Autacoids Pharmacology NEET-PG Style MCQs

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| By Catherine Halcomb
Catherine Halcomb
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Quizzes Created: 3100 | Total Attempts: 6,949,905
| Attempts: 15 | Questions: 10 | Updated: Aug 9, 2026
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1. Which prostaglandin is primarily responsible for maintaining renal blood flow and protecting the gastric mucosa?

Explanation

PGE₂ has important protective effects: it increases gastric mucus and bicarbonate, decreases gastric acid secretion, maintains renal blood flow, and produces vasodilation. PGE₂ = protection + renal perfusion.

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About This Quiz
Autacoids Pharmacology NEET-pg Style MCQs - Quiz

This assessment focuses on autacoids pharmacology, evaluating your understanding of key concepts such as histamine, serotonin, and eicosanoids. It is particularly relevant for NEET-PG aspirants looking to deepen their knowledge in pharmacology. By engaging with this material, learners can enhance their grasp of how autacoids function in therapeutic contexts.

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2. Which prostanoid causes vasodilation and inhibits platelet aggregation?

Explanation

PGI₂ (prostacyclin) is produced mainly by vascular endothelial cells and causes vasodilation and ↓ platelet aggregation. In contrast, TXA₂ causes vasoconstriction and platelet aggregation. PGI₂ = 'I'nhibits platelets.

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3. A patient with pulmonary arterial hypertension is treated with a prostacyclin analogue. Which drug is most appropriate?

Explanation

Epoprostenol is a PGI₂ analogue that causes vasodilation, ↓ pulmonary vascular resistance, and ↓ platelet aggregation — used in pulmonary arterial hypertension. Misoprostol = PGE₁ analogue; Latanoprost = PGF₂α analogue; Dinoprostone = PGE₂.

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4. Which leukotriene receptor antagonist is used for the prophylaxis of bronchial asthma?

Explanation

Montelukast blocks the CysLT₁ receptor → blocks effects of LTC₄/LTD₄/LTE₄. Used in asthma prophylaxis, aspirin-induced asthma, exercise-induced bronchospasm, and allergic rhinitis. Zileuton inhibits 5-lipoxygenase (synthesis inhibitor), while Montelukast is a receptor blocker.

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5. Which autacoid is most strongly associated with itching, bronchoconstriction, vasodilation, and increased vascular permeability?

Explanation

Histamine acts mainly through H₁ receptors to produce vasodilation, ↑ capillary permeability, bronchoconstriction, itching, and pain. H₁ = allergy symptoms. H₂ receptors → gastric acid secretion ↑.

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6. A patient develops severe angioedema after taking an ACE inhibitor. Which mediator is primarily responsible?

Explanation

ACE is also Kininase II, which normally breaks down bradykinin. ACE inhibitor → ↓ bradykinin degradation → ↑ bradykinin → dry cough + angioedema. NEET-PG Pearl: ACE inhibitor → Bradykinin ↑ → dry cough + angioedema.

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7. Which drug is used to prevent NSAID-induced gastric ulceration by replacing the protective prostaglandin effect?

Explanation

Misoprostol is a PGE₁ analogue that ↓ gastric acid secretion, ↑ mucus, ↑ bicarbonate, and protects the gastric mucosa — useful for NSAID-induced ulcer prevention. Important adverse effects: diarrhea and uterine contractions. Contraindicated in pregnancy (can induce abortion).

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8. Which drug is a prostaglandin F₂α analogue used for lowering intraocular pressure in glaucoma?

Explanation

Latanoprost is a PGF₂α analogue that increases uveoscleral outflow → ↓ intraocular pressure. Used in open-angle glaucoma and ocular hypertension. Important adverse effects: iris pigmentation, eyelash growth, and conjunctival hyperemia. Latanoprost → 'lashes long' + iris pigmentation.

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9. A patient with bronchial asthma develops worsening bronchoconstriction after taking aspirin. Which mediator is primarily responsible?

Explanation

Aspirin inhibits COX → arachidonic acid is shunted toward the 5-lipoxygenase pathway → ↑ leukotrienes. LTC₄, LTD₄, LTE₄ (cysteinyl leukotrienes) cause potent bronchoconstriction, mucosal edema, and ↑ mucus secretion. Aspirin asthma → Leukotrienes ↑.

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10. Which drug is a 5-lipoxygenase inhibitor?

Explanation

Zileuton inhibits 5-lipoxygenase (5-LOX) → ↓ leukotriene synthesis from arachidonic acid. Montelukast and Zafirlukast are CysLT₁ receptor antagonists, not enzyme inhibitors. Exam trap: Do not confuse Zileuton with Montelukast.

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Which prostaglandin is primarily responsible for maintaining renal...
Which prostanoid causes vasodilation and inhibits platelet...
A patient with pulmonary arterial hypertension is treated with a...
Which leukotriene receptor antagonist is used for the prophylaxis of...
Which autacoid is most strongly associated with itching,...
A patient develops severe angioedema after taking an ACE inhibitor....
Which drug is used to prevent NSAID-induced gastric ulceration by...
Which drug is a prostaglandin F₂α analogue used for lowering...
A patient with bronchial asthma develops worsening bronchoconstriction...
Which drug is a 5-lipoxygenase inhibitor?
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