MS II Practice Exam

65 Questions | Total Attempts: 13

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Practice Exam Quizzes & Trivia

Practice for MS II exam


Questions and Answers
  • 1. 
    Which of the following nerves of the lumbar and lumbosacral plexus is formed by the most superior (rostral) segments:
    • A. 

      Tibial

    • B. 

      Femoral

    • C. 

      Sciatic

    • D. 

      Lumbrosacral Trunk

    • E. 

      Pudendal

  • 2. 
    Which of the following nerves of the lumbar and lumbosacral plexus is matched correctly:
    • A. 

      Obturator–lateral thigh –adduction –L3L4

    • B. 

      Femoral –anterior thigh –patellar reflex –leg extension

    • C. 

      Tibial –posterior leg (calf) –ankle reflex –plantar extension

    • D. 

      Lateral femoral cutaneous–lateral thigh –abduction –L4L5

    • E. 

      Deep peroneal –anterior leg –foot drop –L5

  • 3. 
    Which of the following nerves DOES NOT contain sensory fibers distal to the patella?
    • A. 

      Femoral Nerve

    • B. 

      Sciatic Nerve

    • C. 

      Deep Peroneal Nerve

    • D. 

      Obturator Nerve

    • E. 

      Tibial Nerve

  • 4. 
    Macrophages can have which of the following effects:
    • A. 

      Release histamine in response to inflammation

    • B. 

      Degrade extracellular matrix proteins

    • C. 

      Responds to cytokines by activating transcription growth factors

    • D. 

      Contains the largest ER of all connective tissue cells

    • E. 

      Contain antigen presenting proteins

  • 5. 
    Which of the following is NOT a major tissue type of connective tissue:
    • A. 

      Fibroblasts

    • B. 

      Mast Cells

    • C. 

      Macrophages

    • D. 

      Lymphocytes

    • E. 

      Collagen IV

  • 6. 
    Choose the one answer that correctly describes a feature of epithelia:
    • A. 

      Blood vessels and lymphatics are present within epithelia

    • B. 

      Type I collagen is deposited between epithelial cells

    • C. 

      The basal layer of epithelium adheres to the basement membrane

    • D. 

      Fibrosis occurs within the epithelium.

    • E. 

      Fibrosis occurs within the epithelium

  • 7. 
    Which function is NOT attributable to macrophages:
    • A. 

      Phagocytosis

    • B. 

      Type I collagen synthesis

    • C. 

      Antigen presentation

    • D. 

      Cytokine secretion

  • 8. 
    Which collagen is found within basement membranes but not connective tissues?
    • A. 

      Type I, a fibrillar collagen

    • B. 

      Type III

    • C. 

      Type IV, a network forming collagen

    • D. 

      Fibril associated collagens (e.g. Type IX)

  • 9. 
    Which of the following peptidases is the most important in protein digestion?
    • A. 

      Carboxypeptidase

    • B. 

      Trypsin

    • C. 

      Chymotrypsin

    • D. 

      Elastase

    • E. 

      Aminopeptidase

  • 10. 
    Which of the following transporters moves amino acids to the portal system?
    • A. 

      Facilitated Amino Acid Transporters

    • B. 

      γ-glutamyltranspeptidase

    • C. 

      Na+-dependent amino acid transporters

    • D. 

      Na+,K+-pump

  • 11. 
    In which of the following tissues protein turnover has the fastest rate?
    • A. 

      Liver

    • B. 

      Kidney

    • C. 

      Brain

    • D. 

      Small Intestine

    • E. 

      Skeletal Muscle

  • 12. 
    Which of the following is NOT an endopeptidase?
    • A. 

      Carboxypeptidase

    • B. 

      Chymotrypsin

    • C. 

      Trypsin

    • D. 

      Pepsin

  • 13. 
    Which of the following classifications would best describe the type of connective tissue in Curt Schillings injury?
    • A. 

      Loose connective tissue

    • B. 

      Dense Irregular Connective Tissue

    • C. 

      Dense Regular Connective tissue

  • 14. 
    Collagen processing is tightly regulated at multiple “levels”in cells. Review the following list of statements and choose the one that is incorrect:
    • A. 

      Collagen I expression is regulated in part by transcriptional controls.

    • B. 

      Proper assembly ofprocollagen requires hydroxylation ofprolines.

    • C. 

      Collagen fibers are assembled in the rough endoplasmic reticulum

    • D. 

      One variant of EhlersDanlos Syndrome has two known lesions: one is dominant negative and involves the peptide sequence that is normally cleaved and resides in the N-terminal propeptide. The other, autosomal recessive, results from a defect in the enzyme that cleaves this peptide.

    • E. 

      Fibrillar and fibril-associated collagens are two distinct groups of collagens

  • 15. 
    Marfan syndrome is an autosomal dominant disorder with defects in the ocular, skeletal and cardiovascular systems.  Cardiovascular abnormalities are life-threatening and include dilation of the ascending aorta.  What would you suspect is the cause of this disorder?
    • A. 

      Overproduction of type I collagen.

    • B. 

      Improper assembly of elastic fibers

    • C. 

      Decreased elastin production.

    • D. 

      Increased hyaluronan deposition

  • 16. 
    Which of the following plays the most critical role in the stability of the collagen triple helix?
    • A. 

      Hydroxylation

    • B. 

      Glycosylation

    • C. 

      Hydroxyproline

    • D. 

      Procollagen-N

  • 17. 
    Which of the following statements is correct?
    • A. 

      Protein turnover leads to hydrolysis and resynthesis of approximately 56 g of body protein each day.

    • B. 

      Amino acids in excess of biosynthetic needs are stored as proteins.

    • C. 

      An aminotransferase reaction using alanine and alpha-ketoglutarate yields glutamate and oxaloacetateas products.

    • D. 

      Urea is quantitatively the most important nitrogen-containing compound in urine.

    • E. 

      Glutamine is not found in tissue proteins

  • 18. 
     Which of the following statement concerning glutamine is INCORRECT?
    • A. 

      Glutamine is found in tissue proteins.

    • B. 

      The only fate of glutamine is hydrolysis to glutamate and ammonia.

    • C. 

      Glutamine is responsible for the transport of ammonia in non-toxic form.

    • D. 

      ATP is required for synthesis of glutamine from glutamate and ammonia

    • E. 

      In liver glutamine is hydrolyzed to glutamate and ammonia.

  • 19. 
    Mutation in the which of the following enzymes of the urea cycle causes arginemia?
    • A. 

      Carbomoyl phosphate synthetase

    • B. 

      Ornithine transcarbomoylase

    • C. 

      Arginase

    • D. 

      Arginosuccinate synthetase

    • E. 

      None of the above

  • 20. 
    In which of the following tissues glucose-alanine cycle is a major route for ammonia detoxification?
    • A. 

      Kidney

    • B. 

      Liver

    • C. 

      Gut

    • D. 

      Brain

    • E. 

      Skeletal Muscle

  • 21. 
    Which of the following chemical reactions is the rate-limiting in the urea cycle?
    • A. 

      NH++ CO+ 2 ATP --> carbomoyl phosphate

    • B. 

      Ornithine + carbomoyl phosphate --> citrulline.

    • C. 

      Citrulline+ aspartate --> arginocuccinate

    • D. 

      Arginosuccinate --> arginine + fumarate.

    • E. 

      Arginine --> urea + ornithine

  • 22. 
    Which of the following enzymes is responsible for brain metabolic deficits in hyperammonemia?
    • A. 

      Arginosuccinate lyase

    • B. 

      Aspartate Amino Transferase

    • C. 

      Glutamate dehydrogenase

    • D. 

      Alanine aminotransferase

    • E. 

      Glutaminase

  • 23. 
    Which of the following is synthesized from an essential amino acid?
    • A. 

      Alanine

    • B. 

      Glutamate

    • C. 

      Proline

    • D. 

      Tyrosine

    • E. 

      Aspartate

  • 24. 
    Select a correct answer.  Two exclusively ketogenic amino acids are:
    • A. 

      Glutamine and glutamate

    • B. 

      Leucine and lysine

    • C. 

      Tyrosine and isoleucine

    • D. 

      Leucine and isoleucine

    • E. 

      None of the above

  • 25. 
    Metabolism of which of the following amino acids is defective in maple syrup urine disease?
    • A. 

      Tryptophan

    • B. 

      Tyrosine

    • C. 

      Aromatic amino acids

    • D. 

      Branched chain amino acids

    • E. 

      Phenylalanine