Otterbein/Grant CRNA A&p Liver And Renal Essay Quiz Review

18 Questions | Total Attempts: 52

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Liver Quizzes & Trivia

Questions and Answers
  • 1. 
    Protein synthesis: All of the following proteins are synthesized in the liver except:
    • A. 

      Albumin

    • B. 

      Pseudocholinesterase

    • C. 

      Urea

    • D. 

      Factor VIII and vWF

    • E. 

      Coagulation factors except VIII vWF

  • 2. 
    Protein synthesis: Urea is formed in the liver by combing two molecules of _________ with CO2.
  • 3. 
    Protein synthesis: In liver disease with decreased protein synthesis, protein-bound drugs will have a lesser clinical effect than in a healthy individual.
    • A. 

      True

    • B. 

      False

  • 4. 
    Drug metabolism/transformation: Phase II reaction conjugates the product of phase I with a subsequent molecule such as glucoronide, sulfate, taurine, or glycine.  Products of phase II have a larger molecular weight and are ionized, making them more _______ soluble, facilitating excreting and decreasing pharmacologic activity.
  • 5. 
    Drug metabolism/biotransformation: P-450 enzyme activity is _________ by a number of drugs including alcohol, phenytoin, and barbiturates.  This is called enzyme induction, meaning that an apparent tolerance develops due to the rapid metabolism of drugs by P-450.  
    • A. 

      Increased

    • B. 

      Decreased

  • 6. 
    Drug metabolism/Biotransformation: Which phase adds or exposes a functional group via oxidation, reduction, deamination, or other processes involving cytochrome P-450 enzymes?
    • A. 

      Phase I

    • B. 

      Phase II

  • 7. 
    Hepatic blood flow: The liver receives approximately 1.5 L/min of blood flow, which is ___% of cardiac output?
    • A. 

      10

    • B. 

      25

    • C. 

      5

    • D. 

      30

  • 8. 
    Hepatic blood flow: The liver can compensate up to 25% of total blood volume during acute hemorrhage by expelling blood immediately from capacitance vessels.
    • A. 

      True

    • B. 

      False

  • 9. 
    Hepatic blood flow: There are alpha and beta receptors in the hepatic artery but only _____ receptors in the portal vein.
  • 10. 
    Hepatic blood flow: A decrease/increase in either arterial or venous circulation is met by a compensatory increase/decrease in blood flow from the other system.  This is called the hepatic artery buffer response (HABR) system, which allows the arterial/venous flow to change but not change overall total hepatic blood flow.
    • A. 

      True

    • B. 

      False

  • 11. 
    GFR: Renal blood flow is approximately 650 mL/min (20%-25% of cardiac output) - what percentage of this blood flow becomes filtrate?
  • 12. 
    GFR: The glomerular _____ pressure is a high pressure (60 mmhg) exerted against the walls of the glomelular capillaries, it is the primary determinant of the amount of filtration occurring. 
  • 13. 
    GFR: The glomerular capillary lining is made up of pores that are __________ charged.
    • A. 

      Positively

    • B. 

      Negatively

    • C. 

      Neutrally

  • 14. 
    GFR: Which of the following will not become filtrate?
    • A. 

      Na+

    • B. 

      Glucose

    • C. 

      Albumin

    • D. 

      RBC

    • E. 

      Amino acids

    • F. 

      Urea

    • G. 

      Creatinine

  • 15. 
    GFR: Juxtaglomerular cells are smooth muscle cells in the arterioles that are sensitive to stretch – when they sense decreased renal blood flow they release renin in an attempt to maintain renal blood flow and GFR.
    • A. 

      True

    • B. 

      False

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