Phchem4 Tth 2:30-4pm Final Exam
.
- 1.It studies the association between the 3D structure of a molecule with its biological, pharmacological, and chemical activity on the receptors.
- A.
Pharmacology
- B.
Medicinal Chemistry
- C.
Structure-activity Relationship
- D.
Organic Medicinals
- 2.Less incidences of side effects occur when
- A.
The pharmacophore is more specific or selective.
- B.
There is modification of chemical group responsible for interactions with unwanted receptors.
- C.
Specificity of the drug is improved
- D.
All of the answers
- 3.The following are improvement of pharmacokinetic properties except: (you can tick more than once)
- A.
Ease of administration
- B.
Long duration of action
- C.
Shorter half-life
- D.
Better tolerability for patient with hepatic conditions
- E.
Better tolerability for patients with renal impairment
- 4.The parent molecule of Catecholamines
- A.
Norepinephrine
- B.
Adrenaline
- C.
B-phenylalalnine
- D.
B-phenylethylamine
- 5.The parent molecule of NE and Epinephrine has a phenyl molecule at one pole which is linked with an amine group at the other end by a two carbon chain which is called _____
- A.
Methyl bridge
- B.
Ethylamine linkage
- C.
Carbon chain
- D.
Ethyl bridge
- 6.In the parent molecular of NE and Epinephrine, the carbon atom which is near to an amine end is termed______.
- A.
B-carbon
- B.
Gamma carbon
- C.
Alpha carbon
- D.
None of the answers
- 7.What are the targets for structural alterations for the parent molecule of catecholamines?
- A.
Amino Group, ethyl bridge, benzene ring
- B.
Hydrogen, nitrogen, carbon chain, aromatic ring
- C.
Benzene ring, alpha and beta carbon in ethyl bridge, amino group and separation of ethyl bridge
- D.
None of the answers
- 8.
![Adding a bulkier group would increase beta agonistic action.
Identify where the substitution takes place - ProProfs]( "Adding a bulkier group would increase beta agonistic action.
Identify where the substitution takes place")
Adding a bulkier group would increase beta agonistic action. Identify where the substitution takes place- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 9.
![Adding a methyl group to increase alpha selectivity
Identify where the substitution takes place. - ProProfs]( "Adding a methyl group to increase alpha selectivity
Identify where the substitution takes place.")
Adding a methyl group to increase alpha selectivity Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 10.
![Production of a potent levorotatory diastereoisomer
Identify where the substitution takes place. - ProProfs]( "Production of a potent levorotatory diastereoisomer
Identify where the substitution takes place.")
Production of a potent levorotatory diastereoisomer Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 11.
![Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity
Identify where the substitution takes place - ProProfs]( "Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity
Identify where the substitution takes place")
Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity Identify where the substitution takes place- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 12.
![Adding a tertiary butyl group to make the drug more selective to beta 2 receptors
Identify where the substitution takes place. - ProProfs]( "Adding a tertiary butyl group to make the drug more selective to beta 2 receptors
Identify where the substitution takes place.")
Adding a tertiary butyl group to make the drug more selective to beta 2 receptors Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 13.
![Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier.
Identify where the substitution takes place. - ProProfs]( "Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier.
Identify where the substitution takes place.")
Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier. Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 14.
![Lengthening with introduction of new groups converting the drug into antagonists.
Identify where the substitution takes place. - ProProfs]( "Lengthening with introduction of new groups converting the drug into antagonists.
Identify where the substitution takes place.")
Lengthening with introduction of new groups converting the drug into antagonists. Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 15.
![Adding a hydroxyl group making the drug act as a direct sympathomimetic.
Identify where the substitution takes place. - ProProfs]( "Adding a hydroxyl group making the drug act as a direct sympathomimetic.
Identify where the substitution takes place.")
Adding a hydroxyl group making the drug act as a direct sympathomimetic. Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 16.
![Adding CH3CH2 which increases the drug to be more selective to beta receptors.
Identify where the substitution takes place. - ProProfs]( "Adding CH3CH2 which increases the drug to be more selective to beta receptors.
Identify where the substitution takes place.")
Adding CH3CH2 which increases the drug to be more selective to beta receptors. Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 17.
![Adding a hydroxyl group which makes the drug more polar thus having poor CNS action
Identify where the substitution takes place. - ProProfs]( "Adding a hydroxyl group which makes the drug more polar thus having poor CNS action
Identify where the substitution takes place.")
Adding a hydroxyl group which makes the drug more polar thus having poor CNS action Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 18.
![Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity.
Identify where the substitution takes place. - ProProfs]( "Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity.
Identify where the substitution takes place.")
Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity. Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 19.
![Producing a potent dextrorotatory diastereoisomer.
Identify where the substitution takes place. - ProProfs]( "Producing a potent dextrorotatory diastereoisomer.
Identify where the substitution takes place.")
Producing a potent dextrorotatory diastereoisomer. Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 20.
![Adding a hydroxyl group which is essential for alpha agonistic action.
Identify where the substitution takes place. - ProProfs]( "Adding a hydroxyl group which is essential for alpha agonistic action.
Identify where the substitution takes place.")
Adding a hydroxyl group which is essential for alpha agonistic action. Identify where the substitution takes place.- A.
3rd Carbon
- B.
4th Carbon
- C.
5th Carbon
- D.
Beta Carbon
- E.
Alpha Carbon
- F.
Ethyl Bridge
- G.
Amine
- 21.Which statement is TRUE about the parent molecule for steroids? (you can tick more than once)
- A.
It is a 17 carbon structure arranged in four fused rings
- B.
First three rings are 5-member cyclopentanes
- C.
The fourth ring is a cyclohexane.
- D.
AKA cyclopentanoperhydrophenanthrene
- 22.Which statement is TRUE about the structure of Corticosteroids? (you can tick more than once)
- A.
It has 2 methyl groups.
- B.
It is a 21 carbon skeletal structure.
- C.
It has a hydroxymethyl group on the 21st carbon
- D.
It only has 1 ketone group.
- E.
One of the methyl groups is attached on the 13th carbon.
- 23.
![It is required for the binding capacity to the opioid receptor. - ProProfs]( "It is required for the binding capacity to the opioid receptor.")
It is required for the binding capacity to the opioid receptor.- A.
Protonated amino nitrogen
- B.
Protonated nitrogen in cationic conjugate
- 24.
![It permits the binding of molecule to the aspartate residue in the opioid receptor - ProProfs]( "It permits the binding of molecule to the aspartate residue in the opioid receptor")
It permits the binding of molecule to the aspartate residue in the opioid receptor- A.
Protonated nitrogen in cationic conjugate
- B.
Phenethyl group in the R1
- 25.
![It significantly the mu receptor affinity and CNS distribution - ProProfs]( "It significantly the mu receptor affinity and CNS distribution")
It significantly the mu receptor affinity and CNS distribution- A.
Phenethyl group in the R1
- B.
Lengthening R1 attachment from the nitrogen atom
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