Hpmt 356- Immunology

60 Questions

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Hpmt 356- Immunology

Review quiz based on PPP for Microbiology Lecture 3- Immunology


Questions and Answers
  • 1. 
    Which of the following does immunology deal with
    • A. 

      The study of molecules, cells organs and systems responsible for the recognition and disposal of nonself material

    • B. 

      How body components respond and interact

    • C. 

      Desirable or undesirable consequences of immune interactions

    • D. 

      How the immune system can be manipulated to protect against or treat disease

    • E. 

      All of the above

  • 2. 
    Which of the following is not apart of the first line of defense
    • A. 

      Skin and mucous membranes

    • B. 

      Normal flora

    • C. 

      Secretions

    • D. 

      Antibodies

    • E. 

      Defensins

  • 3. 
    Which is not a part of the second line of defense
    • A. 

      Phagocytosis

    • B. 

      Complement

    • C. 

      Secretions

    • D. 

      Acute inflammatory reaction

    • E. 

      Interferon and lysozome

  • 4. 
    Adaptive immunity is the ______line of defense
    • A. 

      1st

    • B. 

      2nd

    • C. 

      3rd

  • 5. 
    Recognition, remembrance and response to a specific stimulus or antigen is not a part of
    • A. 

      Specific/adaptive immunity

    • B. 

      3rd line of defense

    • C. 

      Innate or inborn resistance

    • D. 

      Cell mediated immunity

    • E. 

      Humoral immunity

  • 6. 
    Foreign substance capable of stimulating an immune response
    • A. 

      Antigen

    • B. 

      Antibody

  • 7. 
    Structure in the membrane or molecular component that the body recognizes as foreign
    • A. 

      Epitope

    • B. 

      Antigen determinants

    • C. 

      All of the above

    • D. 

      None of the above

  • 8. 
    Which of the following is not a goal of innate immunity
    • A. 

      Recognize microbes encountered by host

    • B. 

      Prevent infection of host

    • C. 

      Initiate adaptive immune responses adjusted to invading microorganisms

    • D. 

      Serve as effector mechanism for adaptive response

    • E. 

      None of the above

  • 9. 
    Pattern recognitions receptors on cell membranes of phagocytic and other mammalian cells allow them to identify foreign cells. Which of the following is not a pattern recognition receptor
    • A. 

      Toll-like receptor

    • B. 

      Protein kinase r

    • C. 

      Mannose receptor

    • D. 

      Epitope

    • E. 

      CD14

  • 10. 
    Often the innate immune system is able to destroy cancerous cells before they develop into more dangerous problems, this is an example of the innate immune system's ability to
    • A. 

      Detect damaged tissue

    • B. 

      Recognize self from nonself

    • C. 

      Detect missing or changed self

    • D. 

      All of the above

    • E. 

      None of the above

  • 11. 
    Innate immunity can do all of the following except
    • A. 

      Increase production of antimicrobial peptides

    • B. 

      Secretion of inflammatory mediators

    • C. 

      Complement activation

    • D. 

      Clotting cascade activation

    • E. 

      None of the above

  • 12. 
    Acute phase reactant response is associated with
    • A. 

      Increase in concentration of some proteins during inflammation

    • B. 

      Disposal of waste

    • C. 

      Opsonization

    • D. 

      None of the above

  • 13. 
    Complement received its name because it complements the action of antibodies
    • A. 

      True

    • B. 

      False

  • 14. 
    Complement is most closely association with
    • A. 

      Promotion of opsonization and lysis of foreign cells

    • B. 

      Detection of self from nonself

    • C. 

      Detection of damaged tissue

    • D. 

      None of the above

  • 15. 
    Complement is present in circulation in active form but can be inhibited by control proteins
    • A. 

      True

    • B. 

      False

  • 16. 
    Which of the following is not a function of complement
    • A. 

      Host defense against infection

    • B. 

      Interference between innate and adaptive immunity

    • C. 

      Disposal of wastes

    • D. 

      All of the above

    • E. 

      None of the above

  • 17. 
    The classical pathway of complement activation is triggered by
    • A. 

      Allergen, foreign substance, or lipopolysaccharide

    • B. 

      Mannose on cell surface

    • C. 

      Antigen/ antibody

    • D. 

      All of the above

    • E. 

      None of the above

  • 18. 
    The alternate pathway of complement activation is triggered by
    • A. 

      Contact with foreign surface

    • B. 

      Antigen/antibody

    • C. 

      Mannose

    • D. 

      All of the above

    • E. 

      None of the above

  • 19. 
    Which is not true about the  Mannose binding lectin pathway
    • A. 

      Associated with MASP1 and MASP 2 protease

    • B. 

      Activated by antigens/antibodies

    • C. 

      Initiated by binding with mannose groups on bacterial cell surfaces

    • D. 

      All of the above

    • E. 

      None of the above

  • 20. 
    The three pathways of complement activation converge
    • A. 

      Cleavage of C5 to C5b

    • B. 

      Cleavage of C3 to C3b

    • C. 

      Cleavage of Membrane attack complex

    • D. 

      None of the above

  • 21. 
    Once complement has been activated, enzyme activation occurs
    • A. 

      True

    • B. 

      False

  • 22. 
    An overactive immune response can lead to
    • A. 

      SIRS - severe inflammatory response syndrome

    • B. 

      Septic shock

    • C. 

      Death

    • D. 

      All of the above

    • E. 

      None of the above

  • 23. 
    Regarding changes in complement levels, which of the following is not true
    • A. 

      Can lead to tissue damage

    • B. 

      Can cause intravascular thrombosis

    • C. 

      Can lead to infection or autoantibody

    • D. 

      All of the above

    • E. 

      None of the above

  • 24. 
    These are chemical messengers involved in all aspects of innate and adaptive immune response and includes Interferons, Chemokines, tissue necrosis factor, transforming growth factors and interleukins
  • 25. 
    Acute phase proteins such as c-reactive protein, C3 and C4 are specific indicators of inflammation
    • A. 

      True

    • B. 

      False

  • 26. 
    Innate immunity is required for initiation of adaptive response
    • A. 

      True

    • B. 

      False

  • 27. 
    Concerning antigen presenting cells, which statement is true
    • A. 

      Macrophages and dendritic cells present to T cells

    • B. 

      T cells present to macrophages and dendritic cells

    • C. 

      Macrophages present to dendritic and T cells

    • D. 

      Dendritic cells present to macrophages and T cells

    • E. 

      None of the above

  • 28. 
    B cells mature in the thymus and T cells mature in the bone marrow before release
    • A. 

      True

    • B. 

      False

  • 29. 
    Antibodies are also known as
  • 30. 
    Which does not describe antibodies/ immunoglobulins
    • A. 

      Found in blood plasma and some body fluids

    • B. 

      May need other agents like complement for bacteria

    • C. 

      Includes IgM, IgG, IgA, IgD and IgE

    • D. 

      Made of 2 heavy chains and 4 light chains with a variable and constant region

    • E. 

      None of the above

  • 31. 
    Name the correct antibody. Produced early in immune response, large molecule
  • 32. 
    Name the correct antibody. Major Ig in normal serum, crosses placenta
  • 33. 
    Name the correct antibody. Predominant in Ig secretions
  • 34. 
    Name the correct antibod. Surface of B Lymphs
  • 35. 
    Name the correct antibody. Mediates hypersensitivity reactions
  • 36. 
    Antigenic binding portion of the antibody
    • A. 

      Fab and Fc regions

    • B. 

      2 heavy chains

    • C. 

      2 light chains

    • D. 

      Variable region

    • E. 

      Constant region

  • 37. 
    Markers that distinguish Ig classes, sites can bind and activate complement
    • A. 

      Variable region

    • B. 

      Heavy chain

    • C. 

      Hinge

    • D. 

      Fc region

    • E. 

      Fab region

  • 38. 
    The antibody molecule is composed of two identical light chains and two identical heavy chains linked by disulfide bonds
    • A. 

      True

    • B. 

      False

  • 39. 
    Anamnestic response/ memory response occurs after
    • A. 

      Trauma

    • B. 

      Repeated exposure to the same antigen

    • C. 

      Taking medication

    • D. 

      None of the above

  • 40. 
    Which of the following is not a phase of the  primary antibody response
    • A. 

      Lag phase

    • B. 

      Plateau phase

    • C. 

      Log phase

    • D. 

      Decline phase

    • E. 

      Competitive phase

  • 41. 
    The secondary (Anamnestic) response has the same 4 phases as the primary response and come with repeated exposure
    • A. 

      True

    • B. 

      False

  • 42. 
    Booster shots are a combination of primary and secondary response
    • A. 

      True

    • B. 

      False

  • 43. 
    This cell, under the stimulation of a Thelper cell, returns to the bone marrow to mature
    • A. 

      Pro-b cell

    • B. 

      Immature b cell

    • C. 

      Mature b cell

    • D. 

      Plasma cell

  • 44. 
    • A. 

      CD8 cells must have partial recognition of MHC class I

    • B. 

      Nk have expression of CD4 but not CD8

    • C. 

      CD4 cells must have recognition of MHC class II

    • D. 

      Must recognize self

  • 45. 
    Humoral immunity describes fluids that defend the body from microbial attack
    • A. 

      True

    • B. 

      False

  • 46. 
    Antibody recognize and bind microbial epitopes
    • A. 

      Agglutination

    • B. 

      Opsonization

    • C. 

      Neutralization

    • D. 

      Complement activation

  • 47. 
    Prevent microbial attachment to host
    • A. 

      Agglutination

    • B. 

      Opsonization

    • C. 

      Neutralization

    • D. 

      Complement activation

  • 48. 
    Promotion of phagocytosis
    • A. 

      Agglutination

    • B. 

      Neutralization

    • C. 

      Opsonization

    • D. 

      Complement activation

  • 49. 
    Activates cascade
    • A. 

      Agglutination

    • B. 

      Neutralization

    • C. 

      Opsonization

    • D. 

      Complement activation

  • 50. 
    Which of the following would not be considered active humoral immunity
    • A. 

      Natural exposure to pathogen

    • B. 

      Given serum or plasma with high concentration of preformed antibody

    • C. 

      Vaccination

    • D. 

      Host makes antibodies

  • 51. 
    The final stage of humoral immunity that features the attack of cells and their destruction without engulfing
    • A. 

      Opsonization

    • B. 

      Antibody-dependent cell mediated toxicity

    • C. 

      Complement activation

    • D. 

      Neutralization

  • 52. 
    This antibody is associated with immediate hypersensitivity such as allergy and anaphylaxis
  • 53. 
    Delayed type hypersensitivity is mediated by CD4+ cells and features interaction between phagocytic cells and T lymphocytes. which of the following would not be considered a delayed type hypersensitivity
    • A. 

      Slow appearance of secondary response in the skin

    • B. 

      PPD

    • C. 

      Rash from Poison Ivy

    • D. 

      Allergy

    • E. 

      Granulomas from M. Tuberculosis

  • 54. 
    Cytotoxic T cells search for infected cells and  either lyse the cells or cause
  • 55. 
    T cells respond directly to antigens or proteins
    • A. 

      True

    • B. 

      False

  • 56. 
    Ag-Ab complexes too small to precipitate, results in soulble complexes
    • A. 

      Zone of antigent excess (Post zone)

    • B. 

      Zone of equivalence

    • C. 

      Zone of antibody excess(prozone)

    • D. 

      None of the above

  • 57. 
    Adequate Ag and Ab available- optimal precipitation, see large visible complexes
    • A. 

      Zone of antigent excess (Post zone)

    • B. 

      Zone of equivalence

    • C. 

      Zone of antibody excess(prozone)

    • D. 

      None of the above

  • 58. 
    Not enough Antigen present to form precipitate- results in soluble complexes
    • A. 

      Zone of antigent excess (Post zone)

    • B. 

      Zone of equivalence

    • C. 

      Zone of antibody excess(prozone)

    • D. 

      None of the above

  • 59. 
    Crosslinkages of antigen-antibody compleses are reversible
    • A. 

      True

    • B. 

      False

  • 60. 
    Process in which particulate Antigen aggregates to form larger complexes in the presence of specific antibody