Kinetics Final (Conceptual Questions)

64 Questions | Total Attempts: 284

SettingsSettingsSettings
Please wait...
Drug Quizzes & Trivia

Conceptual (no math) questions for Kinetics final


Questions and Answers
  • 1. 
    Which is not a part of Pharmacokinetics?
    • A. 

      Absorption

    • B. 

      Distribution

    • C. 

      Metabolism

    • D. 

      Response

    • E. 

      Distribution

  • 2. 
    What is not a use of pharmacokinetic models?
    • A. 

      Predict plasma drug levels

    • B. 

      Calculate optimum dosage for individual patients

    • C. 

      Bioequivalence studies

    • D. 

      Graph dose-response curves

  • 3. 
    In a two compartment model, k21 describes drug elimination from a system.
    • A. 

      True

    • B. 

      False

  • 4. 
    Which is not a method of drug elimination?
    • A. 

      Protein Binding

    • B. 

      Metabolism

    • C. 

      Excretion

    • D. 

      Dialysis

  • 5. 
    In a continuous or intermittent IV infusion, how many half lives does it take to reach steady state?
    • A. 

      2

    • B. 

      5

    • C. 

      8

    • D. 

      11

    • E. 

      E

  • 6. 
    If clearance is reduced by 50%, how many half lives will it take for a drug to reach steady state in a continuous IV infusion.
    • A. 

      2.5

    • B. 

      5

    • C. 

      7.5

    • D. 

      10

  • 7. 
    Only free drug can be distributed to the tissues.
    • A. 

      True

    • B. 

      False

  • 8. 
    The general trend from birth to nine months is that body fat _____________ with age
    • A. 

      Increases

    • B. 

      Decreases

    • C. 

      Stays the same

  • 9. 
    With the exception of 1 y.o.a. through puberty, total body water __________ with age.
    • A. 

      Increases

    • B. 

      Decreases

    • C. 

      Stays the same

  • 10. 
    Which pharmacokinetic parameter would hepatic disease be most likely to affect?
    • A. 

      Absorption

    • B. 

      Distribution

    • C. 

      Metabolism

    • D. 

      Excretion

  • 11. 
    Which drug is not modeled by non-linear pharmacokinetics?
    • A. 

      Alcohol

    • B. 

      Phenobarbital

    • C. 

      Valproic Acid

    • D. 

      Phenytoin

  • 12. 
    Which person is unlikely to be involved in a multidisciplinary approach to individualizing drug therapy?
    • A. 

      Physician

    • B. 

      Nurse

    • C. 

      Accountant

    • D. 

      Pharmacist

  • 13. 
    In the Cockcroft-Gault equation, an increase in serum creatinine will __________ creatinine clearance.
    • A. 

      Increase

    • B. 

      Decrease

    • C. 

      Not change

  • 14. 
    A premature infant is defined as gestation age of less than
    • A. 

      34 weeks

    • B. 

      36 weeks

    • C. 

      38 weeks

    • D. 

      40 weeks

  • 15. 
    In neonates, infants, and young children gastric pH is more _________ than adults.  This will _________ the bio-availability of basic drugs.
    • A. 

      Acidic; increase

    • B. 

      Alkaline; increase

    • C. 

      Acidic; decrease

    • D. 

      Alkaline; decrease

  • 16. 
    Premature infants have _________ biliary function compared to older children and adults.
    • A. 

      Increased

    • B. 

      Decreased

    • C. 

      Unchanged

  • 17. 
    Skin is ________ permeable in neonates and infants than adults.
    • A. 

      More

    • B. 

      Less

  • 18. 
    Aminoglycosides require a(n) _________ weight based dose in neonates and infants in comparison to adults because they have _______ percentage levels of extracellular fluid.
    • A. 

      Increased; higher

    • B. 

      Increased; lower

    • C. 

      Decreased; higher

    • D. 

      Decreased; lower

  • 19. 
    The volume of distribution of diazepam, a liphophilic drug, will be higher in ________.
    • A. 

      Neonates

    • B. 

      Adults

  • 20. 
    Neonates have a decreased level of albumin, and their albumin has decreased affinity for drugs which leads to a decrease in protein binding of drugs.  This increases free drug concentration of drugs like Phenytoin.
    • A. 

      True

    • B. 

      False

  • 21. 
    Glomerular function ________________ during the first year of life.
    • A. 

      Increases

    • B. 

      Decreases

    • C. 

      Stays the same

  • 22. 
    Pharmacodynamics can be defined as...
    • A. 

      What the body does to the drug.

    • B. 

      What the drug does to the body.

    • C. 

      What the body does to the body.

    • D. 

      What the drug does to the drug.

  • 23. 
    In a typical dose response curve, increasing the dose by 1mg will have a larger change in response when the original dose is 1 mg versus when the original dose is 10mg.
    • A. 

      True

    • B. 

      False

  • 24. 
    The pharmacodynamic parameter EC50, is the
    • A. 

      Maximal effect of the drug

    • B. 

      Half the maximal effect of the drug

    • C. 

      Concentration at which the maximal effect of the drug occurs

    • D. 

      Concentration at which half the maximal effect of the drug occurs

  • 25. 
    The _____ coefficient determines the steepness of a dose response curve.  A higher coefficient means a steeper curve.
    • A. 

      Valley

    • B. 

      Mountain

    • C. 

      Hill

    • D. 

      Lake

Back to Top Back to top