Hpmt 356- Immunology
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Review quiz based on PPP for Microbiology Lecture 3- Immunology
- 1.Which of the following does immunology deal with
- A.
The study of molecules, cells organs and systems responsible for the recognition and disposal of nonself material
- B.
How body components respond and interact
- C.
Desirable or undesirable consequences of immune interactions
- D.
How the immune system can be manipulated to protect against or treat disease
- E.
All of the above
- 2.Which of the following is not apart of the first line of defense
- A.
Skin and mucous membranes
- B.
Normal flora
- C.
Secretions
- D.
Antibodies
- E.
Defensins
- 3.Which is not a part of the second line of defense
- A.
Phagocytosis
- B.
Complement
- C.
Secretions
- D.
Acute inflammatory reaction
- E.
Interferon and lysozome
- 4.Adaptive immunity is the ______line of defense
- A.
1st
- B.
2nd
- C.
3rd
- 5.Recognition, remembrance and response to a specific stimulus or antigen is not a part of
- A.
Specific/adaptive immunity
- B.
3rd line of defense
- C.
Innate or inborn resistance
- D.
Cell mediated immunity
- E.
Humoral immunity
- 6.Foreign substance capable of stimulating an immune response
- A.
Antigen
- B.
Antibody
- 7.Structure in the membrane or molecular component that the body recognizes as foreign
- A.
Epitope
- B.
Antigen determinants
- C.
All of the above
- D.
None of the above
- 8.Which of the following is not a goal of innate immunity
- A.
Recognize microbes encountered by host
- B.
Prevent infection of host
- C.
Initiate adaptive immune responses adjusted to invading microorganisms
- D.
Serve as effector mechanism for adaptive response
- E.
None of the above
- 9.Pattern recognitions receptors on cell membranes of phagocytic and other mammalian cells allow them to identify foreign cells. Which of the following is not a pattern recognition receptor
- A.
Toll-like receptor
- B.
Protein kinase r
- C.
Mannose receptor
- D.
Epitope
- E.
CD14
- 10.Often the innate immune system is able to destroy cancerous cells before they develop into more dangerous problems, this is an example of the innate immune system's ability to
- A.
Detect damaged tissue
- B.
Recognize self from nonself
- C.
Detect missing or changed self
- D.
All of the above
- E.
None of the above
- 11.Innate immunity can do all of the following except
- A.
Increase production of antimicrobial peptides
- B.
Secretion of inflammatory mediators
- C.
Complement activation
- D.
Clotting cascade activation
- E.
None of the above
- 12.Acute phase reactant response is associated with
- A.
Increase in concentration of some proteins during inflammation
- B.
Disposal of waste
- C.
Opsonization
- D.
None of the above
- 13.Complement received its name because it complements the action of antibodies
- A.
True
- B.
False
- 14.Complement is most closely association with
- A.
Promotion of opsonization and lysis of foreign cells
- B.
Detection of self from nonself
- C.
Detection of damaged tissue
- D.
None of the above
- 15.Complement is present in circulation in active form but can be inhibited by control proteins
- A.
True
- B.
False
- 16.Which of the following is not a function of complement
- A.
Host defense against infection
- B.
Interference between innate and adaptive immunity
- C.
Disposal of wastes
- D.
All of the above
- E.
None of the above
- 17.The classical pathway of complement activation is triggered by
- A.
Allergen, foreign substance, or lipopolysaccharide
- B.
Mannose on cell surface
- C.
Antigen/ antibody
- D.
All of the above
- E.
None of the above
- 18.The alternate pathway of complement activation is triggered by
- A.
Contact with foreign surface
- B.
Antigen/antibody
- C.
Mannose
- D.
All of the above
- E.
None of the above
- 19.Which is not true about the Mannose binding lectin pathway
- A.
Associated with MASP1 and MASP 2 protease
- B.
Activated by antigens/antibodies
- C.
Initiated by binding with mannose groups on bacterial cell surfaces
- D.
All of the above
- E.
None of the above
- 20.The three pathways of complement activation converge
- A.
Cleavage of C5 to C5b
- B.
Cleavage of C3 to C3b
- C.
Cleavage of Membrane attack complex
- D.
None of the above
- 21.Once complement has been activated, enzyme activation occurs
- A.
True
- B.
False
- 22.An overactive immune response can lead to
- A.
SIRS - severe inflammatory response syndrome
- B.
Septic shock
- C.
Death
- D.
All of the above
- E.
None of the above
- 23.Regarding changes in complement levels, which of the following is not true
- A.
Can lead to tissue damage
- B.
Can cause intravascular thrombosis
- C.
Can lead to infection or autoantibody
- D.
All of the above
- E.
None of the above
- 24.These are chemical messengers involved in all aspects of innate and adaptive immune response and includes Interferons, Chemokines, tissue necrosis factor, transforming growth factors and interleukins
- 25.Acute phase proteins such as c-reactive protein, C3 and C4 are specific indicators of inflammation
- A.
True
- B.
False
- 26.Innate immunity is required for initiation of adaptive response
- A.
True
- B.
False
- 27.Concerning antigen presenting cells, which statement is true
- A.
Macrophages and dendritic cells present to T cells
- B.
T cells present to macrophages and dendritic cells
- C.
Macrophages present to dendritic and T cells
- D.
Dendritic cells present to macrophages and T cells
- E.
None of the above
- 28.B cells mature in the thymus and T cells mature in the bone marrow before release
- A.
True
- B.
False
- 29.Antibodies are also known as
- 30.Which does not describe antibodies/ immunoglobulins
- A.
Found in blood plasma and some body fluids
- B.
May need other agents like complement for bacteria
- C.
Includes IgM, IgG, IgA, IgD and IgE
- D.
Made of 2 heavy chains and 4 light chains with a variable and constant region
- E.
None of the above
- 31.Name the correct antibody. Produced early in immune response, large molecule
- 32.Name the correct antibody. Major Ig in normal serum, crosses placenta
- 33.Name the correct antibody. Predominant in Ig secretions
- 34.Name the correct antibod. Surface of B Lymphs
- 35.Name the correct antibody. Mediates hypersensitivity reactions
- 36.Antigenic binding portion of the antibody
- A.
Fab and Fc regions
- B.
2 heavy chains
- C.
2 light chains
- D.
Variable region
- E.
Constant region
- 37.Markers that distinguish Ig classes, sites can bind and activate complement
- A.
Variable region
- B.
Heavy chain
- C.
Hinge
- D.
Fc region
- E.
Fab region
- 38.The antibody molecule is composed of two identical light chains and two identical heavy chains linked by disulfide bonds
- A.
True
- B.
False
- 39.Anamnestic response/ memory response occurs after
- A.
Trauma
- B.
Repeated exposure to the same antigen
- C.
Taking medication
- D.
None of the above
- 40.Which of the following is not a phase of the primary antibody response
- A.
Lag phase
- B.
Plateau phase
- C.
Log phase
- D.
Decline phase
- E.
Competitive phase
- 41.The secondary (Anamnestic) response has the same 4 phases as the primary response and come with repeated exposure
- A.
True
- B.
False
- 42.Booster shots are a combination of primary and secondary response
- A.
True
- B.
False
- 43.This cell, under the stimulation of a Thelper cell, returns to the bone marrow to mature
- A.
Pro-b cell
- B.
Immature b cell
- C.
Mature b cell
- D.
Plasma cell
- 44.
- A.
CD8 cells must have partial recognition of MHC class I
- B.
Nk have expression of CD4 but not CD8
- C.
CD4 cells must have recognition of MHC class II
- D.
Must recognize self
- 45.Humoral immunity describes fluids that defend the body from microbial attack
- A.
True
- B.
False
- 46.Antibody recognize and bind microbial epitopes
- A.
Agglutination
- B.
Opsonization
- C.
Neutralization
- D.
Complement activation
- 47.Prevent microbial attachment to host
- A.
Agglutination
- B.
Opsonization
- C.
Neutralization
- D.
Complement activation
- 48.Promotion of phagocytosis
- A.
Agglutination
- B.
Neutralization
- C.
Opsonization
- D.
Complement activation
- 49.Activates cascade
- A.
Agglutination
- B.
Neutralization
- C.
Opsonization
- D.
Complement activation
- 50.Which of the following would not be considered active humoral immunity
- A.
Natural exposure to pathogen
- B.
Given serum or plasma with high concentration of preformed antibody
- C.
Vaccination
- D.
Host makes antibodies
- 51.The final stage of humoral immunity that features the attack of cells and their destruction without engulfing
- A.
Opsonization
- B.
Antibody-dependent cell mediated toxicity
- C.
Complement activation
- D.
Neutralization
- 52.This antibody is associated with immediate hypersensitivity such as allergy and anaphylaxis
- 53.Delayed type hypersensitivity is mediated by CD4+ cells and features interaction between phagocytic cells and T lymphocytes. which of the following would not be considered a delayed type hypersensitivity
- A.
Slow appearance of secondary response in the skin
- B.
PPD
- C.
Rash from Poison Ivy
- D.
Allergy
- E.
Granulomas from M. Tuberculosis
- 54.Cytotoxic T cells search for infected cells and either lyse the cells or cause
- 55.T cells respond directly to antigens or proteins
- A.
True
- B.
False
- 56.Ag-Ab complexes too small to precipitate, results in soulble complexes
- A.
Zone of antigent excess (Post zone)
- B.
Zone of equivalence
- C.
Zone of antibody excess(prozone)
- D.
None of the above
- 57.Adequate Ag and Ab available- optimal precipitation, see large visible complexes
- A.
Zone of antigent excess (Post zone)
- B.
Zone of equivalence
- C.
Zone of antibody excess(prozone)
- D.
None of the above
- 58.Not enough Antigen present to form precipitate- results in soluble complexes
- A.
Zone of antigent excess (Post zone)
- B.
Zone of equivalence
- C.
Zone of antibody excess(prozone)
- D.
None of the above
- 59.Crosslinkages of antigen-antibody compleses are reversible
- A.
True
- B.
False
- 60.Process in which particulate Antigen aggregates to form larger complexes in the presence of specific antibody
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