Mode of transmission, dimorphism, systemic semination
Mode of transmission, dimorphism,systemic dissemination
Demographic area, unimorphism, systemic dissemination
Inhalation of infectious conidia
Ingestion of infectious conidia
Cutaneous exposure of conidia
25C: 37C
37C: 25C
42C: 25C
Blastomyces enteritis
Coccidioides immitis
Blastomyces dermatitidis
Michigan and Detroit river basin
Mississippi and Ohio river basin
Colorado and Colorado river basin
Cats and mice
Sheep and cats
Dogs and horses
Old-aged men: water
Middle-aged men: soil
Middle-aged women: soil
Asymptomatic-> Pulmonary disease-> Invasive disease
Asymptomatic-> Pulmonary disease-> cardiac disease
Symptomatic-> Invasive disease-> gasteritis
False
True
Saliva & underneath nails
Sputum & exudative material from cutaneous lesions and tissue
Urine & subcutaneous scrapings
Yeast cells with double walls & buds connected by broad base
Small yeast cells – may be seen in monocytes and macrophages
Narrow neck between mother and daughter cells
Fluorescent Antibody
Fluorescent Antigen
Dark Antigen
White,hard,concentric circles
Black,fluffy,concentric spirals
White,fluffy,concentric circles
H. capsulatum
C. immitis
P. marneffei
Large multipolar budding
Oviod to dumbbell shaped
Elliptical fission (septate) yeasts inside phagocytes
Diffusion
Budding
Teleomorph
Conversion from mold to yeast at 37C
Conversion from yeast to mold at 37C
Conversion from mold to yeast at 25C
Endoantigens
Exoantigens
Enteroantigens
Frozen
Diluted
Concentrated
HL
A
H
H,M
A,L
HL
F,HL,HS
G,HV,HI
A,HM,HT
4,5,6
1,2,3
7,8,9
Michigan,Maine,Texas
Ohio,Mississippi,Missouri
Florida,Georgia,Tennesse
Reticuloendothelial cytomycosis
Cave disease
Spelunker's disease
Conidia's disease
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