Pharmacology Exam 4 Antihistamines

26 Questions

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Pharmacology Exam 4 Antihistamines

When you catch cold, there are some symptoms that accompany it and the use of antihistamines gives you a way of relieving them. Below is the fourth practice exam that is designed to help you review what you understood about these types of drugs. Why don’t you give it a try and see what you know about them so far?


Questions and Answers
  • 1. 
    • A. 

      Cyclizine

    • B. 

      Doxepin

    • C. 

      Doxylamine

    • D. 

      Fexofenadine

  • 2. 
    • A. 

      Second generation H1 antihistamines are relatively free of adverse effects

    • B. 

      The motor coordination involved in driving an automobile is not affected by the use of first gen H1 antihistamines.

    • C. 

      H1 antihistamines can be used in the treatment of acute anaphylaxis.

    • D. 

      Both first and second gen H1 antihistamines readily penetrate the blood brain barrier

  • 3. 
    Which one of the following agents could significantly impair the ability to drive an automobile?
    • A. 

      Ergotamine

    • B. 

      Fexofenadine

    • C. 

      Diphenhydramine

    • D. 

      Ranitidine

  • 4. 
    Which of the following is the most frequent side effect of H1 antihistamines that is less common with second gen antihistamines?
    • A. 

      Decreased appetite

    • B. 

      Sedation

    • C. 

      Bradycardia

    • D. 

      Hypertension

  • 5. 
    Prostaglandins, histamine and serotonin all belong to a group of endogenous compounds called
    • A. 

      Bellacoids

    • B. 

      Autacoids

    • C. 

      Donnacoids

    • D. 

      Don't know

  • 6. 
    Which type of cell is histamine mostly produced in?
    • A. 

      Eosinophil

    • B. 

      Basophil

    • C. 

      Mast cell

    • D. 

      Cytokines

  • 7. 
    Histamine is distributed equally among tissue. 
    • A. 

      True

    • B. 

      False

  • 8. 
    Histamine has no clinical indication.
    • A. 

      True

    • B. 

      False

  • 9. 
    • A. 

      H1 and H4

    • B. 

      H1 and H2

    • C. 

      H2 and H4

    • D. 

      H3 and H1

  • 10. 
    • A. 

      Smooth muscle relaxation and increase in capillary permeability

    • B. 

      Smooth muscle contraction and increase in capillary permeability

  • 11. 
    Histamine stimulates what type of cell in the stomach?
    • A. 

      Alveolar cells

    • B. 

      Interstitial cells

    • C. 

      Gastric acid

    • D. 

      Parietal cell

  • 12. 
    H1 receptor blockers are more effective in reversing symptoms than preventing them.
    • A. 

      True

    • B. 

      False

  • 13. 
    • A. 

      True

    • B. 

      False

  • 14. 
    H1 antihistamines used for motion sickness and nausea include
    • A. 

      Diphenhydramine and meclizine

    • B. 

      Toradol and meclizine

    • C. 

      Epinephrine and loratidine

    • D. 

      Loratidine

  • 15. 
    H1 antihistamines are contraindicated in which patient population?
    • A. 

      Those who need to be awake (now who doesn't?)

    • B. 

      Those with easy jobs

  • 16. 
    What is one of the benefits of the pK of many oral antihistamines?
    • A. 

      Allows for twice daily dosing

    • B. 

      Allows for once daily dosing

    • C. 

      Allows for subq injections

    • D. 

      Allow to divided into many smaller doses

  • 17. 
    Which class doesn't cross the BBB?
    • A. 

      H1

    • B. 

      H2

  • 18. 
    Some H1 receptor blockers have effects on other tissue.  One of the effects of these drugs on serotonin receptors is?
    • A. 

      Decreased appetite

    • B. 

      Increased appetite

    • C. 

      Urinary retention

    • D. 

      Polydipsia

  • 19. 
    Again on the extra effects of H1 receptor blockers...which of these is NOT an effect on H1 receptor blockers at cholinergic receptors?
    • A. 

      Increased hypotension

    • B. 

      Increased dry mouth

    • C. 

      Increased urinary retention

    • D. 

      Sinus tachycardia

  • 20. 
    What effect would antihistamines potentially have on someone taking a CNS depressant?
    • A. 

      Decreased effects of CNS depressant

    • B. 

      No affect on CNS depressant

    • C. 

      Increased effects of CNS depressant

  • 21. 
    Contraindication of antihistamines with patients taking MAOIs - what is the effect?
    • A. 

      Exacerbation of anticholinergic effects

    • B. 

      Decreased anticholinergic effects

    • C. 

      Exacerbation of antimuscarinic effects

    • D. 

      Decreased antimuscarinic effects

  • 22. 
    Nasal decongestants are
    • A. 

      Beta adrenergic agonists

    • B. 

      Alpha adrenergic agonists

    • C. 

      Beta adrenergic antagonists

    • D. 

      Alpha adrenergic antagonists

  • 23. 
    Effect of nasal decongestants......
    • A. 

      Constrict dilated arterioles in nasal mucosa and reduce airway resistance

    • B. 

      Dilate constricted arterioles in nasal mucosa and reduce airway resistance

  • 24. 
    You should not use nasal decongestants longer than how many days?
    • A. 

      1

    • B. 

      5

    • C. 

      7

    • D. 

      3

  • 25. 
    WHAT IS THE term for rebound nasal congestion?
    • A. 

      Rhinitis medusa

    • B. 

      Polly pockets

    • C. 

      Rhinitis medicamentosa

    • D. 

      Rhinitis adversica

  • 26. 
    H1 and H2 receptor blockers can cause a classic "triple response" on skin.  This includes which the following?
    • A. 

      Pain, pallor, pink

    • B. 

      Wheal, reddening and flare

    • C. 

      Purpura, edema and pain

    • D. 

      Wheal, pallor and flare