Antihistamines, GI, And Diuretics
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Which clinical effect is NOT seen with agonists of H1 (histamine-1) receptors?
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Bronchoconstriction
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Increased gastric acid secretion
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Vasodilation
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Pruritis
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About This Quiz
This quiz on 'Antihistamines, GI, and Diuretics' assesses knowledge on drugs used in veterinary medicine, focusing on their mechanisms, clinical uses, and treatment choices for conditions like allergic reactions and asthma in animals.
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- 2.
You're working emergency at a 24 hour clinic. A 2 year old NM Golden Retriever presents to you for a wasp sting. His snout is swollen and the owner said it's getting progressively worse. Which of the following drugs is the treatment of choice to control this hypersensitivity?
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Omeprazole
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Hydroxzine
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Diphenhydramine
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Oclacitinib
Correct Answer
A. DiphenhydramineExplanation
Diphenhydramine is the treatment of choice to control hypersensitivity reactions like a wasp sting in dogs. It is an antihistamine that helps relieve swelling, itching, and other allergic symptoms. It works by blocking the effect of histamine, a substance released during an allergic reaction. Omeprazole is a medication used to reduce stomach acid and is not indicated for allergic reactions. Hydroxyzine is another antihistamine but is not the drug of choice for this specific situation. Oclacitinib is a medication used for the long-term management of allergic skin conditions but may not provide immediate relief in an acute allergic reaction.Rate this question:
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- 3.
What is the clinical use of oclacitinib?
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Allergic dermatopathy
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Type I hypersensitivity
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Asthma
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Anaphylaxis
Correct Answer
A. Allergic dermatopathyExplanation
Oclacitinib is clinically used for treating allergic dermatopathy. Allergic dermatopathy is a skin condition caused by allergies, resulting in itching, inflammation, and discomfort. Oclacitinib is a medication that specifically targets and inhibits certain enzymes involved in the inflammatory response, providing relief from the symptoms of allergic dermatopathy. It is not used for treating Type I hypersensitivity, asthma, or anaphylaxis.Rate this question:
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- 4.
Which of the following drugs inhibits JAK receptors?
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Omeprazole
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Hydroxyzine
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Zafirkulast
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Oclacitinib
Correct Answer
A. OclacitinibExplanation
Oclacitinib is the correct answer because it is a drug that specifically inhibits JAK (Janus kinase) receptors. JAK receptors are involved in the signaling pathway of various cytokines and growth factors, and their inhibition can be used in the treatment of certain inflammatory conditions. Omeprazole, Hydroxyzine, and Zafirkulast are not known to inhibit JAK receptors and have different mechanisms of action.Rate this question:
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- 5.
Which drug can be used for adjunct treatment of feline asthma?
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Apoquel
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Loratadine
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Hydroxyzine
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Zafirkulast
Correct Answer
A. ZafirkulastExplanation
Zafirkulast can be used as an adjunct treatment for feline asthma. Feline asthma is a chronic respiratory condition in cats that causes inflammation and narrowing of the airways. Zafirkulast is a leukotriene receptor antagonist that helps to reduce inflammation and relax the airways, making it easier for the cat to breathe. By using Zafirkulast alongside other asthma medications, it can help to improve the overall management and control of feline asthma symptoms.Rate this question:
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- 6.
What is trazodone's mechanism of action?
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Serotonin antagonist reuptake inhibitor
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JAK-1 and JAK-3 inhibitor
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Leukotriene receptor antagonist
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HI antagonism
Correct Answer
A. Serotonin antagonist reuptake inhibitorExplanation
Trazodone's mechanism of action is as a serotonin antagonist reuptake inhibitor. This means that it blocks the reuptake of serotonin, a neurotransmitter, in the brain, leading to increased levels of serotonin in the synaptic cleft. This helps to alleviate symptoms of depression and anxiety, as serotonin is involved in regulating mood.Rate this question:
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- 7.
What is the mechanism of action of 3% hydrogen peroxide as an emetic?
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D agonism of the CRTZ
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Serotonin antagonist
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Direct irritation of the GIT mucosa
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Alpha-2 agonism of the CRTZ
Correct Answer
A. Direct irritation of the GIT mucosaExplanation
The correct answer is "Direct irritation of the GIT mucosa." 3% hydrogen peroxide acts as an emetic by directly irritating the gastrointestinal (GIT) mucosa. This irritation stimulates the vomiting reflex, leading to the expulsion of stomach contents. It does not act through D agonism of the CRTZ, serotonin antagonism, or alpha-2 agonism of the CRTZ.Rate this question:
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- 8.
The emetic effect of apomorphine can be reversed with naloxone.
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True
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False
Correct Answer
A. FalseExplanation
The statement is false because the emetic effect of apomorphine cannot be reversed with naloxone. Naloxone is an opioid receptor antagonist that is used to reverse the effects of opioid overdose, but it does not have any effect on the emetic properties of apomorphine. Apomorphine is a dopamine agonist that is commonly used to induce vomiting in cases of poisoning or overdose, and its emetic effect cannot be reversed by naloxone.Rate this question:
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- 9.
Which drug is most effective for appetite stimulation in cats?
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Cyproheptadine
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Mirtazapine
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Capromorelin
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Maropitant
Correct Answer
A. CyproheptadineExplanation
Cyproheptadine is the most effective drug for appetite stimulation in cats.Rate this question:
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- 10.
What is FALSE regarding maropitant citrate?
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It is used to treat acute vomiting
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It's safe to use in patients with possible obstruction
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It is a neurokinin antagonist
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It works centrally
Correct Answer
A. It's safe to use in patients with possible obstructionExplanation
Maropitant citrate is a neurokinin antagonist used to treat acute vomiting in animals. However, it is not safe to use in patients with possible obstruction. This is because maropitant citrate works centrally, meaning it acts on the central nervous system to prevent vomiting. If there is a possible obstruction, using maropitant citrate may mask the symptoms and delay appropriate treatment, potentially leading to further complications.Rate this question:
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- 11.
Which antiemetic carries some prokinetic effects?
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Ondansentron
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Maropitant
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Mirtazapine
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Metoclopramide
Correct Answer
A. MetoclopramideExplanation
Metoclopramide is the correct answer because it is an antiemetic medication that also has prokinetic effects. Prokinetic agents help to improve gastrointestinal motility and accelerate the movement of food through the digestive system. This can be beneficial in treating conditions such as gastroparesis, where there is delayed emptying of the stomach. Metoclopramide works by blocking dopamine receptors in the brain and increasing the release of acetylcholine, which enhances gastrointestinal motility. Ondansetron, Maropitant, and Mirtazapine are all antiemetic medications, but they do not have prokinetic effects.Rate this question:
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- 12.
Proton pump inhibitors are more potent than H2 blockers.
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True
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False
Correct Answer
A. TrueExplanation
Proton pump inhibitors (PPIs) are indeed more potent than H2 blockers. PPIs work by inhibiting the action of the proton pump in the stomach, which reduces the production of stomach acid. This leads to a more effective and longer-lasting reduction in acid secretion compared to H2 blockers, which only block the histamine receptors that stimulate acid production. PPIs are commonly used to treat conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers, and they are generally considered to be more effective in reducing stomach acid production.Rate this question:
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- 13.
Which of the following drugs works by inhibition of H2 receptors?
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Misoprostol
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Sucralfate
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Omeprazole
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Famotidine
Correct Answer
A. FamotidineExplanation
Famotidine works by inhibiting H2 receptors. H2 receptors are found on the cells in the stomach lining and are responsible for the production of stomach acid. By inhibiting these receptors, famotidine reduces the production of stomach acid, making it an effective drug for treating conditions such as acid reflux, gastroesophageal reflux disease (GERD), and stomach ulcers. This helps to alleviate symptoms such as heartburn, indigestion, and stomach pain. Famotidine belongs to a class of drugs known as H2 blockers or H2 antagonists, which specifically target and block the action of H2 receptors.Rate this question:
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- 14.
What medication would be the best choice to treat a patient with an active upper GI ulcer?
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Sucralfate
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Misoprostol
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Omeprazole
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Cimetidine
Correct Answer
A. SucralfateExplanation
Sucralfate would be the best choice to treat a patient with an active upper GI ulcer because it forms a protective barrier over the ulcer, preventing further damage and allowing it to heal. Misoprostol is primarily used to prevent ulcers, not to treat active ones. Omeprazole and Cimetidine are both proton pump inhibitors that reduce stomach acid production, but they do not directly protect the ulcer from further damage like sucralfate does.Rate this question:
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- 15.
Which of the following conditions can be treated with lactulose? (Select all that apply)
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Active upper GI ulcer
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Cholestasis
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Megacolon
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Hepatic encephalopathy
Correct Answer(s)
A. Megacolon
A. Hepatic encephalopathyExplanation
Lactulose can be used to treat both megacolon and hepatic encephalopathy. Megacolon is a condition where the colon becomes enlarged and dilated, leading to constipation and difficulty passing stool. Lactulose helps by increasing the water content and softening the stool, making it easier to pass. Hepatic encephalopathy is a condition where there is a buildup of toxins in the blood due to liver dysfunction. Lactulose helps by reducing the amount of ammonia in the blood, which can improve symptoms such as confusion and disorientation.Rate this question:
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- 16.
Which of the following is an antidote for acetaminophen toxicity?
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Lactulose
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N-acetylcysteine
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S-adenosyl-methionine
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Ursodiol
Correct Answer
A. N-acetylcysteineExplanation
N-acetylcysteine is the correct answer because it is an antidote for acetaminophen toxicity. Acetaminophen, also known as paracetamol, is a commonly used pain reliever and fever reducer. However, in high doses, it can cause liver damage. N-acetylcysteine works by replenishing glutathione, a substance in the liver that helps detoxify acetaminophen. By restoring glutathione levels, N-acetylcysteine helps prevent or reduce liver damage caused by acetaminophen overdose.Rate this question:
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- 17.
Which of the following diuretics is potassium-sparing?
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Mannitol
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Spironolactone
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Furosemide
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Hydrochlorothiazide
Correct Answer
A. SpironolactoneExplanation
Spironolactone is a potassium-sparing diuretic because it works by blocking the action of aldosterone, a hormone that promotes sodium and water retention while increasing potassium excretion. By inhibiting aldosterone, spironolactone helps to increase the excretion of sodium and water while decreasing the excretion of potassium, making it a potassium-sparing diuretic. Mannitol, furosemide, and hydrochlorothiazide are not potassium-sparing diuretics.Rate this question:
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- 18.
Which of the following diuretics is the drug of choice for treating cardiogenic pulmonary edema?
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Furosemide
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Mannitol
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Spironolactone
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Acetazolamide
Correct Answer
A. FurosemideExplanation
Furosemide is the drug of choice for treating cardiogenic pulmonary edema because it is a loop diuretic that acts on the ascending limb of the loop of Henle to inhibit sodium and chloride reabsorption. This leads to increased urinary excretion of sodium, chloride, and water, reducing fluid overload in the lungs. Furosemide is particularly effective in cases of pulmonary edema caused by heart failure, as it helps to alleviate the increased fluid volume and congestion in the lungs.Rate this question:
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- 19.
Which of the following diuretics is the drug of choice for treating cerebral edema
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Mannitol
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Furisemide
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Spironolactone
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Acetazolamide
Correct Answer
A. MannitolExplanation
Mannitol is the drug of choice for treating cerebral edema because it is an osmotic diuretic that works by drawing water out of the brain tissue and into the bloodstream, reducing swelling and pressure. It is able to cross the blood-brain barrier and exert its effects directly on the brain. This makes it an effective treatment for conditions such as cerebral edema, where there is an abnormal accumulation of fluid in the brain. Furisemide, Spironolactone, and Acetazolamide are diuretics used for other conditions, but they are not specifically indicated for treating cerebral edema.Rate this question:
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- 20.
Which of the following diuretics acts on sodium reabsorption in the distal tubule?
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Furosemide
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Acetazolamide
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Spironolactone
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Hydrochlorothiazide
Correct Answer
A. HydrochlorothiazideExplanation
Hydrochlorothiazide is a diuretic that acts on sodium reabsorption in the distal tubule. It inhibits the sodium-chloride symporter in the distal convoluted tubule, preventing the reabsorption of sodium and chloride ions from the tubular fluid back into the bloodstream. This results in increased excretion of sodium and water, leading to diuresis. Furosemide, acetazolamide, and spironolactone act on different parts of the renal tubules and have different mechanisms of action.Rate this question:
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- 21.
Which of the following diuretics does not risk hypokalemia?
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Acetazolamide
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Hydrochlorothiazide
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Mannitol
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Spironolactone
Correct Answer
A. SpironolactoneExplanation
Spironolactone is a potassium-sparing diuretic that works by blocking the action of aldosterone, a hormone that promotes sodium reabsorption and potassium excretion in the kidneys. By inhibiting aldosterone, spironolactone helps to retain potassium in the body and reduce the risk of hypokalemia, which is a low potassium level in the blood. In contrast, Acetazolamide, Hydrochlorothiazide, and Mannitol are all diuretics that can increase the excretion of potassium, leading to a higher risk of hypokalemia.Rate this question:
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Current Version
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Mar 21, 2023Quiz Edited by
ProProfs Editorial Team -
Apr 03, 2020Quiz Created by
Jacquelyn Kulish
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