Cholesterol Drug Quiz: Statins & Beyond

1. Which class of antihyperlipidemic drugs works primarily by inhibiting HMG-CoA reductase?

Statins

Fibrates

Bile acid sequestrants

PCSK9 inhibitors

2. What is the most common adverse effect associated with statin use?

Muscle pain and myopathy

Severe hypertension

Acute kidney injury

Pulmonary edema

3. Fibrates primarily reduce triglycerides by activating which nuclear receptor?

Peroxisome proliferator-activated receptor alpha

Steroid hormone receptor beta

Liver X receptor

Farnesoid X receptor

4. Bile acid sequestrants lower LDL cholesterol by which mechanism?

Inhibiting cholesterol synthesis

Binding bile acids in the intestine and increasing fecal excretion

Blocking apolipoprotein B production

Inhibiting triglyceride hydrolysis

5. PCSK9 inhibitors work by preventing the degradation of which receptor?

LDL receptor

Apolipoprotein B receptor

Triglyceride lipase receptor

HDL receptor

6. Which statin is known for having the highest potency in lowering LDL cholesterol?

Pravastatin

Rosuvastatin

Lovastatin

Fluvastatin

7. Ezetimibe reduces cholesterol absorption by inhibiting which intestinal transporter?

Niemann-Pick C1-like 1 protein

Apolipoprotein B transporter

Triglyceride hydrolase

Cholesterol esterase

8. Which antihyperlipidemic drug class increases the risk of myositis when combined with statins?

Fibrates

Niacin

Ezetimibe

Bempedoic acid

9. Niacin (vitamin B3) lowers triglycerides and LDL while raising HDL by which mechanism?

Activating G-protein coupled receptors and inhibiting lipolysis in adipose tissue

Directly binding to LDL particles

Competing with bile acid reabsorption

Inhibiting HMG-CoA reductase

10. What is a major limitation of bile acid sequestrants in terms of drug interactions?

They bind other drugs in the GI tract, reducing their absorption

They inhibit hepatic metabolism of other medications

They compete for renal excretion

They induce CYP3A4 enzymes systemically

11. Bempedoic acid lowers uric acid and LDL by inhibiting which enzyme?

Urate oxidase

Fructose-1,6-bisphosphatase

Acetyl-CoA carboxylase

Xanthine oxidase

12. Statins are contraindicated or require dose adjustment in patients with which condition?

Active liver disease or unexplained persistent LFT elevation

Mild hypertension

Type 2 diabetes alone

Mild renal impairment

13. Inclisiran is a newer antihyperlipidemic that works by which mechanism?

RNA interference targeting PCSK9 mRNA

Direct inhibition of apolipoprotein B

Activating LDL receptors on hepatocytes

Inhibiting cholesterol esterase

14. Which antihyperlipidemic drug commonly causes flushing as a side effect?

Niacin

Ezetimibe

Bempedoic acid

Inclisiran

15. Alirocumab and evolocumab are monoclonal antibodies that belong to which drug class?

PCSK9 inhibitors

Fibrates

Statins

Bile acid sequestrants

Cholesterol Drug Quiz: Statins & Beyond

1. Which class of antihyperlipidemic drugs works primarily by inhibiting HMG-CoA reductase?

2.

What first name or nickname would you like us to use?

2. What is the most common adverse effect associated with statin use?

3. Fibrates primarily reduce triglycerides by activating which nuclear receptor?

4. Bile acid sequestrants lower LDL cholesterol by which mechanism?

5. PCSK9 inhibitors work by preventing the degradation of which receptor?

6. Which statin is known for having the highest potency in lowering LDL cholesterol?

7. Ezetimibe reduces cholesterol absorption by inhibiting which intestinal transporter?

8. Which antihyperlipidemic drug class increases the risk of myositis when combined with statins?

9. Niacin (vitamin B3) lowers triglycerides and LDL while raising HDL by which mechanism?

10. What is a major limitation of bile acid sequestrants in terms of drug interactions?

11. Bempedoic acid lowers uric acid and LDL by inhibiting which enzyme?

12. Statins are contraindicated or require dose adjustment in patients with which condition?

13. Inclisiran is a newer antihyperlipidemic that works by which mechanism?

14. Which antihyperlipidemic drug commonly causes flushing as a side effect?

15. Alirocumab and evolocumab are monoclonal antibodies that belong to which drug class?