Pharmacology Exam 4 Antihistamines

26 Questions | By Perduekm | Last updated: May 2, 2019

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When you catch cold, there are some symptoms that accompany it and the use of antihistamines gives you a way of relieving them. Below is the fourth practice exam that is designed to help you review what you understood about these types of drugs. Why don’t you give it a try and see what you know about them so far?

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Questions and Answers

1.

A 43 yo ship captain complains of seasonal allergies. Which one of the following would be indicated?

Discuss
- A.
  
  Cyclizine
- B.
  
  Doxepin
- C.
  
  Doxylamine
- D.
  
  Fexofenadine
2.

Which one of the following states regarding H1 antihistamines is correct?

Discuss
- A.
  
  Second generation H1 antihistamines are relatively free of adverse effects
- B.
  
  The motor coordination involved in driving an automobile is not affected by the use of first gen H1 antihistamines.
- C.
  
  H1 antihistamines can be used in the treatment of acute anaphylaxis.
- D.
  
  Both first and second gen H1 antihistamines readily penetrate the blood brain barrier
3.

Which one of the following agents could significantly impair the ability to drive an automobile?
- A.
  
  Ergotamine
- B.
  
  Fexofenadine
- C.
  
  Diphenhydramine
- D.
  
  Ranitidine
4.

Which of the following is the most frequent side effect of H1 antihistamines that is less common with second gen antihistamines?
- A.
  
  Decreased appetite
- B.
  
  Sedation
- C.
  
  Bradycardia
- D.
  
  Hypertension
5.

Prostaglandins, histamine and serotonin all belong to a group of endogenous compounds called
- A.
  
  Bellacoids
- B.
  
  Autacoids
- C.
  
  Donnacoids
- D.
  
  Don't know
6.

Which type of cell is histamine mostly produced in?
- A.
  
  Eosinophil
- B.
  
  Basophil
- C.
  
  Mast cell
- D.
  
  Cytokines
7.

Histamine is distributed equally among tissue.
- A.
  
  True
- B.
  
  False
8.

Histamine has no clinical indication.
- A.
  
  True
- B.
  
  False
9.

Histamine is released in response to various stimuli and effects of binding to one of four types of receptors. Which group of receptors are widely expressed and targeted by clinically useful drugs?

Discuss
- A.
  
  H1 and H4
- B.
  
  H1 and H2
- C.
  
  H2 and H4
- D.
  
  H3 and H1
10.

H1 receptors produce what effects?

Discuss
- A.
  
  Smooth muscle relaxation and increase in capillary permeability
- B.
  
  Smooth muscle contraction and increase in capillary permeability
11.

Histamine stimulates what type of cell in the stomach?
- A.
  
  Alveolar cells
- B.
  
  Interstitial cells
- C.
  
  Gastric acid
- D.
  
  Parietal cell
12.

H1 receptor blockers are more effective in reversing symptoms than preventing them.
- A.
  
  True
- B.
  
  False
13.

The drug of choice in systemic anaphylactic shock is H1 receptor blockers.

Discuss
- A.
  
  True
- B.
  
  False
14.

H1 antihistamines used for motion sickness and nausea include
- A.
  
  Diphenhydramine and meclizine
- B.
  
  Toradol and meclizine
- C.
  
  Epinephrine and loratidine
- D.
  
  Loratidine
15.

H1 antihistamines are contraindicated in which patient population?
- A.
  
  Those who need to be awake (now who doesn't?)
- B.
  
  Those with easy jobs
16.

What is one of the benefits of the pK of many oral antihistamines?
- A.
  
  Allows for twice daily dosing
- B.
  
  Allows for once daily dosing
- C.
  
  Allows for subq injections
- D.
  
  Allow to divided into many smaller doses
17.

Which class doesn't cross the BBB?
- A.
  
  H1
- B.
  
  H2
18.

Some H1 receptor blockers have effects on other tissue. One of the effects of these drugs on serotonin receptors is?
- A.
  
  Decreased appetite
- B.
  
  Increased appetite
- C.
  
  Urinary retention
- D.
  
  Polydipsia
19.

Again on the extra effects of H1 receptor blockers...which of these is NOT an effect on H1 receptor blockers at cholinergic receptors?
- A.
  
  Increased hypotension
- B.
  
  Increased dry mouth
- C.
  
  Increased urinary retention
- D.
  
  Sinus tachycardia
20.

What effect would antihistamines potentially have on someone taking a CNS depressant?
- A.
  
  Decreased effects of CNS depressant
- B.
  
  No affect on CNS depressant
- C.
  
  Increased effects of CNS depressant
21.

Contraindication of antihistamines with patients taking MAOIs - what is the effect?
- A.
  
  Exacerbation of anticholinergic effects
- B.
  
  Decreased anticholinergic effects
- C.
  
  Exacerbation of antimuscarinic effects
- D.
  
  Decreased antimuscarinic effects
22.

Nasal decongestants are
- A.
  
  Beta adrenergic agonists
- B.
  
  Alpha adrenergic agonists
- C.
  
  Beta adrenergic antagonists
- D.
  
  Alpha adrenergic antagonists
23.

Effect of nasal decongestants......
- A.
  
  Constrict dilated arterioles in nasal mucosa and reduce airway resistance
- B.
  
  Dilate constricted arterioles in nasal mucosa and reduce airway resistance
24.

You should not use nasal decongestants longer than how many days?
- A.
  
  1
- B.
  
  5
- C.
  
  7
- D.
  
  3
25.

WHAT IS THE term for rebound nasal congestion?
- A.
  
  Rhinitis medusa
- B.
  
  Polly pockets
- C.
  
  Rhinitis medicamentosa
- D.
  
  Rhinitis adversica
26.

H1 and H2 receptor blockers can cause a classic "triple response" on skin. This includes which the following?
- A.
  
  Pain, pallor, pink
- B.
  
  Wheal, reddening and flare
- C.
  
  Purpura, edema and pain
- D.
  
  Wheal, pallor and flare

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