1.
Which of these is not a risk factor for COPD?
Correct Answer
A. Homozygous serum alpHa-1 antitrypsin deficiency.
Explanation
Homozygous serum alpha-1 antitrypsin deficiency is not a risk factor for COPD. COPD is primarily caused by smoking, exposure to environmental pollutants, and genetic factors such as alpha-1 antitrypsin deficiency. However, the question asks for a risk factor that is NOT associated with COPD, and homozygous serum alpha-1 antitrypsin deficiency is not one of them. Therefore, it is the correct answer.
2.
Diagnosis of COPD can be firmly made by:
Correct Answer
A. Spirometery
Explanation
Spirometry is a pulmonary function test that measures the amount and speed of air that can be inhaled and exhaled. It is considered the gold standard for diagnosing COPD because it can accurately assess lung function and determine if there is airflow limitation. X-ray chest can help identify other lung conditions but cannot definitively diagnose COPD. Auscultation involves listening to the lungs with a stethoscope and can provide additional information about lung sounds, but it is not sufficient for a firm diagnosis. Blood tests may be helpful in ruling out other conditions but cannot confirm COPD. Therefore, spirometry is the most reliable and specific test for diagnosing COPD.
3.
Which of these factors if present suggest the diagnosis COPD?
Correct Answer
D. All of the above
Explanation
The presence of a long history of heavy smoking, chronic cough with large amount of sputum production, and breathlessness mainly on exertion which is gradually increasing suggest the diagnosis of COPD. These factors are commonly associated with COPD, a chronic lung disease characterized by airflow limitation and difficulty breathing. Heavy smoking is a major risk factor for developing COPD, while chronic cough with sputum production and breathlessness are common symptoms of the disease. Therefore, when all of these factors are present, it strongly suggests the diagnosis of COPD.
4.
Which of these factors is most important in predicting survival in a patient with COPD?
Correct Answer
C. Post-brochodilator FEV1
Explanation
Post-brochodilator FEV1 is the most important factor in predicting survival in a patient with COPD. FEV1 stands for forced expiratory volume in one second and it measures the amount of air a person can forcefully exhale in one second after taking a deep breath. Post-brochodilator FEV1 specifically measures this after the patient has taken a bronchodilator medication, which helps to relax and open up the airways. This measurement is important because it reflects the severity of airflow limitation and can help determine the prognosis and treatment options for the patient. Age, pre-brochodilator FEV1, and total lung capacity are also important factors, but post-brochodilator FEV1 is the most significant in predicting survival.
5.
Lung function test useful in differentiating COPD from asthma:
Correct Answer
D. All of the above
Explanation
The lung function test is useful in differentiating COPD from asthma because it includes measuring FEV1 after bronchodilation, total lung capacity, and diffusion of gases (DLCO). FEV1 after bronchodilation helps determine the amount of air a person can forcefully exhale after taking a bronchodilator, which can indicate the presence of COPD or asthma. Total lung capacity measures the maximum amount of air the lungs can hold, which can be affected in both conditions. Diffusion of gases (DLCO) measures the ability of the lungs to transfer oxygen from inhaled air into the bloodstream, which can be impaired in both COPD and asthma.
6.
Advanced COPD may lead to:
Correct Answer
D. Any of the above
Explanation
Advanced COPD may lead to various complications including oedema, cor pulmonale, and pulmonary hypertension. Oedema refers to the accumulation of fluid in the body, often seen in the legs and ankles. Cor pulmonale is a condition where the right side of the heart becomes enlarged and weakened due to lung disease. Pulmonary hypertension is high blood pressure in the arteries of the lungs. All of these complications can occur in advanced stages of COPD due to the chronic inflammation and damage to the lungs.
7.
Ipratropium is a
Correct Answer
B. Anticholinergic
Explanation
Ipratropium is classified as an anticholinergic medication. Anticholinergics work by blocking the action of acetylcholine, a neurotransmitter in the body. This helps to relax and widen the airways, making it easier to breathe. Ipratropium is commonly used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
8.
Theophylline benefits COPD patient in many ways. Which of these statements is not true with regard to this medication?
Correct Answer
D. Inhibits central respiratory activity.
Explanation
Theophylline is a medication commonly used in the treatment of chronic obstructive pulmonary disease (COPD). It has several beneficial effects on COPD patients, including reducing pulmonary artery pressure, increasing arterial oxygen tension, and improving right ventricular function. However, the statement "Inhibits central respiratory activity" is not true with regard to this medication. Theophylline does not inhibit central respiratory activity; instead, it acts as a bronchodilator by relaxing the smooth muscles in the airways, making it easier for the patient to breathe.
9.
While evaluating therapeutic potential of any compound used for treatment of COPD, parameters that should be considered apart from FEV1 are:
Correct Answer
A. Symptoms
Explanation
When evaluating the therapeutic potential of a compound used for the treatment of COPD, it is important to consider parameters other than FEV1. Symptoms play a crucial role in assessing the effectiveness of a treatment as they directly impact the quality of life of patients. Monitoring symptoms such as coughing, wheezing, shortness of breath, and sputum production can provide valuable insights into the efficacy of the compound. Additionally, exercise tolerance and exacerbation rates are important indicators of disease progression and response to treatment. Therefore, all of these parameters should be considered when evaluating the therapeutic potential of a compound for COPD treatment.
10.
Potential arrythmogenic factor in COPD patient could be any of these except:
Correct Answer
D. Treatment with Ipratopium
Explanation
Ipratropium is a bronchodilator medication commonly used in the treatment of COPD. It works by relaxing the muscles in the airways, making it easier to breathe. While acid-base disturbance, hypoxemia, and treatment with theophylline can all potentially contribute to arrhythmias in COPD patients, treatment with ipratropium is not known to have any arrhythmogenic effects. Therefore, it is not considered a potential arrhythmogenic factor in COPD patients.
11.
Tremor and tachycardia in a COPD patient could be a side effect of which of these drugs?
Correct Answer
A. Salbutamol
Explanation
Tremor and tachycardia are common side effects of Salbutamol, a bronchodilator commonly used to treat symptoms of COPD. Salbutamol works by relaxing the muscles in the airways, but it can also affect other muscles in the body, leading to tremors. Additionally, Salbutamol can stimulate the heart, causing an increase in heart rate (tachycardia). Therefore, it is likely that the tremor and tachycardia in the COPD patient are side effects of Salbutamol.
12.
Preferred route of administration of beta agonist in COPD patient is:
Correct Answer
A. Oral
Explanation
The preferred route of administration of beta agonist in COPD patients is inhalation. This is because inhalation allows the medication to directly reach the airways, providing quick relief and targeted action. Oral administration may not be as effective as the medication has to go through the digestive system before reaching the lungs. Injectable route is invasive and not commonly used for beta agonists in COPD. Sublingual administration is not typically used for beta agonists in COPD management.
13.
To be beneficial, domiciliary supplementary oxygen therapy should be given for at least:
Correct Answer
D. 15 hours/day
Explanation
Domiciliary supplementary oxygen therapy should be given for at least 15 hours per day in order to be beneficial. This means that the patient should receive oxygen therapy for the majority of the day, allowing their body to receive a consistent supply of oxygen. This duration of therapy is necessary to ensure that the patient's oxygen levels are adequately maintained and to improve their overall health and well-being.
14.
Predicted 3-year survival in a patient aged more than 60 years, with FEV1 40-49% is:
Correct Answer
B. 75%
Explanation
The predicted 3-year survival in a patient aged more than 60 years, with FEV1 40-49%, is 75%. This means that there is a 75% chance that the patient will survive for at least 3 years. The FEV1 value is a measure of lung function, and a lower value indicates poorer lung function. Therefore, a patient with a lower FEV1 value may have a lower predicted survival rate compared to a patient with a higher FEV1 value. In this case, the patient's age and FEV1 value suggest a 75% chance of survival.
15.
Which of the following statements is not true with regard to COPD?
Correct Answer
C. COPD is more common in young age.
Explanation
COPD is not more common in young age. It is a progressive disease that primarily affects individuals over the age of 40, with the majority of cases being diagnosed in individuals over the age of 65.