Final Exam Pcol2 Mw 8:30-10am
.
- 1.Laboratory test used to monitor the anticoagulant effect of warfarin which is prolonged when drug effect is adequate.
- A.
Activated Partial Thromboplastin time (aPTT) test
- B.
Antithrombin III
- C.
Prothrombin time (PT) test
- D.
Glycoprotein IIb/IIIa
- 2.An endogenous anticlotting protein that irreversibly inactivates thrombin and factor Xa.
- A.
Heparin-induced Thrombocytopenia
- B.
Antithrombin III
- C.
Clotting cascade
- D.
LMW heparins
- 3.Fractionated preparations of heparin of molecular weight 2000-6000
- A.
Heparin-induced Thrombocytopenia
- B.
Antithrombin III
- C.
Glycoprotein IIb/IIIa
- D.
LMW heparins
- 4.Its enzymatic action is markedly accelerated by the heparins
- A.
Clotting cascade
- B.
Glycoprotein IIb/IIIa
- C.
Antithrombin III
- D.
Heparin-induced Thrombocytopenia
- 5.Laboratory test used to monitor the anticoagulant effect of unfractionated heparin and direct thrombin inhibitors which is prolonged when drug effect is adequate
- A.
Clotting cascade
- B.
Activated Partial Thromboplastin time (aPTT) test
- C.
Prothrombin time (PT) test
- D.
FTIR
- 6.Unfractionated heparin has a molecular weight range of 5000-30000
- A.
Glycoprotein IIb/IIIa
- B.
Clotting cascade
- C.
Prothrombin time (PT) test
- D.
LMW heparins
- 7.System of serine proteases and substrates in the blood that provides rapid generation of clotting factors in response to blood vessel damage
- A.
Clotting cascade
- B.
Heparin-induced Thrombocytopenia
- C.
LMW heparins
- D.
Prothrombin time (PT) test
- 8.A protein complex on the surface of platelets
- A.
Clotting cascade
- B.
LMW heparins
- C.
Heparin-induced Thrombocytopenia
- D.
Glycoprotein IIb/IIIa
- 9.When activated, it aggregates platelets primarily by binding to fibrin
- A.
LMW heparins
- B.
Heparin-induced Thrombocytopenia
- C.
Glycoprotein IIb/IIIa
- D.
Clotting cascade
- 10.A hypercoagulable state plus thrombocytopenia that occurs in a small number of individuals treated with unfractionated heparin
- A.
Prothrombin time (PT) test
- B.
Glycoprotein IIb/IIIa
- C.
Heparin-induced Thrombocytopenia
- D.
LMW heparins
- 11.It is activated by endogenous factors such as thromboxane A2, ADP and serotonin which initiates a signaling cascade
- A.
Glycoprotein IIb/IIIa
- B.
Antithrombin III
- C.
LMW heparins
- D.
Glycoprotein IIb/IVa
- 12.Site of Action for Heparin
- A.
Small Intestines
- B.
Skin
- C.
Blood
- D.
Liver
- 13.Site of Action for Warfarin
- A.
Small Intestines
- B.
Blood
- C.
Skin
- D.
Liver
- 14.MOA of Heparin
- A.
Activates antithrombin III
- B.
Impairs post-translational modification factors II, VII, IX and X
- C.
Both
- D.
None of the answers
- 15.Antidote for Heparin toxicity or overdose
- A.
Protamine for unfractionated heparin
- B.
Vitamin K
- C.
Plasma
- D.
Prothrombin complex concentrates
- 16.Can Heparin be used for pregnant patients?
- A.
Yes
- B.
No
- C.
Option 3
- D.
Option 4
- 17.Which clotting factor/s is/are inhibited by Heparin?
- A.
IX
- B.
XIa
- C.
II
- D.
X
- 18.Which clotting factor/s is/are inhibited by Oral Anticoagulant drugs?
- A.
XIa
- B.
VIIIa
- C.
X
- D.
Va
- 19.Clinical uses of Heparin
- A.
DVT
- B.
Pulmonary embolism
- C.
Acute MI
- D.
All of the answers
- 20.Which statement is TRUE? (You can tick more than once)
- A.
Heparin is the drug of choice when an anticoagulant must be used in pregnancy.
- B.
Heparin does not cross the placental barrier.
- C.
The action of Heparin is monitored by PT.
- D.
Option 4
- 21.Which statement/s is/are TRUE about Rivaroxaban and Apixaban? (you can tick more than once)
- A.
They are oral Xa Inhibitors
- B.
Have a rapid onset of action and shorter half-lives than warfarin
- C.
They require monitoring
- D.
They undergo cytochrome P450-dependent and cytochrome P450-independent elimination.
- E.
Their MOA is to directly bind to and inhibit both free factor Xa and factor Xa bound in the clotting complex
- 22.This drug inhibits vitamin K epoxide reductase.
- A.
Warfarin
- B.
Heparin
- C.
Xarelto
- D.
Eliquis
- 23.Which statement is true about Warfarin?
- A.
Has a narrow therapeutic window
- B.
Antidote is Protamine
- C.
Can inhibit Xa Factors
- D.
The effect of warfarin is monitored by aPTT test
- 24.Which statement/s is/are TRUE about Thrombolytic Agents? (you can tick more than once)
- A.
It either comes in the form of tPA or a protein synthesized by streptococci.
- B.
All are given in IV
- C.
TPA is an enzyme that directly converts plasmin to plasminogen
- D.
Alteplase is normal human plasminogen activator while Reteplase is a mutated form of human tPA with similar effects but a slightly slower onset of action and longer duration of action.
- E.
The major application of Thrombolytic agents is an alternative to percutaneous coronary angioplasty in the emergency treatment of coronary artery thrombosis.
- 25.Which statement is TRUE on the clinical use of Thrombolytics?
- A.
Cerebral hemorrhage must be positively ruled out before each use.
- B.
It is not indicated for sever pulmonary embolism.
- C.
Under ideal conditions such as treatment within 24hrs, these agents can promptly recanalize the occluded coronary vessel.
- D.
Very prompt use of tPA, such as within 6hrs of the 1st symptoms of ischemic stroke, is associated with a significantly better clinical outcome.
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