Clinical Microbiology Hardest Exam! Quiz

Neuraminidase

Hyaluronidase

Collagenase

Option 4

Collagenase that breaks down the framework of muscles, which facilitates gas gangrene

Streptokinase that convrt plasminogen to plasmin

Phospholipases that hydrolyze phospholipids in cell membranes by removal of polar head groups

Hyaluronidase that attacks the interstitial cement of connective tissue by depolymerizing hyaluronic acid

Skin

Conjunctiva

Outer ear

Nasopharynx

Oropharynx

Small intestine

Colon

Distal urethra

Vagina

Binds to 23s rRNA of 50s Subunit, inhibiting the formation of ribosome mRNA complex

Blocks ribosomal exit tunnel, terminating peptide synthesis

Inhibits isoleucine synthetase, preventing it from binding to tRNA to be incorporated into the peptie chairn

Irreversibly binds 50s subunit, inhibiting peptidyl transferase

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Reversibly binds the 23s rRNA of the 50s subunit, inhibiting the formation of the ribosome-mRNA complex

Reversibly binds the 50s subunit inhibiting translocatio of tRNA from A site to P site

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Reversibly bind the 50s subunit, preventing peptidyl transferase activity, inhibiting the translocation of tRNA from A site to P site

Prevents peptide bond formation during elongation

Binds to RNA Polymerase inhibiting the initiation of trasncription

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Irreversibly binds the 50s subunit preventing peptide bond formation during elongation

Reversibly bind the 50s subunit, inhibiting translocation of tRNA from A site to P site, causing premature dissociation of the peptidyl-tRNA from the ribosome

Energy dependent, sometimes irreversible finding to the 30s subunit, disrupting the formation of ribosome-mRNA complex. causing errors in translation, and blocks translocation

Irreversibly bind to the 50s subunit . Group A prevents peptide bond formation during elongation. Group B causes premature dissociation of peptidyl-tRNA from the ribosome

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Binds to 30s, sometimes irreversibly, disrupting the formation of ribosome-mRNA complex, causes errors in translation, and blocks translocation

Reversibly binds to the 23s rRNA of the 50s subunit, inhibiting the formation of the ribosome-mRNA complex

Blocks the ribosomal exit tunnel, thus terminating peptide synthesis

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Reversibly binds to the 23s rRNA of the 50s subunit, inhibiting the formation of the ribosome-mRNA complex

Binds to the 50s subunit, inhibiting translocation of tRNA from A site to P site, causing premature dissociation of peptidyl-tRNA from the ribosome

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Irreversibly binds to the 50s subunit, inhibiting peptidyl transferase

Energy-dependent, sometimes irreversible binding to the 30s subunit, disrupting the formation of the ribosome-mRNA complex, causing errors in translation, blocking translocation

Blocks the ribosomal exit tunnel, terminating peptide synthesis

Energy dependent, sometimes irreversible binding to the 30s subunit, disrupting the formation of the ribosome-mRNA complex, causes errors in translation, blocking translocation

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of prrotein synthesis

Reversibly binds to the 23s rRNA of the 50s subunit, inhibiting the formation of the ribosome-mRNA complex

Reversibly binds to bacterial isoleucyl-tRNA synthetase, inhibiting this enzyme keeps isoleucine from being added to the forming protein

Energy dependent, sometimes irreversible, binding to the 30s subunit, disrupting the formation of the ribosome-mRNA cmoplex, causing errors in translation, blocks translocation

Binds to 30s subunit and inhibits binding of aminoacyl-tRNA to the A site, interrupting elongation of protein synthesis

Irreversibly binds to the 50s subunit, preventing peptide bond formation during elongation, causing premature dissociation of peptidyl-tRNA from the ribosome

Reversibly bidns to the 50s subunit, inhibiting translocation of tRNA from A site to P site, causing premature dissociation of peptidyl-tRNA from the ribosome

Unwinds the DNA chain after topoisomerase has done its thing

Reverses the twists to relax the stress on the DNA strand

Reverses the twists to relax the stress on the DNA strand

Unwinds the DNA supercoil so that Helicase can do its thing

Structurally similar to PABA so they competitively bind to dihydropteroate synthase, thus preveting synthesis of DNA and proteins

Blocks the production of tetrahydrofolic acid by binding to and reversibly inhibiting dihydrofolate reductase

In an anaerobic environment, passively diffuses into cytoplasm of bacteria and is reduced to form nitroso free radical that interacts with DNA, inhibiting its synthesis and causinff its fragmentation, leading to death of the bacteria

Inhibit DNA Gyrase, leading to fracturing of the DNA and bacterial cell death, targeting Gram – bacteria. Targets Gram + bacteria by inhibiting Topoisomerasae IV, preventing the separation of daughter strands, fracturing DNA

Blocks the production of tetrahydrofolic acid by binding to and reversibly inhibiting dihydrofolate reductase

In an anaerobic environment, passively diffuses into cytoplasm of bacteria and is reduced to form nitroso free radical that interacts with DNA, inhibiting its synthesis and causing its fragmentation, leading to death of the bacteria

Structurally similar to PABA so they competitively bind to dihydropteroate synthase, thus preveting synthesis of DNA and proteins

In an anaerobic environment, passively diffuses into cytoplasm of bacteria and is reduced to form nitroso free radical that interacts with DNA, inhibiting its synthesis and causing its fragmentation, leading to death of the bacteria

Structurally similar to PABA so they competitively bind to dihydropteroate synthase, thus preveting synthesis of DNA and proteins

Blocks the production of tetrahydrofolic acid by binding to and reversibly inhibiting dihydrofolate reductase

Inhibit DNA Gyrase, leading to fracturing of the DNA and bacterial cell death, targeting Gram – bacteria. Targets Gram + bacteria by inhibiting Topoisomerasae IV, preventing the separation of daughter strands, fracturing DNA

Structurally similar to PABA so they competitively bind to dihydropteroate synthase, thus preveting synthesis of DNA and proteins

Blocks the production of tetrahydrofolic acid by binding to and reversibly inhibiting dihydrofolate reductase

In an anaerobic environment, passively diffuses into cytoplasm of bacteria and is reduced to form nitroso free radical that interacts with DNA, inhibiting its synthesis and causing its fragmentation, leading to death of the bacteria

Inhibit DNA Gyrase, leading to fracturing of the DNA and bacterial cell death, targeting Gram – bacteria. Targets Gram + bacteria by inhibiting Topoisomerasae IV, preventing the separation of daughter strands, fracturing DNA

Topoisomerase-->Gyrase-->Tetrahydrofolic Acid-->RNA Polymerase-->DNA Polymerase-->DNA Ligase-->Helicase-->Topoisomerase IV

Topoisomerase IV-->Helicase-->Tetrahydrofolic Acid-->RNA Polymerase-->DNA Polymerase-->DNA Ligase-->DNA Gyrase-->Topoisomerases

Topoisomerase-->Helicase-->Tetrahydrofolic Acid-->RNA Polymerase-->DNA Polymerase-->DNA Ligase-->DNA Gyrase-->Topoisomerase IV

Topoisomerase II-->Helicase-->Tetrahydrofolic Acid-->RNA Polymerase-->DNA polymerase-->DNA ligase--> DNA Gyrase-->Topoisomerase IV

Blocks the production of tetrahydrofolic acid by binding to and reversibly inhibiting dihydrofolate reductase

Structurally similar to PABA so they competitively bind to dihydropteroate synthase, thus preveting synthesis of DNA and proteins

Inhibit DNA Gyrase, leading to fracturing of the DNA and bacterial cell death, targeting Gram – bacteria. Targets Gram + bacteria by inhibiting Topoisomerasae IV, preventing the separation of daughter strands, fracturing DNA

In an anaerobic environment, passively diffuses into cytoplasm of bacteria and is reduced to form nitroso free radical that interacts with DNA, inhibiting its synthesis and causing its fragmentation, leading to death of the bacteria

Streptococcus pyogenes

Staphylococcus aureus

Clostridium tetani

E. Coli

Staph aureus

Streptococcus pyogenes

Clostridium tetani

Corynebacterium diptheriae

Corynebacterium diptheriae

Clostridium botulinum

E. Coli

Streptococcus pyogenes

Strep pyogenes

Clostridium tetani

E. Coli

Staph aureus