Drug Interaction Quiz: Can You Spot the Danger?

1. Which cytochrome P450 enzyme is responsible for metabolizing approximately 25% of all medications?

CYP1A2

CYP2D6

CYP3A4

CYP2E1

2. A patient taking warfarin (anticoagulant) starts ibuprofen therapy. What type of interaction is this?

Decreased anticoagulant effect

Increased bleeding risk

Hepatotoxicity

Renal failure

3. Grapefruit juice inhibits CYP3A4 and increases blood levels of certain medications. Which class is most affected?

Antibiotics

Statins

ACE inhibitors

Beta-blockers

Submit

5. SSRIs combined with MAOIs can cause serotonin syndrome. What is the primary mechanism?

Decreased serotonin reuptake inhibition

Excessive serotonin accumulation in the synapse

Reduced MAOI enzyme activity

Increased dopamine release

6. A CYP3A4 inhibitor increases the plasma concentration of a drug metabolized by this enzyme.

True

False

Submit

8. Which of the following is a classic example of a Type A (pharmacological) drug interaction?

ACE inhibitor + potassium supplement → hyperkalemia

Metformin + contrast dye → lactic acidosis

Penicillin allergy + cephalosporin → anaphylaxis

NSAIDs + aspirin → GI bleeding

9. Cimetidine inhibits multiple CYP450 enzymes. It may increase levels of drugs metabolized by CYP2D6 and CYP3A4.

True

False

Submit

11. Rifampin is a potent enzyme inducer that decreases effectiveness of many drugs. Which medication class is significantly affected?

Oral contraceptives

Antihistamines

Proton pump inhibitors

Antacids

12. Methotrexate + NSAIDs interaction primarily affects which organ system?

Cardiovascular

Renal

Hepatic

Pulmonary

13. St. John's Wort induces CYP3A4 and reduces blood levels of many drugs, including warfarin and SSRIs.

True

False

Submit

15. Quinolone antibiotics chelate divalent cations (Mg2+, Ca2+, Fe2+), reducing their absorption. Which of these interactions is most clinically significant?

Quinolone + antacid containing aluminum hydroxide

Quinolone + vitamin C supplement

Quinolone + acetaminophen

Quinolone + caffeine

16. Ketoconazole (CYP3A4 inhibitor) + simvastatin can cause severe myopathy due to increased statin concentration.

True

False

Drug Interaction Quiz: Can You Spot the Danger?

1. Which cytochrome P450 enzyme is responsible for metabolizing approximately 25% of all medications?

2.

What first name or nickname would you like us to use?

2. A patient taking warfarin (anticoagulant) starts ibuprofen therapy. What type of interaction is this?

3. Grapefruit juice inhibits CYP3A4 and increases blood levels of certain medications. Which class is most affected?

4. When two drugs produce a combined effect greater than the sum of their individual effects, this is called ____.

5. SSRIs combined with MAOIs can cause serotonin syndrome. What is the primary mechanism?

6. A CYP3A4 inhibitor increases the plasma concentration of a drug metabolized by this enzyme.

7. Phenytoin is a strong enzyme inducer. Co-administration with oral contraceptives may result in ____.

8. Which of the following is a classic example of a Type A (pharmacological) drug interaction?

9. Cimetidine inhibits multiple CYP450 enzymes. It may increase levels of drugs metabolized by CYP2D6 and CYP3A4.

10. NSAIDs combined with ACE inhibitors or ARBs increase the risk of ____.

11. Rifampin is a potent enzyme inducer that decreases effectiveness of many drugs. Which medication class is significantly affected?

12. Methotrexate + NSAIDs interaction primarily affects which organ system?

13. St. John's Wort induces CYP3A4 and reduces blood levels of many drugs, including warfarin and SSRIs.

14. A patient on lithium begins taking a thiazide diuretic. The diuretic decreases renal clearance of lithium, raising levels to toxic range. This is a ____ interaction.

15. Quinolone antibiotics chelate divalent cations (Mg2+, Ca2+, Fe2+), reducing their absorption. Which of these interactions is most clinically significant?

16. Ketoconazole (CYP3A4 inhibitor) + simvastatin can cause severe myopathy due to increased statin concentration.