NCLEX Pharmacology Quiz: Essential Meds for RN Success

1. A patient on warfarin requires an antibiotic. Which antibiotic significantly increases warfarin levels and bleeding risk?

Amoxicillin

Ciprofloxacin

Azithromycin

Cephalexin

2. Which ACE inhibitor side effect is most commonly reported and may warrant medication discontinuation?

Persistent dry cough

Hypokalemia

Tachycardia

Hyperglycemia

3. Metformin is contraindicated in patients with severe renal impairment (eGFR

Hypoglycemia

Lactic acidosis

Ketoacidosis

Hyperkalemia

4. A patient develops muscle pain and weakness after starting atorvastatin. What lab value should be checked immediately?

Creatinine kinase (CK)

Liver enzymes

Lipid panel

Complete blood count

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6. Which beta-blocker is safest in patients with asthma or chronic obstructive pulmonary disease (COPD)?

Propranolol

Metoprolol

Cardioselective agents

Beta-blockers are contraindicated

7. A patient taking clarithromycin develops QT prolongation on ECG. This interaction is most likely with which drug class?

Statins

Antiarrhythmics

Antihistamines

NSAIDs

8. Digoxin toxicity commonly presents with nausea, vomiting, and visual disturbances. What is the primary cause at the cellular level?

Increased Na+/K+ ATPase activity

Inhibition of Na+/K+ ATPase pump

Decreased cardiac contractility

Hypomagnesemia alone

9. Vancomycin nephrotoxicity risk increases significantly when combined with which aminoglycoside?

Gentamicin

Tobramycin

Amikacin

Streptomycin

10. A patient on phenytoin develops gingival hyperplasia. This side effect occurs in what percentage of patients?

5-10%

20-30%

50-60%

70-80%

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12. Which proton pump inhibitor is safest in patients with hepatic impairment?

Omeprazole

Pantoprazole

Lansoprazole

Esomeprazole

13. Amiodarone's long half-life (20-100 days) requires monitoring for thyroid dysfunction. Which thyroid test should be checked?

TSH and free T4

T3 resin uptake only

Thyroglobulin level

Anti-TPO antibodies

14. Clopidogrel (Plavix) requires hepatic metabolism via CYP450 enzymes to become active. Patients with which genetic variant may experience reduced efficacy?

CYP2C19 poor metabolizer

CYP3A4 ultra-rapid metabolizer

CYP2D6 extensive metabolizer

TPMT deficiency

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NCLEX Pharmacology Quiz: 40 Must-Know Meds Tested

1. A patient on warfarin requires an antibiotic. Which antibiotic significantly increases warfarin levels and bleeding risk?

2.

What first name or nickname would you like us to use?

2. Which ACE inhibitor side effect is most commonly reported and may warrant medication discontinuation?

3. Metformin is contraindicated in patients with severe renal impairment (eGFR

4. A patient develops muscle pain and weakness after starting atorvastatin. What lab value should be checked immediately?

5. Lisinopril, an ACE inhibitor, works by blocking angiotensin II formation, which decreases____.

6. Which beta-blocker is safest in patients with asthma or chronic obstructive pulmonary disease (COPD)?

7. A patient taking clarithromycin develops QT prolongation on ECG. This interaction is most likely with which drug class?

8. Digoxin toxicity commonly presents with nausea, vomiting, and visual disturbances. What is the primary cause at the cellular level?

9. Vancomycin nephrotoxicity risk increases significantly when combined with which aminoglycoside?

10. A patient on phenytoin develops gingival hyperplasia. This side effect occurs in what percentage of patients?

11. Spironolactone blocks aldosterone and is a potassium-sparing diuretic. Concurrent use with lisinopril increases risk of____.

12. Which proton pump inhibitor is safest in patients with hepatic impairment?

13. Amiodarone's long half-life (20-100 days) requires monitoring for thyroid dysfunction. Which thyroid test should be checked?

14. Clopidogrel (Plavix) requires hepatic metabolism via CYP450 enzymes to become active. Patients with which genetic variant may experience reduced efficacy?

15. NSAIDs increase risk of acute kidney injury by decreasing renal perfusion through inhibition of ____ synthesis.