Phchem 4 Final Exam Mw 4-5:30pm

50 Questions | By Uvrxmaster | Last updated: Mar 26, 2020 | Total Attempts: 33

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1.

It studies the association between the 3D structure of a molecule with its biological, pharmacological, and chemical activity on the receptors.
- A.
  
  Pharmacology
- B.
  
  Medicinal Chemistry
- C.
  
  Structure-activity Relationship
- D.
  
  Organic Medicinals
2.

Less incidences of side effects occur when
- A.
  
  The pharmacophore is more specific or selective.
- B.
  
  There is modification of chemical group responsible for interactions with unwanted receptors.
- C.
  
  Specificity of the drug is improved
- D.
  
  All of the answers
3.

The following are improvement of pharmacokinetic properties except: (you can tick more than once)
- A.
  
  Ease of administration
- B.
  
  Long duration of action
- C.
  
  Shorter half-life
- D.
  
  Better tolerability for patient with hepatic conditions
- E.
  
  Better tolerability for patients with renal impairment
4.

The parent molecule of Catecholamines
- A.
  
  Norepinephrine
- B.
  
  Adrenaline
- C.
  
  B-phenylalalnine
- D.
  
  B-phenylethylamine
5.

The parent molecule of NE and Epinephrine has a phenyl molecule at one pole which is linked with an amine group at the other end by a two carbon chain which is called _____
- A.
  
  Methyl bridge
- B.
  
  Ethylamine linkage
- C.
  
  Carbon chain
- D.
  
  Ethyl bridge
6.

In the parent molecular of NE and Epinephrine, the carbon atom which is near to an amine end is termed______.
- A.
  
  B-carbon
- B.
  
  Gamma carbon
- C.
  
  Alpha carbon
- D.
  
  None of the answers
7.

What are the targets for structural alterations for the parent molecule of catecholamines?
- A.
  
  Amino Group, ethyl bridge, benzene ring
- B.
  
  Hydrogen, nitrogen, carbon chain, aromatic ring
- C.
  
  Benzene ring, alpha and beta carbon in ethyl bridge, amino group and separation of ethyl bridge
- D.
  
  None of the answers
8.

Adding a bulkier group would increase beta agonistic action. Identify where the substitution takes place
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
9.

Adding a methyl group to increase alpha selectivity Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
10.

Production of a potent levorotatory diastereoisomer Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
11.

Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity Identify where the substitution takes place
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
12.

Adding a tertiary butyl group to make the drug more selective to beta 2 receptors Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
13.

Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier. Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
14.

Lengthening with introduction of new groups converting the drug into antagonists. Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
15.

Adding a hydroxyl group making the drug act as a direct sympathomimetic. Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
16.

Adding CH₃CH₂ which increases the drug to be more selective to beta receptors. Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
17.

Adding a hydroxyl group which makes the drug more polar thus having poor CNS action Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
18.

Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity. Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
19.

Producing a potent dextrorotatory diastereoisomer. Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
20.

Adding a hydroxyl group which is essential for alpha agonistic action. Identify where the substitution takes place.
- A.
  
  3^rd Carbon
- B.
  
  4^th Carbon
- C.
  
  5^th Carbon
- D.
  
  Beta Carbon
- E.
  
  Alpha Carbon
- F.
  
  Ethyl Bridge
- G.
  
  Amine
21.

Which statement is TRUE about the parent molecule for steroids? (you can tick more than once)
- A.
  
  It is a 17 carbon structure arranged in four fused rings
- B.
  
  First three rings are 5-member cyclopentanes
- C.
  
  The fourth ring is a cyclohexane.
- D.
  
  AKA cyclopentanoperhydrophenanthrene
22.

Which statement is TRUE about the structure of Corticosteroids? (you can tick more than once)
- A.
  
  It has 2 methyl groups.
- B.
  
  It is a 21 carbon skeletal structure.
- C.
  
  It has a hydroxymethyl group on the 21^st carbon
- D.
  
  It only has 1 ketone group.
- E.
  
  One of the methyl groups is attached on the 13^th carbon.
23.

It is required for the binding capacity to the opioid receptor.
- A.
  
  Protonated amino nitrogen
- B.
  
  Protonated nitrogen in cationic conjugate
24.

It permits the binding of molecule to the aspartate residue in the opioid receptor
- A.
  
  Protonated nitrogen in cationic conjugate
- B.
  
  Phenethyl group in the R1
25.

It significantly the mu receptor affinity and CNS distribution
- A.
  
  Phenethyl group in the R1
- B.
  
  Lengthening R1 attachment from the nitrogen atom

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