Pharm Mt 1 Part IV

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1. The SCr is a _____ sensitive indicator of renal function than the BUN.

Explanation

pg. 26

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Pharm Mt 1 Part IV - Quiz

Principles of Pharm (pgs. 26-39; skipped 31-35)

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2. Use of actual body weight in obese patients may significanly _______ CrCl.

Explanation

In obese patients, need to use adujusted body weight (ABW) instead when calculating CrCl and doses.

pg. 26

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3. The amount of drug required to produce 50% of the maximal response that the drug is capable of inducing is the definition for ___________.
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4. How strongly a drug molecule binds to a binding site is referred to as:

Explanation

pg. 28

The dissociation constant (K sub D) describes the degree of a drug's affinity for the receptor site. This is the concentration of drug in solution necessary for 50% of given receptors to be occupied (pg. 29)

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5. What drug info monograph section should an OD review in order to find info on how the drug actually works?

Explanation

question from lecture

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6. ________ is a concept often used when comparing the effects in the same class of drugs.

Explanation

-vs-
Drug efficacy: used when comparing the effects od drugs in DIFFERENT classes or which have different mechs of

pg. 29

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7. Which of the drug monograph sections should an OD review o find info on the half life, onset of action, binding mechanism and elimination?

Explanation

question from lecture

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8. The creatinine clearance of a female is what percent of a males?

Explanation

pg.26

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9. High doses of agnosits can overcome competitive antagonism.

Explanation

Competitive antagonism: antagonist competes with agonists for receptor site

pg. 29

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10. High doses of agonists can overcome non-competitive antagonism.

Explanation

non-competitive antagonism: antagonist binds to sites OTHER THAN the agonist-binding domain

pg. 29

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11. Renal dose adjustments are not usually needed unless the CrCl is less than ____mL/min.

Explanation

Some drugs do not need to be adjusted until the clearance is lower..

pg. 27

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12. DNA transcription, steroid production, stimulation of red blood production are all examples of what type of event in response to drug binding to receptor sites?

Explanation

pg. 28

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13. The margin between the therapeutic dose and the lethal dose of a drug is termed _____.

Explanation

pg. 30

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14. Which of the following is NOT involved in the hepatobiliary excretion process?

Explanation

liver --> gall bladder --> bile --> feces

pg. 26

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15. What category for Pregnancy Risk Factors is a contra-indication in women who are or may become pregnant?

Explanation

pg. 37

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16. Where do agonists bind?

Explanation

agonists are drugs which change or affect cellular physiology by binding to INTRACELLULAR RECEPTORS or PLASMA MEMBRANES

(pg. 29)

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17. What Pregnancy Risk Factor Category corresponds to a drug that has no animal or female studies available to determine risks.

Explanation

pg. 37

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The SCr is a _____ sensitive indicator of renal function than the BUN.
Use of actual body weight in obese patients may significanly _______...
The amount of drug required to produce 50% of the maximal response...
How strongly a drug molecule binds to a binding site is referred to...
What drug info monograph section should an OD review in order to find...
________ is a concept often used when comparing the effects in the...
Which of the drug monograph sections should an OD review o find info...
The creatinine clearance of a female is what percent of a males?
High doses of agnosits can overcome competitive antagonism.
High doses of agonists can overcome non-competitive antagonism.
Renal dose adjustments are not usually needed unless the CrCl is less...
DNA transcription, steroid production, stimulation of red blood...
The margin between the therapeutic dose and the lethal dose of a drug...
Which of the following is NOT involved in the hepatobiliary excretion...
What category for Pregnancy Risk Factors is a contra-indication in...
Where do agonists bind?
What Pregnancy Risk Factor Category corresponds to a drug that has no...
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