MUSCLE HISTOLOGY Block 2 Sem-1

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1/12 Questions

A 19-year-old male patient and his mother arrive in the emergency room, both suffering with nausea, vomiting, and visual disorders. The physician taking their history notes that they both had canned green beans that "tasted funny." Which of the following possibilities should the physician consider?
- Duchenne muscular dystrophy
- Amyotrophic lateral sclerosis
- Botulism
- Myasthenia gravis
- Myocardial infarct

About This Quiz

This quiz titled 'MUSCLE HISTOLOGY Block 2 Sem-1' assesses knowledge on muscle tissue types, their structures, and functions. It covers skeletal, cardiac, and smooth muscles, focusing on their histological features and mechanisms like calcium binding. Essential for students in medical or biological sciences.

2.

Which of the following statements concerning triads in mammalian skeletal muscle is true?
- They are located in the Z disk.
- They consist of two terminal cisternae of the sarcoplasmic reticulum separated by a T tubule.
- They can be observed with the light microscope.
- They are characterized by a T tubule that sequesters calcium ions
- They consist of two T tubules separated by a central terminal cisterna.
Correct Answer

A. They consist of two terminal cisternae of the sarcoplasmic reticulum separated by a T tubule.

Explanation

A triad in skeletal muscle is composed of three components, a T tubule and two terminal cisternae of the sarcoplasmic reticulum (SR) that flank it. The SR, not the T tubules, sequesters calcium ions.

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3.

Which one of the following statements concerning cardiac muscle cells is true?
- They are spindle shaped.
- They require an external stimulus to undergo contraction
- They are multinuclear cells.
- They are joined together end-to-end by intercalated disks
- They possess numerous caveolae.
Correct Answer

A. They are joined together end-to-end by intercalated disks

Explanation

Cardiac muscle cells are joined together end-to-end by a unique junctional specialization
called the intercalated disk.

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4.

Thick filaments are anchored to Z disks by
- C protein
- Nebulin
- Titin
- Myomesin
- A-actinin
Correct Answer

A. Titin

Explanation

Titin forms an elastic lattice that anchors thick filaments to Z disks.

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5.

Each smooth muscle cell
- Has triads associated with its contraction
- Has dyads associated with its contraction
- Possesses a single centrally located nucleus
- Is characterized by the absence of sarcolemmal vesicles
Correct Answer

A. Possesses a single centrally located nucleus

Explanation

Smooth muscle cells contain one centrally located nucleus.

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6.

The Perimysium is a connective tissue investment that surrounds
- Individual muscle fibers
- Muscle fascicles
- Individual myofibrils
- An entire muscle
- Small bundles of muscle cells
Correct Answer

A. Muscle fascicles

Explanation

Perimysium surrounds Fasicles.
The endomysium is a thin connective tissue layer, composed of reticular fibers and an external lamina, that invests individual muscle fibers (cells).
The EPIMYSIUM surrounds the entire muscle.

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7.

The endomysium is a connective tissue investment that surrounds
- Individual muscle fibers
- Muscle fascicles
- Individual myofibrils
- An entire muscle
- Small bundles of muscle cells
Correct Answer

A. Individual muscle fibers

Explanation

The endomysium is a thin connective tissue layer, composed of reticular fibers and an external
lamina, that invests individual muscle fibers (cells). The epimysium surrounds the entire
muscle, and the perimysium surrounds bundles (fascicles) of muscle fibers.

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8.

Smooth muscle (SELECT 5 OPTIONS)
- T tubules are located at the Z disk
- T tubules are located at the A-I interface
- T tubules are lined by external lamina
- T tubules are absent
- Oxytocin triggers contraction
- Possess(es) dyads
- Possess(es) triads
- Possess caveolae
- Troponin is absent
- Myosin light-chain kinase participates in contraction
- Possess(es) intercalated disks
Correct Answer(s)

A. T tubules are absent
A. Oxytocin triggers contraction
A. Possess caveolae
A. Troponin is absent
A. Myosin light-chain kinase participates in contraction

Explanation

Smooth muscle cells do not have T tubules. Contraction may be initiated by stretching, neural impulses, the intercellular passage of small molecules via gap junctions, or the action of hormones such as oxytocin. The process of contraction is not dependent on troponin, which is absent from the thin filament of smooth muscle. Instead, calcium ions controlled by sarcolemmal vesicles known as caveolae are released into the cytosol, where they bind with calmodulin. The calcium-calmodulin complex activates myosin light chain kinase, which participates in the contraction process.

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1
9.

Contraction in all types of muscle requires calcium ions. Which of the following muscle components can bind or sequester calcium ions?
- Rough endoplasmic reticulum
- Tropomyosin
- Troponin
- Active sites on actin
Correct Answer

A. Troponin

Explanation

Binding of calcium ions to the TnC subunit of troponin leads to the uncovering of myosinbinding
sites on actin (thin filaments).

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10.

Questions 1-3 The response options for the next three items are the same. Each item will state the number of options to select. Choose exactly this number. For each of the following muscle types, select the appropriate description(s). Skeletal muscle (SELECT 2 OPTIONS)
- T tubules are located at the Z disk
- T tubules are located at the A-I interface
- T tubules are lined by external lamina
- T tubules are absent
- Oxytocin triggers contraction
- Possess(es) dyads
- Possess(es) triads
- Possess caveolae
- Troponin is absent
- Myosin light-chain kinase participates in contraction
- Possess(es) intercalated disks
Correct Answer(s)

A. T tubules are located at the A-I interface
A. Possess(es) triads

Explanation

The T tubules of skeletal muscle cells are positioned so that they form triads with the terminal cisternae of the sarcoplasmic reticulum at the interface of the A and I bands.

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11.

Thick filaments are anchored at the M-Line by
- C protein
- Nebulin
- Titin
- Myomesin
- A-actinin
Correct Answer

A. C protein

Explanation

C protein (clamp protein) anchors at the M-line.
Titin forms an elastic lattice that anchors thick filaments to Z disks.
Nebulin anchors to THIN filaments

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12.

Cardiac muscle (SELECT 4 OPTIONS)
- T tubules are located at the Z disk
- T tubules are located at the A-I interface
- T tubules are lined by external lamina
- T tubules are absent
- Oxytocin triggers contraction
- Possess(es) dyads
- Possess(es) triads
- Possess caveolae
- Troponin is absent
- Myosin light-chain kinase participates in contraction
- Possess(es) intercalated disks
Correct Answer(s)

A. T tubules are located at the Z disk
A. T tubules are lined by external lamina
A. Possess(es) dyads
A. Possess(es) intercalated disks

Explanation

The T tubules of cardiac muscle cells are wider than those of skeletal muscle cells and are lined by external lamina (a basal lamina-like material). In contrast to skeletal muscle, the T tubules are located at the Z disk, where they often form dyads. Individual cardiac muscle cells are attached to one another by intercalated disks.

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Current Version
Mar 22, 2023

Quiz Edited by
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Oct 20, 2011

Quiz Created by
Chachelly

Muscle Histology Block 2 Sem-1

A 19-year-old male patient and his mother arrive in the emergency room, both suffering with nausea, vomiting, and visual disorders. The physician taking their history notes that they both had canned green beans that "tasted funny." Which of the following possibilities should the physician consider?

Quiz Preview

Which of the following statements concerning triads in mammalian skeletal muscle is true?

Which one of the following statements concerning cardiac muscle cells is true?

Thick filaments are anchored to Z disks by

Each smooth muscle cell

The Perimysium is a connective tissue investment that surrounds

The endomysium is a connective tissue investment that surrounds

Smooth muscle (SELECT 5 OPTIONS)

Contraction in all types of muscle requires calcium ions. Which of the following muscle components can bind or sequester calcium ions?

Questions 1-3 The response options for the next three items are the same. Each item will state the number of options to select. Choose exactly this number. For each of the following muscle types, select the appropriate description(s). Skeletal muscle (SELECT 2 OPTIONS)

Thick filaments are anchored at the M-Line by

Cardiac muscle (SELECT 4 OPTIONS)