GI Drug Quiz: Master Gut Pharmacology

1. Which drug class irreversibly inhibits gastric H+/K+-ATPase pumps?

H2 receptor antagonists

Proton pump inhibitors

Antacids

Muscarinic antagonists

2. Metoclopramide increases gastric motility primarily by blocking which receptor?

Dopamine D2 receptors

Serotonin 5-HT3 receptors

Histamine H1 receptors

Acetylcholine M1 receptors

3. A patient develops tardive dyskinesia after chronic metoclopramide use. What is the mechanism of this adverse effect?

Prolonged dopamine antagonism in basal ganglia

Serotonin depletion in the brainstem

Cholinergic overstimulation in motor cortex

GABA receptor downregulation

4. Ondansetron prevents chemotherapy-induced nausea by antagonizing which receptor subtype?

5-HT1A

5-HT3

5-HT2C

5-HT7

5. Which H2 receptor antagonist requires dose adjustment in renal impairment?

Famotidine

Cimetidine

Ranitidine

All of the above

6. Cimetidine is known to inhibit hepatic cytochrome P450 enzymes. True or false?

True

False

7. Bismuth subsalicylate eradicates H. pylori when used as monotherapy. True or false?

True

False

Submit

11. Which antidiarrheal agent is contraindicated in infectious diarrhea due to risk of toxic megacolon?

Bismuth subsalicylate

Loperamide

Psyllium husk

Docusate

12. Sucralfate forms a protective barrier over ulcers primarily through which mechanism?

Acid neutralization

Polymerization and adherence to ulcer bed

Stimulation of mucus secretion

Inhibition of pepsin activity

13. Dicyclomine is contraindicated in patients with narrow-angle glaucoma because it blocks which receptor?

M1 muscarinic receptors

M2 muscarinic receptors

Both M1 and M2 receptors

Alpha-1 adrenergic receptors

14. Lubiprostone increases bowel motility by activating ClC-2 chloride channels on intestinal epithelial cells. True or false?

True

False

Submit

GI Drug Quiz: Master Gut Pharmacology

1. Which drug class irreversibly inhibits gastric H+/K+-ATPase pumps?

2.

What first name or nickname would you like us to use?

2. Metoclopramide increases gastric motility primarily by blocking which receptor?

3. A patient develops tardive dyskinesia after chronic metoclopramide use. What is the mechanism of this adverse effect?

4. Ondansetron prevents chemotherapy-induced nausea by antagonizing which receptor subtype?

5. Which H2 receptor antagonist requires dose adjustment in renal impairment?

6. Cimetidine is known to inhibit hepatic cytochrome P450 enzymes. True or false?

7. Bismuth subsalicylate eradicates H. pylori when used as monotherapy. True or false?

8. Loperamide decreases diarrhea by reducing intestinal motility and increasing ____.

9. Diphenoxylate carries a risk of opioid dependence and must be combined with ____ to discourage abuse.

10. Mesalamine (5-ASA) is used to induce and maintain remission in inflammatory bowel disease by reducing ____ production.

11. Which antidiarrheal agent is contraindicated in infectious diarrhea due to risk of toxic megacolon?

12. Sucralfate forms a protective barrier over ulcers primarily through which mechanism?

13. Dicyclomine is contraindicated in patients with narrow-angle glaucoma because it blocks which receptor?

14. Lubiprostone increases bowel motility by activating ClC-2 chloride channels on intestinal epithelial cells. True or false?

15. Prucalopride is a selective 5-HT4 receptor agonist used to treat chronic idiopathic ____.