Phchem4 Tth 2:30-4pm Final Exam

50 Questions | Total Attempts: 54

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Phchem4 Tth 2:30-4pm Final Exam

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Questions and Answers
  • 1. 
    It studies the association between the 3D structure of a molecule with its biological, pharmacological, and chemical activity on the receptors.
    • A. 

      Pharmacology

    • B. 

      Medicinal Chemistry

    • C. 

      Structure-activity Relationship

    • D. 

      Organic Medicinals

  • 2. 
    Less incidences of side effects occur when
    • A. 

      The pharmacophore is more specific or selective.

    • B. 

      There is modification of chemical group responsible for interactions with unwanted receptors.

    • C. 

      Specificity of the drug is improved

    • D. 

      All of the answers

  • 3. 
    The following are improvement of pharmacokinetic properties except: (you can tick more than once)
    • A. 

      Ease of administration

    • B. 

      Long duration of action

    • C. 

      Shorter half-life

    • D. 

      Better tolerability for patient with hepatic conditions

    • E. 

      Better tolerability for patients with renal impairment

  • 4. 
    The parent molecule of Catecholamines
    • A. 

      Norepinephrine

    • B. 

      Adrenaline

    • C. 

      B-phenylalalnine

    • D. 

      B-phenylethylamine

  • 5. 
    The parent molecule of NE and Epinephrine has a phenyl molecule at one pole which is linked with an amine group at the other end by a two carbon chain which is called _____
    • A. 

      Methyl bridge

    • B. 

      Ethylamine linkage

    • C. 

      Carbon chain

    • D. 

      Ethyl bridge

  • 6. 
    In the parent molecular of NE and Epinephrine, the carbon atom which is near to an amine end is termed______.
    • A. 

      B-carbon

    • B. 

      Gamma carbon

    • C. 

      Alpha carbon

    • D. 

      None of the answers

  • 7. 
    What are the targets for structural alterations for the parent molecule of catecholamines?
    • A. 

      Amino Group, ethyl bridge, benzene ring

    • B. 

      Hydrogen, nitrogen, carbon chain, aromatic ring

    • C. 

      Benzene ring, alpha and beta carbon in ethyl bridge, amino group and separation of ethyl bridge

    • D. 

      None of the answers

  • 8. 
    Adding a bulkier group would increase beta agonistic action. Identify where the substitution takes place
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 9. 
    Adding a methyl group to increase alpha selectivity Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 10. 
    Production of a potent levorotatory diastereoisomer Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 11. 
    Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity Identify where the substitution takes place
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 12. 
    Adding a tertiary butyl group to make the drug more selective to beta 2 receptors Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 13. 
    Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier. Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 14. 
    Lengthening with introduction of new groups converting the drug into antagonists. Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 15. 
    Adding a hydroxyl group making the drug act as a direct sympathomimetic. Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 16. 
    Adding CH3CH2 which increases the drug to be more selective to beta receptors. Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 17. 
    Adding a hydroxyl group which makes the drug more polar thus having poor CNS action Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 18. 
    Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity. Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 19. 
    Producing a potent dextrorotatory diastereoisomer. Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 20. 
    Adding a hydroxyl group which is essential for alpha agonistic action. Identify where the substitution takes place.
    • A. 

      3rd Carbon

    • B. 

      4th Carbon

    • C. 

      5th Carbon

    • D. 

      Beta Carbon

    • E. 

      Alpha Carbon

    • F. 

      Ethyl Bridge

    • G. 

      Amine

  • 21. 
    Which statement is TRUE about the parent molecule for steroids? (you can tick more than once)
    • A. 

      It is a 17 carbon structure arranged in four fused rings

    • B. 

      First three rings are 5-member cyclopentanes

    • C. 

      The fourth ring is a cyclohexane.

    • D. 

      AKA cyclopentanoperhydrophenanthrene

  • 22. 
    Which statement is TRUE about the structure of Corticosteroids? (you can tick more than once)
    • A. 

      It has 2 methyl groups.

    • B. 

      It is a 21 carbon skeletal structure.

    • C. 

      It has a hydroxymethyl group on the 21st carbon

    • D. 

      It only has 1 ketone group.

    • E. 

      One of the methyl groups is attached on the 13th carbon.

  • 23. 
    It is required for the binding capacity to the opioid receptor.
    • A. 

      Protonated amino nitrogen

    • B. 

      Protonated nitrogen in cationic conjugate

  • 24. 
    It permits the binding of molecule to the aspartate residue in the opioid receptor
    • A. 

      Protonated nitrogen in cationic conjugate

    • B. 

      Phenethyl group in the R1

  • 25. 
    It significantly the mu receptor affinity and CNS distribution
    • A. 

      Phenethyl group in the R1

    • B. 

      Lengthening R1 attachment from the nitrogen atom

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