Block 9 Enviroment Path And Antibiotic MCQ's

18 Questions | Total Attempts: 264

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Block 9 Enviroment Path And Antibiotic MCQ

Questions and Answers
  • 1. 
    A 65 year old retiree is admitted in respiratory failure. His past medical history is significant for rheumatoid arthritis. He dies and an autopsy reveals distinctive pulmonary lesions with central necrosis, surrounded by palisading fibroblasts, plasma cells, and macrophages containing anthraocotic pigment. What was this patient's most likely occupation?
    • A. 

      Coal miner

    • B. 

      Construction worker

    • C. 

      Quarry miner

    • D. 

      Nuclear plant worker

    • E. 

      Ceramic artist

  • 2. 
    A 16 year old girl commits suicide. A toxicology screen shows the presences of alcohol, cocaine, heroin, and some over the counter pain relievers. A section of her liver reveals massive centrilobular necrosis. Which of the following is most likely the cause of her death?
    • A. 

      Tylenol overdose

    • B. 

      Alcohol overdose

    • C. 

      Cocaine overdose

    • D. 

      Heroin overdose

  • 3. 
    You are asked to implement a cancer screening program for workers at increased risk for developing cancer. Which of the following workers would NOT benefit the most from this information?
    • A. 

      Anthracite coal workers

    • B. 

      Quarry miners

    • C. 

      Asbestos workers

    • D. 

      Nuclear plant workers

    • E. 

      Aerospace plant workers

  • 4. 
    You are asked to give an educational seminar at an alcoholic's anonymous meeting. You begin by saying that chronic alcoholism may affect all organs and tissues. A participant asks you what organs are affected the most. You should respond by saying:
    • A. 

      Brain & bone marrow

    • B. 

      Pancreas & GI tract

    • C. 

      Brain & liver

    • D. 

      Heart & liver

    • E. 

      Liver- & stomach

  • 5. 
    A 12 year-old boy stated to develop episodes of upper respiratory discomfort characterized by nasal stuffiness accompanied by watery nasal and eye discharges. He lives in a small apartment but the "extended" family includes 3 cats and two dogs. He does not have these attacks at school which is several miles from home. Which of the following is germane to his condition?
    • A. 

      He should be isolated from other family members

    • B. 

      A skin test would probably show a" wheal and flare" reaction

    • C. 

      Psychological counseling might help alleviate the situation

    • D. 

      Sjogren's syndrome is a real possibility

    • E. 

      If this persists he is at risk of nasopharyngeal carcinoma

  • 6. 
    A major independent risk factor for myocardial infarction, and acts synergistically with other risk factors, such as high blood pressure and elevated blood cholesterol levels is:
    • A. 

      Repeated viral infections

    • B. 

      Alcohol consumption

    • C. 

      High carbohydrate intake

    • D. 

      Cigarette smoking

    • E. 

      Environmental CO pollution

  • 7. 
    Regarding electrical injury, among the following statements choose the best answer:
    • A. 

      Damage is produced only through an electrical dysfunction of cardiovascular conduction system.

    • B. 

      The amount of current necessary to produce a disruption depends on its pathway through the brain

    • C. 

      Electrical burns of the skin do not reflect the voltage, the area of electrical conductance, and the duration of current flow.

    • D. 

      Because electrical energy has the potential to disrupt the electrical system within the heart, it frequently causes death through ventricular fibrillation

    • E. 

      Damage is caused through the conversion of electrical energy to electromagnetic energy when the current encounters the resistance of the tissues

  • 8. 
    Which of the following beta-lactam antibiotics has only single ring in its structure?  
    • A. 

      Penicillin G

    • B. 

      Cefotetan

    • C. 

      Aztreonam

    • D. 

      Ampicillin

    • E. 

      Imipenem

  • 9. 
    Which of the following molecular actions is catalyzed by the penicillin binding proteins in cell wall synthesis?
    • A. 

      The transport of penicillins through the poring channels

    • B. 

      The transpeptidation reaction

    • C. 

      The breakdown of the beta-lactarn ring

    • D. 

      The binding of penicillins to peptidoglycan layer

  • 10. 
    Which of the following is a mechanism of resistance to beta-lactam antibiotics?
    • A. 

      Increased affinity of penicillin binding protein to the drug

    • B. 

      Inhibition of drug binding to 50S subunit

    • C. 

      Hydrolysis of beta-lactams by bacterial beta-lactamases

    • D. 

      Inhibition of the efflux pump of bacteria membrane

    • E. 

      Increased production of autolytic enzymes

  • 11. 
    A 5-year-old boy presented with fever and sharp pain at his left ear. On physical examination the left tympanic membrane was red, opaque and bulging. Amoxicillin was prescribed but three days later the symptoms were not reduced. The pediatrician decided to modify the therapy and prescribed amoxicillin/potassium clavulanate. Which of the following statement best explains the advantage to add potassium clavulanate to amoxicillin?
    • A. 

      The drug inhibits the bacterial inactivation of amoxicillin

    • B. 

      The drug is active against Pseudornonas and Serratia species

    • C. 

      The drug inhibits the renal secretion of arnoxicillin

    • D. 

      The drug increases amoxicillin penetration through bacterial membrane

    • E. 

      The drug inhibits the synthesis of peptidoglycan

  • 12. 
    Which of the following statements best explains why broad-spectrum penicillins can cause superinfections?
    • A. 

      They lower the immunological defense of the host

    • B. 

      They select viral mutants resistant to most antimicrobial drugs

    • C. 

      They mask the symptoms of the disease which can progress undetected

    • D. 

      They alter the normal microflora of the host

    • E. 

      They block the activity of mediators of the normal inflammatory reaction

  • 13. 
    Which of the following statements regarding fluoroquinolones are correct?    
    • A. 

      They prevent the relaxation of supercoiled DNA

    • B. 

      Their ultimate effect is mainly bacteriostatic

    • C. 

      Resistance is completely crossed between quinolones and sulfonamides

    • D. 

      They are primarily effective against gram positive bacteria

    • E. 

      They are much safer than penicillins during pregnancy

  • 14. 
    A 22-year-old man was admitted to the hospital because of an erythematous, macular eruption on the extremities, followed by the appearance of vesicles and bullae on the lips, oral mucosa, anogenital region and conjunctiva, Few days ago he started a treatment with trimethopr}m-sulfamethoxazole for an acute pharyngitis. Vital signs on admission were: temperature 103 F, pulse 120 bpm, blood pressure 120178 mm Hg, respirations 30/min. Which of the following best explains the syndrome of this patient?
    • A. 

      Lupoid syndrome

    • B. 

      Stevens-Johnson syndrome

    • C. 

      Disulfiram reaction

    • D. 

      Dermatophytosis

    • E. 

      Bilirubin encephalopathy

  • 15. 
    Which of the following statement correctly pairs the binding site of gentamicn with the action that follows that binding?
    • A. 

      30S ribosomal subunit - misreading of mRNA template

    • B. 

      50S ribosomal subunit- blockade of transpeptidase enzymes

    • C. 

      30S ribosomal subunit- blocks the entry of aminoacyl tRNA

    • D. 

      50S ribosomal subunit - blockade of translocation of peptidyl-tRNA

    • E. 

      Cell wall - blockade of elongation of peptidoglycan chain

  • 16. 
    A 67-year-old man has been receiving an antibiotic for three weeks to treat a urinary tract infection apparently due to Pseudomonas aeroginosa. Now the patient complains of headache, nausea and vomiting, vertigo, tinnitus, and a decreasing nearing capacity, The drug used was most likely a member of which of the following antibiotic classes?            
    • A. 

      Penicillins

    • B. 

      Fluoroquinolones

    • C. 

      Cephalosporins

    • D. 

      Sulfonamides

    • E. 

      Aminoglycosides

  • 17. 
    A 25-year-old woman, late in her third trimester of pregnancy, presented with low grade fever and burning upon urination. The history of the patient was significant for a recurrent urinary tract infection. An antibiotic was prescribed which resulted in arthropathy in the new born. The prescribed antibiotic most likely acts by:
    • A. 

      Inhibition of DNA gyrase

    • B. 

      Inhibition of protein synthesis by binding to 30S subunit of ribosome

    • C. 

      Binding to D-Ala-D-Ala terminus of peptidoglycan

    • D. 

      Inhibition of Folic acid synthesis

  • 18. 
    A 6-year-old boy presented with low grade fever, sore throat, nonproductive cough and headache. Physical examination revealed a maculopapular rash over the trunk and chest x- ray showed extensive nodular infiltrates in the left lower lobe. The presumptive diagnosis of mycoplasmal pneumonia was confirmed later by the complement fixation test. Which of the following drugs would be appropriate for this boy?
    • A. 

      Tetracycline

    • B. 

      Erythromycin

    • C. 

      Ampicillin

    • D. 

      Ceftazidime

    • E. 

      Streptomycin

    • F. 

      Metronidazole

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