NSAID Quiz: Can You Catch The GI Risk?

1. A patient with renal impairment requires pain management. Which NSAID approach is safest?

Avoid NSAIDs; use acetaminophen or opioids

Use high-dose NSAIDs with PPI

Use NSAIDs at standard doses

Use NSAIDs with frequent monitoring only

2. True or False: NSAIDs can be safely used long-term without GI prophylaxis in most patients.

True

False

Submit

5. A patient on NSAIDs develops edema and weight gain. What is the likely cause?

NSAID-induced sodium retention and fluid accumulation

Increased appetite from medication

Decreased metabolism

Allergic reaction

6. Which age group requires the most caution with NSAID use?

Elderly patients (>65 years)

Young adults (20–30 years)

Adolescents

All ages equally

7. NSAIDs combined with anticoagulants increase risk of which complication?

Severe GI bleeding

Thromboembolism

Hypertension

Hyperglycemia

8. What patient education is essential for those on chronic NSAIDs?

Take with food, report GI symptoms, avoid alcohol

Take on empty stomach for better absorption

NSAIDs are completely safe with no side effects

Increase dose if pain worsens

9. NSAIDs increase bleeding risk by inhibiting which platelet function?

Thromboxane A2 production

Fibrinogen synthesis

Platelet adhesion only

Red blood cell formation

10. Which symptom warrants immediate NSAID discontinuation?

Black, tarry stools or severe abdominal pain

Mild heartburn

Occasional nausea

Mild joint pain relief

11. Which mechanism best explains how NSAIDs increase gastrointestinal bleeding risk?

Inhibition of COX-1 and COX-2, reducing protective prostaglandins

Direct erosion of gastric mucosa

Increased gastric acid production

Decreased blood clotting factors

12. NSAIDs reduce the effectiveness of which antihypertensive class?

ACE inhibitors and angiotensin receptor blockers

Beta-blockers

Calcium channel blockers

Diuretics only

13. Which lab finding suggests NSAID-induced nephrotoxicity?

Rising creatinine and elevated potassium

Low hemoglobin

Elevated liver enzymes

Low sodium only

14. NSAIDs should be avoided during which trimester of pregnancy?

Third trimester

First trimester only

Second trimester only

All trimesters

15. A patient presents with hematemesis while on ibuprofen. What is the priority action?

Discontinue NSAID immediately and assess for GI bleed

Continue NSAID with PPI coverage

Switch to acetaminophen

Increase NSAID dose to anti-inflammatory level

16. Chronic NSAID use increases cardiovascular risk by which mechanism?

Inhibition of prostacyclin, promoting thrombosis

Direct myocardial toxicity

Increased LDL cholesterol

Arrhythmia induction

17. What is the primary concern when combining NSAIDs with ACE inhibitors?

Increased risk of acute kidney injury

Severe hypertension

Hyperkalemia only

Decreased NSAID efficacy

18. Which NSAID has the lowest GI toxicity profile?

Naproxen

Indomethacin

Celecoxib (COX-2 selective inhibitor)

Ibuprofen at high doses

19. NSAIDs are contraindicated in patients with which condition?

Active peptic ulcer disease

Mild hypertension

Type 2 diabetes without complications

Osteoarthritis alone

20. A patient on chronic NSAID therapy should receive prophylaxis with which medication?

Omeprazole or misoprostol

Famotidine alone

Sucralfate

Antacids only

NSAID Quiz: Can You Catch the GI Risk?