Immunity First

1. The concept if vaccination is to introduce the:

Natural Active

Artificial Active

Natural passive

Artificial passive

2. - splenctomised patients must undergo through life-long prophylactic antibiotics :

True

False

3. One of the follong is not an Antigen presenting Cell:

B cell

Dendritic cell

Macrophages

ICAM

4. )The type of vaccine in which a killed or inactivated disease causing agent is used :

Hepatitis B vaccine

.Polio vaccine

MMR vaccine

5. In organ transplantation we :

Suppress the immune system

Activate the immune system

Non of the above

Both are correct

6. The drug that suppresses immunity by blocking the Calmodulin-Calcineurin signaling pathway is:

Cyclosporine

)Azathioprine

Mycophenolate mofetil

Leflunomide

7. Adaptive and innate immune systems are completely separated?

True

False

8. The type of immunoglobuline that can cross the placenta during pregnancy is:

IgM

. IgG

IgA

IgE

9. which one of the following is an example of passive immunity ?

Immune respons after viral infection

Hepatitis B vaccine

Anti-rabies antibodies after a dog bite

None of the above

10. Di george syndrome is :

Defect that results in immune suppression and convulsions

Abscence of thymus gland and hypercalcemia

Abscence of thymus gland and hypocalcemia

A and c

11. The first antibody to be produced by the B cells during an infection is:

IgM

IgG

IgA

IgE

12. Overreaction of the immune system against environmental substances is called :

Hypersensetivity

Allergey

Autoimmune disease

.Immunodeficiency disease

13. Which one the following is most professional APC

Neutrophils

Macrophages

Dendritic cells

Mast cells

14. In the first line of defence we can find:

Monocytes

Natural killer

Eosinophils

Non of the above

15. -ONe of the following sentences is not true regarding the spleen:

A)splenectomy patient are more immunocompromized against encapsolated bacteria

B)90% of lymph is stored in the spleen ,so it is a good source of lymphocyte

C)the spleen recieve lymphocyte by blood because it doesnt have lymphatic vessels .

None of the above

16. Valence of antibodody for IgM is (number of antigen binding sites) :

2

5

8

10

17. Which one of the following organs is an immunologicaly privileged site ?

Sternum

Cornea

Thymus

Liver

18. مين بتتوقع الفايز بكاس العالم (على الهامش :واضع السؤال مدريدي)

البرازيل

الارجنتين

فرنسا

البرتغال

19. - One of the following pairs is mismatched:

L-selectin ,found in WBC surfacr

MAC integrin ligand , VCAM-1 and endothelium

Selectin , primary adhesion

Stabilization of immune synapse , LFA-1

20. -The integrin on lymphocyte they will be developed by stimulation of:

IL-2 and IL -10

Hormones

Ag -Ab complex

IL-1, TNF

21. Choose the incorrect matching :

IgM: marker for recent or acute infection.

IgG : the most abundant Ig in the serum

IgA: dimer in the serum

IgE: mediates type 1 hypersensetivity reaction

IgD : work as a B cell receptor

22. Choose the Incorrect sentence :

Not all Igs are antibodies.

. IgG is the only one that can opsonize microbes and toxins.

IgM has the highest molecular weight.

IgM levels persist in small amount throughout life after the primary response.

23. The gene segment that isn't transcribed during recombination of the light chain is?

)V

D

C

J

24. TdT enzyme will be active in which of these stages?

Stem cell >>>>> pro b cell

Pro >>>>>> pre b cell

Pre>>>> immature b cell

Mature naïve >>>> mature effector b cell

25. Regarding the adaptive immunity, choose the Incorrect sentence ?

.Adaptive immunity is slower than the innate immunity but more specific.

It is the third line of defense

. Cell mediated immune response eliminate extracellular microbes

Has memory unlike the innate immunity.

26. Ankylosing spndylitis is Highly associated with :

HLA-B27

HLA- A1

HLA-DQ2

HLA-DR2

27. Which of the following is responsible of the inhibtion of T Cells :

Cd3

CD22

IL-2

CLAT-4

28. How many CDR in T cell receptor ?

4

3

8

6

29. Extensive allelic polymorphism is found in MHC ?

Class || beta 2 domain

Class | alpha 3 domain

Beta 2- microglobulin

DRbeta

30. Which of the following is correctly matched

MHC-class 1 — CD8 T-Cells

MHC-class 2 - CD24 T-Cells

B17-1/B17-2 — CD28 T-Cells

Two answers are correct