Immuno Final

1. Which one of the following is the universal recipient ?

AB negative

AB positive

O positive

O negative

2. Which of the following is true about COMB's test ?

Indirect anti-globulin is used to detect HDN

Direct anti-globulin is used to detect in vivo sensitized RBC

Direct anti-globulin is used to detect hemolytic transfusion reaction

B & C are correct

3. Which of the following is one way a cytokine made by TH2 cells contributes to atopic disease (allergy)?

. IL-13 activates eosinophils

IL-22 causes mast cell degranulation

.IL-4 induces B cell class switching to IgE

IL-17 stimulates TNF production by macrophages

4. Which Fc gamma receptor is involved in antibody dependent cellular cytotoxicity and it's a marker for NK cells?

CD32

CD3

CD16

CD4

5. Plasma products are indicated in which of the following situations ?

Hemophilia & VWF disease

Factor VIII deficiency

Fibrinogen

All of the above

6. Binding of Ab to structurally similar antigen refers to:

Avidity

Cross reactivity

Affinity

Specificity

7. In immunoblotting the western test used to detect:

Carbohydrate

HiV soluble protien

Ds DNA

SS DNA

8. The immunity of the baby acquired from his mother during pregnancy is

Natural active

Natural passive

Artificial passive

Artificial active

9. Auchterlony test is term used to describ :

Countercurrent immuno elactrophoresis

Single radial immunodiffusion

Douple immunodiffusion

ELISA

10. All of the following are true except?

MMR vaccine can reach 100% coverage

Live attenuated vaccines should not be given during pregnancy

Vaccines can be given to leukemic patient

HAJ vaccine is meningococcal vaccine

11. Independent IGE mast cells degranulation can caused by:

Temperature change.

Drugs such as Morphine

Excersize.

All of the above

12. Cytotoxic hypersensitivity is immediated by:

IGG or IGM

IGA

IGM

IGA or IGE

IGE

13. Chronic rejection is more frequent when ?

After previous acute rejection

Low number of compatible HLA gens

Inadequate immune suppression

All of the above

14. Which one of the following is not a risk factor for chronic GVH disease ?

Aging

Doner’s leukocytes transfusion

High radiation dose

Transplantation from male to female

15. Find the mismatched pair ?

Autograft: same individual

Xenograft : from different species

Allograft : genetically identical members from the same species

Isograft : genetically identical members from the same species

16. Hyper acute rejection is characterized by :

Thrombotic occlusion of graft

Pre-existing antibodies in the host

Occurs after xenograft transplantation

All of the above

17. Eisinophiles degranulation gives all of the following except:

Peroxidase

Histamine

Major basic proteins

Major cationic proteins

18. All of the following are examples on type 3 (immune complex) hypersensitivity reactions except:

SLE

Autoimmune hemolytic anemia

Arthus reaction

Serum sickness

19. The main immune cells responsible for killing tumor cells are

CD4+ T cells

CD8+ T cells

B cells

Macrophages

20. Which one of the following is false about BCG vaccine ?

BCG is given as one dose attenuated vaccine

It can reach 5 years effect

Its used against melanoma

It can be given as special occupation vaccine

21. Types of sensitivity are classified into 4 types according to:

Winer model

Fisher and race system

Gell and coombs model

Landstiener model

22. The best immune therapy method is ?

Tumor vaccines

T cell inhibitors blockades

LAK

Monoclonal anti-bodies

23. The terminal sugar that is specific for blood group A is ?

N-Acetyle glucosamine

N-Acetyle galactosamine

D- galactose

B & C

24. Sweat is part of the first line of defense and has low PH that kills all of the following microorganisms except ?

C.Diphtheria

S. aureus

MTB

E .coli

25. All of the following are types of the second line of defense except ?

Neutrophils

NK cells

Gastric acids

Lysozymes

26. Which type of MHC is the most polymprphic ?

Hla B

Hla A

HLA DQ

HLA DR

27. Which on of the following infections is treated by non-human antibodies ?

HAV

HBV

Rabies

HIV

28. Which one is true about vaccines ?

Vaccine is an antibodies

Vaccines induce natural active immunity

Vaccines are specific immunogenic agents

Non of the above

29. Which one of the following is false about MHC molecules ?

Located on short arm of Chromosome 6

Class 1a & Class 2 are highly polymorphic

It plays a major role in transplantation rejection

They include blood group antigens

30. Patient with Bombay blood group is characterized by :

Has Anti-H antibodies

Universal recipient

Universal donor

Has both A & B antigens

31. Which of the following organisms characterized by using M cell as rout of invasion through intestinal mucosal barrier?

Salmonella paratyphi c

Salmonella paratyphi b

Salmonella paratyphi a

Salmonella typhimurium

32. Which one of the following receptors binds to plasmodium vivax?

KIDD

DUFFY

Kell

MNS

33. Which of the following are distinct features of microglia?

High activation threshold and CD200

Normal activation threshold and CD200

High activation threshold and CD200L

Low activation threshold and CD200L

34. What is the causative organism of progressive multifocal leukoencephalopathy?

JC polyoma virus

Hepatitis C virus

BC polyoma virus

Epstein Barr virus (EBV)

35. The most common reason for getting incompatible blood transfusion is ?

Absents of screening tools

Unresponsiveness

Similarity of names

Severity of the case that needs urgent transfusion

36. the virus that is mostly responsible for post transfusion infections is ?

HIV-1

HTLV-1

HCV

HBV

37. All are true except?

CTLA-4 binds to B7 with 20-50-fold higher affinity than CD28

PD-1 mainly limits responses of differentiated effector cells in peripheral tissue

PD-1 is mainly involved in programmed T cell death by apoptosis

CTLA-4 mainly controls initial T cell activation in lymphoid organs

38. the term agglutinin refers to:

Antigen

The antibody that binds to the antibody

Radioactive Ab

2nd antibody that bind to the 1 st Ab

39. Stage in which there's binding to MHC self and self- Antigen

CD4 , CD8 double positive

CD4 , CD8 double neg

CD4 + , CD8 –

CD4-,CD8 +

40. Which one is Not involved in the immunoglobulin superfamily

TCR

KIR

RAG type 1 and II

CD8

41. The complement receptor which is used by the EBV to enter the B cell is:

CD20

CD19

CD22

CD21

42. Widal test which performed to to assess typhoid infiction is an example of :

Direct coomb test

Quantitative agglutination test

Qualitative agglutination test

Passive immune diffusion

43. A case of a patient who had an infection and was given in emergency room an antibodies against it , what is the type of adaptive immunity?

Artificial active

Artificial passive

Natural active

Natural passive

44. Penicillin can cause:

Type 1 and type 4 HSV

Only type 1 HSV

Only cytotoxic HSV

Cytotoxic and Immediate HSV

Only type 2 HSV

45. One of the gollowing is used to treat transitional squamous cell carcinoma

MMR

BCG

HBsAg

DPT

46. One of the follwing results in acute phase reaction with high amounts of ESR and CRP

IL-3

IL-7

IL-12

IL-6

47. Drug of choice for MS is:

TNF blockers

NSAIDs

Steroids

Recombinant IFN-B

48. The highest survival rate after one year transplantation that reaches >90% ?

Lung transplantation

Kidney transplantation

Liver transplantation

Heart transplantation

49. All of the following are true regarding the complement fixation test except :

Tests the Ab-ag reaction based on complement consuming

We can use it to detect any type of Ab in the serum

We can make this test quantitative by measuring the ammount of HB released

50. Which of the following drugs act by inhibiting T-cell activation ?

Azathioprine

Cyclosporin

Prednisolone

Non of the above

51. Which of the following tumor antigens is not a marker for melanomas ?

Mutated BCR/ABl

Tyrosinase & MART

GM2/GD2

Non of the above

52. All of the following are tumor evasion mechanisms except ?

Failure to produce Antigens

Mutation in HLA genes

Over expression of P53 gene

Secreting inhibitory cytokines

53. IDDM is considered as ----- HSV caused by ----- allergen

3, Environmental

2, Self-Ag

1, Infectious

4, Self-Ag

Immuno Final

1. Which one of the following is the universal recipient ?

2.

What first name or nickname would you like us to use?

2. Which of the following is true about COMB's test ?

3. Which of the following is one way a cytokine made by TH2 cells contributes to atopic disease (allergy)?

4. Which Fc gamma receptor is involved in antibody dependent cellular cytotoxicity and it's a marker for NK cells?

5. Plasma products are indicated in which of the following situations ?

6. Binding of Ab to structurally similar antigen refers to:

7. In immunoblotting the western test used to detect:

8. The immunity of the baby acquired from his mother during pregnancy is

9. Auchterlony test is term used to describ :

10. All of the following are true except?

11. Independent IGE mast cells degranulation can caused by:

12. Cytotoxic hypersensitivity is immediated by:

13. Chronic rejection is more frequent when ?

14. Which one of the following is not a risk factor for chronic GVH disease ?

15. Find the mismatched pair ?

16. Hyper acute rejection is characterized by :

17. Eisinophiles degranulation gives all of the following except:

18. All of the following are examples on type 3 (immune complex) hypersensitivity reactions except:

19. The main immune cells responsible for killing tumor cells are

20. Which one of the following is false about BCG vaccine ?

21. Types of sensitivity are classified into 4 types according to:

22. The best immune therapy method is ?

23. The terminal sugar that is specific for blood group A is ?

24. Sweat is part of the first line of defense and has low PH that kills all of the following microorganisms except ?

25. All of the following are types of the second line of defense except ?

26. Which type of MHC is the most polymprphic ?

27. Which on of the following infections is treated by non-human antibodies ?

28. Which one is true about vaccines ?

29. Which one of the following is false about MHC molecules ?

30. Patient with Bombay blood group is characterized by :

31. Which of the following organisms characterized by using M cell as rout of invasion through intestinal mucosal barrier?

32. Which one of the following receptors binds to plasmodium vivax?

33. Which of the following are distinct features of microglia?

34. What is the causative organism of progressive multifocal leukoencephalopathy?

35. The most common reason for getting incompatible blood transfusion is ?

36. the virus that is mostly responsible for post transfusion infections is ?

37. All are true except?

38. the term agglutinin refers to:

39. Stage in which there's binding to MHC self and self- Antigen

40. Which one is Not involved in the immunoglobulin superfamily

41. The complement receptor which is used by the EBV to enter the B cell is:

42. Widal test which performed to to assess typhoid infiction is an example of :

43. A case of a patient who had an infection and was given in emergency room an antibodies against it , what is the type of adaptive immunity?

44. Penicillin can cause:

45. One of the gollowing is used to treat transitional squamous cell carcinoma

46. One of the follwing results in acute phase reaction with high amounts of ESR and CRP

47. Drug of choice for MS is:

48. The highest survival rate after one year transplantation that reaches >90% ?

49. All of the following are true regarding the complement fixation test except :

50. Which of the following drugs act by inhibiting T-cell activation ?

51. Which of the following tumor antigens is not a marker for melanomas ?

52. All of the following are tumor evasion mechanisms except ?

53. IDDM is considered as ----- HSV caused by ----- allergen