Practice Quiz About Sickle Cell Disease
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How much do you know about sickle cell disease? This is a practice quiz about sickle cell disease. Take it up and test your knowledge about the same. SCD (sickle cell disease) is a group of inherited disorders that affect hemoglobin and is typically inherited from their parents. The most common type is sickle cell anemia. This quiz contains basic questions related to this disease, and you can learn more about it by playing this quiz. Go for it, then.
Questions and Answers
- 1.
Hemoglobin is a molecule made up of polypeptides ______ and _____
- A.
Proteins
- B.
Alpha globin
- C.
Amino acids
- D.
Beta globin
Correct Answer(s)
B. Alpha globin
D. Beta globinExplanation
Hemoglobin is a molecule made up of polypeptides called alpha globin and beta globin. These two polypeptides combine together to form the complete hemoglobin molecule. Hemoglobin is responsible for carrying oxygen from the lungs to the tissues and removing carbon dioxide from the tissues back to the lungs. The presence of both alpha globin and beta globin is crucial for the proper functioning of hemoglobin.Rate this question:
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- 2.
Hemoglobin is found in the red blood cells and carries oxygen and carbon monoxide from one area of the body to another.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
Hemoglobin is indeed found in the red blood cells and plays a crucial role in transporting oxygen and carbon monoxide throughout the body. It binds to oxygen in the lungs and carries it to tissues and organs, ensuring proper oxygenation. Additionally, hemoglobin can also bind to carbon monoxide, which is a harmful gas produced by combustion, preventing it from binding to other molecules and causing harm. Therefore, the statement "Hemoglobin is found in the red blood cells and carries oxygen and carbon monoxide from one area of the body to another" is true.Rate this question:
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- 3.
Each red blood cell has approxx. ______ hemoglobin molecules.
- A.
270 million
- B.
173.450
- C.
4 trillion
- D.
3
Correct Answer
A. 270 millionExplanation
Each red blood cell contains approximately 270 million hemoglobin molecules. Hemoglobin is a protein found in red blood cells that carries oxygen from the lungs to the rest of the body. The high number of hemoglobin molecules in each red blood cell allows for efficient oxygen transport throughout the body.Rate this question:
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- 4.
Cells can still sickle without hemoglobin.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
This statement is false because sickling of cells is directly related to the abnormal shape of red blood cells caused by the presence of abnormal hemoglobin. Sickle cell disease is a genetic disorder where the red blood cells contain abnormal hemoglobin, causing them to become rigid and sickle-shaped. Without the presence of abnormal hemoglobin, the cells would not sickle. Therefore, hemoglobin is necessary for cells to sickle in sickle cell disease.Rate this question:
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- 5.
The difference between AA and SS is the _______ amino acid of the __________ polypeptide
- A.
9th, beta globin
- B.
6th, beta globin
- C.
6th, alpha globin
- D.
4th, beta globin
Correct Answer
A. 9th, beta globinExplanation
The difference between AA and SS is the 9th amino acid of the beta globin polypeptide.Rate this question:
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- 6.
The enzyme which destroys peptide bonds is called what?
Correct Answer
Protease, proteaseExplanation
Protease is the correct answer because it is an enzyme that specifically breaks down peptide bonds, which are the bonds that hold amino acids together in a protein chain. Protease enzymes play a crucial role in various biological processes, including digestion, protein turnover, and cell signaling. They are responsible for breaking down proteins into smaller peptides and amino acids, allowing for their absorption and utilization by the body. Therefore, protease is the enzyme that destroys peptide bonds.Rate this question:
- 7.
Why is Penicillin is given to Patients with sickle cell disease?
- A.
Because the oxygen found in Penicillin can reduce an SCD episode
- B.
Because Penicillin can change the valine amino acid back into glutamic acid, therefore the hemoglobin molecules unlink from the polypeptide form and the red blood cell becomes normal.
- C.
Because with sickle cell disease comes an increased infection rate
- D.
Because blood clots can form and that can be painful, penicillin can reduce pain in individuals
Correct Answer
C. Because with sickle cell disease comes an increased infection rateExplanation
Patients with sickle cell disease have an increased risk of infections due to the abnormal shape of their red blood cells. The misshapen cells can get stuck in blood vessels, leading to reduced blood flow and oxygen supply to tissues, making them more susceptible to infections. Penicillin, an antibiotic, is given to these patients as a prophylactic measure to prevent bacterial infections, particularly those caused by Streptococcus pneumoniae. By reducing the risk of infections, penicillin helps in managing the complications associated with sickle cell disease.Rate this question:
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- 8.
Hydroxyurea is used to treat fetal hemoglobin.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
Hydroxyurea is indeed used to treat fetal hemoglobin. Fetal hemoglobin is a type of hemoglobin that is present in newborns and infants. It is different from adult hemoglobin and has a higher affinity for oxygen. Hydroxyurea is a medication that can stimulate the production of fetal hemoglobin in adults with certain blood disorders, such as sickle cell disease and beta-thalassemia. By increasing the levels of fetal hemoglobin, hydroxyurea can help to improve the symptoms and complications associated with these conditions. Therefore, the statement is true.Rate this question:
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- 9.
In the African highlands, the SA allele is very common.
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
The statement suggests that the SA allele is not very common in the African highlands.Rate this question:
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- 10.
Which genotype of Sickle cell confers resistance to malaria?
- A.
SA
- B.
AA
- C.
Ss
- D.
F508del
Correct Answer
A. SAExplanation
The genotype SA confers resistance to malaria. Sickle cell trait is caused by the presence of one normal hemoglobin gene (A) and one sickle hemoglobin gene (S). This combination provides some protection against malaria, as the parasite responsible for malaria cannot survive as easily in red blood cells with sickle hemoglobin. Therefore, individuals with the SA genotype have a reduced risk of contracting malaria compared to those with other genotypes.Rate this question:
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- 11.
The reason the S allele confers resistance to malaria is because in the presence of low O2 cells sickle and eventually lyse therefore breaking the parasitic lifecycle.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
The S allele confers resistance to malaria because in low oxygen conditions, the cells containing the S allele sickle and eventually burst, disrupting the lifecycle of the malaria parasite. This disruption prevents the parasite from multiplying and causing the disease.Rate this question:
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- 12.
_________ is the blood group which has an extra layer of carbohydrates to protect the blood cells from the malaria parasite from entering the cell.
Correct Answer
Dantu, dantuExplanation
Dantu blood group has an extra layer of carbohydrates that acts as a protective shield against the malaria parasite. This additional layer prevents the parasite from entering the blood cells, reducing the risk of infection.Rate this question:
- 13.
The molecular basis behind SCD was fond during Lineaus Paulings famous light experiment.
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
The given statement is false. There is no evidence to suggest that the molecular basis behind SCD (Sickle Cell Disease) was found during Linus Pauling's famous light experiment. Linus Pauling was a renowned scientist known for his work on the nature of chemical bonds and his contributions to the field of molecular biology, but there is no direct connection between his experiments and the discovery of the molecular basis of SCD.Rate this question:
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- 14.
Red blood cells need a __________ protein in order for them to sickle.
Correct Answer
Hemoglobin, hemoglobinExplanation
Red blood cells need a specific protein called hemoglobin in order for them to sickle. Hemoglobin is responsible for carrying oxygen throughout the body. In individuals with sickle cell disease, a genetic mutation causes the hemoglobin to form abnormal shapes, leading to the characteristic sickle shape of the red blood cells. This altered hemoglobin causes the cells to become rigid and prone to getting stuck in blood vessels, resulting in various complications.Rate this question:
- 15.
The true molecular basis of sickle cell disease was found using what experimental method
- A.
DNA sequencing
- B.
2-D electrophoresis
- C.
Erythropoientin
- D.
Using chaperones to speed up protein folding
Correct Answer
B. 2-D electrophoresisExplanation
2-D electrophoresis is a technique used to separate and analyze proteins based on their charge and size. In the context of sickle cell disease, this method was used to identify the abnormal hemoglobin protein responsible for the disease. By subjecting the hemoglobin samples from individuals with sickle cell disease to 2-D electrophoresis, researchers were able to observe a distinct band corresponding to the mutated hemoglobin protein. This provided evidence for the molecular basis of sickle cell disease, demonstrating that a specific mutation in the hemoglobin gene leads to the production of abnormal hemoglobin proteins.Rate this question:
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Jun 18, 2023Quiz Edited by
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Jun 07, 2022Quiz Created by
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