Cell Injury MCQs: General Pathology MCQs Cell Injury Quiz

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Cell Injury MCQs: General Pathology MCQs Cell Injury Quiz - Quiz

Do you know what is a cell injury? Check your knowledge of general pathology by answering these MCQs asked in this quiz. Did you know that our cells can also become injured, like bones, muscles, and skin? A cell can suffer various stress changes due to extreme environmental changes, including internal and external both. The below quiz will help you see how much you know about the mechanism of cellular injury. Also, it will evaluate your understanding and give you some extra knowledge regarding cell damage.


Questions and Answers
  • 1. 
    A pathologist notes that a biopsy from the lung of living patients shows the morphologic changes indicative of irreversible injury and cell death. Which of the following is most likely responsible for cell death in a living body? 
    • A. 

      Cytolysis

    • B. 

      Necrosis

    • C. 

      Putrefaction

    • D. 

      Autolysis

    • E. 

      Somatic death

  • 2. 
    In hypoxic cell injury, cell swelling occurs because of increased intracellular:
    • A. 

      Lipid

    • B. 

      Protein

    • C. 

      Lipofuscin

    • D. 

      Water

    • E. 

      Glycogen

  • 3. 
    A patient is admitted with severe substernal chest pain of 4 hours duration. Lab tests reveal an increased level of serum creatine kinase. This is most likely due to:
    • A. 

      Mitochondrial swelling

    • B. 

      Nuclear lysis

    • C. 

      Damage of plasma membranes

    • D. 

      Increased endoplasmic reticulum

    • E. 

      Increased Golgi activity

  • 4. 
    You are asked to review a liver biopsy from a patient with a history of alcohol abuse. Which of the following pathologic changes will most likely lead to the death of hepatocytes and liver cirrhosis?
    • A. 

      Fatty change in liver cells

    • B. 

      Hydropic change of hepatocytes

    • C. 

      Karyolysis in myocardial cells

    • D. 

      Glycogen deposition in hepatocyte nuclei

  • 5. 
    Cell death caused by autolysis is produced by:
    • A. 

      Antibodies

    • B. 

      Endogenous enzymes

    • C. 

      Phagocytic leukocytes

    • D. 

      Bacterial enzymes

    • E. 

      Anoxia

  • 6. 
    A 10-year-old black man with a known history of sickle cell disease presents to the emergency department complaining of left upper quadrant pain suggestive of a splenic infarct. Microscopic examination of the spleen would most likely reveal:
    • A. 

      Caseous necrosis

    • B. 

      Coagulative necrosis

    • C. 

      Fibrinoid necrosis

    • D. 

      Gangrenous necrosis

    • E. 

      Liquefactive necrosis

  • 7. 
    A pathologist notes cloudy swelling, hydropic change, and fatty change in a patient's liver with a history of alcohol abuse. These morphological changes are all examples of:
    • A. 

      Early neoplastic change

    • B. 

      Hyaline change

    • C. 

      Patterns of cell death

    • D. 

      Postmortem artifact

    • E. 

      Reversible cell injury

  • 8. 
    Which of the following is an example of an agent capable of producing a toxic metabolite and indirect chemical injury?
    • A. 

      Alcohol

    • B. 

      Aspirin

    • C. 

      Carbon monoxide

    • D. 

      Mercury poisoning

    • E. 

      Cyanide

  • 9. 
    A circumscribed mass of light yellow crumbly to pasty material associated microscopically with a macrophage response is characteristic of:
    • A. 

      Caseous necrosis

    • B. 

      Coagulative necrosis

    • C. 

      Fibrinoid necrosis

    • D. 

      Gangrenous necrosis

  • 10. 
    A well-demarcated lesion with increased cytoplasmic eosinophilia, karyolysis, and intact tissue architecture is characteristic of:
    • A. 

      Caseous necrosis

    • B. 

      Enzymatic fat necrosis

    • C. 

      Coagulative necrosis

    • D. 

      Cloudy swelling

    • E. 

      Liquefactive necrosis

  • 11. 
    The pattern of cell death that is characterized by the conversion of a single cell to an acidophilic body, usually with loss of the nucleus but with preservation of its shape to permit recognition of cell boundaries, is termed:
    • A. 

      Apoptosis

    • B. 

      Caseous necrosis

    • C. 

      Fibrinoid necrosis

    • D. 

      Liquefactive necrosis

  • 12. 
    The action of putrefactive bacteria on necrotic tissue results in:
    • A. 

      Coagulation

    • B. 

      Infarction

    • C. 

      Gangrene

    • D. 

      Embolism

    • E. 

      Caseation

  • 13. 
    A well-demarcated area of the myocardium appears paler than surrounding tissue and microscopically consists of eosinophilic muscle fibers with only a few karyorrhectic and pyknotic nuclei remaining. Many polys are seen, especially at the margin of this area. The age of the myocardial infarct is most likely:
    • A. 

      2 minutes

    • B. 

      2 hours

    • C. 

      2 days

    • D. 

      2 weeks

    • E. 

      2 months

  • 14. 
    You are asked to write a microscopic description of the coagulative necrosis that was noted in the heart of a patient who died of a heart attack because of cocaine abuse. Which of the following best described coagulative necrosis?
    • A. 

      Eosinophilic cytoplasm with cell outlines preserved

    • B. 

      Granular, friable mass of material devoid of cell outlines

    • C. 

      A localized, solid, basophilic lesion with calcification

    • D. 

      Necrosis in which tissue is converted into a fluid

  • 15. 
    Caseous necrosis is characterized morphologically by:
    • A. 

      Preservation of tissue outlines

    • B. 

      Basophilia

    • C. 

      Semi-liquid consistency

    • D. 

      Wedge-shaped periphery

    • E. 

      Amorphous appearance

  • 16. 
    What would be an example of hypertrophy?
    • A. 

      Breast development at puberty

    • B. 

      Enlargement of the uterus during pregnancy

    • C. 

      Enlargement of the uterus during menstruation

    • D. 

      A papillomavirus induced skin wart

    • E. 

      Liver regeneration after partial hepatectomy

  • 17. 
    Which tissue is the most susceptible to liquefactive necrosis following ischemic injury?
    • A. 

      Pancreas

    • B. 

      Liver

    • C. 

      Spleen

    • D. 

      Brain

    • E. 

      Intestine

  • 18. 
    A patient suffers a stroke and has left-sided weakness and paralysis in the upper extremity. The type of necrosis associated with a well-developed infarct of the brain is:
    • A. 

      Coagulative

    • B. 

      Enzymatic fat

    • C. 

      Liquefactive

    • D. 

      Gangrenous

  • 19. 
    Which of the following types of myocardial cell death would best account for these findings? A 75-year-old woman has a complaint of shortness of breath and chest pain that radiates to the left shoulder. Serum levels of CK-MB (myocardial creatine kinase) and cardiac muscle troponin I (cTnI) are elevated.
    • A. 

      Apoptosis

    • B. 

      Caseous necrosis

    • C. 

      Coagulative necrosis

    • D. 

      Fat necrosis

    • E. 

      Liquefactive necrosis

  • 20. 
    Coagulative necrosis usually results from:
    • A. 

      Abscess formation

    • B. 

      Ischemia

    • C. 

      Trauma

    • D. 

      Tuberculosis

    • E. 

      Syphilis

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