Pharm Mt 1 Part II
Principles of Pharm (Pgs. 9-18)
- 1.Describe the key factors of drug stability.
- 2.Describe the purpose for using a loading dose followed by maitenance doses.
- 3.The setting in which the drug will be used i.e. IV meds occurs in hopsitals whereas oral meds are more appropriate for outpatient use describes the "clinical situation" of a drug.
- A.
True
- B.
False
- 4.25-50 mg of oral metoprolol has the same minimum effective dose in the serum as 2.5-5 mg of IV metoprolol.
- A.
True
- B.
False
- 5.How can one determine when steady state is reached for an continuous infusion, based on analyzing a drug serum concentration graph?
- A.
Drug concentration will "flat line"
- B.
Drug concentration peaks and troughs will be equal
- C.
Drug concentration will show steady increase
- D.
More than one of the above
- 6.Blood from the mesenteric circulation (GI tract) passed through the_______ before entering other organs.
- 7.Which of the following is FALSE in regard to oral drug administration?
- A.
One of the easiest routes for pts to dose themselves
- B.
Should be acid-stable
- C.
Should not be absorbed by the intestinal lining in order to enter bloodstream
- D.
Intestinal peristalsis can affect the absorption
- 8.Sublingual drug administration uses percutaneous absorption through the mouth and gums
- A.
True
- B.
False
- 9.Indicate which drugs have a high first pass effect according to lecture.
- A.
Metoprolol
- B.
Mannitol
- C.
Beta blockers
- 10.Choose ALL that apply to the formulation of drugs.
- A.
Capability of the drug to pass through one or more barriers in the body
- B.
Adverse effects of the drug
- C.
Intended use of the drug
- D.
Clinical situation
- E.
Potential misuse of the drug
- F.
First pass effect
- G.
Drug stability
- 11.The abbreviation for sublingual administration is SL
- A.
True
- B.
False
- 12.Which of the following is NOT considered a topical form of drug administration?
- A.
Ophthalmic
- B.
Sublingual
- C.
Dermatologic
- D.
Nasal
- E.
Otic
- 13.The administration technique which bypasses/avoids use of the ___________ for medication absorption is called Parenteral.
- 14.If the dose of a drug is 100 mg (assume 100% bioavailability) and the half life is 8 hours, how many half-lifes will it take for less than 2 mg of the drug to still be circulating the serum?
- A.
4
- B.
5
- C.
6
- D.
7
- 15.Legible, clear notice of the condition for which a drug or device is being prescribed is legally necessary when writing a Rx
- A.
True
- B.
False
- 16.Which of the following drugs was presented as an example for having poor drug stability when taken orally.
- A.
Vigamox
- B.
Dicloxacillin
- C.
Insulin
- D.
Catapress
- 17.Azithromycin, concentrates ________ and after several doses its half life ___________.
- A.
Intracellularly; decreases
- B.
Extracellularly; decreases
- C.
Extracellularly; increases
- D.
Intracellularly; increases
- 18.Another name for intermittent IV administration is "piggyback"
- A.
True
- B.
False
- 19.Which of the following is NOT an appropriate match?
- A.
Aa = of each
- B.
QD = once a day
- C.
Supp = supplemental
- D.
U.D. = as directed
- E.
None of the above (they are all correct)
- F.
More than one of the above is incorrect
- 20.Both continuous infusion and single doses will eventually reach a steady state after 4-5 half lives.
- A.
True
- B.
False
- 21.The optimum recommended dosage frequency of many drugs is often (but not always) determined to be _______ times the half life.
- A.
1-2
- B.
2-3
- C.
3-4
- D.
4-5
- 22.The half life of a drug often relates to:
- A.
Duration of action
- B.
Onset of action
- C.
Distribution phase
- D.
Therapeutic range
- 23.Check off ALL the options that are required on an Rx label.
- A.
Patient address
- B.
Refills
- C.
Date of birth
- D.
Dr's license classification
- E.
Directions for use
- 24.Drugs administered ________ reach maximum serum concentration rapidly compared to drugs administered by many other routes.
- 25.Check ALL the correct matches
- A.
T.I.D. = two times per day
- B.
Ung = ointment
- C.
Qs = one half
- D.
Tab = tablet
- E.
Sig = significant warnings
- F.
Dr = drop(s)
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