Anemia Types Quiz: Iron, B12, Folate Deficiency

1. Which finding would differentiate B12 deficiency from folate deficiency?

Elevated methylmalonic acid in B12 deficiency only

Macrocytic RBCs in folate deficiency only

Low reticulocyte count in both

Neurological symptoms in folate deficiency only

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3. A patient presents with macrocytic anemia, elevated homocysteine, and normal methylmalonic acid. The likely diagnosis is:

Vitamin B12 deficiency

Folate deficiency

Iron deficiency

Hemolytic anemia

4. A patient with pernicious anemia requires lifelong treatment with:

Oral ferrous sulfate

Intramuscular vitamin B12 injections

Oral folic acid tablets

Dietary iron-rich foods

5. Which lab finding is most characteristic of iron deficiency anemia?

Low serum ferritin and low transferrin saturation

Elevated methylmalonic acid and homocysteine

Low folate levels with normal B12

Macrocytic RBCs with hypersegmented neutrophils

6. A patient with folate deficiency anemia would benefit most from which intervention?

Ferrous sulfate supplementation

Vitamin B12 injections

Folic acid supplementation and dietary counseling

Blood transfusion

7. A patient takes metformin chronically. Which anemia type is he at risk for?

Iron deficiency anemia

Vitamin B12 deficiency anemia

Folate deficiency anemia

Hemolytic anemia

8. Which clinical symptom is most specific to vitamin B12 deficiency?

Glossitis and angular cheilitis

Paresthesias and ataxia from peripheral neuropathy

Fatigue and dyspnea on exertion

Jaundice and dark urine

9. Folate deficiency anemia presents with which characteristic blood smear finding?

Microcytic, hypochromic RBCs

Macrocytic RBCs with hypersegmented neutrophils

Target cells and schistocytes

Spherocytes and polychromasia

10. A patient with pernicious anemia has intrinsic factor antibodies. What is the primary cause?

Autoimmune destruction of gastric parietal cells

Inadequate dietary intake of B12

Malabsorption in the small intestine

Chronic use of proton pump inhibitors

11. Which of the following is a gastrointestinal cause of iron deficiency in adults?

Celiac disease

Chronic GI bleeding

Poor dietary intake

Pregnancy

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15. Which lab value is elevated in both iron deficiency and B12 deficiency anemia?

Total iron-binding capacity

Homocysteine

Reticulocyte count

Mean corpuscular hemoglobin

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17. Which patient population is at highest risk for folate deficiency anemia?

Vegetarians avoiding all animal products

Pregnant women with inadequate intake

Older adults with decreased gastric acid

Patients on long-term phenytoin therapy

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19. A patient with chronic kidney disease develops anemia primarily due to decreased:

Iron absorption

Erythropoietin production

Vitamin B12 synthesis

Folate metabolism

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Anemia Quiz: Iron, B12 or Folate Deficiency?

1. Which finding would differentiate B12 deficiency from folate deficiency?

2.

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2. Iron deficiency anemia causes microcytic RBCs because iron is needed to synthesize ____.

3. A patient presents with macrocytic anemia, elevated homocysteine, and normal methylmalonic acid. The likely diagnosis is:

4. A patient with pernicious anemia requires lifelong treatment with:

5. Which lab finding is most characteristic of iron deficiency anemia?

6. A patient with folate deficiency anemia would benefit most from which intervention?

7. A patient takes metformin chronically. Which anemia type is he at risk for?

8. Which clinical symptom is most specific to vitamin B12 deficiency?

9. Folate deficiency anemia presents with which characteristic blood smear finding?

10. A patient with pernicious anemia has intrinsic factor antibodies. What is the primary cause?

11. Which of the following is a gastrointestinal cause of iron deficiency in adults?

12. Vitamin B12 is primarily absorbed in the ____.

13. In iron deficiency anemia, the transferrin saturation is typically ____.

14. Folate deficiency is most commonly caused by poor ____ in developed countries.

15. Which lab value is elevated in both iron deficiency and B12 deficiency anemia?

16. The hallmark neurological complication of untreated B12 deficiency is ____ degeneration.

17. Which patient population is at highest risk for folate deficiency anemia?

18. Intrinsic factor is a glycoprotein produced by gastric ____ that is essential for B12 absorption.

19. A patient with chronic kidney disease develops anemia primarily due to decreased:

20. Iron deficiency anemia is classified as microcytic because the MCV is ____ fL.