Breast Cancer Quiz: Screening to Treatment

1. Which imaging modality is most sensitive for detecting breast cancer in women under 40 with dense breast tissue?

Mammography alone

Ultrasound

MRI

Clinical breast examination

2. A patient presents with a dimpled appearance of the breast skin and nipple retraction. What clinical sign is this?

Paget's disease

Peau d'orange

Inflammatory breast cancer

Phyllodes tumor

3. What is the primary mechanism of action of tamoxifen in hormone receptor-positive breast cancer?

Aromatase inhibition

Selective estrogen receptor modulator

CDK4/6 inhibition

HER2 receptor blockade

4. A 45-year-old woman has a BRCA1 mutation. What is her approximate lifetime risk of developing breast cancer?

15-20%

40-50%

70-80%

90-95%

5. Which chemotherapy regimen is standard adjuvant therapy for HER2-positive breast cancer?

AC-T (Adriamycin, Cyclophosphamide, Taxol)

AC-T plus trastuzumab (Herceptin)

5-FU and methotrexate

Capecitabine monotherapy

6. Lymphedema is a common complication after axillary lymph node dissection. When does it typically develop?

Within 1 week post-op

Within 1-3 months post-op

Months to years post-op

Only in advanced disease

7. A patient on aromatase inhibitor therapy reports joint pain and stiffness. What is this adverse effect called?

Arthralgias

Arthritis

Osteoporosis

Myalgia

8. What is the TNM staging system component that describes the number of involved axillary lymph nodes?

T stage

N stage

M stage

Grade

9. A patient presents with unilateral breast swelling, skin erythema, and rapid onset. What breast cancer subtype is suspected?

Invasive lobular carcinoma

Inflammatory breast cancer

Mucinous carcinoma

Tubular carcinoma

10. Which hormone receptor status typically indicates a better prognosis in early breast cancer?

ER/PR negative, HER2 positive

ER/PR positive, HER2 negative

Triple negative

HER2 positive only

11. A patient completing chemotherapy reports persistent numbness and tingling in fingers and toes. What is this condition?

Chemotherapy-induced peripheral neuropathy

Carpal tunnel syndrome

Diabetic neuropathy

Guillain-Barré syndrome

Submit

13. True or False: Ductal carcinoma in situ (DCIS) is considered invasive breast cancer.

True

False

14. A 60-year-old woman is newly diagnosed with metastatic breast cancer. What is the primary goal of treatment?

Cure the disease

Prolong survival and maintain quality of life

Eliminate all cancer cells

Avoid all side effects

15. CDK4/6 inhibitors such as palbociclib are used in combination with which class of endocrine therapy?

Aromatase inhibitors or tamoxifen

Chemotherapy agents

Immunotherapy drugs

Targeted HER2 therapy