B59: Eicosanoids

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B59: Eicosanoids - Quiz

SGU Biochemistry - Fall 2009, Lecture 59: Eicosanoids Review questions from Lippincott, Mark's, BRS, and lecture notes from Dr. Trotz


Questions and Answers
  • 1. 
    Prostaglandins, and the related compounds thromboxanes and ____, are collectively known as eicosanoids (L p. 213).
  • 2. 
    Eicosanoids differ from the true hormones in that they are produced in very ____ amounts in almost all tissues rather than in specialized glands (L p. 213).
    • A. 

      Large

    • B. 

      Small

  • 3. 
    Eicosanoids act ____ rather than after transport in the blood to ____ sites, as occurs with true hormones such as insulin (L p. 213).
    • A. 

      Locally, distant

    • B. 

      Distally, local

  • 4. 
    Eicosanoids are not stored, and they have an extremely ____ half-life (L p. 213).
    • A. 

      Long

    • B. 

      Short

  • 5. 
    Free ____ ____ yields PGH2 (L p. 213).
  • 6. 
    PGH synthase, or prostaglandin endoperoxide synthase, has two catalytic activities: fatty acid cyclooxygenase and _____ (L p. 213 and Trotz Lectures 53-59 p.61).
  • 7. 
    COX-1 is _____, while COX-2 is ______ (L p. 213 and Trotz Lectures 53-59 p.63).
    • A. 

      Inducible, constitutive

    • B. 

      Constitutive, inducible

  • 8. 
    Asthma treatment can include inhibition of ____ synthesis or inhibition of _____ receptors (same word) (L p. 214 and Trotz Lectures 53-59 p.67).
  • 9. 
    Eicosanoids are highly active physiological compounds that are synthesized upon demand from a fatty acid with ___ carbons (L p. 213 and Trotz Lectures 53-59 p.58).
  • 10. 
    _____ and thromboxanes are involved in many physiological actions, often counteracting each other.  They are needed to uphold normal cell functions. Trotz Lectures 53-59 p.58
  • 11. 
    ____ mainly act as inflammatory mediators together with lipoxins and HETE. Trotz Lectures 53-59 p.58
  • 12. 
    The release of arachidonic acid provides the substrate for the synthesis of eicosanoids.  This release can involve phospholipase A2, which is inhibited by _____. Trotz Lectures 53-59 p.59
  • 13. 
    5-HPETE is an intermediate of _____ synthesis. Trotz Lectures 53-59 p.58
  • 14. 
    LTC4, LTD4, and ____ are inflammatory mediators that are components of SRS-A and lead to severe bronchoconstriction and lung edema. Trotz Lectures 53-59 p.59
  • 15. 
    PGH2 is an intermediate of prostaglandin and ____ synthesis. Trotz Lectures 53-59 p.59
  • 16. 
    ___ and TXA2 have opposing effects. Trotz Lectures 53-59 p.59
  • 17. 
    ____ and PGF2-alpha have partially opposing effects. Trotz Lectures 53-59 p.59
  • 18. 
    The ___ pathway includes fatty acid cyclooxygenase and leads to prostaglandins or thromboxane. Trotz Lectures 53-59 p.60
    • A. 

      Cyclic

    • B. 

      Linear

  • 19. 
    The ___ pathway includes lipoxygenases and leads to leukotrienes, HETE, and lipoxins. Trotz Lectures 53-59 p.60
    • A. 

      Cyclic

    • B. 

      Linear

  • 20. 
    Aspirin is an ___ inhibitor of COX. Trotz Lectures 53-59 p.61
    • A. 

      Reversible

    • B. 

      Irreversible

  • 21. 
    Thromboxane leads to platelet _____, while prostacyclin leads to platelet _____. Trotz Lectures 53-59 p.61
    • A. 

      Aggregation, inhibition

    • B. 

      Inhibition, aggregation

  • 22. 
    Inhibition of COX by aspirin is done by acetylation of a ____ residue in the active site. Trotz Lectures 53-59 p.63
  • 23. 
    ____ is involved with normal physiological functions of PG and TX, like gastric protection and limiting acid secretion, maintenance of renal blood flow, vascular homostasis and hemostasis.
    • A. 

      COX-1

    • B. 

      COX-2

  • 24. 
    Continuous severe inhibition of ____ at high aspirin doses can lead to stomach ulcers and kidney damage. Trotz Lectures 53-59 p.63
  • 25. 
    _____, in general, can induce labor.  Trotz Lectures 53-59 p.64
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