Phchem 4 Final Exam Mw 4-5:30pm

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  • 1/50 Questions

    Less incidences of side effects occur when

    • The pharmacophore is more specific or selective.
    • There is modification of chemical group responsible for interactions with unwanted receptors.
    • Specificity of the drug is improved
    • All of the answers
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Phchem 4 Final Exam Mw 4-5:30pm - Quiz

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  • 2. 
    Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity Identify where the substitution takes place - ProProfs

    Adding two carbons between amine and phenyl to have the best sympathetic agonistic activity Identify where the substitution takes place

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Ethyl Bridge
  • 3. 

    Loratadine is an example of a second-generation antihistamine

    • True

    • False

    Correct Answer
    A. True
  • 4. 
    It significantly the mu receptor affinity and CNS distribution - ProProfs

    It significantly the mu receptor affinity and CNS distribution

    • Phenethyl group in the R1

    • Lengthening R1 attachment from the nitrogen atom

    Correct Answer
    A. Phenethyl group in the R1
  • 5. 
    Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity. Identify where the substitution takes place. - ProProfs

    Adding small molecules to make the drug more MAO resistant thus increasing duration of action of pharmacological activity. Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Alpha Carbon
  • 6. 

    The spacer is an Oxygen atom in the ethylenediamine series

    • True

    • False

    Correct Answer
    A. False
  • 7. 

    Ethanolamine series structure possesses additional antimuscarinic activity.

    • True

    • False

    Correct Answer
    A. True
  • 8. 

    Phenothiazine derivatives are First Generation Antihistamines

    • True

    • False

    Correct Answer
    A. True
  • 9. 

    It studies the association between the 3D structure of a molecule with its biological, pharmacological, and chemical activity on the receptors.

    • Pharmacology

    • Medicinal Chemistry

    • Structure-activity Relationship

    • Organic Medicinals

    Correct Answer
    A. Structure-activity Relationship
  • 10. 

    The parent molecule of NE and Epinephrine has a phenyl molecule at one pole which is linked with an amine group at the other end by a two carbon chain which is called _____

    • Methyl bridge

    • Ethylamine linkage

    • Carbon chain

    • Ethyl bridge

    Correct Answer
    A. Ethyl bridge
  • 11. 

    In the parent molecular of NE and Epinephrine, the carbon atom which is near to an amine end is termed______.

    • B-carbon

    • Gamma carbon

    • Alpha carbon

    • None of the answers

    Correct Answer
    A. Alpha carbon
  • 12. 

    When the alkyl group in the two carbon of the spacer has higher size, it increases anticholinergic effect

    • True

    • False

    Correct Answer
    A. True
  • 13. 
    Adding a tertiary butyl group to make the drug more selective to beta 2 receptors Identify where the substitution takes place. - ProProfs

    Adding a tertiary butyl group to make the drug more selective to beta 2 receptors Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Amine
  • 14. 
    Adding a hydroxyl group making the drug act as a direct sympathomimetic. Identify where the substitution takes place. - ProProfs

    Adding a hydroxyl group making the drug act as a direct sympathomimetic. Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Beta Carbon
  • 15. 
    Adding a hydroxyl group which makes the drug more polar thus having poor CNS action Identify where the substitution takes place. - ProProfs

    Adding a hydroxyl group which makes the drug more polar thus having poor CNS action Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Beta Carbon
  • 16. 
    Adding a bulkier group would increase beta agonistic action. Identify where the substitution takes place - ProProfs

    Adding a bulkier group would increase beta agonistic action. Identify where the substitution takes place

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Amine
  • 17. 
    Production of a potent levorotatory diastereoisomer Identify where the substitution takes place. - ProProfs

    Production of a potent levorotatory diastereoisomer Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Beta Carbon
  • 18. 
    Lengthening with introduction of new groups converting the drug into antagonists. Identify where the substitution takes place. - ProProfs

    Lengthening with introduction of new groups converting the drug into antagonists. Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Ethyl Bridge
  • 19. 
    Adding a hydroxyl group which is essential for alpha agonistic action. Identify where the substitution takes place. - ProProfs

    Adding a hydroxyl group which is essential for alpha agonistic action. Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. 3rd Carbon
  • 20. 
    It permits the binding of molecule to the aspartate residue in the opioid receptor - ProProfs

    It permits the binding of molecule to the aspartate residue in the opioid receptor

    • Protonated nitrogen in cationic conjugate

    • Phenethyl group in the R1

    Correct Answer
    A. Protonated nitrogen in cationic conjugate
  • 21. 
    Mast cell degranulation and results in Allergy - ProProfs

    Mast cell degranulation and results in Allergy

    • –OH at C-6

    • Keto group at C-6

    Correct Answer
    A. –OH at C-6
  • 22. 

    When the spacer is Carbon itself then the compound is called alkylamines

    • True

    • False

    Correct Answer
    A. True
  • 23. 
    Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier. Identify where the substitution takes place. - ProProfs

    Adding an aryl group which increases its lipophilic nature and can cross the blood brain barrier. Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Amine
  • 24. 

    Which statement is TRUE about the parent molecule for steroids? (you can tick more than once)

    • It is a 17 carbon structure arranged in four fused rings

    • First three rings are 5-member cyclopentanes

    • The fourth ring is a cyclohexane.

    • AKA cyclopentanoperhydrophenanthrene

    Correct Answer(s)
    A. It is a 17 carbon structure arranged in four fused rings
    A. AKA cyclopentanoperhydrophenanthrene
  • 25. 

    When two aromatic groups present in the antihistamines are connected to each other with heteroatoms like N or S then the compound is called Tricyclic antihistamines

    • True

    • False

    Correct Answer
    A. True
  • 26. 

    Addition of bulker and short-chain molecules to the alkyl group in the tertiary amine produces antihistamines with less lipophilicity and less blood brain barrier entry called second-generation antihistamines

    • True

    • False

    Correct Answer
    A. False
  • 27. 
    Pure mu receptor antagonism - ProProfs

    Pure mu receptor antagonism

    • Adding OH group C-14 and cyclopropane in the R1

    • R1 substitution is cyclobutylmethyl group

    • Option 3

    • Option 4

    Correct Answer
    A. Adding OH group C-14 and cyclopropane in the R1
  • 28. 
    Very low bioavailability - ProProfs

    Very low bioavailability

    • –OH at C-3

    • –OH at C-14

    • Option 3

    • Option 4

    Correct Answer
    A. –OH at C-3
  • 29. 
    Provides significant resistance to metabolism with high bioavailability - ProProfs

    Provides significant resistance to metabolism with high bioavailability

    • RCOOR at C-3

    • OH at C-14

    • Option 3

    • Option 4

    Correct Answer
    A. RCOOR at C-3
  • 30. 

    The parent molecule of Catecholamines

    • Norepinephrine

    • Adrenaline

    • B-phenylalalnine

    • B-phenylethylamine

    Correct Answer
    A. B-phenylethylamine
  • 31. 

    What are the targets for structural alterations for the parent molecule of catecholamines?

    • Amino Group, ethyl bridge, benzene ring

    • Hydrogen, nitrogen, carbon chain, aromatic ring

    • Benzene ring, alpha and beta carbon in ethyl bridge, amino group and separation of ethyl bridge

    • None of the answers

    Correct Answer
    A. Benzene ring, alpha and beta carbon in ethyl bridge, amino group and separation of ethyl bridge
  • 32. 
    Adding CH3CH2 which increases the drug to be more selective to beta receptors. Identify where the substitution takes place. - ProProfs

    Adding CH3CH2 which increases the drug to be more selective to beta receptors. Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Alpha Carbon
  • 33. 
    Mu receptor antagonism is retained but the molecule gains additional Kappa receptor agonism. - ProProfs

    Mu receptor antagonism is retained but the molecule gains additional Kappa receptor agonism.

    • R1 substitution is cyclobutylmethyl group

    • Phenol group at C-3

    • Option 3

    • Option 4

    Correct Answer
    A. R1 substitution is cyclobutylmethyl group
  • 34. 

    Essential criterion for mu and kappa receptor binding

    • Phenol group at C-3

    • Mu and Kappa receptor binding

    • Option 3

    • Option 4

    Correct Answer
    A. Phenol group at C-3
  • 35. 
    Increase CNS penetration and agonism at mu and kappa receptor but decrease antitussive activity - ProProfs

    Increase CNS penetration and agonism at mu and kappa receptor but decrease antitussive activity

    • –OH at C-14

    • OH at C-6

    • Option 3

    • Option 4

    Correct Answer
    A. –OH at C-14
  • 36. 
    It is required for the binding capacity to the opioid receptor. - ProProfs

    It is required for the binding capacity to the opioid receptor.

    • Protonated amino nitrogen

    • Protonated nitrogen in cationic conjugate

    Correct Answer
    A. Protonated amino nitrogen
  • 37. 
    Producing a potent dextrorotatory diastereoisomer. Identify where the substitution takes place. - ProProfs

    Producing a potent dextrorotatory diastereoisomer. Identify where the substitution takes place.

    • 3rd Carbon

    • 4th Carbon

    • 5th Carbon

    • Beta Carbon

    • Alpha Carbon

    • Ethyl Bridge

    • Amine

    Correct Answer
    A. Alpha Carbon
  • 38. 
    Antagonism of mu receptor - ProProfs

    Antagonism of mu receptor

    • Lengthening R1 attachment from the nitrogen atom

    • Adding OH group C-14 and cyclopropane in the R1

    Correct Answer
    A. Lengthening R1 attachment from the nitrogen atom
  • 39. 

    In the case of the ethanolamine series, the spacer will be carbon atom linked to the nitrogen molecule and then to the tertiary amine

    • True

    • False

    Correct Answer
    A. False
  • 40. 

    When the alkyl group substituted in the 2 carbon of the spacer has shorter size, then the antihistaminic activity has decreased dramatically

    • True

    • False

    Correct Answer
    A. False
  • 41. 
    Class of Antihistamine does the drug belong - ProProfs

    Class of Antihistamine does the drug belong

    • Ethanolamine

    • Piperazine derivatives

    • Ethylene diamine derivatives

    • Propylamines

    • Phenothiazine derivatives

    Correct Answer
    A. Ethanolamine
  • 42. 
    Becomes significantly metabolized and inactivated by glucuronic conjugation in GIT - ProProfs

    Becomes significantly metabolized and inactivated by glucuronic conjugation in GIT

    • –OH at C-3

    • RCOOR at C-3

    • Option 3

    • Option 4

    Correct Answer
    A. –OH at C-3
  • 43. 

    Which one do you like?

    • Option 1

    • Option 2

    • Option 3

    • Option 4

    Correct Answer
    A. Option 1
  • 44. 
    Effect of adding methoxy-esters at C-3. - ProProfs

    Effect of adding methoxy-esters at C-3.

    • Mu and Kappa receptor binding

    • –OH at C-3

    • Option 3

    • Option 4

    Correct Answer
    A. Mu and Kappa receptor binding
  • 45. 

    Piperazine derivatives are First Generation Antihistamines

    • True

    • False

    Correct Answer
    A. True
  • 46. 
    Class of Antihistamine does this drug belong to: - ProProfs

    Class of Antihistamine does this drug belong to:

    • Ethanolamine

    • Piperazine derivatives

    • Ethylene diamine derivatives

    • Propylamines

    • Phenothiazine derivatives

    Correct Answer
    A. Phenothiazine derivatives
  • 47. 

    Alkylamines possess long duration of action with low CNS penetration

    • True

    • False

    Correct Answer
    A. False
  • 48. 

    The following are improvement of pharmacokinetic properties except: (you can tick more than once)

    • Ease of administration

    • Long duration of action

    • Shorter half-life

    • Better tolerability for patient with hepatic conditions

    • Better tolerability for patients with renal impairment

    Correct Answer(s)
    A. Ease of administration
    A. Long duration of action
    A. Better tolerability for patient with hepatic conditions
    A. Better tolerability for patients with renal impairment
  • 49. 

    Which statement is TRUE about the structure of Corticosteroids? (you can tick more than once)

    • It has 2 methyl groups.

    • It is a 21 carbon skeletal structure.

    • It has a hydroxymethyl group on the 21st carbon

    • It only has 1 ketone group.

    • One of the methyl groups is attached on the 13th carbon.

    Correct Answer(s)
    A. It has 2 methyl groups.
    A. It is a 21 carbon skeletal structure.
    A. It has a hydroxymethyl group on the 21st carbon
    A. It only has 1 ketone group.
    A. One of the methyl groups is attached on the 13th carbon.

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