old woman presents with a sore throat, fever and fatigue. A rapid serologic test revealed the presence of heterophile antibodies  Confirmation of  the woman’s diagnosis can be made by detection of antibodies against which of the following?
    • A. 

      Sheep and horse erythrocytes

    • B. 

      Peptidoglycan

    • C. 

      DNA

    • D. 

      Parvovirus B19

    • E. 

      None of the above

  • 3. 
    ………..continuation: A 17-year old woman presents with a sore throat, fever and fatigue. A rapid serologic test performed revealed the presence of heterophile antibodies, indicative of a viral infection. Which of the following is the pathogen?
    • A. 

      Herpesvirus

    • B. 

      Adenovirus

    • C. 

      Measles virus

    • D. 

      Parvovirus B19

    • E. 

      None of the above

  • 4. 
    Which of the following tumors is caused by a herpesvirus that uses the C3d complement receptor?
    • A. 

      Leyomyoma

    • B. 

      Hodgkin’s Lymphoma

    • C. 

      Chondrosarcoma

    • D. 

      Osteosarcoma

    • E. 

      T cell lymphotropic lymphoma

  • 5. 
    The cellular response typical of infectious mononucleosis caused by Epstein-Barr virus is due to:
    • A. 

      Production of homophile antibodies

    • B. 

      Agglutination with T cells

    • C. 

      Proliferation of T cells

    • D. 

      Macrophages responding to dead epithelial cells

    • E. 

      None of the above

  • 6. 
    An 18-year old woman presents with mild pharyngitis without exudate. She claims to have fever and fatigue. No  heterophile antibodies were detected. Which of the following is most likely the causative agent?
    • A. 

      Human simplex virus type 1

    • B. 

      Cytomegalovirus

    • C. 

      Epstein-Barr virus

    • D. 

      Epstein-Barr virus

    • E. 

      Non of the above

  • 7. 
    What conclusions would you draw from the following HIV-1 ELISA test?                                                     HIV-1 p24 ELISA
    • A. 

      All 3 patients are seropositive

    • B. 

      All 3 patients are seronegative

    • C. 

      Only patient 1 is seropositive

    • D. 

      Only patient 2 is seropositive

    • E. 

      Only patient 3 is seropositive

    • F. 

      Patients 1 and 2 are seropositive

    • G. 

      Patients 1 and 3 are seropositive

    • H. 

      Patients 2 and 3 are seropositive

  • 8. 
    Knowing that HIV-1 primarily infects leukocytes, which of the following individuals, if any, is more likely to contract HIV-1?
    • A. 

      An otherwise healthy individual who has a sexual intercourse with an HIV-1-infected person

    • B. 

      An individual suffering from a cold who has a sexual intercourse with an HIV-1-infected person

    • C. 

      An individual suffering from a genital herpes flare-up who has a sexual intercourse with an HIV-1-infected person

    • D. 

      An otherwise healthy intravenous drug user who has a sexual intercourse with an HIV-1-infected person

    • E. 

      All previous individuals are equally likely to contract HIV-1

  • 9. 
    And why?
    • A. 

      Because the immune system of the healthy individual is not activated, making this individual more at risk of contracting HIV-1

    • B. 

      Because the individual suffering from a cold is likely to exhibit a strong immune response, therefore offering more cellular targets (leucocytes) to the virus and putting this individual more at risk of contracting HIV-1

    • C. 

      Because the individual suffering from genital herpes is likely to exhibit a localized immune response conducive to the spread of the virus and putting this individual more at risk of contracting HIV-1

    • D. 

      Because the otherwise healthy intravenous drug user has a depressed immune system, making this individual more at risk of contracting HIV-1

    • E. 

      This answer seems so alien to us that, surely, it has to be right…

  • 10. 
    Presented in the following figure is the natural progression of an HIV infection. Which event is marks a critical turning point in the pathogenesis of AIDS?
    • A. 

      Emergence of CCR5-tropic virus strain

    • B. 

      Emergence of CXCR4-tropic virus strain

    • C. 

      Emergence of CD8-tropic virus strain

    • D. 

      Emergence of CD4-tropic virus strain

    • E. 

      Emergence of macrophage-tropic virus strain

  • 11. 
    HIV carries the templates required for the production of a number of essential proteins. Specifically the env gene encodes gp 120 and gp 41. Which of the following correctly describe function of the two glycoproteins?
    • A. 

      Gp 120 binds to chemokine receptors CCR5 and CXCR4, while gp41 binds to CD4

    • B. 

      Gp 120 is used for fusion, while gp 41 binds to CD4

    • C. 

      Gp 120 binds to CD4 and gp 41 binds to chemokine receptors CCR5 and CXCR4

    • D. 

      Gp 120 binds to CD4 and gp41 is used for fusion

  • 12. 
    After infection with HIV, there is an initial increase in patient viral load, followed by marked, but not permanent, decrease in viral load. If you were to examine the patients lymphocyte populations during this period of viral load decrease, what would you expect to find?
    • A. 

      Lowered CD4+ and CD8+ T cells; CD4/CD8 ratio greater than 1

    • B. 

      Raised CD4+ and CD8 + T cells; CD4/CD8 ratio greater than 1

    • C. 

      CD4+ T cells within the normal range, CD8+ T cells raised; CD4/CD8 ratio less than 1

    • D. 

      Lowered CD4+, raised CD8+ T cells; CD4/CD8 ratio less than 1

  • 13. 
    In the course of an HIV-1 prevalence study in a high risk group, for which you are the principal investigator, a week’s worth of sera is screened in the laboratory by ELISA. Serum samples yielding a positive result are then re-tested by western blot analysis for confirmation. The following results are obtained: Which samples are indicative of HIV-1 infection?
    • A. 

      I, II, IV, and V

    • B. 

      II, IV, and V

    • C. 

      I, II, III, and V

    • D. 

      I, II, III, IV, and V

    • E. 

      V

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