Phchem4 Tth 2:30-4pm Final Exam

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1. Loratadine is an example of a second-generation antihistamine
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Phchem4 Tth 2:30-4pm Final Exam - Quiz

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2. When two aromatic groups present in the antihistamines are connected to each other with heteroatoms like N or S then the compound is called Tricyclic antihistamines
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3. When the alkyl group in the two carbon of the spacer has higher size, it increases anticholinergic effect
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4. Ethanolamine series structure possesses additional antimuscarinic activity.
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5. Piperazine derivatives are First Generation Antihistamines
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6. Less incidences of side effects occur when
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7. It studies the association between the 3D structure of a molecule with its biological, pharmacological, and chemical activity on the receptors.
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8. It significantly the mu receptor affinity and CNS distribution
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9. Pure mu receptor antagonism
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10. When the spacer is Carbon itself then the compound is called alkylamines
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11. Mu receptor antagonism is retained but the molecule gains additional Kappa receptor agonism.
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12. Antagonism of mu receptor
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13. Provides significant resistance to metabolism with high bioavailability
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14. Mast cell degranulation and results in Allergy
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15. Phenothiazine derivatives are First Generation Antihistamines
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16. Very low bioavailability
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17. The parent molecule of Catecholamines
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18. It permits the binding of molecule to the aspartate residue in the opioid receptor
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19. It is required for the binding capacity to the opioid receptor.
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20. Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier. Identify where the substitution takes place.
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21. Increase CNS penetration and agonism at mu and kappa receptor but decrease antitussive activity
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22. When the alkyl group substituted in the 2 carbon of the spacer has shorter size, then the antihistaminic activity has decreased dramatically
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23. In the parent molecular of NE and Epinephrine, the carbon atom which is near to an amine end is termed______.
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24. In the case of the ethanolamine series, the spacer will be carbon atom linked to the nitrogen molecule and then to the tertiary amine
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25. The parent molecule of NE and Epinephrine has a phenyl molecule at one pole which is linked with an amine group at the other end by a two carbon chain which is called _____
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26. Lengthening with introduction of new groups converting the drug into antagonists. Identify where the substitution takes place.
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27. Essential criterion for mu and kappa receptor binding
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28. Becomes significantly metabolized and inactivated by glucuronic conjugation in GIT
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29. Addition of bulker and short-chain molecules to the alkyl group in the tertiary amine produces antihistamines with less lipophilicity and less blood brain barrier entry called second-generation antihistamines
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30. Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity. Identify where the substitution takes place.
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31. Production of a potent levorotatory diastereoisomer Identify where the substitution takes place.
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32. Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity Identify where the substitution takes place
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33. Adding a tertiary butyl group to make the drug more selective to beta 2 receptors Identify where the substitution takes place.
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34. Which one do you like?
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35. The spacer is an Oxygen atom in the ethylenediamine series
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36. Alkylamines possess long duration of action with low CNS penetration
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37. What are the targets for structural alterations for the parent molecule of catecholamines?
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38. Producing a potent dextrorotatory diastereoisomer. Identify where the substitution takes place.
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39. Adding a bulkier group would increase beta agonistic action. Identify where the substitution takes place
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40. Adding a hydroxyl group making the drug act as a direct sympathomimetic. Identify where the substitution takes place.
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41. Adding CH3CH2 which increases the drug to be more selective to beta receptors. Identify where the substitution takes place.
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42. Class of Antihistamine does this drug belong to:
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43. Adding a hydroxyl group which makes the drug more polar thus having poor CNS action Identify where the substitution takes place.
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44. Class of Antihistamine does the drug belong
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45. Adding a hydroxyl group which is essential for alpha agonistic action. Identify where the substitution takes place.
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46. Which statement is TRUE about the parent molecule for steroids? (you can tick more than once)
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47. Effect of adding methoxy-esters at C-3.
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48. The following are improvement of pharmacokinetic properties except: (you can tick more than once)
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49. Which statement is TRUE about the structure of Corticosteroids? (you can tick more than once)
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50. Adding a methyl group to increase alpha selectivity Identify where the substitution takes place.
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Loratadine is an example of a second-generation antihistamine
When two aromatic groups present in the antihistamines are connected...
When the alkyl group in the two carbon of the spacer has higher size,...
Ethanolamine series structure possesses additional antimuscarinic...
Piperazine derivatives are First Generation Antihistamines
Less incidences of side effects occur when
It studies the association between the 3D structure of a molecule with...
It significantly the mu receptor affinity and CNS distribution
Pure mu receptor antagonism
When the spacer is Carbon itself then the compound is called...
Mu receptor antagonism is retained but the molecule gains additional...
Antagonism of mu receptor
Provides significant resistance to metabolism with high...
Mast cell degranulation and results in Allergy
Phenothiazine derivatives are First Generation Antihistamines
Very low bioavailability
The parent molecule of Catecholamines
It permits the binding of molecule to the aspartate residue in the...
It is required for the binding capacity to the opioid receptor.
Adding an aryl group which increases its lipophilic nature and can...
Increase CNS penetration and agonism at mu and kappa receptor but...
When the alkyl group substituted in the 2 carbon of the spacer has...
In the parent molecular of NE and Epinephrine, the carbon atom which...
In the case of the ethanolamine series, the spacer will be carbon atom...
The parent molecule of NE and Epinephrine has a phenyl molecule at one...
Lengthening with introduction of new groups converting the drug into...
Essential criterion for mu and kappa receptor binding
Becomes significantly metabolized and inactivated by glucuronic...
Addition of bulker and short-chain molecules to the alkyl group in the...
Adding small molecules to make the drug more MAO resistant thus...
Production of a potent levorotatory diastereoisomer ...
Adding two carbons between amine and phenyl to have the best...
Adding a tertiary butyl group to make the drug more selective to beta...
Which one do you like?
The spacer is an Oxygen atom in the ethylenediamine series
Alkylamines possess long duration of action with low CNS penetration
What are the targets for structural alterations for the parent...
Producing a potent dextrorotatory diastereoisomer. ...
Adding a bulkier group would increase beta agonistic action. ...
Adding a hydroxyl group making the drug act as a direct...
Adding CH3CH2 which increases the drug to be more selective to beta...
Class of Antihistamine does this drug belong to:
Adding a hydroxyl group which makes the drug more polar thus having...
Class of Antihistamine does the drug belong
Adding a hydroxyl group which is essential for alpha agonistic...
Which statement is TRUE about the parent molecule for steroids? (you...
Effect of adding methoxy-esters at C-3.
The following are improvement of pharmacokinetic properties except:...
Which statement is TRUE about the structure of Corticosteroids? (you...
Adding a methyl group to increase alpha selectivity ...
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