Alkadhi's Local Anesthetics
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Test your knowledge of important concepts in local anesthetics
- 1.Place the following sensory modalities in the order in which they are affected by local anesthetics (first to last)1. Pressure2. Temperature3. Motor function4. Pain5. Touch
- A.
1, 5, 4, 2, 3
- B.
4, 5, 2, 1, 3
- C.
4, 2, 5, 1, 3
- D.
4, 2, 1, 5, 3
- E.
3, 1, 5, 2, 4
- 2.Toxic effects of cocaine include all of the following except
- A.
Tonic-clonic convulsion
- B.
Severe bruxism
- C.
Respiratory depression followed by stimulation
- D.
Pseudohallucinations
- E.
Formication
- 3.The proposed mechanism of action of local anesthetics is:
- A.
Blocking K+ channels
- B.
Blocking Ca++ channels
- C.
Blocking release of NE
- D.
Blocking the extracellular part of Na channels
- E.
Blocking the intracellular part of Na channels
- 4.Which of the following is true regarding local anesthetics?
- A.
Given with a vasodilator to increase duration of action
- B.
Thicker nerve fibers are more sensitive to local anesthetics than thinner ones
- C.
The more negative the membrane potential, the greater the degree of Na channel block
- D.
An active nerve is more sensitive to local anesthetics than a resting nerve
- E.
Local anesthetics alter Na and K permeability in neurons
- 5.Which of the following is an advantage of using epinephrine with local anesthetics?
- A.
Limits toxicity
- B.
Increases concentration of local anesthetic by preventing its metabolism by the liver
- C.
Causes tissue edema
- D.
May lead to hypoxia and tissue damage
- E.
Prevents hypotension
- 6.Which of the following is not an adverse effect associated with local anesthetics?
- A.
Initial stimulation and then depression of CNS pathways
- B.
Local necrosis from vasoconstrictor actions
- C.
Blockage of muscarinic ACh receptors at high concentrations
- D.
Urticarial rashes
- E.
Decreased electrical excitability in myocardium
- 7.Which of the following is true with regards to local anesthetics?
- A.
Procaine is faster and longer lasting than lidocaine
- B.
Cocaine is good for topical anesthesia of upper respiratory tract
- C.
Bupivacaine and cocaine are the only natural anesthetic products
- D.
Procaine is hydrolyzed in vivo to GABA
- E.
Lidocaine is very lipid soluble
- 8.All of the following are clinical uses for local anesthetics except:
- A.
Antiarrhytmic
- B.
Therapeutic nerve block and field block
- C.
Stimulant, euphoriant
- D.
Anticonvulsant in status epilepticus
- E.
None of these. All of the above are clinical uses for local anesthetics
- 9.Which of the following characteristics is true for local anesthetics?
- A.
Molecule has to be lipid soluble to exert its Na channel blocking effect
- B.
Some topical local anesthetics can be absorbed systemically and can cause toxicity
- C.
The blocking effect of local anesthetics is gone when the molecule is in the cationic form
- D.
Entry of local anesthetics in the brain results in CNS depression initially followed by CNS stimulation
- E.
Cocaine also has anti-arrhythmic properties
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