Phchem 4 Final Exam Mw 4-5:30pm

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1. Less incidences of side effects occur when
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Phchem 4 Final Exam Mw 4-5:30pm - Quiz

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2. Loratadine is an example of a second-generation antihistamine
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3. Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity Identify where the substitution takes place
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4. It significantly the mu receptor affinity and CNS distribution
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5. Ethanolamine series structure possesses additional antimuscarinic activity.
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6. Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity. Identify where the substitution takes place.
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7. Phenothiazine derivatives are First Generation Antihistamines
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8. The spacer is an Oxygen atom in the ethylenediamine series
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9. It studies the association between the 3D structure of a molecule with its biological, pharmacological, and chemical activity on the receptors.
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10. When the alkyl group in the two carbon of the spacer has higher size, it increases anticholinergic effect
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11. The parent molecule of NE and Epinephrine has a phenyl molecule at one pole which is linked with an amine group at the other end by a two carbon chain which is called _____
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12. In the parent molecular of NE and Epinephrine, the carbon atom which is near to an amine end is termed______.
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13. Adding a hydroxyl group making the drug act as a direct sympathomimetic. Identify where the substitution takes place.
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14. Adding a hydroxyl group which makes the drug more polar thus having poor CNS action Identify where the substitution takes place.
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15. Adding a tertiary butyl group to make the drug more selective to beta 2 receptors Identify where the substitution takes place.
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16. Lengthening with introduction of new groups converting the drug into antagonists. Identify where the substitution takes place.
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17. When the spacer is Carbon itself then the compound is called alkylamines
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18. Adding a hydroxyl group which is essential for alpha agonistic action. Identify where the substitution takes place.
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19. Adding a bulkier group would increase beta agonistic action. Identify where the substitution takes place
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20. Mast cell degranulation and results in Allergy
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21. It permits the binding of molecule to the aspartate residue in the opioid receptor
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22. Production of a potent levorotatory diastereoisomer Identify where the substitution takes place.
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23. Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier. Identify where the substitution takes place.
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24. When two aromatic groups present in the antihistamines are connected to each other with heteroatoms like N or S then the compound is called Tricyclic antihistamines
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25. Addition of bulker and short-chain molecules to the alkyl group in the tertiary amine produces antihistamines with less lipophilicity and less blood brain barrier entry called second-generation antihistamines
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26. Which statement is TRUE about the parent molecule for steroids? (you can tick more than once)
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27. Pure mu receptor antagonism
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28. Very low bioavailability
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29. Provides significant resistance to metabolism with high bioavailability
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30. Adding CH3CH2 which increases the drug to be more selective to beta receptors. Identify where the substitution takes place.
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31. The parent molecule of Catecholamines
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32. Mu receptor antagonism is retained but the molecule gains additional Kappa receptor agonism.
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33. Essential criterion for mu and kappa receptor binding
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34. What are the targets for structural alterations for the parent molecule of catecholamines?
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35. Increase CNS penetration and agonism at mu and kappa receptor but decrease antitussive activity
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36. It is required for the binding capacity to the opioid receptor.
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37. Antagonism of mu receptor
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38. Producing a potent dextrorotatory diastereoisomer. Identify where the substitution takes place.
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39. In the case of the ethanolamine series, the spacer will be carbon atom linked to the nitrogen molecule and then to the tertiary amine
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40. When the alkyl group substituted in the 2 carbon of the spacer has shorter size, then the antihistaminic activity has decreased dramatically
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41. Class of Antihistamine does the drug belong
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42. Becomes significantly metabolized and inactivated by glucuronic conjugation in GIT
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43. Which one do you like?
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44. Piperazine derivatives are First Generation Antihistamines
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45. Effect of adding methoxy-esters at C-3.
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46. Class of Antihistamine does this drug belong to:
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47. Alkylamines possess long duration of action with low CNS penetration
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48. The following are improvement of pharmacokinetic properties except: (you can tick more than once)
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49. Which statement is TRUE about the structure of Corticosteroids? (you can tick more than once)
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50. Adding a methyl group to increase alpha selectivity Identify where the substitution takes place.
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Less incidences of side effects occur when
Loratadine is an example of a second-generation antihistamine
Adding two carbons between amine and phenyl to have the best...
It significantly the mu receptor affinity and CNS distribution
Ethanolamine series structure possesses additional antimuscarinic...
Adding small molecules to make the drug more MAO resistant thus...
Phenothiazine derivatives are First Generation Antihistamines
The spacer is an Oxygen atom in the ethylenediamine series
It studies the association between the 3D structure of a molecule with...
When the alkyl group in the two carbon of the spacer has higher size,...
The parent molecule of NE and Epinephrine has a phenyl molecule at one...
In the parent molecular of NE and Epinephrine, the carbon atom which...
Adding a hydroxyl group making the drug act as a direct...
Adding a hydroxyl group which makes the drug more polar thus having...
Adding a tertiary butyl group to make the drug more selective to beta...
Lengthening with introduction of new groups converting the drug into...
When the spacer is Carbon itself then the compound is called...
Adding a hydroxyl group which is essential for alpha agonistic...
Adding a bulkier group would increase beta agonistic action. ...
Mast cell degranulation and results in Allergy
It permits the binding of molecule to the aspartate residue in the...
Production of a potent levorotatory diastereoisomer ...
Adding an aryl group which increases its lipophilic nature and can...
When two aromatic groups present in the antihistamines are connected...
Addition of bulker and short-chain molecules to the alkyl group in the...
Which statement is TRUE about the parent molecule for steroids? (you...
Pure mu receptor antagonism
Very low bioavailability
Provides significant resistance to metabolism with high...
Adding CH3CH2 which increases the drug to be more selective to beta...
The parent molecule of Catecholamines
Mu receptor antagonism is retained but the molecule gains additional...
Essential criterion for mu and kappa receptor binding
What are the targets for structural alterations for the parent...
Increase CNS penetration and agonism at mu and kappa receptor but...
It is required for the binding capacity to the opioid receptor.
Antagonism of mu receptor
Producing a potent dextrorotatory diastereoisomer. ...
In the case of the ethanolamine series, the spacer will be carbon atom...
When the alkyl group substituted in the 2 carbon of the spacer has...
Class of Antihistamine does the drug belong
Becomes significantly metabolized and inactivated by glucuronic...
Which one do you like?
Piperazine derivatives are First Generation Antihistamines
Effect of adding methoxy-esters at C-3.
Class of Antihistamine does this drug belong to:
Alkylamines possess long duration of action with low CNS penetration
The following are improvement of pharmacokinetic properties except:...
Which statement is TRUE about the structure of Corticosteroids? (you...
Adding a methyl group to increase alpha selectivity ...
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